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All pwCF registered in the UK CF Registry were eligible for this study. Linear and Poisson regressions, adjusted for age, gender, genotype, BMI,\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      and deprivation, were used to quantify associations between distance to a PCS and percent predicted forced expiratory volume in one second (ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      ), pulmonary exacerbations (#IVdays), and fungal and bacterial infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of the 9,361 pwCF (3,931 children and 5,430 adults) studied was 20.1 (\n                      <jats:italic>SD<\/jats:italic>\n                      \u2009=\u200914.1) years; 53.3% were male; and 49.2% were homozygous\n                      <jats:italic>F508del<\/jats:italic>\n                      . Over 10% of pwCF (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20091,015) lived within 4\u00a0km of a PCS. We found no statistically significant difference in ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      and #IVdays\/year in children. However, in adults, ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      was -1.07% lower (95% confidence interval (CI): -2.29%, 0.16%)\u00a0and #IVdays\/year were 1.02\u00a0day higher (95%CI: 1.01, 1.04) within 4\u00a0km of a PCS. Furthermore, there were statistically significant differences in mean ppFEV\n                      <jats:sub>1<\/jats:sub>\n                      in CF adults with\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      (58.2.%\n                      <jats:italic>vs<\/jats:italic>\n                      62.0%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005)\n                      <jats:italic>and Candida spp.<\/jats:italic>\n                      (56.9%\n                      <jats:italic>vs<\/jats:italic>\n                      59.9%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.029) residing within 4\u00a0km of a PCS. No associations were identified for allergic bronchopulmonary aspergillosis,\n                      <jats:italic>P. aeruginosa<\/jats:italic>\n                      or\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This novel national study provides evidence that adults with CF living near a PCS may experience small reductions in lung function, an increased risk of pulmonary exacerbations, and more frequent fungal infections. If confirmed by studies using refined exposure assessment methods accounting for bioaerosol dispersion, these results could have important implications for the living environment of pwCF.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12940-022-00932-1","type":"journal-article","created":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T23:29:07Z","timestamp":1671060547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Assessing the health risk of living near composting facilities on lung health, fungal and bacterial disease in cystic fibrosis: a UK CF Registry study"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6092-2021","authenticated-orcid":false,"given":"Muhammad Saleem","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Douglas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna L.","family":"Hansell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Simmonds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8131-7728","authenticated-orcid":false,"given":"Fr\u00e9d\u00e9ric B.","family":"Piel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"932_CR1","volume-title":"UK Cystic Fibrosis Registry Annual Data Report 2020","author":"UK CF Registry","year":"2020","unstructured":"UK CF Registry. 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