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Both a water extract and a supercritical carbon dioxide extract of <jats:italic>C. longa<\/jats:italic> showed anti-inflammatory activities in animal studies. However, the anti-inflammatory effect in humans of a mixture of these two <jats:italic>C. longa<\/jats:italic> extracts (CLE) is poorly understood. Therefore, we investigated the effect of CLE containing anti-inflammatory turmeronols on chronic inflammation and general health.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a randomized, double-blind, placebo-controlled study in healthy subjects aged 50 to 69\u2009years with overweight. Participants took two capsules containing CLE (CLE group, <jats:italic>n<\/jats:italic>\u2009=\u200945) or two placebo capsules (placebo group, n\u2009=\u200945) daily for 12\u2009weeks, and serum inflammatory markers were measured. Participants also completed two questionnaires: the Medical Outcomes Study (MOS) 36-Item Short-Form Health Survey (SF-36) and the Profile of Mood States (POMS) scale. Treatment effects were analyzed by two way analysis of variance followed by a <jats:italic>t<\/jats:italic> test (significance level, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009\u00a00.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After the intervention, the CLE group had a significantly lower body weight (p\u2009&lt;\u2009\u00a00.05) and body mass index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) than the placebo group and significantly lower serum levels of C-reactive protein (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and complement component 3 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, the CLE group showed significant improvement of the MOS SF-36 mental health score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and POMS anger-hostility score (p\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>CLE may ameliorate chronic low-grade inflammation and thus help to improve mental health and mood disturbance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>UMIN-CTR, UMIN000037370. Registered 14 July 2019, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr\/ctr_view.cgi?recptno=R000042607\">https:\/\/upload.umin.ac.jp\/cgi-open-bin\/ctr\/ctr_view.cgi?recptno=R000042607<\/jats:ext-link><\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12937-021-00748-8","type":"journal-article","created":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T11:02:37Z","timestamp":1636801357000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5924-4534","authenticated-orcid":false,"given":"Ryusei","family":"Uchio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kengo","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinatsu","family":"Okuda-Hanafusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Saji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koutarou","family":"Muroyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Murosaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,13]]},"reference":[{"key":"748_CR1","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/ni.3790","volume":"18","author":"MG Netea","year":"2017","unstructured":"Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, et al. 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