{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:31:28Z","timestamp":1790422288320,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"S1","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BioMed Eng OnLine"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1186\/s12938-018-0564-7","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T09:20:07Z","timestamp":1542705607000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus"],"prefix":"10.1186","volume":"17","author":[{"given":"Francisco","family":"Cavas-Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Fern\u00e1ndez-Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolores","family":"Parras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J. F.","family":"Ca\u00f1avate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Bataille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Ali\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,11,20]]},"reference":[{"issue":"4","key":"564_CR1","doi-asserted-by":"publisher","first-page":"1948","DOI":"10.1167\/iovs.09-4177","volume":"51","author":"DP Pinero","year":"2010","unstructured":"Pinero DP, Alio JL, Barraquer RI, Michael R, Jimenez R. Corneal biomechanics, refraction, and corneal aberrometry in keratoconus: an integrated study. Invest Ophthalmol Vis Sci. 2010;51(4):1948\u201355.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"564_CR2","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1016\/j.jcrs.2014.04.013","volume":"40","author":"CJ Roberts","year":"2014","unstructured":"Roberts CJ, Dupps WJ Jr. Biomechanics of corneal ectasia and biomechanical treatments. J Cataract Refract Surg. 2014;40(6):991\u20138.","journal-title":"J Cataract Refract Surg"},{"key":"564_CR3","first-page":"T1","volume":"114","author":"WJ Dupps Jr","year":"2016","unstructured":"Dupps WJ Jr, Seven I. A large-scale computational analysis of corneal structural response and ectasia risk in myopic laser refractive surgery. Trans Am Ophthalmol Soc. 2016;114:T1.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"564_CR4","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40662-016-0036-8","volume":"3","author":"F Cavas-Martinez","year":"2016","unstructured":"Cavas-Martinez F, De la Cruz Sanchez E, Nieto Martinez J, Fernandez Canavate FJ, Fernandez-Pacheco DG. Corneal topography in keratoconus: state of the art. Eye and vision. 2016;3:5.","journal-title":"Eye and vision."},{"issue":"10","key":"564_CR5","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1097\/OPX.0b013e3182279ff8","volume":"88","author":"D Ramos-Lopez","year":"2011","unstructured":"Ramos-Lopez D, Martinez-Finkelshtein A, Castro-Luna GM, Pinero D, Alio JL. Placido-based indices of corneal irregularity. Optom Vis Sci. 2011;88(10):1220\u201331.","journal-title":"Optom Vis Sci"},{"issue":"5","key":"564_CR6","doi-asserted-by":"crossref","first-page":"S537","DOI":"10.3928\/1081-597X-20040901-25","volume":"20","author":"SD Klyce","year":"2004","unstructured":"Klyce SD, Karon MD, Smolek MK. Advantages and disadvantages of the Zernike expansion for representing wave aberration of the normal and aberrated eye. J Refrac Surg. 2004;20(5):S537\u201341.","journal-title":"J Refrac Surg."},{"issue":"4","key":"564_CR7","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1111\/opo.12065","volume":"33","author":"JP Trevino","year":"2013","unstructured":"Trevino JP, Gomez-Correa JE, Iskander DR, Chavez-Cerda S. Zernike vs. Bessel circular functions in visual optics. Ophthalmic Physiol Optics. 2013;33(4):394\u2013402.","journal-title":"Ophthalmic Physiol Optics"},{"issue":"27","key":"564_CR8","doi-asserted-by":"publisher","first-page":"6954","DOI":"10.1364\/AO.45.006954","volume":"45","author":"M Ares","year":"2006","unstructured":"Ares M, Royo S. Comparison of cubic B-spline and Zernike-fitting techniques in complex wavefront reconstruction. Appl Opt. 2006;45(27):6954\u201364.","journal-title":"Appl Opt"},{"issue":"8","key":"564_CR9","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/j.media.2013.05.008","volume":"17","author":"A Eklund","year":"2013","unstructured":"Eklund A, Dufort P, Forsberg D, LaConte SM. Medical image processing on the GPU\u2014past, present and future. Med Image Anal. 2013;17(8):1073\u201394.","journal-title":"Med Image Anal"},{"issue":"Pt 1","key":"564_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1042\/BA20030108","volume":"39","author":"W Sun","year":"2004","unstructured":"Sun W, Darling A, Starly B, Nam J. Computer-aided tissue engineering: overview, scope and challenges. Biotechnol Appl Biochem. 2004;39(Pt 1):29\u201347.","journal-title":"Biotechnol Appl Biochem"},{"key":"564_CR11","doi-asserted-by":"publisher","first-page":"117","DOI":"10.2495\/BIO130111","volume":"17","author":"HA Almeida","year":"2013","unstructured":"Almeida HA, B\u00e1rtolo PJ. Computational technologies in tissue engineering. WIT Trans Biomed Health. 