{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:19:21Z","timestamp":1777695561751,"version":"3.51.4"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Key R&D Program of Tibet","award":["XZ202001ZY0050G"],"award-info":[{"award-number":["XZ202001ZY0050G"]}]},{"name":"Central Government Guides Local Scienceand Technology Development Program","award":["XZ202201YD0014C"],"award-info":[{"award-number":["XZ202201YD0014C"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Essential trace elements (ETEs), such as copper (Cu), iron (Fe), manganese (Mn), molybdenum (Mo), selenium (Se), zinc (Zn), are very important elements for human health.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this study, 89 drinking water samples and 85 highland barleys were collected from 48 villages in 11 townships, and the average daily dose (<jats:italic>ADD<\/jats:italic>) of ETEs were calculated, in addition, health effects of ETEs to rural residents in Luolong County, a typical Kashin-Beck disease (KBD) endemic area in Tibet, were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean concentrations of Cu, Fe, Mn, Mo, Se, Zn in drinking water were 0.278\u2009\u00b1\u20090.264\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>, 0.766\u2009\u00b1\u20090.312\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>, 0.411\u2009\u00b1\u20090.526\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>,\u00a00.119\u2009\u00b1\u20090.223\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>, 0.155\u2009\u00b1\u20090.180\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>, and 0.804\u2009\u00b1\u20091.112\u00a0\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>, respectively; and mean concentrations of Cu, Fe, Mn, Mo, Se and Zn in highland barley were 3.550\u2009\u00b1\u20090.680\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, 81.17\u2009\u00b1\u200938.14\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, 14.03\u2009\u00b1\u20091.42\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, 0.350\u2009\u00b1\u20090.200\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, 0.0028\u2009\u00b1\u20090.0056\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, and 23.58\u2009\u00b1\u20093.10\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, respectively. The <jats:italic>ADD<\/jats:italic> of Cu in the study area was appropriate; the <jats:italic>ADD<\/jats:italic> of Fe and Mn in each township were higher than the maximum oral reference dose recommended by the National Health Commission of China, indicating that Fe and Mn had non-carcinogenic health risks; the <jats:italic>ADD<\/jats:italic> of Mo and Zn in 36.36% and 54.55% of the townships exceeded the maximum oral reference dose; and 72.73% of the townships had insufficient <jats:italic>ADD<\/jats:italic> of Se. The <jats:italic>ADD<\/jats:italic> of Mo, Cu and Se in different townships was significantly correlated with the prevalence of KBD.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Therefore, in order to prevent and control the prevalence of KBD and ensure the health of local residents, it is necessary to reduce the intake of high concentrations of Fe, Mn and Zn in diet, as well as increase the intake of Mo, Cu, especially Se.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1186\/s12940-022-00898-0","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T11:03:52Z","timestamp":1663326232000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Dietary and drinking water intake of essential trace elements in a typical Kashin-Beck disease endemic area of Tibet, China"],"prefix":"10.1186","volume":"21","author":[{"given":"Xinjie","family":"Zha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"An","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"898_CR1","doi-asserted-by":"publisher","unstructured":"Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. 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