{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:37:08Z","timestamp":1790552228488,"version":"4.1.0"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["51775506"],"award-info":[{"award-number":["51775506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY18E050022"],"award-info":[{"award-number":["LY18E050022"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"crossref","award":["LGG19E050022"],"award-info":[{"award-number":["LGG19E050022"]}],"id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["D16004"],"award-info":[{"award-number":["D16004"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BioMed Eng OnLine"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of the study was to validate biomechanical characteristics of a 3D-printed, novel-designated fixation plate for treating mandibular angle fracture, and compare it with two commonly used fixation plates by finite element (FE) simulations and experimental testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A 3D virtual mandible was created from a patient\u2019s CT images as the master model. A custom-designed plate and two commonly used fixation plates were reconstructed onto the master model for FE simulations. Modeling of angle fracture, simulation of muscles of mastication, and defining of boundary conditions were integrated into the theoretical model. Strain levels during different loading conditions were analyzed using a finite element method (FEM). For mechanical test design, samples of the virtual mandible with angle fracture and the custom-designed fixation plates were printed using selective laser sintering (SLS) and selective laser melting (SLM) printing methods. Experimental data were collected from a testing platform with attached strain gauges to the mandible and the plates at different 10 locations during mechanical tests. Simulation of muscle forces and temporomandibular joint conditions were built into the physical models to improve the accuracy of clinical conditions. The experimental\n                      <jats:italic>vs<\/jats:italic>\n                      the theoretical data collected at the 10 locations were compared, and the correlation coefficient was calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results show that use of the novel-designated fixation plate has significant mechanical advantages compared to the two commonly used fixation plates. The results of measured strains at each location show a very high correlation between the physical model and the virtual mandible of their biomechanical behaviors under simulated occlusal loading conditions when treating angle fracture of the mandible.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Based on the results from our study, we validate the accuracy of our computational model which allows us to use it for future clinical applications under more sophisticated biomechanical simulations and testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12938-021-00851-1","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T23:28:35Z","timestamp":1612740515000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Experimental validation of finite element simulation of a new custom-designed fixation plate to treat mandibular angle fracture"],"prefix":"10.1186","volume":"20","author":[{"given":"Xu","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang-jie","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8487-0078","authenticated-orcid":false,"given":"Yun-feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-ying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale A.","family":"Baur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian-feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-tao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"key":"851_CR1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12938-019-0655-0","volume":"18","author":"S Hatefi","year":"2019","unstructured":"Hatefi S, Etemadi ShM, Yihun Y, Mansouri R, Akhlaghi A. Continuous distraction osteogenesis device with MAAC controller for mandibular reconstruction applications. Biomed Eng Online. 