{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T10:13:25Z","timestamp":1793960005930,"version":"4.8.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Health"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12940-019-0462-x","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T05:48:41Z","timestamp":1553838521000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Bootstrap approach to validate the performance of models for predicting mortality risk temperature in Portuguese Metropolitan Areas"],"prefix":"10.1186","volume":"18","author":[{"given":"M\u00f3nica","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Rocha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"462_CR1","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/S0140-6736(14)62114-0","volume":"386","author":"A Gasparrini","year":"2015","unstructured":"Gasparrini A, Guo Y, Hashizume M, Lavigne E, Zanobetti A, Schwartz J, et al. Mortality risk attributable to high and low ambient temperature: a multicountry observational study. Lancet. 2015;386:369\u201375.","journal-title":"Lancet."},{"key":"462_CR2","doi-asserted-by":"publisher","unstructured":"Rodrigues M, Santana P, Rocha A. Effects of Extreme temperatures on cerebrovascular mortality in Lisbon: a distributed lag non-linear model. Int J Biometeorol. 2019;63:549. https:\/\/doi.org\/10.1007\/s00484-019-01685-2 .","DOI":"10.1007\/s00484-019-01685-2"},{"key":"462_CR3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.envpol.2013.01.037","volume":"4","author":"J Vasconcelos","year":"2013","unstructured":"Vasconcelos J, Freire E, Almendra R, Silva GL, Santana P. The impact of winter cold weather on acute myocardial infarctions in Portugal. Environ Pollut. 2013;4:14\u20138.","journal-title":"Environ Pollut"},{"key":"462_CR4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1097\/EDE.0b013e318176bfcd","volume":"19","author":"M Baccini","year":"2008","unstructured":"Baccini M, Biggeri A, Accetta G, Kosatsky T, Katsouyanni K, Analitis A, et al. Heat effects on mortality in 15 European cities. Epidemiology. 2008;19:711\u20139.","journal-title":"Epidemiology."},{"key":"462_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/1476-069X-9-37","volume":"9","author":"D D\u2019Ippoliti","year":"2010","unstructured":"D\u2019Ippoliti D, Michelozzi P, Marino C, de\u2019Donato F, Menne B, Katsouyanni K, Kirchmayer U, Analitis A, Medina-Ram\u00f3n M, Paldy A, Atkinson R, Kovats S, Bisanti L, Schneider A, Lefranc A, I\u00f1iguez C, Perucci CA. The impact of heat waves on mortality in 9 European cities: results from the EuroHEAT project. Environ Health. 2010;9:37.","journal-title":"Environ Health"},{"key":"462_CR6","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/01.ede.0000164559.41092.2a","volume":"16","author":"S Hajat","year":"2005","unstructured":"Hajat S, Armstrong BG, Gouveia N, Wilkinson P. Mortality displacement of heat-related deaths: a comparison of Delhi, S\u00e3o Paulo and London. Epidemiology. 2005;16:613\u201320.","journal-title":"Epidemiology."},{"key":"462_CR7","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1016\/S0140-6736(96)12338-2","volume":"349","author":"The Eurowinter Group","year":"1997","unstructured":"The Eurowinter Group. Cold exposure and winter mortality from ischaemic heart disease, cerebrovascular disease, respiratory disease, and all causes in warm and cold regions of Europe. Lancet. 1997;349:1341\u20136.","journal-title":"Lancet."},{"key":"462_CR8","first-page":"7","volume":"32","author":"R Almendra","year":"2016","unstructured":"Almendra R, Santana P, Freire E, Vasconcelos J. Seasonal mortality patterns and regional contrasts in Portugal. Bull Geogr Socio-econ Ser. 2016;32:7\u201318.","journal-title":"Bull Geogr Socio-econ Ser"},{"key":"462_CR9","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1002\/joc.1546","volume":"28","author":"P Nogueira","year":"2008","unstructured":"Nogueira P, Paix\u00e3o E. Models for mortality associated with heatwaves: update of the Portuguese heat health warning system. Int J Climatol. 