{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:37:46Z","timestamp":1787020666195,"version":"build-2736575974"},"reference-count":124,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BioMed Eng OnLine"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Diabetic retinopathy (DR) is an eye disease that causes blindness and vision loss in diabetic. Risk factors for DR include high blood glucose levels and some environmental factors. The pathogenesis is based on inflammation caused by interferon and other nuclear proteins. This review article provides an overview of DR and discusses the role of nuclear proteins in the pathogenesis of the disease. Some core proteins such as MAPK, transcription co-factors, transcription co-activators, and others are part of this review. In addition, some current advanced treatment resulting from the role of nuclear proteins will be analyzes, including epigenetic modifications, the use of methylation, acetylation, and histone modifications. Stem cell technology and the use of nanobiotechnology are proposed as promising approaches for a more effective treatment of DR.<\/jats:p>","DOI":"10.1186\/s12938-024-01258-4","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T06:03:07Z","timestamp":1719295387000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nuclear proteins and diabetic retinopathy: a review"],"prefix":"10.1186","volume":"23","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahab","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Liang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Yi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarfraz","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talat Bilal","family":"Yasoob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Kun","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Ying","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Long","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"issue":"1","key":"1258_CR1","doi-asserted-by":"publisher","first-page":"72","DOI":"10.14310\/horm.2002.11172","volume":"5","author":"G Kalantzis","year":"2006","unstructured":"Kalantzis G, Angelou M, Poulakou-Rebelakou E. Diabetic retinopathy: an historical assessment. Hormones. 2006;5(1):72\u20135.","journal-title":"Hormones"},{"issue":"1","key":"1258_CR2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s13105-021-00867-0","volume":"78","author":"P Kaur","year":"2022","unstructured":"Kaur P, et al. miRNA signatures in diabetic retinopathy and nephropathy: delineating underlying mechanisms. J Physiol Biochem. 2022;78(1):19\u201337.","journal-title":"J Physiol Biochem"},{"key":"1258_CR3","doi-asserted-by":"publisher","first-page":"16012","DOI":"10.1038\/nrdp.2016.12","volume":"2","author":"TY Wong","year":"2016","unstructured":"Wong TY, et al. Diabetic retinopathy. Nat Rev Dis Primers. 2016;2:16012.","journal-title":"Nat Rev Dis Primers"},{"key":"1258_CR4","volume-title":"Exudative retinal detachment, in StatPearls","author":"UV Shukla","year":"2023","unstructured":"Shukla UV, Gupta A, Tripathy K. Exudative retinal detachment, in StatPearls. Saint Petersburg: StatPearls Publishing; 2023."},{"key":"1258_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061816","author":"W Wang","year":"2018","unstructured":"Wang W, Lo ACY. Diabetic retinopathy: pathophysiology and treatments. Int J Mol Sci. 2018. https:\/\/doi.org\/10.3390\/ijms19061816.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1258_CR6","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1001\/jama.2010.1111","volume":"304","author":"X Zhang","year":"2010","unstructured":"Zhang X, et al. Prevalence of diabetic retinopathy in the United States, 2005\u20132008. JAMA. 2010;304(6):649\u201356.","journal-title":"JAMA"},{"issue":"8","key":"1258_CR7","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1016\/j.ophtha.2007.12.004","volume":"115","author":"DJ Browning","year":"2008","unstructured":"Browning DJ, et al. Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema. Ophthalmology. 2008;115(8):1366\u201371.","journal-title":"Ophthalmology"},{"issue":"4","key":"1258_CR8","doi-asserted-by":"publisher","first-page":"e14425","DOI":"10.1111\/dme.14425","volume":"38","author":"J Lawrenson","year":"2021","unstructured":"Lawrenson J, et al. Trends in diabetic retinopathy screening attendance and associations with vision impairment attributable to diabetes in a large nationwide cohort. Diabet Med. 2021;38(4):e14425.","journal-title":"Diabet Med"},{"key":"1258_CR9","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-023-00314-8","author":"M Kropp","year":"2023","unstructured":"Kropp M, et al. Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications\u2014risks and mitigation. EPMA J. 2023. https:\/\/doi.org\/10.1007\/s13167-023-00314-8.","journal-title":"EPMA J"},{"issue":"4","key":"1258_CR10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/dme.12119","volume":"30","author":"L Ruta","year":"2013","unstructured":"Ruta L, et al. Prevalence of diabetic retinopathy in type 2 diabetes in developing and developed countries. Diabet Med. 2013;30(4):387\u201398.","journal-title":"Diabet Med"},{"issue":"7","key":"1258_CR11","first-page":"01","volume":"11","author":"NK Srinivasan","year":"2017","unstructured":"Srinivasan NK, et al. Diabetes and diabetic retinopathy: knowledge, attitude, practice (KAP) among diabetic patients in a tertiary eye care centre. J Clin Diagn Res JCDR. 2017;11(7):01.","journal-title":"J Clin Diagn Res JCDR"},{"issue":"1","key":"1258_CR12","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s13167-023-00314-8","volume":"14","author":"M Kropp","year":"2023","unstructured":"Kropp M, et al. Diabetic retinopathy as the leading cause of blindness and early predictor of cascading complications-risks and mitigation. Epma J. 2023;14(1):21\u201342.","journal-title":"Epma J"},{"issue":"3","key":"1258_CR13","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s00592-022-02007-6","volume":"60","author":"D Tarasewicz","year":"2023","unstructured":"Tarasewicz D, et al. Quantification of risk factors for diabetic retinopathy progression. Acta Diabetol. 