2019;18:43. https:\/\/doi.org\/10.1186\/s12938-019-0655-0.","journal-title":"Biomed Eng Online"},{"key":"851_CR2","doi-asserted-by":"publisher","first-page":"2743","DOI":"10.1016\/j.joms.2010.05.080","volume":"68","author":"EE Iii","year":"2010","unstructured":"Iii EE. A prospective study of 3 treatment methods for isolated fractures of the mandibular angle. J Oral Maxillofac Surg. 2010;68:2743\u201354. https:\/\/doi.org\/10.1016\/j.joms.2010.05.080.","journal-title":"J Oral Maxillofac Surg"},{"key":"851_CR3","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1002\/lary.25405","volume":"126","author":"WD Hsueh","year":"2016","unstructured":"Hsueh WD, Schechter CB, Shaw IT, Stupak HD. Comparison of intraoral and extraoral approaches to mandibular angle fracture repair with cost implications. Laryngoscope. 2016;126:591\u20135. https:\/\/doi.org\/10.1002\/lary.25405.","journal-title":"Laryngoscope"},{"key":"851_CR4","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bjoms.2006.08.016","volume":"45","author":"A Siddiqui","year":"2007","unstructured":"Siddiqui A, Markose G, Moos KF, McMahon J, Ayoub AF. One miniplate versus two in the management of mandibular angle fractures: a prospective randomised study. Br J Oral Maxillofac Surg. 2007;45:223\u20135. https:\/\/doi.org\/10.1016\/j.bjoms.2006.08.016.","journal-title":"Br J Oral Maxillofac Surg"},{"key":"851_CR5","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.tripleo.2008.01.018","volume":"106","author":"P Scolozzi","year":"2008","unstructured":"Scolozzi P, Jaques B. Intraoral open reduction and internal fixation of displaced mandibular angle fractures using a specific ad hoc reduction-compression forceps: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;106:497\u2013501. https:\/\/doi.org\/10.1016\/j.tripleo.2008.01.018.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"851_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s40001-017-0244-2","volume":"22","author":"Y Liu","year":"2017","unstructured":"Liu Y, Wei B, Li Y, Gu D, Yin G, Wang B, Xu D, Zhang X, Kong D. The 3-dimensional miniplate is more effective than the standard miniplate for the management of mandibular fractures: a meta-analysis. Eur J Med Res. 2017;22:5\u201315. https:\/\/doi.org\/10.1186\/s40001-017-0244-2.","journal-title":"Eur J Med Res"},{"key":"851_CR7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/edt.12312","volume":"33","author":"MS Monnazzi","year":"2017","unstructured":"Monnazzi MS, Gabrielli MAC, Gabrielli MFR, Trivellato A. Mandibular angle fractures: a comparative study between one- and two-plate fixation. Dent Traumatol. 2017;33:121\u20135. https:\/\/doi.org\/10.1111\/edt.12312.","journal-title":"Dent Traumatol"},{"key":"851_CR8","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.ijom.2010.11.023","volume":"40","author":"RCW Wong","year":"2011","unstructured":"Wong RCW, Tideman H, Merk MAW, Jansen J, Goh SM, Liao K. Review of biomechanical models used in studying the biomechanics of reconstructed mandibles. Int J Oral Maxillofac Surg. 2011;40:393\u2013400. https:\/\/doi.org\/10.1016\/j.ijom.2010.11.023.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"851_CR9","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1590\/S1677-32252013000200002","volume":"12","author":"M Ribeiro","year":"2013","unstructured":"Ribeiro M, Lauria A, Sato F, Moreira R. Biomechanical analysis on different fixation techniques for treatment of mandibular body fractures. Braz J Oral Sci. 2013;12:80\u20133. https:\/\/doi.org\/10.1590\/S1677-32252013000200002.","journal-title":"Braz J Oral Sci"},{"key":"851_CR10","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/ar.22597","volume":"296","author":"F Gr\u00f6ning","year":"2013","unstructured":"Gr\u00f6ning F, Fagan M, O\u2019Higgins P. Comparing the distribution of strains with the distribution of bone tissue in a human mandible: a finite element study. Anat Rec. 2013;296:9\u201318. https:\/\/doi.org\/10.1002\/ar.22597.","journal-title":"Anat