2013;17:117\u201329.","journal-title":"WIT Trans Biomed Health."},{"issue":"5","key":"564_CR12","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1080\/10255842.2012.697556","volume":"17","author":"C Ic","year":"2014","unstructured":"Ic C, Shyh-Yuan L, Ming-Chang W, Sun CW, Jiang CP. Finite element modelling of implant designs and cortical bone thickness on stress distribution in maxillary type IV bone. Comput Methods Biomech Biomed Eng. 2014;17(5):516\u201326.","journal-title":"Comput Methods Biomech Biomed Eng"},{"issue":"10","key":"564_CR13","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1007\/s10439-005-5873-x","volume":"33","author":"S Lohfeld","year":"2005","unstructured":"Lohfeld S, Barron V, McHugh PE. Biomodels of bone: a review. Ann Biomed Eng. 2005;33(10):1295\u2013311.","journal-title":"Ann Biomed Eng"},{"key":"564_CR14","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.compbiomed.2014.08.023","volume":"54","author":"EA Ovcharenko","year":"2014","unstructured":"Ovcharenko EA, Klyshnikov KU, Vlad AR, Sizova IN, Kokov AN, Nushtaev DV, Yuzhalin AE, Zhuravleva IU. Computer-aided design of the human aortic root. Comput Biol Med. 2014;54:109\u201315.","journal-title":"Comput Biol Med"},{"key":"564_CR15","unstructured":"Rocha M, Pereira JP, De Castro AV. 3D modeling mechanisms for educational resources in medical and health area. In: Proceedings of the 6th Iberian conference on information systems and technologies (CISTI 2011). Piscataway: IEEE; 2011. p 1\u20136."},{"issue":"2","key":"564_CR16","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1136\/bjophthalmol-2013-304446","volume":"98","author":"C Schubert","year":"2014","unstructured":"Schubert C, van Langeveld MC, Donoso LA. Innovations in 3D printing: a 3D overview from optics to organs. Br J Ophthalmol. 2014;98(2):159\u201361.","journal-title":"Br J Ophthalmol"},{"issue":"2","key":"564_CR17","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1007\/s10439-014-1147-9","volume":"43","author":"R Asher","year":"2015","unstructured":"Asher R, Gefen A, Moisseiev E, Varssano D. An analytical approach to corneal mechanics for determining practical, clinically-meaningful patient-specific tissue mechanical properties in the rehabilitation of vision. Ann Biomed Eng. 2015;43(2):274\u201386.","journal-title":"Ann Biomed Eng"},{"key":"564_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jmbbm.2015.07.023","volume":"51","author":"MA Lago","year":"2015","unstructured":"Lago MA, Ruperez MJ, Monserrat C, Martinez-Martinez F, Martinez-Sanchis S, Larra E, Diez-Ajenjo MA, Peris-Martinez C. Patient-specific simulation of the intrastromal ring segment implantation in corneas with keratoconus. J Mech Behav Biomed Mater. 2015;51:260\u20138.","journal-title":"J Mech Behav Biomed Mater"},{"issue":"14","key":"564_CR19","doi-asserted-by":"publisher","first-page":"6287","DOI":"10.1167\/iovs.16-19948","volume":"57","author":"I Seven","year":"2016","unstructured":"Seven I, Vahdati A, De Stefano VS, Krueger RR, Dupps WJ Jr. Comparison of patient-specific computational modeling predictions and clinical outcomes of LASIK for Myopia. Invest Ophthalmol Vis Sci. 2016;57(14):6287\u201397.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"564_CR20","doi-asserted-by":"publisher","first-page":"e0130426","DOI":"10.1371\/journal.pone.0130426","volume":"10","author":"I Simonini","year":"2015","unstructured":"Simonini I, Pandolfi A. Customized Finite Element Modelling of the Human Cornea. PLoS ONE. 2015;10(6):e0130426.","journal-title":"PLoS ONE"},{"issue":"12","key":"564_CR21","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1016\/j.jcrs.2012.10.022","volume":"38","author":"DP Pinero","year":"2012","unstructured":"Pinero DP, Nieto JC, Lopez-Miguel A. Characterization of corneal structure in keratoconus. J Cataract Refract Surg. 2012;38(12):2167\u201383.","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"564_CR22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0039-6257(97)00119-7","volume":"42","author":"YS Rabinowitz","year":"1998","unstructured":"Rabinowitz YS. Keratoconus. Surv Ophthalmol. 1998;42(4):297\u2013319.","journal-title":"Surv Ophthalmol"},{"issue":"3","key":"564_CR23","doi-asserted-by":"publisher","first-page":"e0121486","DOI":"10.1371\/journal.pone.0121486","volume":"10","author":"MA Ariza-Gracia","year":"2015","unstructured":"Ariza-Gracia MA, Zurita JF, Pinero DP, Rodriguez-Matas JF, Calvo B. Coupled biomechanical response of the cornea assessed by non-contact tonometry. A simulation study. PloS ONE. 2015;10(3):e0121486.","journal-title":"PloS ONE"},{"issue":"10","key":"564_CR24","doi-asserted-by":"publisher","first-page":"e110249","DOI":"10.1371\/journal.pone.0110249","volume":"9","author":"F Cavas-Martinez","year":"2014","unstructured":"Cavas-Martinez F, Fernandez-Pacheco DG, De la Cruz-Sanchez E, Nieto Martinez J, Fernandez Canavate FJ, Vega-Estrada A, Plaza-Puche AB, Alio JL. Geometrical custom modeling of human cornea in vivo and its use for the diagnosis of corneal ectasia. PLoS ONE. 2014;9(10):e110249.","journal-title":"PLoS ONE"},{"issue":"7","key":"564_CR25","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1097\/ICO.0b013e3182904950","volume":"32","author":"R Montalban","year":"2013","unstructured":"Montalban R, Alio JL, Javaloy J, Pinero DP. Correlation of anterior and posterior corneal shape in keratoconus. Cornea. 