2023;60(3):363\u20139.","journal-title":"Acta Diabetol"},{"issue":"5","key":"1258_CR14","doi-asserted-by":"publisher","first-page":"408","DOI":"10.4239\/wjd.v13.i5.408","volume":"13","author":"X-L Wang","year":"2022","unstructured":"Wang X-L, et al. Changes and significance of retinal blood oxygen saturation and oxidative stress indexes in patients with diabetic retinopathy. World J Diabetes. 2022;13(5):408.","journal-title":"World J Diabetes"},{"key":"1258_CR15","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1007\/s40618-014-0172-8","volume":"37","author":"Z-H Tang","year":"2014","unstructured":"Tang Z-H, et al. Human genetics of diabetic retinopathy. J Endocrinol Invest. 2014;37:1165\u201374.","journal-title":"J Endocrinol Invest"},{"issue":"5","key":"1258_CR16","doi-asserted-by":"publisher","first-page":"108182","DOI":"10.1016\/j.jdiacomp.2022.108182","volume":"36","author":"S Sarray","year":"2022","unstructured":"Sarray S, et al. Association of MMP-2 genes variants with diabetic retinopathy in Tunisian population with type 2 diabetes. J Diabetes Complicat. 2022;36(5):108182.","journal-title":"J Diabetes Complicat"},{"issue":"9","key":"1258_CR17","first-page":"67","volume":"19","author":"J Han","year":"2019","unstructured":"Han J, et al. Genetics of diabetic retinopathy. Curr DiabRep. 2019;19(9):67.","journal-title":"Curr DiabRep"},{"issue":"10","key":"1258_CR18","doi-asserted-by":"publisher","first-page":"2288","DOI":"10.1007\/s00125-015-3697-2","volume":"58","author":"KP Burdon","year":"2015","unstructured":"Burdon KP, et al. Genome-wide association study for sight-threatening diabetic retinopathy reveals association with genetic variation near the GRB2 gene. Diabetologia. 2015;58(10):2288\u201397.","journal-title":"Diabetologia"},{"issue":"5","key":"1258_CR19","first-page":"192","volume":"2","author":"P Pradhan","year":"2016","unstructured":"Pradhan P, et al. Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression. New Front Ophthalmol. 2016;2(5):192\u2013204.","journal-title":"New Front Ophthalmol"},{"key":"1258_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/5016916","volume":"2020","author":"RL Gurung","year":"2020","unstructured":"Gurung RL, et al. Identifying genetic risk factors for diabetic macular edema and the response to treatment. J Diabetes Res. 2020;2020:1\u201312.","journal-title":"J Diabetes Res"},{"issue":"6","key":"1258_CR21","doi-asserted-by":"publisher","first-page":"531","DOI":"10.2337\/diacare.17.6.531","volume":"17","author":"AA Alzaid","year":"1994","unstructured":"Alzaid AA, et al. The role of growth hormone in the development of diabetic retinopathy. Diabetes Care. 1994;17(6):531\u20134.","journal-title":"Diabetes Care"},{"issue":"14","key":"1258_CR22","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1056\/NEJM199309303291401","volume":"329","author":"DM Nathan","year":"1993","unstructured":"Nathan DM, et al. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993;329(14):977\u201386.","journal-title":"N Engl J Med"},{"issue":"7160","key":"1258_CR23","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1136\/bmj.317.7160.703","volume":"317","author":"UK Prospective Diabetes Study Group","year":"1998","unstructured":"UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. BMJ. 1998;317(7160):703\u201313.","journal-title":"BMJ"},{"issue":"3","key":"1258_CR24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1056\/NEJMoa1001288","volume":"363","author":"EY Chew","year":"2010","unstructured":"Chew EY, et al. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010;363(3):233\u201344.","journal-title":"N Engl J Med"},{"issue":"7","key":"1258_CR25","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1002\/dmr.5610050703","volume":"5","author":"R Klein","year":"1989","unstructured":"Klein R, Klein BE, Moss SE. The Wisconsin epidemiological study of diabetic retinopathy: a review. Diabetes Metab Rev. 1989;5(7):559\u201370.","journal-title":"Diabetes Metab Rev"},{"issue":"42","key":"1258_CR26","doi-asserted-by":"publisher","first-page":"e22695","DOI":"10.1097\/MD.0000000000022695","volume":"99","author":"Y Hou","year":"2020","unstructured":"Hou Y, et al. Risk factors and prevalence of diabetic retinopathy: a protocol for meta-analysis. Medicine. 2020;99(42):e22695.","journal-title":"Medicine"},{"issue":"12","key":"1258_CR27","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.2337\/diacare.15.12.1875","volume":"15","author":"R Klein","year":"1992","unstructured":"Klein R, Klein BE, Moss SE. Epidemiology of proliferative diabetic retinopathy. Diabetes Care. 1992;15(12):1875\u201391.","journal-title":"Diabetes Care"},{"issue":"1","key":"1258_CR28","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0161-6420(95)31052-4","volume":"102","author":"R Klein","year":"1995","unstructured":"Klein R, et al. The Wisconsin epidemiologic study of diabetic retinopathy. XV. The long-term incidence of macular edema. Ophthalmology. 1995;102(1):7\u201316.","journal-title":"Ophthalmology"},{"issue":"3","key":"1258_CR29","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1001\/archopht.116.3.297","volume":"116","author":"EM Kohner","year":"1998","unstructured":"Kohner EM, et al. United Kingdom prospective diabetes study, 30: diabetic retinopathy at diagnosis of non-insulin-dependent diabetes mellitus and associated risk factors. Arch Ophthalmol. 