{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T01:04:47Z","timestamp":1784077487141,"version":"3.55.0"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":54,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["\u201cPRIN 2022\u201d (No. 2022MHMRPR)"],"award-info":[{"award-number":["\u201cPRIN 2022\u201d (No. 2022MHMRPR)"]}],"id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009104","name":"Universit\u00e0 Degli Studi di Modena e Reggio Emilia","doi-asserted-by":"publisher","award":["\u201cUNIMORE FAR 2023\u201d"],"award-info":[{"award-number":["\u201cUNIMORE FAR 2023\u201d"]}],"id":[{"id":"10.13039\/100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Environ Health"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The contribution of environmental determinants in the etiology of amyotrophic lateral sclerosis (ALS) is still unclear. Among the various environmental factors, exposure to green spaces, also known as greenness, is attracting considerable interest as many studies have reported its beneficial associations to health outcomes, particularly to neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To investigate the relation between greenness and ALS risk, we conducted a population-based case-control study in a Northern Italy population (from Modena, Reggio Emilia and Parma provinces), including 499 cases of ALS newly-diagnosed from 1998 to 2011 and 1,935 sex-, age-, and province-matched controls randomly selected from study provinces residents. We evaluated the association between greenness in the proximity of residence and ALS risk, assessing exposure through multiple satellite-based and land-use derived indices, both conventional and novel devised, for a total of six indices, each providing specific information, including annual and seasonal Normalized Difference Vegetation Index (NDVI), NDVI-weighted to green areas, green cover ratio, accessibility index, and their combined Green Exposure Index (GEI). We used conditional logistic regression models to evaluate disease risk for increasing exposure through both fixed-categories and non-linear restricted cubic splines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a non-linear U-shaped association between greenness and ALS risk with increased odds ratios at both low and high levels. Results were more defined when using NDVI-based indices, while the associations were smoother when considering GEI. The higher risk at low levels may be related to lower accessibility to green spaces with lower physical activity and higher exposure to outdoor air pollutants, whilst elevated greenness may reflect higher exposure to neurotoxic pesticides. These results were confirmed also after adjustment for potential confounders, namely magnetic fields and light at night. Sex stratified analysis yielded similar results, except for more distinct associations in females for GEI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Despite the limitations due to possible unmeasured confounding and exposure misclassification related to the use of residential data, our results provide evidence of an inverse association between intermediate residential greenness and ALS risk, and may have public health implications including disease prevention and urban planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12940-026-01311-w","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T02:45:13Z","timestamp":1779417913000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green space exposure and risk of amyotrophic lateral sclerosis: a population-based case-control study in Northern Italy"],"prefix":"10.1186","volume":"25","author":[{"given":"Asia","family":"Sarti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Mandrioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Costanzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guigo Xavier","family":"Balbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Malagoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Despini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Violi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcella","family":"Malavolti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Giacchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Donelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Canali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Zinno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Teggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vinceti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Filippini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"issue":"10","key":"1311_CR1","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1111\/ene.14393","volume":"27","author":"P Masrori","year":"2020","unstructured":"Masrori P, Van Damme P. Amyotrophic lateral sclerosis: a clinical review. Eur J Neurol. 2020;27(10):1918\u201329. https:\/\/doi.org\/10.1111\/ene.14393.","journal-title":"Eur J Neurol"},{"issue":"10360","key":"1311_CR2","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","volume":"400","author":"EL Feldman","year":"2022","unstructured":"Feldman EL, Goutman SA, Petri S, Mazzini L, Savelieff MG, Shaw PJ, Sobue G. Amyotrophic lateral sclerosis. Lancet. 