Rec"},{"key":"851_CR11","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s12663-013-0510-y","volume":"13","author":"U Joshi","year":"2014","unstructured":"Joshi U, Kurakar M. Comparison of stability of fracture segments in mandible fracture treated with different designs of mini-plates using fem analysis. J Maxillofac Oral Surg. 2014;13:310\u20139. https:\/\/doi.org\/10.1007\/s12663-013-0510-y.","journal-title":"J Maxillofac Oral Surg"},{"key":"851_CR12","doi-asserted-by":"publisher","first-page":"041001","DOI":"10.1115\/1.4029503","volume":"137","author":"DC Ackland","year":"2015","unstructured":"Ackland DC, Moskaljuk A, Hart C, Lee PVS, Dimitroulis G. Prosthesis loading after temporomandibular joint replacement surgery: a musculoskeletal modeling study. J Biomech Eng. 2015;137:041001. https:\/\/doi.org\/10.1115\/1.4029503.","journal-title":"J Biomech Eng"},{"key":"851_CR13","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1016\/j.joms.2017.02.028","volume":"75","author":"A Ayali","year":"2017","unstructured":"Ayali A, Erkmen E. Biomechanical evaluation of different plating methods used in mandibular angle fractures with 3-Dimensional finite element analysis: Favorable fractures. J Oral Maxillofac Surg. 2017;75:1464\u201374. https:\/\/doi.org\/10.1016\/j.joms.2017.02.028.","journal-title":"J Oral Maxillofac Surg"},{"key":"851_CR14","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.bjoms.2016.09.017","volume":"55","author":"DMC Gonzales","year":"2017","unstructured":"Gonzales DMC, Spagnol G, Sverzut CE, Trivellato AE. In vitro evaluation of the resistance of three types of fixation to treat fractures of the mandibular angle. Br J Oral Maxillofac Surg. 2017;55:136\u201340. https:\/\/doi.org\/10.1016\/j.bjoms.2016.09.017.","journal-title":"Br J Oral Maxillofac Surg"},{"key":"851_CR15","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.compbiomed.2015.10.015","volume":"68","author":"S Huang","year":"2016","unstructured":"Huang S, Lo L, Lin C. Biomechanical optimization of a custom-made positioning and fixing bone plate for Le Fort I osteotomy by finite element analysis. Comput Biol Med. 2016;68:49\u201356. https:\/\/doi.org\/10.1016\/j.compbiomed.2015.10.015.","journal-title":"Comput Biol Med"},{"key":"851_CR16","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1080\/10255842.2016.1240788","volume":"20","author":"R Gutwald","year":"2017","unstructured":"Gutwald R, Jaeger R, Lambers F. Customized mandibular reconstruction plates improve mechanical performance in a mandibular reconstruction model. Comput Methods Biomech Biomed Engin. 2017;20:426\u201335. https:\/\/doi.org\/10.1080\/10255842.2016.1240788.","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"851_CR17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1186\/s12938-017-0422-z","volume":"16","author":"Y Liu","year":"2017","unstructured":"Liu Y, Fan Y, Jiang X, Baur DA. A customized fixation plate with novel structure designed by topological optimization for mandibular angle fracture based on finite element analysis. Biomed Eng Online. 2017;16:131\u201347. https:\/\/doi.org\/10.1186\/s12938-017-0422-z.","journal-title":"Biomed Eng Online"},{"key":"851_CR18","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1002\/ar.a.20170","volume":"283","author":"CF Ross","year":"2005","unstructured":"Ross CF, Patel BA, Slice DE, Strait DS, Dechow PC, Richmond BG, Spencer MA. Modeling masticatory muscle force in finite element analysis: sensitivity analysis using principal coordinates analysis. Anat Rec A Discov Mol Cell Evol Biol. 2005;283:288\u201399. https:\/\/doi.org\/10.1002\/ar.a.20170.","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"851_CR19","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.ijom.2012.10.009","volume":"42","author":"TP Bezerra","year":"2013","unstructured":"Bezerra TP, Junior FIS, Scarparo HC, Costa FWG, Studart-Soares EC. Do erupted third molars weaken the mandibular angle after trauma to the chin region? A 3D finite element study. Int J Oral Maxillofac Surg. 2013;42:474\u201380. https:\/\/doi.org\/10.1016\/j.ijom.2012.10.009.