2008;28:545\u201362.","journal-title":"Int J Climatol"},{"key":"462_CR10","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1289\/ehp.1409070","volume":"123","author":"A Gasparrini","year":"2015","unstructured":"Gasparrini A, Guo Y, Hashizume M, Kinney PL, Petkova EP, Lavigne E, Zanobetti A, Schwartz JD, Tobias A, Leone M, Tong S, Honda Y, Kim H, Armstrong BG. Temporal variation in heat-mortality associations: a multicountry study. Environ Health Perspect. 2015;123:1200\u20137.","journal-title":"Environ Health Perspect"},{"key":"462_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s00484-016-1196-x","volume":"61","author":"L Antunes","year":"2016","unstructured":"Antunes L, Silva SP, Marques J, Nunes B, Antunes S. The effect of extreme cold temperatures on the risk of death in the two major Portuguese cities. Int J Biometeorol. 2016;61:127\u201335.","journal-title":"Int J Biometeorol"},{"key":"462_CR12","unstructured":"DGS \u2013 Dire\u00e7\u00e3o Geral da Sa\u00fade. Plano de conting\u00eancia para temperaturas extremas adversas - M\u00f3dulo inverno. 2016. https:\/\/www.dgs.pt\/documentos-e-publicacoes\/saude-sazonal-inverno-saude-.aspx . Accessed 16 Oct 2017."},{"key":"462_CR13","unstructured":"DGS - Dire\u00e7\u00e3o Geral da Sa\u00fade. Plano de conting\u00eancia para temperaturas extremas adversas \u2013 M\u00f3dulo de calor. 2014. https:\/\/www.dgs.pt\/documentos-e-publicacoes\/plano-de-contingencia-para-temperaturas-extremas-adversas-modulo-calor-2014.aspx. Accessed 16 Oct 2017."},{"key":"462_CR14","first-page":"1","volume":"12","author":"M Sanderson","year":"2017","unstructured":"Sanderson M, Arbuthnott K, Kovats S, Hajat S, Falloon P. The use of climate information to estimate future mortality from high ambient temperature: a systematic literature review. PLoS One. 2017;12:1\u201334.","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"462_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s12940-016-0100-9","volume":"15","author":"C Heaviside","year":"2016","unstructured":"Heaviside C, Vardoulakis S, Cai X-M. Attribution of mortality to the urban heat island during heatwaves in the west midlands, UK. Environ Health. 2016;15(Suppl 1):27.","journal-title":"Environ Health"},{"key":"462_CR16","doi-asserted-by":"publisher","first-page":"211","DOI":"10.2166\/nh.2010.004","volume":"41","author":"W Yang","year":"2010","unstructured":"Yang W, Andre\u00e1sson J, Graham LP, Olsson J, Rosberg J, Wetterhall F. Distribution-based scaling to improve usability of regional climate model projections for hydrological climate change impacts studies. Hydrol Res. 2010;41:211\u201328.","journal-title":"Hydrol Res"},{"key":"462_CR17","first-page":"47","volume-title":"Downscaled CMIP3 and CMIP5 Climate and Hydrology Projections: Release of Downscaled CMIP5 Climate Projections, Comparison with Preceding Information, and Summary of User Needs","author":"L Brekke","year":"2013","unstructured":"Brekke L, Thrasher BL, Maurer EP, Pruitt T. Downscaled CMIP3 and CMIP5 Climate and Hydrology Projections: Release of Downscaled CMIP5 Climate Projections, Comparison with Preceding Information, and Summary of User Needs. Denver, Colorado: Prepared by the U.S. Department of the Interior, Bureau of Reclamation, Technical Services Center; 2013. p. 47."},{"key":"462_CR18","doi-asserted-by":"publisher","unstructured":"Li H, Sheffield J, Wood EF. Bias correction of monthly precipitation and temperature fields from intergovernmental panel on climate change AR4 models using equidistant quantile matching. J Geophysical Res. 2010;115. https:\/\/doi.org\/10.1029\/2009JD012882 .","DOI":"10.1029\/2009JD012882"},{"key":"462_CR19","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1186\/s12874-017-0412-7","volume":"17","author":"H Lee","year":"2017","unstructured":"Lee H, Kim H, Hwang S, Zanobetti A, Schwartz JD, Chung Y. Monte Carlo simulation-based estimation for the minimum mortality temperature in temperature-mortality association study. BMC Med Res Methodol. 