{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:07:29Z","timestamp":1793232449350,"version":"4.5.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>HACEK (<jats:italic>Haemophilus<\/jats:italic> spp., <jats:italic>Aggregatibacter<\/jats:italic> spp., <jats:italic>Cardiobacterium<\/jats:italic> spp., <jats:italic>Eikenella corrodens<\/jats:italic>, and <jats:italic>Kingella<\/jats:italic> spp.) group organisms are responsible for 0.8% to 6% of all infective endocarditis cases, with <jats:italic>Cardiobacterium <\/jats:italic>spp. being the third most commonly implicated HACEK microorganism. Within this genus is <jats:italic>Cardiobacterium valvarum<\/jats:italic> (<jats:italic>C. valvarum<\/jats:italic>), a novel organism described in 2004. To date, only 15 cases of <jats:italic>C. valvarum<\/jats:italic> infection have been reported in the English-language literature, and have primarily been cases of infective endocarditis in patients with valvular disease. <jats:italic>C. valvarum<\/jats:italic> has not been reported to cause infections spreading to the surrounding bone.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Case presentation<\/jats:title>\n                <jats:p>We present a case of a 57-year-old man with a history of aortic dissection followed by aortic endograft replacement who presented with back pain. He was found to have radiographic evidence of an infected aortic endograft, along with vertebral osteomyelitis, discitis, and epidural phlegmon. Blood cultures identified <jats:italic>C. valvarum<\/jats:italic> as the causative organism. The patient was treated with ceftriaxone and surgical intervention was deferred due to the patient\u2019s complex anatomy. His course was complicated by septic cerebral emboli resulting in cerebrovascular accident.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This case report highlights <jats:italic>C. valvarum<\/jats:italic>, a rare and emerging HACEK group microorganism that warrants consideration in high-risk patients with evidence of subacute infection and disseminated disease. While <jats:italic>C. valvarum<\/jats:italic> classically presents as infective endocarditis, extra-cardiac manifestations have also been described. As demonstrated in this case, endograft involvement and osteomyelitis may occur in rare circumstances.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12941-021-00419-w","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T16:03:42Z","timestamp":1614441822000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An unusual case of Cardiobacterium valvarum causing aortic endograft infection and osteomyelitis"],"prefix":"10.1186","volume":"20","author":[{"given":"Eric G.","family":"Hauser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9534-5831","authenticated-orcid":false,"given":"Imran","family":"Nizamuddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett B.","family":"Yarusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M.","family":"Krueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"419_CR1","doi-asserted-by":"publisher","first-page":"e63181","DOI":"10.1371\/journal.pone.0063181","volume":"8","author":"ST Chambers","year":"2013","unstructured":"Chambers ST, Murdoch D, Morris A, et al. 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The procedures used in this study adhere to the tenets of the Declaration of Helsinki. The patient has consented to the submission of the case report to the journal.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written and verbal consent was obtained from the patient prior to manuscript submission.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this paper.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"14"}}