1998;116(3):297\u2013303.","journal-title":"Arch Ophthalmol"},{"issue":"12","key":"1258_CR30","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1046\/j.1464-5491.2002.00854.x","volume":"19","author":"N Younis","year":"2002","unstructured":"Younis N, et al. Prevalence of diabetic eye disease in patients entering a systematic primary care-based eye screening programme. Diabet Med. 2002;19(12):1014\u201321.","journal-title":"Diabet Med"},{"issue":"3","key":"1258_CR31","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1007\/s001250050679","volume":"40","author":"A Kernell","year":"1997","unstructured":"Kernell A, et al. Prevalence of diabetic retinopathy in children and adolescents with IDDM. A population-based multicentre study. Diabetologia. 1997;40(3):307\u201310.","journal-title":"Diabetologia"},{"issue":"11","key":"1258_CR32","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/BF02221680","volume":"35","author":"G Joner","year":"1992","unstructured":"Joner G, et al. A nationwide cross-sectional study of retinopathy and microalbuminuria in young Norwegian type 1 (insulin-dependent) diabetic patients. Diabetologia. 1992;35(11):1049\u201354.","journal-title":"Diabetologia"},{"issue":"3","key":"1258_CR33","doi-asserted-by":"publisher","first-page":"522","DOI":"10.2337\/diacare.24.3.522","volume":"24","author":"JI Malone","year":"2001","unstructured":"Malone JI, et al. Prevalence and significance of retinopathy in subjects with type 1 diabetes of less than 5 years\u2019 duration screened for the diabetes control and complications trial. Diabetes Care. 2001;24(3):522\u20136.","journal-title":"Diabetes Care"},{"issue":"9","key":"1258_CR34","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.2337\/diacare.26.9.2604","volume":"26","author":"AM Spijkerman","year":"2003","unstructured":"Spijkerman AM, et al. Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice: the hoorn screening study. Diabetes Care. 2003;26(9):2604\u20138.","journal-title":"Diabetes Care"},{"issue":"3","key":"1258_CR35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/j.1755-3768.2008.01207.x","volume":"87","author":"T Bek","year":"2009","unstructured":"Bek T, et al. The prevalence of diabetic retinopathy in patients with screen-detected type 2 diabetes in Denmark: the ADDITION study. Acta Ophthalmol. 2009;87(3):270\u20134.","journal-title":"Acta Ophthalmol"},{"issue":"11","key":"1258_CR36","first-page":"844","volume":"82","author":"S Resnikoff","year":"2004","unstructured":"Resnikoff S, et al. Global data on visual impairment in the year 2002. Bull World Health Organ. 2004;82(11):844\u201351.","journal-title":"Bull World Health Organ"},{"issue":"2","key":"1258_CR37","doi-asserted-by":"publisher","first-page":"383","DOI":"10.4103\/ijo.IJO_1218_19","volume":"68","author":"D Venugopal","year":"2020","unstructured":"Venugopal D, et al. Awareness and knowledge of diabetic retinopathy and associated factors in Goa: a hospital-based cross-sectional study. Indian J Ophthalmol. 2020;68(2):383.","journal-title":"Indian J Ophthalmol"},{"issue":"1","key":"1258_CR38","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1186\/s13098-023-01003-2","volume":"15","author":"TA Chagas","year":"2023","unstructured":"Chagas TA, et al. Prevalence of diabetic retinopathy in Brazil: a systematic review with meta-analysis. Diabetol Metab Syndr. 2023;15(1):34.","journal-title":"Diabetol Metab Syndr"},{"key":"1258_CR39","doi-asserted-by":"publisher","first-page":"107840","DOI":"10.1016\/j.diabres.2019.107840","volume":"157","author":"R Thomas","year":"2019","unstructured":"Thomas R, et al. IDF diabetes atlas: a review of studies utilising retinal photography on the global prevalence of diabetes related retinopathy between 2015 and 2018. Diabetes Res Clin Pract. 2019;157:107840.","journal-title":"Diabetes Res Clin Pract"},{"issue":"5","key":"1258_CR40","doi-asserted-by":"publisher","first-page":"937","DOI":"10.4314\/ejhs.v32i5.9","volume":"32","author":"GN Gelcho","year":"2022","unstructured":"Gelcho GN, Gari FS. Time to diabetic retinopathy and its risk factors among diabetes mellitus patients in Jimma University Medical Center, Jimma, Southwest Ethiopia. Ethiop J Health Sci. 2022;32(5):937\u201346.","journal-title":"Ethiop J Health Sci"},{"issue":"11","key":"1258_CR41","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","volume":"128","author":"ZL Teo","year":"2021","unstructured":"Teo ZL, et al. Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis. Ophthalmology. 2021;128(11):1580\u201391.","journal-title":"Ophthalmology"},{"issue":"4","key":"1258_CR42","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1111\/ceo.12696","volume":"44","author":"DSW Ting","year":"2016","unstructured":"Ting DSW, Cheung GCM, Wong TY. Diabetic retinopathy: global prevalence, major risk factors, screening practices and public health challenges: a review. Clin Exp Ophthalmol. 2016;44(4):260\u201377.","journal-title":"Clin Exp Ophthalmol"},{"issue":"12","key":"1258_CR43","doi-asserted-by":"publisher","first-page":"e0260936","DOI":"10.1371\/journal.pone.0260936","volume":"16","author":"S Bechange","year":"2021","unstructured":"Bechange S, et al. Diabetic retinopathy service delivery and integration into the health system in Pakistan\u2014findings from a multicentre qualitative study. PLoS ONE. 2021;16(12):e0260936.","journal-title":"PLoS ONE"},{"issue":"4","key":"1258_CR44","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1093\/fampra\/cmh417","volume":"21","author":"KS Coyne","year":"2004","unstructured":"Coyne KS, et al. The impact of diabetic retinopathy: perspectives from patient focus groups. Fam Pract. 