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"851_CR20","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jcms.2015.03.025","volume":"43","author":"S Antic","year":"2015","unstructured":"Antic S, Vukicevic AM, Milasinovic M, Saveljic I, Jovicic G, Filipovic N, Rakocevic Z, Djuric M. Impact of the lower third molar presence and position on the fragility of mandibular angle and condyle: A Three-dimensional finite element study. J Craniomaxillofac Surg. 2015;43:870\u20138. https:\/\/doi.org\/10.1016\/j.jcms.2015.03.025.","journal-title":"J Craniomaxillofac Surg"},{"key":"851_CR21","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.ijom.2009.11.003","volume":"39","author":"RCW Wong","year":"2010","unstructured":"Wong RCW, Tideman H, Kin L, Merkx MAW. Biomechanics of mandibular reconstruction: a review. Int J Oral Maxillofac Surg. 2010;39:313\u20139. https:\/\/doi.org\/10.1016\/j.ijom.2009.11.003.","journal-title":"Int J Oral Maxillofac Surg"},{"key":"851_CR22","doi-asserted-by":"publisher","first-page":"103758","DOI":"10.1016\/j.jmbbm.2020.103758","volume":"107","author":"K Cheng","year":"2020","unstructured":"Cheng K, Liu Y, Wang R, Zhang J, Jiang X, Dong X, Xu X. Topological optimization of 3D printed bone analog with PEKK for surgical mandibular reconstruction. J Mech Behav Biomed. 2020;107:103758. https:\/\/doi.org\/10.1016\/j.jmbbm.2020.103758.","journal-title":"J Mech Behav Biomed"},{"key":"851_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.tripleo.2010.01.025","volume":"110","author":"P Bujt\u00e1r","year":"2010","unstructured":"Bujt\u00e1r P, S\u00e1ndor G, Bojtos A, Sz\u00fccs A, Barab\u00e1s J. Finite element analysis of the human mandible at 3 different stages of life. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:301\u20139. https:\/\/doi.org\/10.1016\/j.tripleo.2010.01.025.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"851_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1115\/1.4037633","volume":"139","author":"Y Liu","year":"2017","unstructured":"Liu Y, Fan Y, Dong H, Zhang J. An investigation of two finite element modeling solutions for biomechanical simulation using a case study of a mandibular bone. J Biomech Eng. 2017;139:1\u201311. https:\/\/doi.org\/10.1115\/1.4037633.","journal-title":"J Biomech Eng"},{"key":"851_CR25","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nmat832","volume":"2","author":"RK Nalla","year":"2003","unstructured":"Nalla RK, Kinney JH, Ritchie RO. Mechanistic fracture criteria for the failure of human cortical bone. Nat Mater. 2003;2:164\u20138. https:\/\/doi.org\/10.1038\/nmat832.","journal-title":"Nat Mater"},{"key":"851_CR26","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1016\/j.bjps.2016.10.026","volume":"70","author":"R Wang","year":"2017","unstructured":"Wang R, Liu Y, Wang JH, Baur DA. Effect of interfragmentary gap on the mechanical behavior of mandibular angle fracture with three fixation designs: a finite element analysis. J Plast Reconstr Aesthet Surg. 2017;70:360\u20139. https:\/\/doi.org\/10.1016\/j.bjps.2016.10.026.","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"851_CR27","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1007\/s11837-015-1436-2","volume":"67","author":"C Haden","year":"2015","unstructured":"Haden C, Collins P, Harlow D. Yield strength prediction of titanium alloys. Jom. 2015;67:1357\u201361. https:\/\/doi.org\/10.1007\/s11837-015-1436-2.","journal-title":"Jom"},{"key":"851_CR28","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1097\/SCS.0000000000004327","volume":"29","author":"A Ayali","year":"2018","unstructured":"Ayali A, Erkmen E. Three-dimensional finite element analysis of different plating techniques for unfavorable mandibular angle fractures. J Craniofac Surg. 2018;29:603\u20137. https:\/\/doi.org\/10.1097\/SCS.0000000000004327.","journal-title":"J Craniofac Surg"},{"key":"851_CR29","doi-asserted-by":"publisher","first-page":"e445","DOI":"10.1097\/SCS.0000000000001890","volume":"26","author":"FM Coskunses","year":"2015","unstructured":"Coskunses FM, Kocyigit ID, Atil F, Tekin U, Suer BT, Tuz HH, Ozgul