2022;400(10360):1363\u201380. https:\/\/doi.org\/10.1016\/S0140-6736(22)01272-7.","journal-title":"Lancet"},{"key":"1311_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2147\/DNND.S84956","volume":"6","author":"AA Alsultan","year":"2016","unstructured":"Alsultan AA, Waller R, Heath PR, Kirby J. The genetics of amyotrophic lateral sclerosis: current insights. Degener Neurol Neuromuscul Dis. 2016;6:49\u201364. https:\/\/doi.org\/10.2147\/DNND.S84956.","journal-title":"Degener Neurol Neuromuscul Dis"},{"issue":"10","key":"1311_CR4","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.jgg.2025.05.008","volume":"52","author":"L Yuan","year":"2025","unstructured":"Yuan L, Yang Y, Guo Y, Deng H. Genetic architecture of amyotrophic lateral sclerosis: a comprehensive review. J Genet Genomics. 2025;52(10):1155\u201376. https:\/\/doi.org\/10.1016\/j.jgg.2025.05.008.","journal-title":"J Genet Genomics"},{"issue":"8","key":"1311_CR5","doi-asserted-by":"publisher","first-page":"e213467","DOI":"10.1212\/WNL.0000000000213467","volume":"104","author":"R Vasta","year":"2025","unstructured":"Vasta R, De Mattei F, Tafaro S, Canosa A, Manera U, Grassano M, Palumbo F, Cabras S, Matteoni E, Di Pede F, et al. Changes to average survival of patients with amyotrophic lateral sclerosis (1995\u20132018): results from the Piemonte and Valle d\u2019Aosta Registry. Neurology. 2025;104(8):e213467. https:\/\/doi.org\/10.1212\/WNL.0000000000213467","journal-title":"Neurology"},{"issue":"6","key":"1311_CR6","doi-asserted-by":"publisher","first-page":"e613","DOI":"10.1212\/WNL.0000000000207474","volume":"101","author":"C Wolfson","year":"2023","unstructured":"Wolfson C, Gauvin DE, Ishola F, Oskoui M. Global prevalence and incidence of amyotrophic lateral sclerosis: a systematic review. Neurology. 2023;101(6):e613\u201323. https:\/\/doi.org\/10.1212\/WNL.0000000000207474","journal-title":"Neurology"},{"issue":"1","key":"1311_CR7","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1515\/reveh-2012-0002","volume":"27","author":"M Vinceti","year":"2012","unstructured":"Vinceti M, Bottecchi I, Fan A, Finkelstein Y, Mandrioli J. Are environmental exposures to selenium, heavy metals, and pesticides risk factors for amyotrophic lateral sclerosis? Rev Environ Health. 2012;27(1):19\u201341. https:\/\/doi.org\/10.1515\/reveh-2012-0002.","journal-title":"Rev Environ Health"},{"issue":"5","key":"1311_CR8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/S1474-4422(21)00414-2","volume":"21","author":"SA Goutman","year":"2022","unstructured":"Goutman SA, Hardiman O, Al-Chalabi A, Chio A, Savelieff MG, Kiernan MC, Feldman EL. Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis. Lancet Neurol. 2022;21(5):465\u201379. https:\/\/doi.org\/10.1016\/S1474-4422(21)00414-2.","journal-title":"Lancet Neurol"},{"key":"1311_CR9","doi-asserted-by":"publisher","first-page":"1177431","DOI":"10.3389\/fnins.2023.1177431","volume":"17","author":"QQ Duan","year":"2023","unstructured":"Duan QQ, Jiang Z, Su WM, Gu XJ, Wang H, Cheng YF, Cao B, Gao X, Wang Y, Chen YP. Risk factors of amyotrophic lateral sclerosis: a global meta-summary. Front Neurosci. 2023;17:1177431. https:\/\/doi.org\/10.3389\/fnins.2023.1177431.","journal-title":"Front Neurosci"},{"key":"1311_CR10","doi-asserted-by":"publisher","unstructured":"Vasta R, Chia R, Traynor BJ, Chio A. Unraveling the complex interplay between genes, environment, and climate in ALS. EBioMedicine 2022, 75:103795. https:\/\/doi.org\/10.1016\/j.ebiom.2021.103795","DOI":"10.1016\/j.ebiom.2021.103795"},{"key":"1311_CR11","doi-asserted-by":"publisher","first-page":"1541779","DOI":"10.3389\/fnagi.2025.1541779","volume":"17","author":"Q Wu","year":"2025","unstructured":"Wu Q, Yang J, Duan Y, Ma Y, Zhang Y, Tan S, Wang J, Wang Y, Liu B, Zhang J, et al. Environmental risk factors, protective factors, and biomarkers for amyotrophic lateral sclerosis: an umbrella review. Front Aging Neurosci. 2025;17:1541779. https:\/\/doi.org\/10.3389\/fnagi.2025.1541779.","journal-title":"Front Aging Neurosci"},{"issue":"5","key":"1311_CR12","first-page":"407","volume":"24","author":"M Vinceti","year":"2012","unstructured":"Vinceti M, Fiore M, Signorelli C, Odone A, Tesauro M, Consonni M, Arcolin E, Malagoli C, Mandrioli J, Marmiroli S, et al. Environmental risk factors for amyotrophic lateral sclerosis: methodological issues in epidemiologic studies. Ann Ig. 2012;24(5):407\u201315.","journal-title":"Ann Ig"},{"issue":"5\u20136","key":"1311_CR13","doi-asserted-by":"publisher","first-page":"377","DOI":"10.3109\/21678421.2016.1154575","volume":"17","author":"CA Harwood","year":"2016","unstructured":"Harwood CA, Westgate K, Gunstone S, Brage S, Wareham NJ, McDermott CJ, Shaw PJ. Long-term physical activity: an exogenous risk factor for sporadic amyotrophic lateral sclerosis? Amyotroph Lateral Scler Frontotemporal Degener. 2016;17(5\u20136):377\u201384. https:\/\/doi.org\/10.3109\/21678421.2016.1154575.","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"1311_CR14","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.pneurobio.2016.05.004","volume":"142","author":"M Zufiria","year":"2016","unstructured":"Zufiria M, Gil-Bea FJ, Fernandez-Torron R, Poza JJ, Munoz-Blanco JL, Rojas-Garcia R, Riancho J, Lopez de Munain A. ALS: a bucket of genes, environment, metabolism and unknown ingredients. Prog Neurobiol. 