{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T03:13:23Z","timestamp":1792120403204,"version":"4.4.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:00:00Z","timestamp":1711584000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Health"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The largest documented episode of human contamination by PFOA in the world (approximately 150,000 actual residents on 1 January 2020) has occurred in Italy\u2019s Veneto Region. In this large, mostly flat plain area, a cluster of testicular cancers has also been observed. Preliminary data are reported, and the most relevant and recent recommendations regarding the health surveillance of exposed individuals are emphasized.<\/jats:p>","DOI":"10.1186\/s12940-024-01064-4","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T06:02:22Z","timestamp":1711605742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["PFOA and testis cancer in the Veneto Region (Italy)"],"prefix":"10.1186","volume":"23","author":[{"given":"Mario","family":"Saugo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Ioverno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Olivieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Pasinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Ducatman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,28]]},"reference":[{"key":"1064_CR1","doi-asserted-by":"publisher","unstructured":"Zahm S, Bonde JP, Chiu WA, Hoppin J, Kanno J, Abdallah M, et al. Carcinogenicity of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). Lancet Oncol. 2023. https:\/\/doi.org\/10.1016\/S1470-2045(23)00622-8. Published online 30 November 2023.","DOI":"10.1016\/S1470-2045(23)00622-8"},{"key":"1064_CR2","unstructured":"Sistema Epidemiologico Regionale. (2016). Ricognizione epidemiologica iniziale sulle orchiectomie per tumore del testicolo rilevate nell\u2019area interessata dalla contaminazione idropotabile da PFAS. Padua, Italy. Available from: https:\/\/sian.aulss9.veneto.it\/index.cfm?method=mys.apridoc&iddoc=809 [Italian]."},{"issue":"12","key":"1064_CR3","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1289\/ehp.0800379","volume":"117","author":"SJ Frisbee","year":"2009","unstructured":"Frisbee SJ, Brooks AP Jr, Maher A, Flensborg P, Arnold S, Fletcher T, Steenland K, Shankar A, Knox SS, Pollard C, Halverson JA, Vieira VM, Jin C, Leyden KM, Ducatman AM. The C8 health project: design, methods, and participants. Environ Health Perspect. 2009;117(12):1873\u201382. https:\/\/doi.org\/10.1289\/ehp.0800379. Epub 2009 Jul 13. PMID: 20049206; PMCID: PMC2799461.","journal-title":"Environ Health Perspect"},{"issue":"2","key":"1064_CR4","doi-asserted-by":"publisher","first-page":"27007","DOI":"10.1289\/EHP5337","volume":"128","author":"G Pitter","year":"2020","unstructured":"Pitter G, Da Re F, Canova C, Barbieri G, Zare Jeddi M, Dapr\u00e0 F, Manea F, Zolin R, Bettega AM, Stopazzolo G, Vittorii S, Zambelli L, Martuzzi M, Mantoan D, Russo F. Serum levels of Perfluoroalkyl Substances (PFAS) in adolescents and young adults exposed to contaminated drinking Water in the Veneto Region, Italy: a cross-sectional study based on a Health Surveillance Program. Environ Health Perspect. 2020;128(2):27007. https:\/\/doi.org\/10.1289\/EHP5337. Epub 2020 Feb 18. PMID: 32068468; PMCID: PMC7064325.","journal-title":"Environ Health Perspect"},{"issue":"1","key":"1064_CR5","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1136\/oemed-2017-104651","volume":"75","author":"Y Li","year":"2018","unstructured":"Li Y, Fletcher T, Mucs D, Scott K, Lindh CH, Tallving P, Jakobsson K. Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water. Occup Environ Med. 2018;75(1):46\u201351. https:\/\/doi.org\/10.1136\/oemed-2017-104651. Epub 2017 Nov 13. PMID: 29133598; PMCID: PMC5749314.","journal-title":"Occup Environ Med"},{"key":"1064_CR6","unstructured":"Registro Tumori del Veneto. Registrazione dei tumori maligni diagnosticati nella popolazione residente nei 21 Comuni del Veneto di cui alla nota regionale 203887 del 24 Maggio 2016 Direttore Generale Area Sanit\u00e0 e Sociale. Padua, Italy. Available from: https:\/\/sian.aulss9.veneto.it\/index.cfm?method=mys.apridoc&iddoc=806"},{"key":"1064_CR7","unstructured":"De Felip E, Ingelido AM. (2017). The human biomonitoring study. Presentation at the Workshop Designing an epidemiological study on PFAS exposed population in the Veneto Region. Venice, 22\u201323 February 2017. (Unpublished data)."