O, Yagiz A. Finite-element analysis of a new designed miniplate which is used via intraoral approach to the mandible angle fracture: comparison of the different fixation techniques. J Craniofac Surg. 2015;26:e445\u20138. https:\/\/doi.org\/10.1097\/SCS.0000000000001890.","journal-title":"J Craniofac Surg"},{"key":"851_CR30","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.jcms.2006.11.006","volume":"35","author":"C Meyer","year":"2007","unstructured":"Meyer C, Martin E, Kahn J, Zink S. Development and biomechanical testing of a new osteosynthesis plate (TCP) designed to stabilize mandibular condyle fractures. J Craniomaxillofac Surg. 2007;35:84\u201390. https:\/\/doi.org\/10.1016\/j.jcms.2006.11.006.","journal-title":"J Craniomaxillofac Surg"},{"key":"851_CR31","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.bjoms.2011.12.001","volume":"50","author":"P Christopoulos","year":"2012","unstructured":"Christopoulos P, Stathopoulos P, Alexandridis C, Shetty V, Caputo A. Comparative biomechanical evaluation of mono-cortical osteosynthesis systems for condylar fractures using photoelastic stress analysis. Br J Oral Maxillofac Surg. 2012;50:636\u201341. https:\/\/doi.org\/10.1016\/j.bjoms.2011.12.001.","journal-title":"Br J Oral Maxillofac Surg"},{"key":"851_CR32","doi-asserted-by":"publisher","first-page":"778","DOI":"10.1016\/j.joms.2015.11.009","volume":"74","author":"RC de Medeiros","year":"2016","unstructured":"de Medeiros RC, Sigua EA, Navarro P, Olate S, Barbosa J. In vitro mechanical analysis of different techniques of internal fixation of combined mandibular angle and body fractures. J Oral Maxillofac Surg. 2016;74:778\u201385. https:\/\/doi.org\/10.1016\/j.joms.2015.11.009.","journal-title":"J Oral Maxillofac Surg"},{"key":"851_CR33","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1067\/moe.2002.126451","volume":"94","author":"A Wagner","year":"2002","unstructured":"Wagner A, Krach W, Schicho K, Undt G, Ploder O, Ewers R. A 3-dimensional finite-element analysis investigating the biomechanical behavior of the mandible and plate osteosynthesis in cases of fractures of the condylar process. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94:678\u201386. https:\/\/doi.org\/10.1067\/moe.2002.126451.","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"851_CR34","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/0021-9290(85)90014-4","volume":"18","author":"JW Osbom","year":"1985","unstructured":"Osbom JW, Baragar FA. Predicted pattern of human muscle activity during clenching derived from a computer assisted model: symmetric vertical bite force. J Biomech. 1985;18:599\u2013612. https:\/\/doi.org\/10.1016\/0021-9290(85)90014-4.","journal-title":"J Biomech"},{"key":"851_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40902-015-0001-9","volume":"37","author":"H Rotaru","year":"2015","unstructured":"Rotaru H, Schumacher R, Kim S, Dinu C. Selective laser melted titanium implants: a new technique for the reconstruction of extensive zygomatic complex defects. Maxillofac Plast Reconstr Surg. 2015;37:1\u20136. https:\/\/doi.org\/10.1186\/s40902-015-0001-9.","journal-title":"Maxillofac Plast Reconstr Surg"}],"container-title":["BioMedical Engineering OnLine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12938-021-00851-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12938-021-00851-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12938-021-00851-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T23:30:32Z","timestamp":1612740632000},"score":1,"resource":{"primary":{"URL":"https:\/\/biomedical-engineering-online.biomedcentral.com\/articles\/10.1186\/s12938-021-00851-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["851"],"URL":"https:\/\/doi.org\/10.1186\/s12938-021-00851-1","relation":{},"ISSN":["1475-925X"],"issn-type":[{"value":"1475-925X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,5]]},"assertion":[{"value":"4 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors have provided consent for publication.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"15"}}