{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T06:49:09Z","timestamp":1793947749840,"version":"4.8.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"National High Level Hospital Clinical Research Funding","award":["2023-GSP-RC-05"],"award-info":[{"award-number":["2023-GSP-RC-05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Nutr J"],"DOI":"10.1186\/s12937-025-01078-9","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:19:55Z","timestamp":1737116395000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Validation of the role of apolipoproteins in coronary artery disease patients with impaired kidney function for prognosis: a prospective cohort study in China"],"prefix":"10.1186","volume":"24","author":[{"given":"Zixiang","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enmin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangyu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefei","family":"Dou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"issue":"3 Suppl 1","key":"1078_CR1","doi-asserted-by":"publisher","first-page":"A7","DOI":"10.1053\/j.ajkd.2016.12.004","volume":"69","author":"R Saran","year":"2017","unstructured":"Saran R, Robinson B, Abbott KC, Agodoa LY, Albertus P, Ayanian J, et al. US Renal Data System 2016 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am J Kidney Dis. 2017;69(3 Suppl 1):A7\u20138.","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"1078_CR2","doi-asserted-by":"publisher","first-page":"123","DOI":"10.5551\/jat.12849","volume":"20","author":"WF Keane","year":"2013","unstructured":"Keane WF, Tomassini JE, Neff DR. Lipid abnormalities in patients with chronic kidney disease: implications for the pathophysiology of atherosclerosis. J Atheroscler Thromb. 2013;20(2):123\u201333.","journal-title":"J Atheroscler Thromb"},{"issue":"6","key":"1078_CR3","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1053\/j.ajkd.2015.06.028","volume":"66","author":"AB Reiss","year":"2015","unstructured":"Reiss AB, Voloshyna I, De Leon J, Miyawaki N, Mattana J. Cholesterol Metabolism in CKD. Am J Kidney Dis. 2015;66(6):1071\u201382.","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"1078_CR4","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.kint.2016.02.026","volume":"90","author":"ND Vaziri","year":"2016","unstructured":"Vaziri ND. Disorders of lipid metabolism in nephrotic syndrome: mechanisms and consequences. Kidney Int. 2016;90(1):41\u201352.","journal-title":"Kidney Int"},{"issue":"13","key":"1078_CR5","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1056\/NEJMoa041031","volume":"351","author":"AS Go","year":"2004","unstructured":"Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351(13):1296\u2013305.","journal-title":"N Engl J Med"},{"key":"1078_CR6","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.addr.2020.07.019","volume":"159","author":"J Soppert","year":"2020","unstructured":"Soppert J, Lehrke M, Marx N, Jankowski J, Noels H. Lipoproteins and lipids in cardiovascular disease: from mechanistic insights to therapeutic targeting. Adv Drug Deliv Rev. 2020;159:4\u201333.","journal-title":"Adv Drug Deliv Rev"},{"issue":"3","key":"1078_CR7","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/s41569-021-00613-5","volume":"19","author":"A Mehta","year":"2022","unstructured":"Mehta A, Shapiro MD. Apolipoproteins in vascular biology and atherosclerotic disease. Nat Rev Cardiol. 2022;19(3):168\u201379.","journal-title":"Nat Rev Cardiol"},{"key":"1078_CR8","doi-asserted-by":"publisher","first-page":"113634","DOI":"10.1016\/j.biopha.2022.113634","volume":"154","author":"AS Bhale","year":"2022","unstructured":"Bhale AS, Venkataraman K. Leveraging knowledge of HDLs major protein ApoA1: Structure, function, mutations, and potential therapeutics. Biomed Pharmacother. 2022;154:113634.","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"1078_CR9","doi-asserted-by":"publisher","first-page":"1886","DOI":"10.1161\/STROKEAHA.119.027898","volume":"51","author":"C Ducroux","year":"2020","unstructured":"Ducroux C, Desilles JP, Mawhin MA, Delbosc S, Ho-Tin-Noe B, Ollivier V, et al. Protective Effect of ApoA1 (Apolipoprotein A1)-Milano in a Rat Model of Large Vessel Occlusion Stroke. Stroke. 2020;51(6):1886\u201390.","journal-title":"Stroke"},{"issue":"11","key":"1078_CR10","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1093\/ndt\/gfv428","volume":"31","author":"B Kollerits","year":"2016","unstructured":"Kollerits B, Drechsler C, Krane V, Lamina C, Marz W, Dieplinger H, et al. Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study. Nephrol Dial Transplant. 