2016;142:104\u201329. https:\/\/doi.org\/10.1016\/j.pneurobio.2016.05.004","journal-title":"Prog Neurobiol"},{"key":"1311_CR15","doi-asserted-by":"publisher","first-page":"109530","DOI":"10.1016\/j.envres.2020.109530","volume":"186","author":"M Fiore","year":"2020","unstructured":"Fiore M, Parisio R, Filippini T, Mantione V, Platania A, Odone A, Signorelli C, Pietrini V, Mandrioli J, Teggi S, et al. Living near waterbodies as a proxy of cyanobacteria exposure and risk of amyotrophic lateral sclerosis: a population based case-control study. Environ Res. 2020;186:109530. https:\/\/doi.org\/10.1016\/j.envres.2020.109530.","journal-title":"Environ Res"},{"issue":"3","key":"1311_CR16","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3390\/ijerph17030857","volume":"17","author":"T Filippini","year":"2020","unstructured":"Filippini T, Fiore M, Tesauro M, Malagoli C, Consonni M, Violi F, Arcolin E, Iacuzio L, Oliveri Conti G, Cristaldi A, et al. Clinical and lifestyle factors and risk of amyotrophic lateral sclerosis: a population-based case-control study. Int J Environ Res Public Health. 2020;17(3):857. https:\/\/doi.org\/10.3390\/ijerph17030857","journal-title":"Int J Environ Res Public Health"},{"issue":"1","key":"1311_CR17","doi-asserted-by":"publisher","first-page":"11939","DOI":"10.1038\/s41598-021-91349-2","volume":"11","author":"T Filippini","year":"2021","unstructured":"Filippini T, Hatch EE, Vinceti M. Residential exposure to electromagnetic fields and risk of amyotrophic lateral sclerosis: a dose-response meta-analysis. Sci Rep. 2021;11(1):11939. https:\/\/doi.org\/10.1038\/s41598-021-91349-2.","journal-title":"Sci Rep"},{"issue":"3","key":"1311_CR18","doi-asserted-by":"publisher","first-page":"973","DOI":"10.3390\/ijerph18030973","volume":"18","author":"T Filippini","year":"2021","unstructured":"Filippini T, Mandrioli J, Malagoli C, Costanzini S, Cherubini A, Maffeis G, Vinceti M. Risk of amyotrophic lateral sclerosis and exposure to particulate matter from vehicular traffic: a case-control study. Int J Environ Res Public Health. 2021;18(3):973. https:\/\/doi.org\/10.3390\/ijerph18030973","journal-title":"Int J Environ Res Public Health"},{"issue":"Pt A","key":"1311_CR19","doi-asserted-by":"publisher","first-page":"108742","DOI":"10.1016\/j.envres.2019.108742","volume":"179","author":"M Vinceti","year":"2019","unstructured":"Vinceti M, Filippini T, Malagoli C, Violi F, Mandrioli J, Consonni D, Rothman KJ, Wise LA. Amyotrophic lateral sclerosis incidence following exposure to inorganic selenium in drinking water: a long-term follow-up. Environ Res. 2019;179(Pt A):108742. https:\/\/doi.org\/10.1016\/j.envres.2019.108742","journal-title":"Environ Res"},{"key":"1311_CR20","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.envres.2017.02.025","volume":"155","author":"M Vinceti","year":"2017","unstructured":"Vinceti M, Violi F, Tzatzarakis M, Mandrioli J, Malagoli C, Hatch EE, Fini N, Fasano A, Rakitskii VN, Kalantzi OI, et al. Pesticides, polychlorinated biphenyls and polycyclic aromatic hydrocarbons in cerebrospinal fluid of amyotrophic lateral sclerosis patients: a case-control study. Environ Res. 2017;155:261\u20137. https:\/\/doi.org\/10.1016\/j.envres.2017.02.025.","journal-title":"Environ Res"},{"issue":"9","key":"1311_CR21","doi-asserted-by":"publisher","first-page":"097023","DOI":"10.1289\/EHP1115","volume":"125","author":"M Seelen","year":"2017","unstructured":"Seelen M, Toro Campos RA, Veldink JH, Visser AE, Hoek G, Brunekreef B, van der Kooi AJ, de Visser M, Raaphorst J, van den Berg LH, et al. Long-term air pollution exposure and amyotrophic lateral sclerosis in Netherlands: a population-based case-control Sstudy. Environ Health Perspect. 2017;125(9):097023. https:\/\/doi.org\/10.1289\/EHP1115","journal-title":"Environ Health Perspect"},{"key":"1311_CR22","doi-asserted-by":"publisher","first-page":"122232","DOI":"10.1016\/j.envres.2025.122232","volume":"284","author":"D Saucier","year":"2025","unstructured":"Saucier D, Belanger M, Liu Z, Lavigne E, O\u2019Connell C. Associations between long-term air pollution exposure and the development of amyotrophic lateral sclerosis: a matched case-control study. Environ Res. 2025;284:122232. https:\/\/doi.org\/10.1016\/j.envres.2025.122232","journal-title":"Environ Res"},{"key":"1311_CR23","doi-asserted-by":"publisher","first-page":"152504","DOI":"10.1016\/j.scitotenv.2021.152504","volume":"817","author":"ME Newell","year":"2022","unstructured":"Newell ME, Adhikari S, Halden RU. Systematic and state-of the science review of the role of environmental factors in Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig\u2019s Disease. Sci Total Environ. 