2017;17:137. https:\/\/doi.org\/10.1186\/s12874-017-0412-7 .","journal-title":"BMC Med Res Methodol"},{"key":"462_CR20","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/EDE.0000000000000567","volume":"28","author":"A Tob\u00edas","year":"2017","unstructured":"Tob\u00edas A, Armstrong B, Gasparrini A. Brief report: investigating uncertainty in the minimum mortality temperature: methods and application to 52 Spanish cities. Epidemiology (Cambridge, Mass). 2017;28:72\u20136.","journal-title":"Epidemiology (Cambridge, Mass)"},{"key":"462_CR21","unstructured":"Skamarock WC, Klemp JB, Dudhia J, Gill DO, Barker D, Wang W, et al. A description of the Advanced Research WRF Version 3. http:\/\/opensky.ucar.edu\/islandora\/object\/technotes:500 . Accessed 20 May 2016."},{"key":"462_CR22","unstructured":"IPCC, 2013. Climate Change 2013: The Physical Science Basis. Contribution of Working Group I to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge University Press, Cambridge and New York, p. 1535."},{"key":"462_CR23","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.pce.2016.03.010","volume":"94","author":"M Marta-Almeida","year":"2016","unstructured":"Marta-Almeida M, Teixeira JC, Carvalho MJ, Melo-Gon\u00e7alves P, Rocha A. High resolution WRF climatic simulations for the Iberian Peninsula: model validation. Phys Chem Earth. 2016;94:94\u2013105.","journal-title":"Phys Chem Earth"},{"key":"462_CR24","doi-asserted-by":"publisher","first-page":"5192","DOI":"10.1002\/joc.5158","volume":"37","author":"SC Pereira","year":"2017","unstructured":"Pereira SC, Marta-Almeida M, Carvalho AC, Rocha A. Heat wave and cold spell changes in Iberia for a future climate scenario. Int J Climatol. 2017;37:5192\u2013205.","journal-title":"Int J Climatol"},{"key":"462_CR25","doi-asserted-by":"publisher","first-page":"4390","DOI":"10.1002\/joc.5094","volume":"37","author":"C Viceto","year":"2017","unstructured":"Viceto C, Marta-Almeida M, Rocha A. Future climate change of stability indices for the Iberian Peninsula. Int J Climatol. 2017;37:4390\u2013408.","journal-title":"Int J Climatol"},{"key":"462_CR26","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.pce.2015.12.005","volume":"94","author":"D Fonseca","year":"2016","unstructured":"Fonseca D, Carvalho MJ, Marta-Almeida M, Melo-Gon\u00e7alves P, Rocha A. Recent trends of extreme temperature indices for the Iberian Peninsula. Phys Chem Earth. 2016;94:66\u201376.","journal-title":"Phys Chem Earth"},{"key":"462_CR27","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.pce.2016.06.005","volume":"94","author":"S Bartolomeu","year":"2016","unstructured":"Bartolomeu S, Carvalho MJ, Marta-Almeida M, Melo-Gon\u00e7alves P, Rocha A. Recent trends of extreme precipitation indices in the Iberian Peninsula using observations and WRF model results. Phys Chem Earth. 2016;94:10\u201321.","journal-title":"Phys Chem Earth"},{"key":"462_CR28","doi-asserted-by":"publisher","DOI":"10.1029\/2012JD017968","volume":"117","author":"A Dosio","year":"2012","unstructured":"Dosio A, Paruolo P, Rojas R. Bias correction of the ENSEMBLES high resolution climate change projections for use by impact models: analysis of the climate change signal. J Geophys Res. 2012;117:D17110 https:\/\/doi.org\/10.1029\/2012JD017968 .","journal-title":"J Geophys Res"},{"key":"462_CR29","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1002\/2015JD024411","volume":"121","author":"A Dosio","year":"2016","unstructured":"Dosio A. Projections of climate change indices of temperature and precipitation from an ensemble of bias-adjusted high-resolution EURO-CORDEX regional climate models. J Geophys Res. 2016;121:5488\u2013511.","journal-title":"J Geophys Res"},{"key":"462_CR30","doi-asserted-by":"publisher","first-page":"2934","DOI":"10.1002\/joc.4890","volume":"37","author":"J Hnilica","year":"2017","unstructured":"Hnilica J, Hanel M, Pu\u0161 V. Multisite bias correction of precipitation data from regional climate models. Int J Climatol. 2017;37:2934\u201346.","journal-title":"Int J Climatol"},{"key":"462_CR31","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00704-009-0134-9","volume":"99","author":"C Piani","year":"2010","unstructured":"Piani C, Haerter JO, Coppola E. Statistical bias correction for daily precipitation in regional climate models over Europe. Theor Appl Climatol. 