},{"key":"1064_CR8","unstructured":"Istituto Superiore di Sanit\u00e0. Reparto Di Chimica Tossicologica, Dipartimento Ambiente E Salute (2017). Biomonitoraggio Di Sostanze Perfluoroalchiliche (PFAS) Nella Regione Veneto. Risultati della determinazione della concentrazione di PFAS nel siero di operatori e residenti in aziende agricole e zootecniche. Roma, Italy: Istituto Superiore di Sanit\u00e0. (Unpublished data)."},{"issue":"3","key":"1064_CR9","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1289\/ehp.1205829","volume":"121","author":"VM Vieira","year":"2013","unstructured":"Vieira VM, Hoffman K, Shin HM, Weinberg JM, Webster TF, Fletcher T. Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis. Environ Health Perspect. 2013;121(3):318\u201323. https:\/\/doi.org\/10.1289\/ehp.1205829. Epub 2013 Jan 8. PMID: 23308854; PMCID: PMC3621179.","journal-title":"Environ Health Perspect"},{"key":"1064_CR10","doi-asserted-by":"publisher","unstructured":"Mastrantonio M, Bai E, Uccelli R, Cordiano V, Screpanti A, Crosignani P. Drinking water contamination from perfluoroalkyl substances (PFAS): an ecological mortality study in the Veneto Region, Italy. Eur J Public Health. 2018;28(1):180\u2013185. https:\/\/doi.org\/10.1093\/eurpub\/ckx066. Erratum in: Eur J Public Health. 2023;33(6):1203. PMID: 28541558.","DOI":"10.1093\/eurpub\/ckx066"},{"key":"1064_CR11","doi-asserted-by":"publisher","unstructured":"Biggeri A, Stoppa G, Facciolo L, Fin G, Mancini S, Manno V, Minelli G, Zamagni F, Zamboni M, Catelan D. All-cause, circulatory disease and cancer mortality in the population of a large Italian area contaminated by perfluoroalkyl and polyfluoroalkyl substances (1980\u20132018). https:\/\/doi.org\/10.1101\/2023.12.09.23299764.","DOI":"10.1101\/2023.12.09.23299764"},{"key":"1064_CR12","unstructured":"C8 Medical Panel. (2013). Information on the C8 (PFOA medical monitoring program screening tests prepared by the Medical Panel for the C8 Class Members. Available from: http:\/\/www.c-8medicalmonitoringprogram.com\/docs\/med_panel_education_doc.pdf."},{"key":"1064_CR13","doi-asserted-by":"publisher","DOI":"10.17226\/26156","volume-title":"Guidance on PFAS exposure, testing, and clinical Follow-Up","author":"National Academies of Sciences, Engineering, and Medicine","year":"2022","unstructured":"National Academies of Sciences, Engineering, and Medicine. Guidance on PFAS exposure, testing, and clinical Follow-Up. Washington, DC: The National Academies; 2022. https:\/\/doi.org\/10.17226\/26156."},{"key":"1064_CR14","unstructured":"Silent Spring Institute. PFAS-REACH. Available from: https:\/\/pfas-exchange.org\/about-us\/."}],"container-title":["Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12940-024-01064-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12940-024-01064-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12940-024-01064-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T06:06:06Z","timestamp":1711605966000},"score":1,"resource":{"primary":{"URL":"https:\/\/ehjournal.biomedcentral.com\/articles\/10.1186\/s12940-024-01064-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,28]]},"references-count":14,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["1064"],"URL":"https:\/\/doi.org\/10.1186\/s12940-024-01064-4","relation":{},"ISSN":["1476-069X"],"issn-type":[{"value":"1476-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,28]]},"assertion":[{"value":"24 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Alan Ducatman served as the West Virginia University principal investigator for the creation and health communications of the C8 Health Project in the United States. He has assisted as a paid consultant to attorneys for residents of contaminated communities in the United States who have sought medical monitoring following PFAS water contamination.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"33"}}