2022;817:152504. https:\/\/doi.org\/10.1016\/j.scitotenv.2021.152504.","journal-title":"Sci Total Environ"},{"issue":"1","key":"1311_CR24","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s40572-018-0179-y","volume":"5","author":"KC Fong","year":"2018","unstructured":"Fong KC, Hart JE, James P. A review of epidemiologic studies on greenness and health: updated literature through 2017. Curr Environ Health Rep. 2018;5(1):77\u201387. https:\/\/doi.org\/10.1007\/s40572-018-0179-y","journal-title":"Curr Environ Health Rep"},{"issue":"2","key":"1311_CR25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s40471-015-0043-7","volume":"2","author":"P James","year":"2015","unstructured":"James P, Banay RF, Hart JE, Laden F. A review of the health benefits of greenness. Curr Epidemiol Rep. 2015;2(2):131\u201342. https:\/\/doi.org\/10.1007\/s40471-015-0043-7","journal-title":"Curr Epidemiol Rep"},{"issue":"1","key":"1311_CR26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1093\/ije\/dyab089","volume":"51","author":"T Astell-Burt","year":"2022","unstructured":"Astell-Burt T, Hartig T, Eckermann S, Nieuwenhuijsen M, McMunn A, Frumkin H, Feng X. More green, less lonely? A longitudinal cohort study. Int J Epidemiol. 2022;51(1):99\u2013110. https:\/\/doi.org\/10.1093\/ije\/dyab089.","journal-title":"Int J Epidemiol"},{"key":"1311_CR27","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.envres.2017.06.028","volume":"158","author":"I Markevych","year":"2017","unstructured":"Markevych I, Schoierer J, Hartig T, Chudnovsky A, Hystad P, Dzhambov AM, de Vries S, Triguero-Mas M, Brauer M, Nieuwenhuijsen MJ, et al. Exploring pathways linking greenspace to health: theoretical and methodological guidance. Environ Res. 2017;158:301\u201317. https:\/\/doi.org\/10.1016\/j.envres.2017.06.028","journal-title":"Environ Res"},{"key":"1311_CR28","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1097\/EDE.0000000000000549","volume":"28","author":"MJ Nieuwenhuijsen","year":"2017","unstructured":"Nieuwenhuijsen MJ, Khreis H, Triguero-Mas M, Gascon M, Payam Dadvand P. Fifty shades of green: pathway to healthy urban living. Epidemiology. 2017;28:63\u201371. https:\/\/doi.org\/10.1097\/EDE.0000000000000549","journal-title":"Epidemiology"},{"issue":"1","key":"1311_CR29","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s12940-022-00863-x","volume":"21","author":"L Rodriguez-Loureiro","year":"2022","unstructured":"Rodriguez-Loureiro L, Gadeyne S, Bauwelinck M, Lefebvre W, Vanpoucke C, Casas L. Long-term exposure to residential greenness and neurodegenerative disease mortality among older adults: a 13-year follow-up cohort study. Environ Health. 2022;21(1):49. https:\/\/doi.org\/10.1186\/s12940-022-00863-x.","journal-title":"Environ Health"},{"key":"1311_CR30","doi-asserted-by":"publisher","first-page":"163173","DOI":"10.1016\/j.scitotenv.2023.163173","volume":"878","author":"Z Zhu","year":"2023","unstructured":"Zhu Z, Yang Z, Yu L, Xu L, Wu Y, Zhang X, Shen P, Lin H, Shui L, Tang M, et al. Residential greenness, air pollution and incident neurodegenerative disease: a cohort study in China. Sci Total Environ. 2023;878:16317. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.163173","journal-title":"Sci Total Environ"},{"key":"1311_CR31","doi-asserted-by":"publisher","first-page":"108739","DOI":"10.1016\/j.envint.2024.108739","volume":"188","author":"JO Klompmaker","year":"2024","unstructured":"Klompmaker JO, Mork D, Zanobetti A, Braun D, Hankey S, Hart JE, Hystad P, Jimenez MP, Laden F, Larkin A, et al. Associations of street-view greenspace with Parkinson\u2019s disease hospitalizations in an open cohort of elderly US Medicare beneficiaries. Environ Int. 2024;188:108739. https:\/\/doi.org\/10.1016\/j.envint.2024.108739.","journal-title":"Environ Int"},{"issue":"6","key":"1311_CR32","doi-asserted-by":"publisher","first-page":"3491","DOI":"10.3390\/ijerph19063491","volume":"19","author":"J Jung","year":"2022","unstructured":"Jung J, Park JY, Myung W, Lee JY, Ko H, Lee H. Association between residential greenness and incidence of Parkinson\u2019s Disease: a population-based cohort study in South Korea. Int J Environ Res Public Health. 2022;19(6):3491. https:\/\/doi.org\/10.3390\/ijerph19063491","journal-title":"Int J Environ Res Public Health"},{"issue":"4","key":"1311_CR33","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3390\/biomedicines10040819","volume":"10","author":"G Gianferrari","year":"2022","unstructured":"Gianferrari G, Martinelli I, Zucchi E, Simonini C, Fini N, Vinceti M, Ferro S, Gessani A, Canali E, Valzania F, et al. Epidemiological, clinical and genetic features of ALS in the last decade: a prospective population-based study in the Emilia Romagna Region of Italy. Biomedicines. 2022;10(4):819. https:\/\/doi.org\/10.3390\/biomedicines10040819","journal-title":"Biomedicines"},{"issue":"8","key":"1311_CR34","doi-asserted-by":"publisher","first-page":"941","DOI":"10.3390\/life14080941","volume":"14","author":"G Gianferrari","year":"2024","unstructured":"Gianferrari G, Zucchi E, Martinelli I, Simonini C, Fini N, Ferro S, Mercati A, Ferri L, Filippini T, Vinceti M, et al. Trends in hospital admissions for patients with amyotrophic lateral sclerosis: insights from a retrospective cohort study in a province in Northern Italy. Life (Basel). 2024;14(8):9. https:\/\/doi.org\/10.3390\/life14080941","journal-title":"Life (Basel)"},{"issue":"5","key":"1311_CR35","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron D. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000;1(5):293\u20139. https:\/\/doi.org\/10.1080\/146608200300079536.","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"1","key":"1311_CR36","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12940-017-0297-2","volume":"16","author":"M Vinceti","year":"2017","unstructured":"Vinceti M, Filippini T, Violi F, Rothman KJ, Costanzini S, Malagoli C, Wise LA, Odone A, Signorelli C, Iacuzio L, et al. Pesticide exposure assessed through agricultural crop proximity and risk of amyotrophic lateral sclerosis. Environ Health. 2017;16(1):91. https:\/\/doi.org\/10.1186\/s12940-017-0297-2.","journal-title":"Environ Health"},{"issue":"7\u20138","key":"1311_CR37","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1080\/21678421.2017.1332078","volume":"18","author":"M Vinceti","year":"2017","unstructured":"Vinceti M, Malagoli C, Fabbi S, Kheifets L, Violi F, Poli M, Caldara S, Sesti D, Violanti S, Zanichelli P, et al. Magnetic fields exposure from high-voltage power lines and risk of amyotrophic lateral sclerosis in two Italian populations. Amyotroph Lateral Scler Frontotemporal Degener. 2017;18(7\u20138):583\u20139. https:\/\/doi.org\/10.1080\/21678421.2017.1332078.","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"1311_CR38","unstructured":"QGIS Geographic Information System. Open Source Geospatial Foundation. [https:\/\/qgis.org\/]"},{"key":"1311_CR39","doi-asserted-by":"publisher","first-page":"124254","DOI":"10.1016\/j.envres.2026.124254","volume":"298","author":"N Martini","year":"2026","unstructured":"Martini N, Despini F, Filippini T, Vinceti M, Teggi S, Costanzini S. Assessing green space exposure: from traditional metrics to the Green Exposure Index (GEI) with application to a Northern Italy residential dataset. Environ Res. 2026;298:124254. https:\/\/doi.org\/10.1016\/j.envres.2026.124254.","journal-title":"Environ Res"},{"issue":"6","key":"1311_CR40","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.3390\/rs15061549","volume":"15","author":"Y Cao","year":"2023","unstructured":"Cao Y, Li G, Huang Y. Spatiotemporal evolution of residential exposure to green space in Beijing. Remote Sens. 2023;15(6):1549. https:\/\/doi.org\/10.3390\/rs15061549","journal-title":"Remote Sens"},{"issue":"1","key":"1311_CR41","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3390\/smartcities4010006","volume":"4","author":"C Moreno","year":"2021","unstructured":"Moreno C, Allam Z, Chabaud D, Gall C, Pratlong F. Introducing the 15-minute city: sustainability, resilience and place identity in future post-pandemic cities. Smart Cities. 2021;4(1):93\u2013111. https:\/\/doi.org\/10.3390\/smartcities4010006","journal-title":"Smart Cities"},{"issue":"16","key":"1311_CR42","doi-asserted-by":"publisher","first-page":"3967","DOI":"10.3390\/rs14163967","volume":"14","author":"Y Xu","year":"2022","unstructured":"Xu Y, Yang Y, Chen X, Liu Y. Bibliometric analysis of global NDVI research trends from 1985 to 2021. Remote Sens. 2022;14(16):3967. https:\/\/doi.org\/10.3390\/rs14163967","journal-title":"Remote Sens"},{"key":"1311_CR43","unstructured":"Measuring Vegetation (NDVI & EVI.) [http:\/\/earthobservatory.nasa.gov\/Features\/MeasuringVegetation\/measuring_vegetation_2.php]"},{"key":"1311_CR44","doi-asserted-by":"publisher","first-page":"111012","DOI":"10.1016\/j.envres.2021.111012","volume":"197","author":"J Stanhope","year":"2021","unstructured":"Stanhope J, Liddicoat C, Weinstein P. Outdoor artificial light at night: a forgotten factor in green space and health research. Environ Res. 2021;197:111012. https:\/\/doi.org\/10.1016\/j.envres.2021.111012","journal-title":"Environ Res"},{"key":"1311_CR45","doi-asserted-by":"publisher","unstructured":"HarrellFE. Regression Modeling Strategies. New York, NY, USA: Springer; 2001. https:\/\/doi.org\/10.1007\/978-1-4757-3462-1.","DOI":"10.1007\/978-1-4757-3462-1"},{"issue":"7","key":"1311_CR46","doi-asserted-by":"publisher","first-page":"e14812","DOI":"10.1111\/cns.14812","volume":"30","author":"Z Li","year":"2024","unstructured":"Li Z, Wen J, Wu W, Dai Z, Liang X, Zhang N, Cheng Q, Zhang H. Causal relationship and shared genes between air pollutants and amyotrophic lateral sclerosis: a large-scale genetic analysis. CNS Neurosci Ther. 2024;30(7):e14812. https:\/\/doi.org\/10.1111\/cns.14812","journal-title":"CNS Neurosci Ther"},{"key":"1311_CR47","doi-asserted-by":"publisher","first-page":"119552","DOI":"10.1016\/j.envres.2024.119552","volume":"259","author":"S Peters","year":"2024","unstructured":"Peters S, Bouma F, Hoek G, Janssen N, Vermeulen R. Air pollution exposure and mortality from neurodegenerative diseases in the Netherlands: a population-based cohort study. Environ Res. 2024;259:119552. https:\/\/doi.org\/10.1016\/j.envres.2024.119552","journal-title":"Environ Res"},{"issue":"8","key":"1311_CR48","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.3390\/ijerph20085591","volume":"20","author":"A Antonioni","year":"2023","unstructured":"Antonioni A, Govoni V, Brancaleoni L, Dona A, Granieri E, Bergamini M, Gerdol R, Pugliatti M. Amyotrophic lateral sclerosis and air pollutants in the province of Ferrara, Northern Italy: an ecological study. Int J Environ Res Public Health. 