2010a;99:187\u201392.","journal-title":"Theor Appl Climatol"},{"key":"462_CR32","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.jhydrol.2010.10.024","volume":"395","author":"C Piani","year":"2010","unstructured":"Piani C, Weedon GP, Best M, Gomes SM, Viterbo P, Hagemann S, Haerter JO. Statistical bias correction of global simulated daily precipitation and temperature for the application of hydrological models. J Hydrol. 2010b;395:199\u2013215.","journal-title":"J Hydrol"},{"key":"462_CR33","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1175\/JCLI-D-10-05024.1","volume":"25","author":"A Amengual","year":"2012","unstructured":"Amengual A, Homar V, Romero R, Alonso S, Ramis C. A statistical adjustment of regional climate model outputs to local scales: application to Platja de Palma, Spain. J Clim. 2012;25:939\u201357.","journal-title":"J Clim"},{"key":"462_CR34","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1136\/hrt.2010.217166","volume":"97","author":"W Yu","year":"2011","unstructured":"Yu W, Hu W, Mengersen K, Guo Y, Pan X, Connell D, et al. Time course of temperature effects on cardiovascular mortality in Brisbane, Australia. Heart. 2011;97:1089\u201393.","journal-title":"Heart."},{"key":"462_CR35","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/sim.5963","volume":"33","author":"A Gasparrini","year":"2014","unstructured":"Gasparrini A. Modeling exposure-lag-response associations with distributed lag non-linear models. Stat Med. 2014;33:881\u201399.","journal-title":"Stat Med"},{"key":"462_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v043.i08","volume":"43","author":"A Gasparrini","year":"2011","unstructured":"Gasparrini A. Distributed lag linear and non-linear models in R: the package dlnm. J Stat Softw. 2011;43:1\u201320.","journal-title":"J Stat Softw"},{"issue":"Suppl 1","key":"462_CR37","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1289\/ehp.98106s1241","volume":"106","author":"WJ Martens","year":"1998","unstructured":"Martens WJ. Health impacts of climate change and ozone depletion: an ecoepidemiologic modeling approach. Environ Health Perspect. 1998;106(Suppl 1):241\u201351.","journal-title":"Environ Health Perspect"},{"key":"462_CR38","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1097\/EDE.0000000000000165","volume":"25","author":"Y Guo","year":"2014","unstructured":"Guo Y, Gasparrini A, Armstrong B, Li S, Tawatsupa B, Tobias A, et al. Global variation in the effects of ambient temperature on mortality: a systematic evaluation. Epidemiology. 2014;25:781\u20139.","journal-title":"Epidemiology."},{"key":"462_CR39","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1289\/ehp.9074","volume":"114","author":"M Medina-Ram\u00f3n","year":"2006","unstructured":"Medina-Ram\u00f3n M, Zanobetti A, Cavanagh DP, Schwartz J. Extreme temperatures and mortality: assessing effect modification by personal characteristics and specific cause of death in a multi-city case-only analysis. Environ Health Perspect. 2006;114:1331\u20136.","journal-title":"Environ Health Perspect"},{"key":"462_CR40","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1002\/sim.4343","volume":"31","author":"M Abrahamowicz","year":"2012","unstructured":"Abrahamowicz M, Beauchamp ME, Sylvestre MP. Comparison of alternative models for linking drug exposure with adverse effects. Stat Med. 2012;31:1014\u201330.","journal-title":"Stat Med"},{"key":"462_CR41","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1175\/BAMS-85-8-1067","volume":"85","author":"K Ebi","year":"2004","unstructured":"Ebi K, Teisberg TJ, Kalkstein LS, Robinson L, Weiher RF. Heat watch\/warning systems save lives: estimated costs and benefits for Philadelphia 1995-1998. Bull Am Meteorol Soc. 2004;85:1067\u201373.","journal-title":"Bull Am Meteorol Soc"},{"key":"462_CR42","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1175\/BAMS-85-12-1931","volume":"85","author":"SC Sheridan","year":"2004","unstructured":"Sheridan SC, Kalkstein LS. Progress in heat watch-warning system technology. Bull