2016;31(11):1901\u20138.","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"1078_CR11","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/0002-9149(85)90839-2","volume":"56","author":"JT Salonen","year":"1985","unstructured":"Salonen JT, Salonen R, Penttila I, Herranen J, Jauhiainen M, Kantola M, et al. Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease. Am J Cardiol. 1985;56(4):226\u201331.","journal-title":"Am J Cardiol"},{"issue":"1","key":"1078_CR12","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1161\/CIRCULATIONAHA.124.068885","volume":"150","author":"D De Oliveira-Gomes","year":"2024","unstructured":"De Oliveira-Gomes D, Joshi PH, Peterson ED, Rohatgi A, Khera A, Navar AM. Apolipoprotein B: Bridging the Gap Between Evidence and Clinical Practice. Circulation. 2024;150(1):62\u201379.","journal-title":"Circulation"},{"issue":"1","key":"1078_CR13","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/s12916-017-0976-4","volume":"15","author":"VA Katzke","year":"2017","unstructured":"Katzke VA, Sookthai D, Johnson T, Kuhn T, Kaaks R. Blood lipids and lipoproteins in relation to incidence and mortality risks for CVD and cancer in the prospective EPIC-Heidelberg cohort. BMC Med. 2017;15(1):218.","journal-title":"BMC Med"},{"issue":"9","key":"1078_CR14","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1093\/eurjpc\/zwae080","volume":"31","author":"J Zhang","year":"2024","unstructured":"Zhang J, Song X, Li Z, Xu H, Shu H, Li J, et al. Association of apolipoprotein levels with all-cause and cardiovascular mortality. Eur J Prev Cardiol. 2024;31(9):1183\u201394.","journal-title":"Eur J Prev Cardiol"},{"key":"1078_CR15","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1186\/s12944-015-0155-6","volume":"14","author":"Y Song","year":"2015","unstructured":"Song Y, Yang Y, Zhang J, Wang Y, He W, Zhang X, et al. The apoB100\/apoAI ratio is independently associated with the severity of coronary heart disease: a cross sectional study in patients undergoing coronary angiography. Lipids Health Dis. 2015;14:150.","journal-title":"Lipids Health Dis"},{"issue":"5","key":"1078_CR16","doi-asserted-by":"publisher","first-page":"840","DOI":"10.2215\/CJN.09830915","volume":"11","author":"Y Sato","year":"2016","unstructured":"Sato Y, Fujimoto S, Toida T, Nakagawa H, Yamashita Y, Iwakiri T, et al. Apoprotein B\/Apoprotein A-1 Ratio and Mortality among Prevalent Dialysis Patients. Clin J Am Soc Nephrol. 2016;11(5):840\u20136.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"1078_CR17","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604\u201312.","journal-title":"Ann Intern Med"},{"issue":"20","key":"1078_CR18","doi-asserted-by":"publisher","first-page":"e030625","DOI":"10.1161\/JAHA.123.030625","volume":"12","author":"K Cui","year":"2023","unstructured":"Cui K, Song Y, Yin D, Song W, Wang H, Zhu C, et al. Uric acid levels, number of standard modifiable cardiovascular risk factors, and prognosis in patients with coronary artery disease: a large cohort study in Asia. J Am Heart Assoc. 2023;12(20):e030625.","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"1078_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v074.i07","volume":"74","author":"A Kowarik","year":"2016","unstructured":"Kowarik A, Templ M. Imputation with the R Package VIM. J Stat Softw. 2016;74(7):1\u201316.","journal-title":"J Stat Softw"},{"key":"1078_CR20","doi-asserted-by":"crossref","unstructured":"van Buuren S G-OK. mice: Multivariate Imputation by Chained Equations in R. J Statistical Software. 2011;45:1\u201367.","DOI":"10.18637\/jss.v045.i03"},{"issue":"24","key":"1078_CR21","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1001\/jama.1992.03480240088040","volume":"267","author":"AM Scanu","year":"1992","unstructured":"Scanu AM. Lipoprotein(a). A genetic risk factor for premature coronary heart disease. JAMA. 1992;267(24):3326\u20139.","journal-title":"JAMA"},{"issue":"4","key":"1078_CR22","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1463-1326.2007.00714.x","volume":"10","author":"M Andrikoula","year":"2008","unstructured":"Andrikoula M, McDowell IF. The contribution of ApoB and ApoA1 measurements to cardiovascular risk assessment. Diabetes Obes Metab. 2008;10(4):271\u20138.","journal-title":"Diabetes Obes Metab"},{"issue":"10","key":"1078_CR23","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.cjca.2017.08.004","volume":"33","author":"YM Zhu","year":"2017","unstructured":"Zhu YM, Verma S, Fung M, McQueen MJ, Anderson TJ, Lonn EM. Association of Apolipoproteins B and A-1 With Markers of Vascular Health or Cardiovascular Events. Can J Cardiol. 