2023;20(8):5591. https:\/\/doi.org\/10.3390\/ijerph20085591","journal-title":"Int J Environ Res Public Health"},{"issue":"9","key":"1311_CR49","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1093\/aje\/kwad099","volume":"192","author":"Y Nunez","year":"2023","unstructured":"Nunez Y, Balalian A, Parks RM, He MZ, Hansen J, Raaschou-Nielsen O, Ketzel M, Khan J, Brandt J, Vermeulen R, et al. Exploring relevant time windows in the association between PM2.5 exposure and amyotrophic lateral sclerosis: a case-control study in Denmark. Am J Epidemiol. 2023;192(9):1499\u2013508. https:\/\/doi.org\/10.1093\/aje\/kwad099","journal-title":"Am J Epidemiol"},{"key":"1311_CR50","doi-asserted-by":"publisher","first-page":"1108383","DOI":"10.3389\/fneur.2023.1108383","volume":"14","author":"D Saucier","year":"2023","unstructured":"Saucier D, Registe PPW, Belanger M, O\u2019Connell C. Urbanization, air pollution, and water pollution: identification of potential environmental risk factors associated with amyotrophic lateral sclerosis using systematic reviews. Front Neurol. 2023;14:1108383. https:\/\/doi.org\/10.3389\/fneur.2023.1108383","journal-title":"Front Neurol"},{"issue":"Pt 1","key":"1311_CR51","doi-asserted-by":"publisher","first-page":"114510","DOI":"10.1016\/j.envres.2022.114510","volume":"216","author":"AM Malek","year":"2023","unstructured":"Malek AM, Arena VC, Song R, Whitsel EA, Rager JR, Stewart J, Yanosky JD, Liao D, Talbott EO. Long-term air pollution and risk of amyotrophic lateral sclerosis mortality in the Women\u2019s Health Initiative cohort. Environ Res. 2023;216(Pt 1):114510. https:\/\/doi.org\/10.1016\/j.envres.2022.114510.","journal-title":"Environ Res"},{"issue":"6","key":"1311_CR52","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1097\/EDE.0000000000001536","volume":"33","author":"RM Parks","year":"2022","unstructured":"Parks RM, Nunez Y, Balalian AA, Gibson EA, Hansen J, Raaschou-Nielsen O, Ketzel M, Khan J, Brandt J, Vermeulen R, et al. Long-term traffic-related air pollutant exposure and amyotrophic lateral sclerosis diagnosis in Denmark: a Bayesian hierarchical analysis. Epidemiology. 2022;33(6):757\u201366. https:\/\/doi.org\/10.1097\/EDE.0000000000001536","journal-title":"Epidemiology"},{"issue":"8","key":"1311_CR53","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1136\/jnnp-2018-319779","volume":"90","author":"AE Visser","year":"2019","unstructured":"Visser AE, D\u2019Ovidio F, Peters S, Vermeulen RC, Beghi E, Chio A, Veldink JH, Logroscino G, Hardiman O, van den Berg LH, et al. Multicentre, population-based, case-control study of particulates, combustion products and amyotrophic lateral sclerosis risk. J Neurol Neurosurg Psychiatry. 2019;90(8):854\u201360. https:\/\/doi.org\/10.1136\/jnnp-2018-319779.","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"1311_CR54","doi-asserted-by":"publisher","first-page":"123398","DOI":"10.1016\/j.envres.2025.123398","volume":"289","author":"M Pedde","year":"2026","unstructured":"Pedde M, Adar SD, D\u2019Souza J, Feldman EL, Goutman SA. Air pollution and disease progression in a University of Michigan amyotrophic lateral sclerosis cohort. Environ Res. 2026;289:123398. https:\/\/doi.org\/10.1016\/j.envres.2025.123398.","journal-title":"Environ Res"},{"key":"1311_CR55","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.envint.2019.04.047","volume":"128","author":"DL Crouse","year":"2019","unstructured":"Crouse DL, Pinault L, Balram A, Brauer M, Burnett RT, Martin RV, van Donkelaar A, Villeneuve PJ, Weichenthal S. Complex relationships between greenness, air pollution, and mortality in a population-based Canadian cohort. Environ Int. 2019;128:292\u2013300. https:\/\/doi.org\/10.1016\/j.envint.2019.04.047.","journal-title":"Environ Int"},{"key":"1311_CR56","doi-asserted-by":"publisher","first-page":"110348","DOI":"10.1016\/j.envres.2020.110348","volume":"196","author":"MI Kasdagli","year":"2021","unstructured":"Kasdagli MI, Katsouyanni K, de Hoogh K, Lagiou P, Samoli E. Associations of air pollution and greenness with mortality in Greece: an ecological study. Environ Res. 2021;196:110348. https:\/\/doi.org\/10.1016\/j.envres.2020.110348","journal-title":"Environ Res"},{"key":"1311_CR57","doi-asserted-by":"publisher","unstructured":"Chevet ML, Garnier M, Fadel M, Scherer C, Cassereau J, Levaillant M, Codron P. Epidemiology of amyotrophic lateral sclerosis in the Pays de la Loire, France: A 20-year study from a centralized diagnostic center. Neuroepidemiology 2026:1\u20138. https:\/\/doi.org\/10.1159\/000550417.","DOI":"10.1159\/000550417"},{"issue":"1","key":"1311_CR58","doi-asserted-by":"publisher","first-page":"e16464","DOI":"10.1111\/ene.16464","volume":"32","author":"U Manera","year":"2025","unstructured":"Manera U, Callegaro S, Canosa A, Palumbo F, Grassano M, Bombaci A, Dagliati A, Bosoni P, Daviddi M, Casale F, et al. Croplands proximity is associated with amyotrophic lateral sclerosis incidence and age at onset. Eur J Neurol. 