2004;21(4):447\u201353.","journal-title":"Fam Pract"},{"key":"1258_CR45","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.93751","author":"EJ Duh","year":"2017","unstructured":"Duh EJ, Sun JK, Stitt AW. Diabetic retinopathy: current understanding, mechanisms, and treatment strategies. JCI Insight. 2017. https:\/\/doi.org\/10.1172\/jci.insight.93751.","journal-title":"JCI Insight"},{"issue":"6","key":"1258_CR46","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1097\/01.nmd.0000221177.51089.7d","volume":"194","author":"J Kreyenbuhl","year":"2006","unstructured":"Kreyenbuhl J, et al. Extent and management of cardiovascular risk factors in patients with type 2 diabetes and serious mental illness. J Nerv Ment Dis. 2006;194(6):404.","journal-title":"J Nerv Ment Dis"},{"issue":"49","key":"1258_CR47","doi-asserted-by":"publisher","first-page":"19194","DOI":"10.1523\/JNEUROSCI.3513-13.2013","volume":"33","author":"KA Tennant","year":"2013","unstructured":"Tennant KA, Brown CE. Diabetes augments in vivo microvascular blood flow dynamics after stroke. J Neurosci. 2013;33(49):19194\u2013204.","journal-title":"J Neurosci"},{"issue":"10","key":"1258_CR48","doi-asserted-by":"publisher","first-page":"3107","DOI":"10.2337\/diabetes.51.10.3107","volume":"51","author":"HP Hammes","year":"2002","unstructured":"Hammes HP, Lin J, Renner O, Shani M, Lundqvist A, Betsholtz C, Brownlee M, Deutsch U. Pericytes and the pathogenesis of diabetic retinopathy. Diabetes 2002;51(10):3107\u201312.","journal-title":"Diabetes"},{"issue":"2","key":"1258_CR49","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1159\/000491897","volume":"48","author":"J Xu","year":"2018","unstructured":"Xu J, et al. Involvement of advanced glycation end products in the pathogenesis of diabetic retinopathy. Cell Physiol Biochem. 2018;48(2):705\u201317.","journal-title":"Cell Physiol Biochem"},{"issue":"5","key":"1258_CR50","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1080\/02713683.2020.1826980","volume":"46","author":"N Alsabaani","year":"2021","unstructured":"Alsabaani N. Inhibition of protein kinase R by C16 protects the retinal ganglion cells from hypoxia-induced oxidative stress, inflammation, and apoptosis. Curr Eye Res. 2021;46(5):719\u201330.","journal-title":"Curr Eye Res"},{"key":"1258_CR51","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s11427-015-4856-x","volume":"58","author":"AJ Barber","year":"2015","unstructured":"Barber AJ. Diabetic retinopathy: recent advances towards understanding neurodegeneration and vision loss. Sci China Life Sci. 2015;58:541\u20139.","journal-title":"Sci China Life Sci"},{"key":"1258_CR52","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.redox.2017.05.027","volume":"13","author":"S-H Chan","year":"2017","unstructured":"Chan S-H, et al. SIRT1 inhibition causes oxidative stress and inflammation in patients with coronary artery disease. Redox Biol. 2017;13:301\u20139.","journal-title":"Redox Biol"},{"issue":"20","key":"1258_CR53","doi-asserted-by":"publisher","first-page":"7432","DOI":"10.3390\/ijms21207432","volume":"21","author":"M Gliozzi","year":"2020","unstructured":"Gliozzi M, et al. Role of TSPO\/VDAC1 upregulation and matrix metalloproteinase-2 localization in the dysfunctional myocardium of hyperglycaemic rats. Int J Mol Sci. 2020;21(20):7432.","journal-title":"Int J Mol Sci"},{"key":"1258_CR54","doi-asserted-by":"publisher","first-page":"583687","DOI":"10.3389\/fimmu.2020.583687","volume":"11","author":"JV Forrester","year":"2020","unstructured":"Forrester JV, Kuffova L, Delibegovic M. The role of inflammation in diabetic retinopathy. Front Immunol. 2020;11:583687.","journal-title":"Front Immunol"},{"issue":"9","key":"1258_CR55","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.1167\/iovs.17-21461","volume":"58","author":"Q Chen","year":"2017","unstructured":"Chen Q, et al. Macular vascular fractal dimension in the deep capillary layer as an early indicator of microvascular loss for retinopathy in type 2 diabetic patients. Invest Ophthalmol Vis Sci. 2017;58(9):3785\u201394.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"1258_CR56","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","volume":"30","author":"J Tang","year":"2011","unstructured":"Tang J, Kern TS. Inflammation in diabetic retinopathy. Prog Retin Eye Res. 2011;30(5):343\u201358.","journal-title":"Prog Retin Eye Res"},{"issue":"2","key":"1258_CR57","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s00281-008-0111-x","volume":"30","author":"AP Adamis","year":"2008","unstructured":"Adamis AP, Berman AJ. Immunological mechanisms in the pathogenesis of diabetic retinopathy. Semin Immunopathol. 2008;30(2):65\u201384.","journal-title":"Semin Immunopathol"},{"issue":"1","key":"1258_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.preteyeres.2006.09.002","volume":"26","author":"SX Zhang","year":"2007","unstructured":"Zhang SX, Ma J-X. Ocular neovascularization: Implication of endogenous angiogenic inhibitors and potential therapy. Prog Retin Eye Res. 2007;26(1):1\u201337.","journal-title":"Prog Retin Eye Res"},{"key":"1258_CR59","doi-asserted-by":"publisher","first-page":"95103","DOI":"10.1155\/2007\/95103","volume":"2007","author":"TS Kern","year":"2007","unstructured":"Kern TS. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Res. 2007;2007:95103.","journal-title":"Exp Diabetes Res"},{"key":"1258_CR60","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.preteyeres.2013.02.001","volume":"34","author":"I Klaassen","year":"2013","unstructured":"Klaassen I, Van Noorden CJF, Schlingemann RO. Molecular basis of the inner blood-retinal barrier and its breakdown in diabetic macular edema and other pathological conditions. Prog Retin Eye Res. 2013;34:19\u201348.","journal-title":"Prog Retin Eye Res"},{"issue":"12","key":"1258_CR61","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1096\/fj.03-1476fje","volume":"18","author":"AM Joussen","year":"2004","unstructured":"Joussen AM, et al. A central role for inflammation in the pathogenesis of diabetic retinopathy. Faseb j. 2004;18(12):1450\u20132.","journal-title":"Faseb j"},{"key":"1258_CR62","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19040942","author":"A R\u00fcbsam","year":"2018","unstructured":"R\u00fcbsam A, Parikh S, Fort PE. Role of inflammation in diabetic retinopathy. Int J Mol Sci. 2018. https:\/\/doi.org\/10.3390\/ijms19040942.","journal-title":"Int J Mol Sci"},{"issue":"6","key":"1258_CR63","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.preteyeres.2009.07.001","volume":"28","author":"A Bringmann","year":"2009","unstructured":"Bringmann A, et al. Cellular signaling and factors involved in M\u00fcller cell gliosis: neuroprotective and detrimental effects. Prog Retin Eye Res. 2009;28(6):423\u201351.","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"1258_CR64","doi-asserted-by":"publisher","first-page":"813","DOI":"10.2337\/diacare.27.3.813","volume":"27","author":"JC Pickup","year":"2004","unstructured":"Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27(3):813\u201323.","journal-title":"Diabetes Care"},{"issue":"3","key":"1258_CR65","doi-asserted-by":"publisher","first-page":"222","DOI":"10.2174\/187152909789007052","volume":"9","author":"N Patel","year":"2009","unstructured":"Patel N. Targeting leukostasis for the treatment of early diabetic retinopathy. Cardiovasc Haematol Disord-Drug Targets Former Curr Drug Targets-Cardiovasc Hematol Disord. 2009;9(3):222\u20139.","journal-title":"Cardiovasc Haematol Disord-Drug Targets Former Curr Drug Targets-Cardiovasc Hematol Disord"},{"issue":"3","key":"1258_CR66","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1016\/j.jhep.2020.11.048","volume":"74","author":"V Arroyo","year":"2021","unstructured":"Arroyo V, et al. The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis. J Hepatol. 2021;74(3):670\u201385.","journal-title":"J Hepatol"},{"issue":"11","key":"1258_CR67","doi-asserted-by":"publisher","first-page":"3035","DOI":"10.4103\/ijo.IJO_1326_21","volume":"69","author":"A Sheemar","year":"2021","unstructured":"Sheemar A, Soni D, Takkar B, Basu S, Venkatesh P. Inflammatory mediators in diabetic retinopathy: deriving clinicopathological correlations for potential targeted therapy. Indian J Ophthalmol. 2021;69(11):3035\u201349. https:\/\/doi.org\/10.4103\/ijo.IJO_1326_21","journal-title":"Indian J Ophthalmol."},{"issue":"5","key":"1258_CR68","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1097\/IAE.0000000000000955","volume":"36","author":"BC Toy","year":"2016","unstructured":"Toy BC, et al. Smartphone-based dilated fundus photography and near visual acuity testing as inexpensive screening tools to detect referral warranted diabetic eye disease. Retina. 2016;36(5):1000\u20138.","journal-title":"Retina"},{"issue":"12","key":"1258_CR69","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1016\/j.jcrs.2009.07.010","volume":"35","author":"K Hayashi","year":"2009","unstructured":"Hayashi K, Manabe S-I, Hayashi H. Visual acuity from far to near and contrast sensitivity in eyes with a diffractive multifocal intraocular lens with a low addition power. J Cataract Refract Surg. 2009;35(12):2070\u20136.","journal-title":"J Cataract Refract Surg"},{"issue":"07","key":"1258_CR70","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1055\/a-1377-2596","volume":"87","author":"Z Cheng","year":"2021","unstructured":"Cheng Z, et al. The potential application of pentacyclic triterpenoids in the prevention and treatment of retinal diseases. Planta Med. 2021;87(07):511\u201327.","journal-title":"Planta Med"},{"issue":"3","key":"1258_CR71","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1002\/mp.12071","volume":"44","author":"A ElTanboly","year":"2017","unstructured":"ElTanboly A, et al. A computer-aided diagnostic system for detecting diabetic retinopathy in optical coherence tomography images. Med Phys. 2017;44(3):914\u201323.","journal-title":"Med Phys"},{"issue":"1","key":"1258_CR72","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/clinchem\/hvaa275","volume":"67","author":"P Libby","year":"2021","unstructured":"Libby P. Inflammation in atherosclerosis\u2014no longer a theory. Clin Chem. 2021;67(1):131\u201342.","journal-title":"Clin Chem"},{"issue":"1","key":"1258_CR73","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1442-9071.2009.02015.x","volume":"37","author":"LM Sakata","year":"2009","unstructured":"Sakata LM, et al. Optical coherence tomography of the retina and optic nerve\u2013a review. Clin Exp Ophthalmol. 2009;37(1):90\u20139.","journal-title":"Clin Exp Ophthalmol"},{"issue":"05","key":"1258_CR74","first-page":"449","volume":"48","author":"EC Horace","year":"1934","unstructured":"Horace EC. Genital tuberculosis in the male: a rationale of epididymo-vasectomy. Chinese Med J. 1934;48(05):449\u201356.","journal-title":"Chinese Med J"},{"issue":"4","key":"1258_CR75","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.nano.2011.08.006","volume":"8","author":"JR Kanwar","year":"2012","unstructured":"Kanwar JR, et al. Nanoparticles in the treatment and diagnosis of neurological disorders: untamed dragon with fire power to heal. Nanomed Nanotechnol Biol Med. 2012;8(4):399\u2013414.","journal-title":"Nanomed Nanotechnol Biol Med"},{"issue":"3","key":"1258_CR76","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0092-8674(91)90233-O","volume":"64","author":"PA Silver","year":"1991","unstructured":"Silver PA. How proteins enter the nucleus. Cell. 1991;64(3):489\u201397.","journal-title":"Cell"},{"issue":"7","key":"1258_CR77","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1038\/nrm2928","volume":"11","author":"C Strambio-De-Castillia","year":"2010","unstructured":"Strambio-De-Castillia C, Niepel M, Rout MP. The nuclear pore complex: bridging nuclear transport and gene regulation. Nat Rev Mol Cell Biol. 2010;11(7):490\u2013501.