2017;33(10):1305\u201311.","journal-title":"Can J Cardiol"},{"key":"1078_CR24","doi-asserted-by":"publisher","unstructured":"Silbernagel G, Scharnagl H, Saely CH, Reinthaler M, Rief M, Kleber ME, Larcher B, Chapman J, Schaefer JR, Drexel H, M\u00e4rz W. The LDL Apolipoprotein B-to-LDL Cholesterol Ratio: Association with Cardiovascular Mortality and a Biomarker of Small, Dense LDLs. Biomedicines. 2022;10(6):1302. https:\/\/doi.org\/10.3390\/biomedicines10061302.","DOI":"10.3390\/biomedicines10061302"},{"key":"1078_CR25","doi-asserted-by":"publisher","first-page":"709756","DOI":"10.1155\/2014\/709756","volume":"2014","author":"D Ding","year":"2014","unstructured":"Ding D, Li X, Qiu J, Li R, Zhang Y, Su D, et al. Serum lipids, apolipoproteins, and mortality among coronary artery disease patients. Biomed Res Int. 2014;2014:709756.","journal-title":"Biomed Res Int"},{"issue":"11","key":"1078_CR26","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1016\/j.jacc.2021.01.027","volume":"77","author":"CDL Johannesen","year":"2021","unstructured":"Johannesen CDL, Mortensen MB, Langsted A, Nordestgaard BG. Apolipoprotein B and Non-HDL Cholesterol Better Reflect Residual Risk Than LDL Cholesterol in Statin-Treated Patients. J Am Coll Cardiol. 2021;77(11):1439\u201350.","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"1078_CR27","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1177\/2047487319871733","volume":"27","author":"SU Khan","year":"2020","unstructured":"Khan SU, Khan MU, Valavoor S, Khan MS, Okunrintemi V, Mamas MA, et al. Association of lowering apolipoprotein B with cardiovascular outcomes across various lipid-lowering therapies: Systematic review and meta-analysis of trials. Eur J Prev Cardiol. 2020;27(12):1255\u201368.","journal-title":"Eur J Prev Cardiol"},{"issue":"1","key":"1078_CR28","doi-asserted-by":"publisher","first-page":"47","DOI":"10.2215\/CJN.07320619","volume":"15","author":"JA Lamprea-Montealegre","year":"2020","unstructured":"Lamprea-Montealegre JA, Staplin N, Herrington WG, Haynes R, Emberson J, Baigent C, et al. Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD. Clin J Am Soc Nephrol. 2020;15(1):47\u201360.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"39","key":"1078_CR29","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1093\/eurheartj\/ehw272","volume":"37","author":"AL Catapano","year":"2016","unstructured":"Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, et al. 2016 ESC\/EAS Guidelines for the Management of Dyslipidaemias. Eur Heart J. 2016;37(39):2999\u20133058.","journal-title":"Eur Heart J"},{"issue":"11","key":"1078_CR30","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1161\/ATVBAHA.108.168690","volume":"28","author":"AJ Murphy","year":"2008","unstructured":"Murphy AJ, Woollard KJ, Hoang A, Mukhamedova N, Stirzaker RA, McCormick SP, et al. High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol. 2008;28(11):2071\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"1078_CR31","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1186\/s12944-018-0771-z","volume":"17","author":"X Zhan","year":"2018","unstructured":"Zhan X, Chen Y, Yan C, Liu S, Deng L, Yang Y, et al. Apolipoprotein B\/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients. Lipids Health Dis. 2018;17(1):117.","journal-title":"Lipids Health Dis"},{"issue":"2","key":"1078_CR32","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3109\/07853890.2012.679962","volume":"45","author":"N Oksala","year":"2013","unstructured":"Oksala N, Seppala I, Hernesniemi J, Lyytikainen LP, Kahonen M, Makela KM, et al. Complementary prediction of cardiovascular events by estimated apo- and lipoprotein concentrations in the working age population The Health 2000 Study. Ann Med. 2013;45(2):141\u20138.","journal-title":"Ann Med"},{"key":"1078_CR33","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.cca.2022.09.020","volume":"536","author":"T Fukase","year":"2022","unstructured":"Fukase T, Dohi T, Nishio R, Takeuchi M, Takahashi N, Chikata Y, et al. Combined impacts of low apolipoprotein A-I levels and reduced renal function on long-term prognosis in patients with coronary artery disease undergoing percutaneous coronary intervention. Clin Chim Acta. 2022;536:180\u201390.","journal-title":"Clin Chim Acta"},{"issue":"3","key":"1078_CR34","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1365-2796.2005.01610.x","volume":"259","author":"G Walldius","year":"2006","unstructured":"Walldius G, Aastveit AH, Jungner I. Stroke mortality and the apoB\/apoA-I