{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:13:10Z","timestamp":1784193190544,"version":"3.55.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T00:00:00Z","timestamp":1590796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of cases in the Northeast of the US during 2013\u20132015 described a new Borrelia species, <jats:italic>Borrelia miyamotoi<\/jats:italic>, which is transmitted by the same tick species that transmits Lyme disease and causes a relapsing fever-like illness. The geographic expansion of <jats:italic>B. miyamotoi<\/jats:italic> in the US also extends to other Lyme endemic areas such as the Midwestern US. Co-infections with other tick borne diseases (TBD) may contribute to the severity of the disease. On Long Island, NY, 3\u20135% of ticks are infected by <jats:italic>B. miyamotoi<\/jats:italic>, but little is known about the frequency of <jats:italic>B. miyamotoi<\/jats:italic> infections in humans in this particular region. The aim of this study was to perform a chart review in all patients diagnosed with <jats:italic>B. miyamotoi<\/jats:italic> infection in Stony Brook Medicine (SBM) system to describe the clinical and epidemiological features of <jats:italic>B. miyamotoi<\/jats:italic> infection in Suffolk County, NY. In a 5\u00a0year time period (2013\u20132017), a total of 28 cases were positive for either IgG EIA (n\u2009=\u200919) or PCR (n\u2009=\u20099). All 9 PCR-positive cases (median age: 67; range: 22\u201390\u00a0years) had clinical findings suggestive of acute or relapsing infection. All these patients were thought to have a TBD, prompting the healthcare provider to order the TBD panel which includes a <jats:italic>B. miyamotoi<\/jats:italic> PCR test. In conclusion, <jats:italic>B. miyamotoi<\/jats:italic> infection should be considered in the differential diagnosis for flu-like syndromes during the summer after a deer tick bite and to prevent labeling a case with Lyme disease.<\/jats:p>","DOI":"10.1186\/s12941-020-00364-0","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T08:02:22Z","timestamp":1590825742000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Presence of Borrelia miyamotoi infection in a highly endemic area of Lyme disease"],"prefix":"10.1186","volume":"19","author":[{"given":"Luis A.","family":"Marcos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalie","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Reardon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredric","family":"Weinbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Spitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,5,30]]},"reference":[{"key":"364_CR1","unstructured":"Department of Health, New York State. 2017. https:\/\/www.health.ny.gov\/statistics\/diseases\/communicable\/2017\/docs\/cases.pdf."},{"issue":"3","key":"364_CR2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1056\/NEJMc1215469","volume":"368","author":"PJ Krause","year":"2013","unstructured":"Krause PJ, Narasimhan S, Wormser GP, Rollend L, Fikrig E, Lepore T, Barbour A, Fish D. Human Borrelia miyamotoi infection in the United States. N Engl J Med. 2013;368(3):291\u20133.","journal-title":"N Engl J Med"},{"issue":"7","key":"364_CR3","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/j.cmi.2015.02.006","volume":"21","author":"PJ Krause","year":"2015","unstructured":"Krause PJ, Fish D, Narasimhan S, Barbour AG. Borrelia miyamotoi infection in nature and in humans. Clin Microbiol Infect. 