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Magnetic resonance imaging (MRI) showed ring enhancing lesions, biopsy of the skin and brain lesions grew\n                      <jats:italic>N. otitidiscaviarum.<\/jats:italic>\n                      She was empirically treated with TMP\u2013SMX and Imipenem\u2013Cilastatin, however, almost three weeks into therapy, susceptibility results revealed it to be resistant to both antimicrobials, she was subsequently changed to Amikacin, Linezolid, Moxifloxacin, and Doxycycline but ultimately died.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      This case report highlights the importance of suspecting a rare\n                      <jats:italic>Nocardia<\/jats:italic>\n                      species in patients at risk with proper occupational exposure, moreover, TMP\u2013SMX resistance should be suspected with lack of clinical response, this may have important implications on clinical practice when facing similar infections.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12941-022-00511-9","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T12:04:32Z","timestamp":1652702672000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A fatal case of disseminated nocardiosis due to Nocardia otitidiscaviarum resistant to trimethoprim\u2013sulfamethoxazole: case report and literature review"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2274-007X","authenticated-orcid":false,"given":"Mazin","family":"Barry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahad","family":"AlShehri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahlam","family":"alguhani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Alhijji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalifa","family":"Binkhamis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Al-Majid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatimah S.","family":"Al-Shahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taim","family":"Muayqil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,16]]},"reference":[{"key":"511_CR1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s15010-009-9193-9","volume":"38","author":"J Ambrosioni","year":"2010","unstructured":"Ambrosioni J, Lew D, Garbino J. 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