ratio: results of the AMORIS prospective study. J Intern Med. 2006;259(3):259\u201366.","journal-title":"J Intern Med"},{"issue":"6","key":"1078_CR35","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1093\/eurheartj\/ehn347","volume":"30","author":"J Sierra-Johnson","year":"2009","unstructured":"Sierra-Johnson J, Fisher RM, Romero-Corral A, Somers VK, Lopez-Jimenez F, Ohrvik J, et al. Concentration of apolipoprotein B is comparable with the apolipoprotein B\/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population. Eur Heart J. 2009;30(6):710\u20137.","journal-title":"Eur Heart J"},{"issue":"6","key":"1078_CR36","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/j.1365-2796.2009.02074.x","volume":"265","author":"M Chmielewski","year":"2009","unstructured":"Chmielewski M, Carrero JJ, Qureshi AR, Axelsson J, Heimburger O, Berglund L, et al. Temporal discrepancies in the association between the apoB\/apoA-I ratio and mortality in incident dialysis patients. J Intern Med. 2009;265(6):708\u201316.","journal-title":"J Intern Med"},{"issue":"7","key":"1078_CR37","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1016\/j.jcmg.2013.12.015","volume":"7","author":"A Hakeem","year":"2014","unstructured":"Hakeem A, Bhatti S, Chang SM. Screening and risk stratification of coronary artery disease in end-stage renal disease. JACC Cardiovasc Imaging. 2014;7(7):715\u201328.","journal-title":"JACC Cardiovasc Imaging"},{"issue":"3","key":"1078_CR38","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.jacc.2007.03.037","volume":"50","author":"DE Weiner","year":"2007","unstructured":"Weiner DE, Tighiouart H, Elsayed EF, Griffith JL, Salem DN, Levey AS, et al. The Framingham predictive instrument in chronic kidney disease. J Am Coll Cardiol. 2007;50(3):217\u201324.","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"1078_CR39","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1046\/j.1523-1755.2003.00803.x","volume":"63","author":"K Kalantar-Zadeh","year":"2003","unstructured":"Kalantar-Zadeh K, Block G, Humphreys MH, Kopple JD. Reverse epidemiology of cardiovascular risk factors in maintenance dialysis patients. Kidney Int. 2003;63(3):793\u2013808.","journal-title":"Kidney Int"},{"issue":"2","key":"1078_CR40","doi-asserted-by":"publisher","first-page":"505","DOI":"10.2215\/CJN.03670807","volume":"3","author":"P Stenvinkel","year":"2008","unstructured":"Stenvinkel P, Carrero JJ, Axelsson J, Lindholm B, Heimburger O, Massy Z. Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle? Clin J Am Soc Nephrol. 2008;3(2):505\u201321.","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"1078_CR41","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1093\/ndt\/gfl510","volume":"22","author":"M Suliman","year":"2007","unstructured":"Suliman M, Stenvinkel P, Qureshi AR, Kalantar-Zadeh K, Barany P, Heimburger O, et al. The reverse epidemiology of plasma total homocysteine as a mortality risk factor is related to the impact of wasting and inflammation. Nephrol Dial Transplant. 2007;22(1):209\u201317.","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"1078_CR42","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1159\/000082012","volume":"23","author":"K Kalantar-Zadeh","year":"2005","unstructured":"Kalantar-Zadeh K, Kilpatrick RD, Kuwae N, Wu DY. Reverse epidemiology: a spurious hypothesis or a hardcore reality? Blood Purif. 2005;23(1):57\u201363.","journal-title":"Blood Purif"}],"container-title":["Nutrition Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12937-025-01078-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12937-025-01078-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12937-025-01078-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T12:20:03Z","timestamp":1737116403000},"score":1,"resource":{"primary":{"URL":"https:\/\/nutritionj.biomedcentral.com\/articles\/10.1186\/s12937-025-01078-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,17]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1078"],"URL":"https:\/\/doi.org\/10.1186\/s12937-025-01078-9","relation":{},"ISSN":["1475-2891"],"issn-type":[{"value":"1475-2891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,17]]},"assertion":[{"value":"23 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The research adhered to the ethical principles outlined in the Declaration of Helsinki and received approval from the Institutional Review Board of Fuwai Hospital (Approval Number 2016\u2013847). All participants provided written informed consent before their inclusion in the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"11"}}