{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:13:35Z","timestamp":1767651215752,"version":"3.37.3"},"reference-count":10,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr J"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T-cell leukemia virus type 1 was isolated as the retrovirus to be identified in humans. Here, we focused on <jats:italic>Ficus pumila L.<\/jats:italic> as a factor that be effective against human T-cell leukemia virus type 1. The significant and novel findings is that symptoms of patients with drinking <jats:italic>Ficus pumila L.<\/jats:italic> extracts did not worsen despite a lack of aggressive pharmacotherapy against adult T-cell leukemia, a human T-cell leukemia virus type 1-associated myelopathy, or T-cell leukemia virus type 1 uveitis. Twenty-eight of the 194 inpatients who underwent showed high levels of human T-cell leukemia virus type 1.<\/jats:p><jats:p>Among human T-cell leukemia virus type 1-infected patients, those who were administered <jats:italic>Ficus pumila L<\/jats:italic>. extracts had no human T-cell leukemia virus type 1-related symptoms, while those who were not administered <jats:italic>Ficus pumila L.<\/jats:italic> extracts had human T-cell leukemia virus type 1-related diseases and a significantly poorer prognosis. This suggests that the <jats:italic>Ficus pumila L.<\/jats:italic> extracts may show some utility against virus infection.<\/jats:p>","DOI":"10.1186\/s12937-021-00672-x","type":"journal-article","created":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T17:04:01Z","timestamp":1613063041000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ficus pumila L. improves the prognosis of patients infected with HTLV-1, an RNA virus"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7671-1808","authenticated-orcid":false,"given":"Kenji","family":"Gonda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Sunabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Kono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichi","family":"Takenoshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,2,11]]},"reference":[{"key":"672_CR1","doi-asserted-by":"crossref","unstructured":"Suzuki K, Gonda K, Kishimoto Y, Katsumoto Y, Takenoshita S. Potential curing and beneficial effects of Ooitabi (Ficus pumila L.) on hypertension and dyslipidaemia in Okinawa. J Hum Nutr Diet. 2020; Online ahead of print.","DOI":"10.1111\/jhn.12806"},{"key":"672_CR2","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3389\/fgene.2012.00295","volume":"3","author":"GC Sampey","year":"2012","unstructured":"Sampey GC, Van Duyne R, Currer R, Das R, Narayanan A, Kashanchi F. Complex role of microRNAs in HTLV-1 infections. Front Genet. 2012;3:295.","journal-title":"Front Genet"},{"key":"672_CR3","doi-asserted-by":"crossref","unstructured":"Liao CR, Kao CP, Peng WH, Chang YS, Lai SC, Ho YL. Analgesic and Anti-Inflammatory Activities of Methanol Extract of Ficus pumila L in Mice. Evid Based Complement Alternat Med. 2012:340141.","DOI":"10.1155\/2012\/340141"},{"key":"672_CR4","doi-asserted-by":"crossref","unstructured":"Tomita M. Important Roles of Cellular MicroRNA miR-155 in Leukemogenesis by Human T-Cell Leukemia Virus Type 1 Infection. ISRN Microbiol. 2012; Print 2012.","DOI":"10.5402\/2012\/978607"},{"issue":"10","key":"672_CR5","doi-asserted-by":"publisher","first-page":"2300","DOI":"10.1002\/ijc.25115","volume":"130","author":"M Tomita","year":"2012","unstructured":"Tomita M, Tanaka Y, Mori N. MicroRNA miR-146a is induced by HTLV-1 tax and increases the growth of HTLV-1-infected T-cells. Int J Cancer. 2012;130(10):2300\u20139.","journal-title":"Int J Cancer"},{"issue":"1","key":"672_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.ccr.2011.12.015","volume":"21","author":"M Yamagishi","year":"2012","unstructured":"Yamagishi M, Nakano K, Miyake A, Yamochi T, Kagami Y, Tsutsumi A, et al. Polycomb-mediated loss of miR-31 activates NIK-dependent NF-\u03baB pathway in adult T cell leukemia and other cancers. Cancer Cell. 2012;21(1):121\u201335.","journal-title":"Cancer Cell"},{"issue":"6","key":"672_CR7","doi-asserted-by":"publisher","first-page":"675","DOI":"10.4103\/0253-7613.194847","volume":"48","author":"R Yavari","year":"2016","unstructured":"Yavari R, Badalzadeh R, Alipour MR, Tabatabaei SM. Modulation of hippocampal gene expression of microRNA-146a\/microRNA-155-nuclear factor-kappa B inflammatory signaling by troxerutin in healthy and diabetic rats. Indian J Pharmacol. 2016;48(6):675\u201380.","journal-title":"Indian J Pharmacol"},{"issue":"4","key":"672_CR8","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/mnfr.201400705","volume":"59","author":"D Arango","year":"2015","unstructured":"Arango D, Diosa-Toro M, Rojas-Hernandez LS, Cooperstone JL, Schwartz SJ, Mo X, et al. Dietary apigenin reduces LPS-induced expression of miR-155 restoring immune balance during inflammation. Mol Nutr Food Res. 2015;59(4):763\u201372.","journal-title":"Mol Nutr Food Res"},{"issue":"1","key":"672_CR9","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1089\/jmf.2019.0059","volume":"23","author":"JA Gutierrez-Uribe","year":"2020","unstructured":"Gutierrez-Uribe JA, Salinas-Santander M, Serna-Guerrero D, Serna-Saldivar SRO, Rivas-Estilla AM, Rios-Ibarra CP. Inhibition of miR31 and miR92a as oncological biomarkers in RKO Colon Cancer cells treated with Kaempferol-3-O-glycoside isolated from black bean. J Med Food. 2020;23(1):50\u20135.","journal-title":"J Med Food"},{"key":"672_CR10","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.intimp.2019.02.014","volume":"69","author":"R Jiang","year":"2019","unstructured":"Jiang R, Hao P, Yu G, Liu C, Yu C, Huang Y, et al. Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a. Int Immunopharmacol. 2019;69:373\u201381.","journal-title":"Int Immunopharmacol"}],"container-title":["Nutrition Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12937-021-00672-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12937-021-00672-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12937-021-00672-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T17:11:44Z","timestamp":1613063504000},"score":1,"resource":{"primary":{"URL":"https:\/\/nutritionj.biomedcentral.com\/articles\/10.1186\/s12937-021-00672-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,11]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["672"],"URL":"https:\/\/doi.org\/10.1186\/s12937-021-00672-x","relation":{},"ISSN":["1475-2891"],"issn-type":[{"type":"electronic","value":"1475-2891"}],"subject":[],"published":{"date-parts":[[2021,2,11]]},"assertion":[{"value":"27 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"According to the local ethics guidelines, all blood samples were obtained for storage and analysis only after the patient gave written informed consent on a form that was approved by the local ethics committee (the Ethics Review Board of Daido Central Hospital: No.30).All procedures were in accordance with the ethical standards of the responsible committee on human experimentation at Fukushima Medical University and with the 1975.Declaration of Helsinki and its later revisions","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent to participate in the study was obtained from the legal guardians or representatives of the 194 subjects with ATL, HAM and UA.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"16"}}