Am Meteorol Soc. 2004;85:1931\u201341.","journal-title":"Bull Am Meteorol Soc"},{"key":"462_CR43","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1056\/NEJMra1807873","volume":"380","author":"A Haines","year":"2019","unstructured":"Haines A, Ebi K. The imperative for climate action to protect health. N Engl J Med. 2019;380:263\u201373.","journal-title":"N Engl J Med"},{"key":"462_CR44","doi-asserted-by":"publisher","first-page":"438","DOI":"10.3390\/ijerph13040438","volume":"13","author":"S Paz","year":"2016","unstructured":"Paz S, Negev M, Clermont A, Green MS. Health aspects of climate change in cities with mediterranean climate, and local adaptation plans. Int J Environ Res Public Health. 2016;13:438.","journal-title":"Int J Environ Res Public Health"},{"key":"462_CR45","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1007\/s10113-018-1290-1","volume":"18","author":"P Lionello","year":"2018","unstructured":"Lionello P, Scarascia L. The relation between climate change in the Mediterranean regions and global warming. Reg Environ Chang. 2018;18:1481\u201393.","journal-title":"Reg Environ Chang"},{"key":"462_CR46","first-page":"709","volume-title":"The Working Group II contribution to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change","author":"IPCC","year":"2014","unstructured":"IPCC. Climate Change 2014: Impacts, Adaptation, and Vulnerability. In: The Working Group II contribution to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge, United Kingdom and New York, NY, USA: Cambridge University Press; 2014. p. 709\u201354."},{"key":"462_CR47","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/nclimate2022","volume":"3","author":"DO \u00c5str\u00f6m","year":"2013","unstructured":"\u00c5str\u00f6m DO, Forsberg B, Ebi KL, Rockl\u00f6v J. Attributing mortality from extreme temperatures to climate change in Stockholm, Sweden. Nat Clim Chang. 2013;3:1050\u2013105.","journal-title":"Nat Clim Chang"},{"key":"462_CR48","volume-title":"Heat-waves: risks and responses \/ by Christina Koppe","author":"C Koppe","year":"2004","unstructured":"Koppe C, Kovats S, Menne B, Jendritzky G, World Health Organization, et al. Regional Office for Europe. In: Heat-waves: risks and responses \/ by Christina Koppe. Copenhagen, Denmark: WHO Regional Office for Europe; 2004."},{"key":"462_CR49","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1038\/s41558-018-0299-2","volume":"8","author":"W Cramer","year":"2018","unstructured":"Cramer W, Guiot J, Fader M, Garrabou J, Gattuso J, Iglesias A, Lange M, Lionello P, Llasat M, Paz S, Pe\u00f1uelas J, Snoussi M, Toreti A, Tsimplis M, Xoplaki E. Climate change and interconnected risks to sustainable development in the Mediterranean. Nat Clim Chang. 2018;8:972\u201380.","journal-title":"Nat Clim Chang"},{"key":"462_CR50","doi-asserted-by":"publisher","first-page":"4623","DOI":"10.3390\/ijerph8124623","volume":"8","author":"D Lowe","year":"2011","unstructured":"Lowe D, Ebi K, Forsberg B. Heatwave early warning systems and adaptation advice to reduce human health consequences of heatwaves. Int J Environ Res Public Health. 2011;8:4623\u201348.","journal-title":"Int J Environ Res Public Health"}],"container-title":["Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12940-019-0462-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12940-019-0462-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12940-019-0462-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T12:07:25Z","timestamp":1607083645000},"score":1,"resource":{"primary":{"URL":"https:\/\/ehjournal.biomedcentral.com\/articles\/10.1186\/s12940-019-0462-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["462"],"URL":"https:\/\/doi.org\/10.1186\/s12940-019-0462-x","relation":{},"ISSN":["1476-069X"],"issn-type":[{"value":"1476-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]},"assertion":[{"value":"12 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Not applicable.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All the authors reviewed and approved the final version.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"25"}}