2025;32(1):e16464. https:\/\/doi.org\/10.1111\/ene.16464.","journal-title":"Eur J Neurol"},{"issue":"5","key":"1311_CR59","doi-asserted-by":"publisher","first-page":"e96556","DOI":"10.1371\/journal.pone.0096556","volume":"9","author":"J Rooney","year":"2014","unstructured":"Rooney J, Heverin M, Vajda A, Crampsie A, Tobin K, Byrne S, Staines A, Hardiman O. An exploratory spatial analysis of ALS incidence in Ireland over 17.5 years (1995-July 2013). PLoS ONE. 2014;9(5):e96556. https:\/\/doi.org\/10.1371\/journal.pone.0096556.","journal-title":"PLoS ONE"},{"issue":"1","key":"1311_CR60","doi-asserted-by":"publisher","first-page":"58","DOI":"10.3109\/21678421.2012.733401","volume":"14","author":"G Migliaretti","year":"2013","unstructured":"Migliaretti G, Berchialla P, Dalmasso P, Cavallo F, Chio A. Amyotrophic lateral sclerosis in Piedmont (Italy): a Bayesian spatial analysis of the incident cases. Amyotroph Lateral Scler Frontotemporal Degener. 2013;14(1):58\u201365. https:\/\/doi.org\/10.3109\/21678421.2012.733401.","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"11","key":"1311_CR61","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1007\/s00415-005-0859-z","volume":"252","author":"V Govoni","year":"2005","unstructured":"Govoni V, Granieri E, Fallica E, Casetta I. Amyotrophic lateral sclerosis, rural environment and agricultural work in the Local Health District of Ferrara, Italy, in the years 1964\u20131998. J Neurol. 2005;252(11):1322\u20137. https:\/\/doi.org\/10.1007\/s00415-005-0859-z.","journal-title":"J Neurol"},{"issue":"3\u20134","key":"1311_CR62","doi-asserted-by":"publisher","first-page":"262","DOI":"10.3109\/21678421.2013.865752","volume":"15","author":"J Mandrioli","year":"2014","unstructured":"Mandrioli J, Biguzzi S, Guidi C, Venturini E, Sette E, Terlizzi E, Ravasio A, Casmiro M, Salvi F, Liguori R, et al. Epidemiology of amyotrophic lateral sclerosis in Emilia Romagna Region (Italy): a population based study. Amyotroph Lateral Scler Frontotemporal Degener. 2014;15(3\u20134):262\u20138. https:\/\/doi.org\/10.3109\/21678421.2013.865752","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"6","key":"1311_CR63","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1590\/s0004-282x2011000700003","volume":"69","author":"M Bettini","year":"2011","unstructured":"Bettini M, Gargiulo-Monachelli GM, Rodriguez G, Rey RC, Peralta LM, Sica RE. Epidemiology of amyotrophic lateral sclerosis patients in a centre in Buenos Aires. Arq Neuropsiquiatr. 2011;69(6):867\u201370. https:\/\/doi.org\/10.1590\/s0004-282x2011000700003.","journal-title":"Arq Neuropsiquiatr"},{"issue":"5","key":"1311_CR64","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1007\/s00415-009-5419-5","volume":"257","author":"A Furby","year":"2010","unstructured":"Furby A, Beauvais K, Kolev I, Rivain JG, Sebille V. Rural environment and risk factors of amyotrophic lateral sclerosis: a case-control study. J Neurol. 2010;257(5):792\u20138. https:\/\/doi.org\/10.1007\/s00415-009-5419-5.","journal-title":"J Neurol"},{"issue":"4","key":"1311_CR65","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1159\/000110266","volume":"10","author":"N Kalfakis","year":"1991","unstructured":"Kalfakis N, Vassilopoulos D, Voumvourakis C, Ndjeveleka M, Papageorgiou C. Amyotrophic lateral sclerosis in southern Greece: an epidemiologic study. Neuroepidemiology. 1991;10(4):170\u20133. https:\/\/doi.org\/10.1159\/000110266.","journal-title":"Neuroepidemiology"},{"issue":"4","key":"1311_CR66","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1212\/01.wnl.0000048208.54755.78","volume":"60","author":"J Mandrioli","year":"2003","unstructured":"Mandrioli J, Faglioni P, Merelli E, Sola P. The epidemiology of ALS in Modena, Italy. Neurology. 2003;60(4):683\u20139. https:\/\/doi.org\/10.1212\/01.wnl.0000048208.54755.78.","journal-title":"Neurology"},{"issue":"1","key":"1311_CR67","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1001\/archneur.1990.00530010046017","volume":"47","author":"DG Sienko","year":"1990","unstructured":"Sienko DG, Davis JP, Taylor JA, Brooks BR. Amyotrophic lateral sclerosis. A case-control study following detection of a cluster in a small Wisconsin community. Arch Neurol. 1990;47(1):38\u201341. https:\/\/doi.org\/10.1001\/archneur.1990.00530010046017.","journal-title":"Arch Neurol"},{"key":"1311_CR68","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1476-069X-9-77","volume":"9","author":"M Vinceti","year":"2010","unstructured":"Vinceti M, Bonvicini F, Rothman KJ, Vescovi L, Wang F. The relation between amyotrophic lateral sclerosis and inorganic selenium in drinking water: a population-based case-control study. Environ Health. 