2015;21(7):631\u20139. https:\/\/doi.org\/10.1016\/j.cmi.2015.02.006.","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"364_CR4","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.3201\/eid2208.151878","volume":"22","author":"DA Jobe","year":"2016","unstructured":"Jobe DA, Lovrich SD, Oldenburg DG, Kowalski TJ, Callister SM. Borrelia miyamotoi infection in patients from upper midwestern United States, 2014-2015. Emerg Infect Dis. 2016;22(8):1471\u20133. https:\/\/doi.org\/10.3201\/eid2208.151878.","journal-title":"Emerg Infect Dis"},{"key":"364_CR5","doi-asserted-by":"publisher","first-page":"860","DOI":"10.3201\/eid2405.170829","volume":"24","author":"L Karan","year":"2018","unstructured":"Karan L, et al. Dynamics of spirochetemia and early PCR detection of Borrelia miyamotoi. Emerg Infect Dis. 2018;24:860\u20137. https:\/\/doi.org\/10.3201\/eid2405.170829.","journal-title":"Emerg Infect Dis"},{"issue":"5","key":"364_CR6","doi-asserted-by":"publisher","first-page":"e02055","DOI":"10.1128\/mbio.02055-19","volume":"10","author":"S Sanchez-Vicente","year":"2019","unstructured":"Sanchez-Vicente S, Tagliafierro T, Coleman JL, Benach JL, Tokarz R. Polymicrobial Nature of Tick-Borne Diseases. MBio. 2019;10(5):e02055. https:\/\/doi.org\/10.1128\/mbio.02055-19.","journal-title":"MBio."},{"issue":"4","key":"364_CR7","doi-asserted-by":"publisher","first-page":"748","DOI":"10.3201\/eid2504.181509","volume":"25","author":"GP Wormser","year":"2019","unstructured":"Wormser GP, McKenna D, Scavarda C, Cooper D, El Khoury MY, Nowakowski J, Sudhindra P, Ladenheim A, Wang G, Karmen CL, Demarest V, Dupuis AP 2nd, Wong SJ. Co-infections in persons with early lyme disease,\u00a0New York, USA. Emerg Infect Dis. 2019;25(4):748\u201352. https:\/\/doi.org\/10.3201\/eid2504.181509.","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"364_CR8","doi-asserted-by":"publisher","first-page":"91","DOI":"10.7326\/M15-0333","volume":"163","author":"PJ Molloy","year":"2015","unstructured":"Molloy PJ, Telford SR 3rd, Chowdri HR, Lepore TJ, Gugliotta JL, Weeks KE, Hewins ME, Goethert HK, Berardi VP. Borrelia miyamotoi disease in the Northeastern United States: a case series. Ann Intern Med. 2015;163(2):91\u20138. https:\/\/doi.org\/10.7326\/M15-0333PMID: 26053877.","journal-title":"Ann Intern Med"},{"issue":"1","key":"364_CR9","doi-asserted-by":"publisher","first-page":"21","DOI":"10.7326\/0003-4819-159-1-201307020-00005","volume":"159","author":"HR Chowdri","year":"2013","unstructured":"Chowdri HR, Gugliotta JL, Berardi VP, Goethert HK, Molloy PJ, Sterling SL, Telford SR. Borrelia miyamotoi infection presenting as human granulocytic anaplasmosis: a case report. Ann Intern Med. 2013;159(1):21\u20137. https:\/\/doi.org\/10.7326\/0003-4819-159-1-201307020-00005PMID: 23817701.","journal-title":"Ann Intern Med"},{"key":"364_CR10","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2020.00055","author":"M Franck","year":"2020","unstructured":"Franck M, et al. Borrelia miyamotoi: 43 cases diagnosed in France by real-time PCR in patients with persistent polymorphic signs and symptoms. Front Med. 2020. https:\/\/doi.org\/10.3389\/fmed.2020.00055.","journal-title":"Front Med"},{"issue":"9","key":"364_CR11","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/cid\/cix1023","volume":"66","author":"PJ Molloy","year":"2018","unstructured":"Molloy PJ, Weeks KE, Todd B, Wormser GP. Seroreactivity to the C6 peptide in Borrelia miyamotoi infections occurring in the Northeastern United States. Clin Infect Dis. 2018;66(9):1407\u201310.","journal-title":"Clin Infect Dis"},{"issue":"4","key":"364_CR12","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/j.cll.2015.08.002","volume":"35","author":"SR Telford 3rd","year":"2015","unstructured":"Telford SR 3rd, Goethert HK, Molloy PJ, Berardi VP, Chowdri HR, Gugliotta JL, Lepore TJ. Borrelia miyamotoi disease: neither lyme disease nor relapsing fever. 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