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In this study, we sought to describe the epidemiology of ESBL-producing <jats:italic>Escherichia coli<\/jats:italic> strains isolated from Vietnamese individuals with BSI, to investigate the concordance of genotypic-phenotypic resistance, and clinical outcome of ESBL <jats:italic>E. coli<\/jats:italic> BSI.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 459 hospitalized patients with BSI were screened between October 2014 and May 2016. 115 <jats:italic>E. coli<\/jats:italic> strains from 115 BSI patients were isolated and tested for antibiotic resistance using the VITEK\u00ae2 system. The ESBL phenotype was determined by double disk diffusion method following the guideline of Clinical and Laboratory Standards Institute. Screening for beta-lactamase (ESBL and carbapenemase) genes was performed using a multiplex-PCR assay.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>58% (67\/115) of the <jats:italic>E. coli<\/jats:italic> strains were ESBL-producers and all were susceptible to both imipenem and meropenem. Resistance to third-generation cephalosporin was common, 70% (81\/115) were cefotaxime-resistant and 45% (52\/115) were ceftazidime-resistant. <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> was the most common ESBL gene detected (70%; 80\/115) The sensitivity and specificity of <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub>-detection to predict the ESBL phenotype was 87% (76\u201393% 95% CI) and 54% (39\u201348% 95% CI), respectively. 28%% (22\/80) of <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> were classified as non-ESBL producers by phenotypic testing for ESBL production. The detection of <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> in ESBL-negative <jats:italic>E. coli<\/jats:italic> BSI was associated with fatal clinical outcome (27%; 6\/22 versus 8%; 2\/26, p\u2009=\u20090.07).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>A high prevalence of ESBL-producing <jats:italic>E. coli<\/jats:italic> isolates harbouring <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> was observed in BSI patients in Vietnam. The genotypic detection of <jats:italic>bla<\/jats:italic><jats:sub>CTX-M<\/jats:sub> may have added benefit in optimizing and guiding empirical antibiotic therapy of <jats:italic>E. coli<\/jats:italic> BSI to improve clinical outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12941-021-00466-3","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T12:02:48Z","timestamp":1630756968000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Molecular detection of blaCTX-M gene to predict phenotypic cephalosporin resistance and clinical outcome of Escherichia coli bloodstream infections in Vietnam"],"prefix":"10.1186","volume":"20","author":[{"given":"Trinh Van","family":"Son","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Dang","family":"Manh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngo Tat","family":"Trung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao Thanh","family":"Quyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Kim","family":"Phuong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phan Quoc","family":"Hoan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Viet","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Nurjadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirumalaisamy P.","family":"Velavan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai Hong","family":"Bang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le Huu","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"issue":"12","key":"466_CR1","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1097\/CCM.0000000000003342","volume":"46","author":"CJ Paoli","year":"2018","unstructured":"Paoli CJ, Reynolds MA, Sinha M, Gitlin M, Crouser E. 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