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1258_CR78","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-64961-5_8","volume-title":"Nucleic acids, their components and related compounds","author":"R Markham","year":"1955","unstructured":"Markham R. Nucleic acids, their components and related compounds. Berlin, Heidelberg: Springer; 1955."},{"issue":"5","key":"1258_CR79","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1002\/bies.20027","volume":"26","author":"MD Evans","year":"2004","unstructured":"Evans MD, Cooke MS. Factors contributing to the outcome of oxidative damage to nucleic acids. BioEssays. 2004;26(5):533\u201342.","journal-title":"BioEssays"},{"key":"1258_CR80","volume-title":"Molecular biology","author":"DP Clark","year":"2012","unstructured":"Clark DP, Pazdernik NJ. Molecular biology. Amsterdam: Elsevier; 2012."},{"key":"1258_CR81","volume-title":"Nucleic acids in chemistry and biology","author":"GM Blackburn","year":"2006","unstructured":"Blackburn GM, et al. Nucleic acids in chemistry and biology. London: Royal Society of Chemistry; 2006."},{"issue":"3","key":"1258_CR82","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1128\/mr.58.3.401-465.1994","volume":"58","author":"SC Kowalczykowski","year":"1994","unstructured":"Kowalczykowski SC, et al. Biochemistry of homologous recombination in Escherichia coli. Microbiol Rev. 1994;58(3):401\u201365.","journal-title":"Microbiol Rev"},{"issue":"1","key":"1258_CR83","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/j.1749-6632.2002.tb02095.x","volume":"959","author":"VP Skulachev","year":"2002","unstructured":"Skulachev VP. Programmed death phenomena: from organelle to organism. Ann N Y Acad Sci. 2002;959(1):214\u201337.","journal-title":"Ann N Y Acad Sci"},{"key":"1258_CR84","volume-title":"A textbook of biotechnology","author":"R Dubey","year":"1993","unstructured":"Dubey R. A textbook of biotechnology. Chennai: S. Chand Publishing; 1993."},{"issue":"3","key":"1258_CR85","doi-asserted-by":"publisher","first-page":"J178","DOI":"10.1016\/j.jaut.2009.11.013","volume":"34","author":"MH Hoffmann","year":"2010","unstructured":"Hoffmann MH, et al. Nucleic acid-associated autoantigens: pathogenic involvement and therapeutic potential. J Autoimmun. 2010;34(3):J178\u2013206.","journal-title":"J Autoimmun"},{"issue":"6","key":"1258_CR86","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1128\/jvi.69.6.3799-3806.1995","volume":"69","author":"C Albo","year":"1995","unstructured":"Albo C, Valencia A, Portela A. Identification of an RNA binding region within the N-terminal third of the influenza A virus nucleoprotein. J Virol. 1995;69(6):3799\u2013806.","journal-title":"J Virol"},{"issue":"2","key":"1258_CR87","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/0003-9861(72)90174-9","volume":"148","author":"P Byvoet","year":"1972","unstructured":"Byvoet P, et al. The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cells. Arch Biochem Biophys. 1972;148(2):558\u201367.","journal-title":"Arch Biochem Biophys"},{"issue":"9","key":"1258_CR88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/gb-2007-8-9-227","volume":"8","author":"R Balhorn","year":"2007","unstructured":"Balhorn R. The protamine family of sperm nuclear proteins. Genome Biol. 2007;8(9):1\u20138.","journal-title":"Genome Biol"},{"issue":"6921","key":"1258_CR89","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/nature01411","volume":"421","author":"G Felsenfeld","year":"2003","unstructured":"Felsenfeld G, Groudine M. Controlling the double helix. Nature. 2003;421(6921):448\u201353.","journal-title":"Nature"},{"key":"1258_CR90","first-page":"113","volume-title":"Genetics and male infertility. Infertility-diagnosis, management & IVF","author":"A Hamada","year":"2012","unstructured":"Hamada A, Esteves SC, Agarwal A. Genetics and male infertility. Infertility-diagnosis, management & IVF. 1st ed. New Delhi: Jaypee Brothers Medical Publishers; 2012. p. 113\u201360.","edition":"1"},{"key":"1258_CR91","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/31867","author":"ZA Khan","year":"2007","unstructured":"Khan ZA, Chakrabarti S. Cellular signaling and potential new treatment targets in diabetic retinopathy. Exp Diabetes Res. 2007. https:\/\/doi.org\/10.1155\/2007\/31867.","journal-title":"Exp Diabetes Res"},{"key":"1258_CR92","doi-asserted-by":"publisher","first-page":"101799","DOI":"10.1016\/j.redox.2020.101799","volume":"37","author":"Q Kang","year":"2020","unstructured":"Kang Q, Yang C. Oxidative stress and diabetic retinopathy: molecular mechanisms, pathogenetic role and therapeutic implications. Redox Biol. 2020;37:101799.","journal-title":"Redox Biol"},{"key":"1258_CR93","doi-asserted-by":"publisher","first-page":"101701","DOI":"10.1016\/j.artmed.2019.07.009","volume":"99","author":"N Asiri","year":"2019","unstructured":"Asiri N, et al. Deep learning based computer-aided diagnosis systems for diabetic retinopathy: a survey. Artif Intell Med. 2019;99:101701.","journal-title":"Artif Intell Med"},{"issue":"1","key":"1258_CR94","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0002-9440(10)62950-1","volume":"167","author":"HM Wilson","year":"2005","unstructured":"Wilson HM, et al. Inhibition of macrophage nuclear factor-\u03baB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo. Am J Pathol. 