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Pacific people in Aotearoa\/New Zealand experience significant inequities, with over three times the gout prevalence of the non-Pacific non-M\u0101ori populations. Pacific people receive less regular urate-lowering drugs to prevent gout flare-ups, and have nine times the hospitalisation from gout compared with non-Pacific non-M\u0101ori people. Rates for Indigenous M\u0101ori lie between Pacific and non-Pacific non-M\u0101ori. A long-established Collective comprising community members from the Pacific People\u2019s Health Advisory Group, clinical staff from the Pacific Practice-Based Research Network, and University of Auckland researchers have identified that improving Pacific urate-lowering therapy use as the research question of prime importance for improved health outcomes of Pacific people in South Auckland. Building on the existing knowledge, this study aims to develop, implement and evaluate a novel innovative intervention to improve the uptake of urate-lowering therapy by Pacific patients with gout.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Three-phase mixed methods co-design study using the Fa\u2019afaletui research framework following the STROBE statement. Phase1 is observational times series of prevalence of patients with gout, proportion with urate blood-level monitoring and use of urate-lowering medication over past 5 years. In Phase 2 the Collective will workshop new interventions to address previous uptake barriers, using culturally-appropriate Talanga communications with results synthesised in line with Kakala principles. The designed intervention will be implemented and process and outcome evaluations conducted. Finally, an implementation framework will be produced to facilitate further roll-out.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>The study aims to enhance health and reduce inequities for Pacific people, contribute to creation of Pacific health knowledge and translation of research findings into Pacific health gains. Potential longer-term impact is a gout-management pathway for use throughout Aotearoa\/New Zealand. M\u0101ori have similar issues with high gout prevalence and low urate-lowering therapy use hence the intervention is likely to translate to M\u0101ori healthcare. The project will contribute to Pacific research capacity and capability-building as well as general upskilling of community and practice members involved in the co-design processes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>The Australian New Zealand Clinical Trial Registry is in process, request number 38206, 1-09-2021.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12939-021-01601-4","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T12:03:51Z","timestamp":1640261031000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Design and implementation of a Pacific intervention to increase uptake of urate-lowering therapy for gout: a study protocol"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2431-0399","authenticated-orcid":false,"given":"Malakai","family":"Ofanoa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9880-7176","authenticated-orcid":false,"given":"Samuela Malakai","family":"Ofanoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3629-2984","authenticated-orcid":false,"given":"Maryann","family":"Heather","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8955-1364","authenticated-orcid":false,"given":"Siobhan","family":"Tu\u2019akoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hinamaha","family":"Lutui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4632-4476","authenticated-orcid":false,"given":"Nicola","family":"Dalbeth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1751-1934","authenticated-orcid":false,"given":"Corina","family":"Grey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3072-5937","authenticated-orcid":false,"given":"Bert","family":"van der Werf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6657-9401","authenticated-orcid":false,"given":"Felicity","family":"Goodyear-Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"key":"1601_CR1","unstructured":"Health Quality & Safety Commission. 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