{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:00:40Z","timestamp":1787166040600,"version":"build-2736575974"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2016,4,26]],"date-time":"2016-04-26T00:00:00Z","timestamp":1461628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Vancomycin may be inferior to \u03b2-lactams for the empiric treatment of methicillin-susceptible\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MSSA) bacteremia. We compared empiric \u03b2-lactams to vancomycin to assess clinical outcomes in patients with MSSA bacteremia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study of adult inpatients with their first episode of MSSA bacteremia at two tertiary care hospitals in Vancouver, Canada, between 2007 and 2014. Exposure was either empiric \u03b2-lactam with or without vancomycin or vancomycin monotherapy. All patients received definitive treatment with cloxacillin or cefazolin. The primary outcome was 28-day mortality. Secondary outcomes were 90-day mortality, duration of bacteremia, and hospital length-of-stay. Outcomes were adjusted using multivariable logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 669 patients identified, 255 met inclusion criteria (\u03b2-lactam\u00a0=\u00a0131, vancomycin\u00a0=\u00a0124). Overall 28-day mortality was 7.06\u00a0% (n\u00a0=\u00a018). There were more cases of infective endocarditis in the \u03b2-lactam than in the vancomycin group [24 (18.3\u00a0%) vs 12 (9.7\u00a0%),\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.05]. Adjusted mortality at 28\u00a0days was similar between the two groups (OR 0.85; 95\u00a0% CI 0.27\u20132.67). The duration of bacteremia was longer in the vancomycin group (97.1 vs 70.7\u00a0h,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.007). Transition to cloxacillin or cefazolin occurred within a median of 68.3\u00a0h in the vancomycin group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Empiric \u03b2-lactams was associated with earlier clearance of bacteremia by a median of 1\u00a0day compared to vancomycin. Future prospective studies are needed to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12941-016-0143-3","type":"journal-article","created":{"date-parts":[[2016,4,25]],"date-time":"2016-04-25T21:48:34Z","timestamp":1461620914000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Comparative effectiveness of \u03b2-lactam versus vancomycin empiric therapy in patients with methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia"],"prefix":"10.1186","volume":"15","author":[{"given":"Davie","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Romney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,4,26]]},"reference":[{"key":"143_CR1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1128\/CMR.05022-11","volume":"25","author":"SJ Van Hal","year":"2012","unstructured":"Van Hal SJ, Jensen SO, Vaska VL, Espedido BJ, Paterson DL, Gosbell IB. 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