2005;167(1):27\u201337.","journal-title":"Am J Pathol"},{"issue":"4","key":"1258_CR95","doi-asserted-by":"publisher","first-page":"e1003266","DOI":"10.1371\/journal.ppat.1003266","volume":"9","author":"Y Yu","year":"2013","unstructured":"Yu Y, et al. PKR-like endoplasmic reticulum kinase is necessary for lipogenic activation during HCMV infection. PLoS Pathog. 2013;9(4):e1003266.","journal-title":"PLoS Pathog"},{"key":"1258_CR96","volume-title":"Investigation and manipulation of SOD1 mutant misfolding, aggregation and seeding","author":"W-W Li","year":"2017","unstructured":"Li W-W. Investigation and manipulation of SOD1 mutant misfolding, aggregation and seeding. London: University College London; 2017."},{"issue":"1","key":"1258_CR97","doi-asserted-by":"publisher","first-page":"85","DOI":"10.4161\/viru.23134","volume":"4","author":"M Munir","year":"2013","unstructured":"Munir M, Berg M. The multiple faces of proteinkinase R in antiviral defense. Virulence. 2013;4(1):85\u20139.","journal-title":"Virulence"},{"issue":"1","key":"1258_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-88610-z","volume":"11","author":"T Cesaro","year":"2021","unstructured":"Cesaro T, et al. PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs. Sci Rep. 2021;11(1):1\u201316.","journal-title":"Sci Rep"},{"key":"1258_CR99","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S236637","author":"SE Mansour","year":"2020","unstructured":"Mansour SE, et al. The evolving treatment of diabetic retinopathy. Clin Ophthalmol. 2020. https:\/\/doi.org\/10.2147\/OPTH.S236637.","journal-title":"Clin Ophthalmol"},{"issue":"12","key":"1258_CR100","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1111\/liv.15380","volume":"42","author":"H Huang","year":"2022","unstructured":"Huang H, et al. The role of macrophage TAM receptor family in the acute-to-chronic progression of liver disease: from friend to foe? Liver Int. 2022;42(12):2620\u201331.","journal-title":"Liver Int"},{"issue":"6","key":"1258_CR101","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1111\/j.1365-2796.2005.01570.x","volume":"258","author":"B Fadeel","year":"2005","unstructured":"Fadeel B, Orrenius S. Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease. J Intern Med. 2005;258(6):479\u2013517.","journal-title":"J Intern Med"},{"key":"1258_CR102","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00018-005-4527-3","volume":"62","author":"R Zwaal","year":"2005","unstructured":"Zwaal R, Comfurius P, Bevers E. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci CMLS. 2005;62:971\u201388.","journal-title":"Cell Mol Life Sci CMLS"},{"key":"1258_CR103","doi-asserted-by":"publisher","first-page":"095103","DOI":"10.1155\/2007\/95103","volume":"2007","author":"TS Kern","year":"2007","unstructured":"Kern TS. Contributions of inflammatory processes to the development of the early stages of diabetic retinopathy. Exp Diabetes Res. 2007;2007:095103.","journal-title":"Exp Diabetes Res"},{"key":"1258_CR104","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22644","author":"Q Zhong","year":"2010","unstructured":"Zhong Q, Kowluru RA. Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon. J Cell Biochem. 2010. https:\/\/doi.org\/10.1002\/jcb.22644.","journal-title":"J Cell Biochem"},{"key":"1258_CR105","doi-asserted-by":"publisher","first-page":"591","DOI":"10.3389\/fendo.2020.00591","volume":"11","author":"F Gui","year":"2020","unstructured":"Gui F, et al. Endothelial dysfunction in diabetic retinopathy. Front Endocrinol (Lausanne). 2020;11:591.","journal-title":"Front Endocrinol (Lausanne)"},{"key":"1258_CR106","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20171157","author":"Q Gong","year":"2017","unstructured":"Gong Q, Su G. Roles of miRNAs and long noncoding RNAs in the progression of diabetic retinopathy. 2017. Biosci Reports. https:\/\/doi.org\/10.1042\/BSR20171157."},{"issue":"1","key":"1258_CR107","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.diabet.2017.10.014","volume":"44","author":"S Feldman-Billard","year":"2018","unstructured":"Feldman-Billard S, Larger \u00c9, Massin P. Early worsening of diabetic retinopathy after rapid improvement of blood glucose control in patients with diabetes. Diabetes Metab. 2018;44(1):4\u201314.","journal-title":"Diabetes Metab"},{"key":"1258_CR108","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.biopha.2017.10.075","volume":"97","author":"H Karbasforooshan","year":"2018","unstructured":"Karbasforooshan H, Karimi G. The role of SIRT1 in diabetic retinopathy. Biomed Pharmacother. 2018;97:190\u20134.","journal-title":"Biomed Pharmacother"},{"key":"1258_CR109","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.preteyeres.2014.07.003","volume":"43","author":"R Mastropasqua","year":"2014","unstructured":"Mastropasqua R, et al. Role of microRNAs in the modulation of diabetic retinopathy. Prog Retin Eye Res. 2014;43:92\u2013107.","journal-title":"Prog Retin Eye Res"},{"issue":"4","key":"1258_CR110","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.2337\/db10-1557","volume":"60","author":"K McArthur","year":"2011","unstructured":"McArthur K, et al. MicroRNA-200b regulates vascular endothelial growth factor\u2013mediated alterations in diabetic retinopathy. Diabetes. 2011;60(4):1314\u201323.","journal-title":"Diabetes"},{"issue":"2","key":"1258_CR111","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1167\/iovs.13-13221","volume":"55","author":"B Yan","year":"2014","unstructured":"Yan B, et al. Aberrant expression of long noncoding RNAs in early diabetic retinopathy. Invest Ophthalmol Vis Sci. 2014;55(2):941\u201351.","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"1258_CR112","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.clbc.2022.04.001","volume":"22","author":"MN Uddin","year":"2022","unstructured":"Uddin MN, Wang X. Identification of breast cancer subtypes based on gene expression profiles in breast cancer stroma. Clin Breast Cancer. 