2010;9:77. https:\/\/doi.org\/10.1186\/1476-069X-9-77.","journal-title":"Environ Health"},{"key":"1311_CR69","doi-asserted-by":"publisher","first-page":"117652","DOI":"10.1016\/j.envres.2023.117652","volume":"242","author":"M Tondelli","year":"2024","unstructured":"Tondelli M, Chiari A, Vinceti G, Galli C, Salemme S, Filippini T, Carbone C, Minafra C, De Luca C, Prandi R, et al. Greenness and neuropsychiatric symptoms in dementia. Environ Res. 2024;242:117652. https:\/\/doi.org\/10.1016\/j.envres.2023.117652.","journal-title":"Environ Res"},{"issue":"3","key":"1311_CR70","doi-asserted-by":"publisher","first-page":"710","DOI":"10.14283\/jpad.2024.38","volume":"11","author":"SC Brown","year":"2024","unstructured":"Brown SC, Aitken WW, Lombard J, Parrish A, Dewald JR, Ma R, Messinger S, Liu S, Nardi MI, Rundek T, et al. Longitudinal impacts of precision greenness on Alzheimer\u2019s disease. J Prev Alzheimers Dis. 2024;11(3):710\u201320. https:\/\/doi.org\/10.14283\/jpad.2024.38","journal-title":"J Prev Alzheimers Dis"},{"issue":"1","key":"1311_CR71","doi-asserted-by":"publisher","first-page":"26823","DOI":"10.1038\/s41598-025-11552-3","volume":"15","author":"W Peng","year":"2025","unstructured":"Peng W, Liu T. Greenness modified the association of PM(2.5) and ozone with global disease burden of Alzheimer\u2019s disease and other dementias. Sci Rep. 2025;15(1):26823. https:\/\/doi.org\/10.1038\/s41598-025-11552-3.","journal-title":"Sci Rep"},{"issue":"1","key":"1311_CR72","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12940-020-0565-4","volume":"19","author":"W Yuchi","year":"2020","unstructured":"Yuchi W, Sbihi H, Davies H, Tamburic L, Brauer M. Road proximity, air pollution, noise, green space and neurologic disease incidence: a population-based cohort study. Environ Health. 2020;19(1):8. https:\/\/doi.org\/10.1186\/s12940-020-0565-4.","journal-title":"Environ Health"},{"issue":"2","key":"1311_CR73","doi-asserted-by":"publisher","first-page":"597","DOI":"10.3233\/JAD-201179","volume":"81","author":"WW Aitken","year":"2021","unstructured":"Aitken WW, Lombard J, Wang K, Toro M, Byrne M, Nardi MI, Kardys J, Parrish A, Dong C, Szapocznik J, et al. Relationship of neighborhood greenness to Alzheimer\u2019s disease and non-Alzheimer\u2019s dementia among 249,405 U.S. Medicare beneficiaries. J Alzheimers Dis. 2021;81(2):597\u2013606. https:\/\/doi.org\/10.3233\/JAD-201179","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"1311_CR74","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1136\/jnnp-2024-334339","volume":"96","author":"M Benatar","year":"2025","unstructured":"Benatar M, Heiman-Patterson TD, Cooper-Knock J, Brickman D, Casaletto KB, Goutman SA, Vinceti M, Dratch L, Arias JJ, Swidler J, et al. Guidance for clinical management of pathogenic variant carriers at elevated genetic risk for ALS\/FTD. J Neurol Neurosurg Psychiatry. 2025;96(3):209\u201318. https:\/\/doi.org\/10.1136\/jnnp-2024-334339.","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"1311_CR75","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s40572-022-00365-5","volume":"9","author":"F Zagnoli","year":"2022","unstructured":"Zagnoli F, Filippini T, Jimenez MP, Wise LA, Hatch EE, Vinceti M. Is greenness associated with dementia? A systematic review and dose-response meta-analysis. Curr Environ Health Rep. 2022;9(4):574\u20139. https:\/\/doi.org\/10.1007\/s40572-022-00365-5","journal-title":"Curr Environ Health Rep"},{"issue":"9","key":"1311_CR76","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1001\/jamaneurol.2017.1387","volume":"74","author":"A Chio","year":"2017","unstructured":"Chio A, Mora G, Moglia C, Manera U, Canosa A, Cammarosano S, Ilardi A, Bertuzzo D, Bersano E, Cugnasco P, et al. Secular trends of amyotrophic lateral sclerosis: the Piemonte and Valle d\u2019Aosta Register. JAMA Neurol. 2017;74(9):1097\u2013104. https:\/\/doi.org\/10.1001\/jamaneurol.2017.1387","journal-title":"JAMA Neurol"},{"issue":"1","key":"1311_CR77","doi-asserted-by":"publisher","first-page":"8","DOI":"10.53225\/BEN_082","volume":"5","author":"MG Gatti","year":"2024","unstructured":"Gatti MG, Berselli N, Bonora K, Masciocco E, Carrozzi G. [Effetti delle ondate di calore e distribuzione della fragilit\u00e0 e della mitigazione del calore nel Comune di Modena (anno 2022): quali indirizzi per un intervento?]. Boll Epidemiol Naz. 2024;5(1):8\u201314. https:\/\/doi.org\/10.53225\/BEN_082.","journal-title":"Boll Epidemiol Naz"},{"issue":"5","key":"1311_CR78","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1002\/ijpg.231","volume":"7","author":"FC Billari","year":"2001","unstructured":"Billari FC, Philipov D, Baiz\u00e1n P. Leaving home in Europe: the experience of cohorts born around 1960. Int J Popul Geogr. 2001;7(5):339\u20135. https:\/\/doi.org\/10.1002\/ijpg.231","journal-title":"Int J Popul Geogr"}],"container-title":["Environmental Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12940-026-01311-w","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12940-026-01311-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12940-026-01311-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:33:18Z","timestamp":1784075598000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12940-026-01311-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":78,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1311"],"URL":"https:\/\/doi.org\/10.1186\/s12940-026-01311-w","relation":{},"ISSN":["1476-069X"],"issn-type":[{"value":"1476-069X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"2 April 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Modena Hospital Ethics Committee (approval no. 80.11 on May 26, 2011).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"61"}}