2013;32(7):916\u201321.","journal-title":"Cornea"},{"issue":"6","key":"564_CR26","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1097\/ICO.0b013e31827bf898","volume":"32","author":"R Montalban","year":"2013","unstructured":"Montalban R, Pinero DP, Javaloy J, Alio JL. Correlation of the corneal toricity between anterior and posterior corneal surfaces in the normal human eye. Cornea. 2013;32(6):791\u20138.","journal-title":"Cornea"},{"issue":"6","key":"564_CR27","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1097\/ICO.0000000000000119","volume":"33","author":"MA Anayol","year":"2014","unstructured":"Anayol MA, Guler E, Yagci R, Sekeroglu MA, Ylmazoglu M, Trhs H, Kulak AE, Ylmazbas P. Comparison of central corneal thickness, thinnest corneal thickness, anterior chamber depth, and simulated keratometry using galilei, Pentacam, and Sirius devices. Cornea. 2014;33(6):582\u20136.","journal-title":"Cornea"},{"issue":"9","key":"564_CR28","doi-asserted-by":"publisher","first-page":"616","DOI":"10.3928\/1081597X-20140815-02","volume":"30","author":"JC Hernandez-Camarena","year":"2014","unstructured":"Hernandez-Camarena JC, Chirinos-Saldana P, Navas A, Ramirez-Miranda A, de la Mota A, Jimenez-Corona A, Graue-Hernindez EO. Repeatability, reproducibility, and agreement between three different Scheimpflug systems in measuring corneal and anterior segment biometry. J Refrac Surg. 2014;30(9):616\u201321.","journal-title":"J Refrac Surg."},{"issue":"8","key":"564_CR29","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.1167\/iovs.14-15055","volume":"55","author":"R Shetty","year":"2014","unstructured":"Shetty R, Arora V, Jayadev C, Nuijts RM, Kumar M, Puttaiah NK, Kummelil MK. Repeatability and agreement of three Scheimpflug-based imaging systems for measuring anterior segment parameters in keratoconus. Invest Ophthalmol Vis Sci. 2014;55(8):5263\u20138.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"564_CR30","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1097\/OPX.0b013e3182843f2a","volume":"90","author":"D Ramos-Lopez","year":"2013","unstructured":"Ramos-Lopez D, Martinez-Finkelshtein A, Castro-Luna GM, Burguera-Gimenez N, Vega-Estrada A, Pinero D, Alio JL. Screening subclinical keratoconus with placido-based corneal indices. Optometry Vision Sci. 2013;90(4):335\u201343.","journal-title":"Optometry Vision Sci"},{"issue":"6","key":"564_CR31","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1007\/s00417-013-2261-3","volume":"251","author":"R Montalban","year":"2013","unstructured":"Montalban R, Alio JL, Javaloy J, Pinero DP. Comparative analysis of the relationship between anterior and posterior corneal shape analyzed by Scheimpflug photography in normal and keratoconus eyes. Graefe\u2019s Arch Clin Exp Ophthalmol. 2013;251(6):1547\u201355.","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol."},{"issue":"7","key":"564_CR32","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.1016\/S0161-6420(00)00159-7","volume":"107","author":"A Tomidokoro","year":"2000","unstructured":"Tomidokoro A, Oshika T, Amano S, Higaki S, Maeda N, Miyata K. Changes in anterior and posterior corneal curvatures in keratoconus. Ophthalmology. 2000;107(7):1328\u201332.","journal-title":"Ophthalmology"},{"issue":"8","key":"564_CR33","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1097\/ICO.0b013e318243e42d","volume":"31","author":"JS Wolffsohn","year":"2012","unstructured":"Wolffsohn JS, Safeen S, Shah S, Laiquzzaman M. Changes of corneal biomechanics with keratoconus. Cornea. 2012;31(8):849\u201354.","journal-title":"Cornea"}],"container-title":["BioMedical Engineering OnLine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12938-018-0564-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12938-018-0564-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12938-018-0564-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T15:53:40Z","timestamp":1605455620000},"score":1,"resource":{"primary":{"URL":"https:\/\/biomedical-engineering-online.biomedcentral.com\/articles\/10.1186\/s12938-018-0564-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":33,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["564"],"URL":"https:\/\/doi.org\/10.1186\/s12938-018-0564-7","relation":{},"ISSN":["1475-925X"],"issn-type":[{"value":"1475-925X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"20 November 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"161"}}