2022;22(6):521\u201337.","journal-title":"Clin Breast Cancer"},{"issue":"6","key":"1258_CR113","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1007\/s40123-022-00581-0","volume":"11","author":"L Hong","year":"2022","unstructured":"Hong L, et al. A narrative review of STAT proteins in diabetic retinopathy: from mechanisms to therapeutic prospects. Ophthalmol Therapy. 2022;11(6):2005\u201326.","journal-title":"Ophthalmol Therapy"},{"key":"1258_CR114","first-page":"1679","volume":"25","author":"S Liu","year":"2019","unstructured":"Liu S, et al. Identification of key circRNAs\/lncRNAs\/miRNAs\/mRNAs and pathways in preeclampsia using bioinformatics analysis. Med Sci Monitor Int Med J Exp Clin Res. 2019;25:1679.","journal-title":"Med Sci Monitor Int Med J Exp Clin Res"},{"issue":"3","key":"1258_CR115","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1128\/IAI.71.3.1068-1074.2003","volume":"71","author":"F B\u00e9tis","year":"2003","unstructured":"B\u00e9tis F, et al. The Afa\/Dr adhesins of diffusely adhering Escherichia coli stimulate interleukin-8 secretion, activate mitogen-activated protein kinases, and promote polymorphonuclear transepithelial migration in T84 polarized epithelial cells. Infect Immun. 2003;71(3):1068\u201374.","journal-title":"Infect Immun"},{"issue":"11","key":"1258_CR116","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1038\/nm.2052","volume":"15","author":"P Geraldes","year":"2009","unstructured":"Geraldes P, et al. Activation of PKC-\u03b4 and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009;15(11):1298\u2013306.","journal-title":"Nat Med"},{"issue":"7","key":"1258_CR117","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.2337\/diabetes.49.7.1239","volume":"49","author":"J-Y Park","year":"2000","unstructured":"Park J-Y, et al. Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation. Diabetes. 2000;49(7):1239\u201348.","journal-title":"Diabetes"},{"key":"1258_CR118","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.lfs.2016.02.002","volume":"148","author":"V Rani","year":"2016","unstructured":"Rani V, et al. Oxidative stress and metabolic disorders: pathogenesis and therapeutic strategies. Life Sci. 2016;148:183\u201393.","journal-title":"Life Sci"},{"key":"1258_CR119","doi-asserted-by":"publisher","first-page":"777347","DOI":"10.3389\/fnins.2021.777347","volume":"15","author":"SN Rai","year":"2021","unstructured":"Rai SN, et al. Therapeutic potential of vital transcription factors in Alzheimer\u2019s and Parkinson\u2019s disease with particular emphasis on transcription factor EB mediated autophagy. Front Neurosci. 2021;15:777347.","journal-title":"Front Neurosci"},{"issue":"6","key":"1258_CR120","doi-asserted-by":"publisher","first-page":"E1089","DOI":"10.1152\/ajpendo.00540.2002","volume":"284","author":"S Chen","year":"2003","unstructured":"Chen S, et al. Differential activation of NF-\u03baB and AP-1 in increased fibronectin synthesis in target organs of diabetic complications. Am J Physiol-Endocrinol Metabolism. 2003;284(6):E1089\u201397.","journal-title":"Am J Physiol-Endocrinol Metabolism"},{"issue":"2","key":"1258_CR121","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.cell.2004.09.037","volume":"119","author":"BM Spiegelman","year":"2004","unstructured":"Spiegelman BM, Heinrich R. Biological control through regulated transcriptional coactivators. Cell. 2004;119(2):157\u201367.","journal-title":"Cell"},{"key":"1258_CR122","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1007\/s00018-007-7005-2","volume":"64","author":"A Mabb","year":"2007","unstructured":"Mabb A, Miyamoto S. SUMO and NF-\u03baB ties. Cell Mol Life Sci. 2007;64:1979\u201396.","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"1258_CR123","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/imm.12510","volume":"146","author":"PS Lim","year":"2015","unstructured":"Lim PS, Sutton CR, Rao S. Protein kinase C in the immune system: from signalling to chromatin regulation. Immunology. 2015;146(4):508\u201322.","journal-title":"Immunology"},{"issue":"3","key":"1258_CR124","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/j.2040-1124.2010.00018.x","volume":"1","author":"M Kitada","year":"2010","unstructured":"Kitada M, et al. Molecular mechanisms of diabetic vascular complications. J Diabetes Invest. 2010;1(3):77\u201389.","journal-title":"J Diabetes Invest"}],"updated-by":[{"DOI":"10.1186\/s12938-024-01293-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T00:00:00Z","timestamp":1728518400000}}],"container-title":["BioMedical Engineering OnLine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12938-024-01258-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12938-024-01258-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12938-024-01258-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T11:07:21Z","timestamp":1728558441000},"score":1,"resource":{"primary":{"URL":"https:\/\/biomedical-engineering-online.biomedcentral.com\/articles\/10.1186\/s12938-024-01258-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":124,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1258"],"URL":"https:\/\/doi.org\/10.1186\/s12938-024-01258-4","relation":{"references":[{"id-type":"uri","id":"","asserted-by":"subject"}]},"ISSN":["1475-925X"],"issn-type":[{"value":"1475-925X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]},"assertion":[{"value":"29 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 October 2024","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12938-024-01293-1","URL":"https:\/\/doi.org\/10.1186\/s12938-024-01293-1","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that there are no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"62"}}