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Evidence suggested that intake of curcumin and coenzyme Q10 may have therapeutic effects in the management of MetS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Aims<\/jats:title>\n                <jats:p>We investigated the effects of curcumin and\/or coenzyme Q10 supplementation on metabolic syndrome components including systolic blood pressure (SBP), diastolic blood pressure (DBP), waist circumference (WC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and fasting plasma glucose (FPG) as primary outcomes, and total cholesterol (TC), low density lipoprotein-cholesterol (LDL-c) and body mass index (BMI) as secondary outcomes in subjects with MetS.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this 2\u2009\u00d7\u20092 factorial, randomized, double-blinded, placebo-controlled study, 88 subjects with MetS were randomly assigned into four groups including curcumin plus placebo (CP), or coenzyme Q10 plus placebo (QP), or curcumin plus coenzyme Q10 (CQ), or double placebo (DP) for 12\u2009weeks.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The CP group compared with the three other groups showed a significant reduction in HDL-c (<jats:italic>P<\/jats:italic>\u2009=\u20090.001), TG (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001), TC (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001), and LDL-c (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009\u00a00.001). No significant differences were seen between the four groups in terms of SBP, DBP, FPG, WC, BMI and weight.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Curcumin improved dyslipidemia, but had no effect on body composition, hypertension and glycemic control. Furthermore, coenzyme Q10 as well as the combination of curcumin and coenzyme Q10 showed no therapeutic effects in subjects with MetS. The trial was registered on 09\/21\/2018 at the Iranian clinical trials website (IRCT20180201038585N2), URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.irct.ir\/trial\/32518\">https:\/\/www.irct.ir\/trial\/32518<\/jats:ext-link>.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12937-022-00816-7","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T05:02:18Z","timestamp":1664773338000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Effects of curcumin and\/or coenzyme Q10 supplementation on metabolic control in subjects with metabolic syndrome: a randomized clinical trial"],"prefix":"10.1186","volume":"21","author":[{"given":"Abbas Ali","family":"Sangouni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Taghdir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Mirahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Sepandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-663X","authenticated-orcid":false,"given":"Karim","family":"Parastouei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"issue":"1","key":"816_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/obr.12229","volume":"16","author":"S O\u2019Neill","year":"2015","unstructured":"O\u2019Neill S, O\u2019Driscoll L. 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The ethical committee of Baqiyatallah University of Medical Sciences approved the informed written consent (code number: IR.Bmsu.rec.1397.449). The informed written consent was obtained from all participants before the data collection.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have declared no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"62"}}