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It is urgent to investigate the carbapenem resistance and virulence of CRAB for clinicians to choose appropriate antibiotics. A retrospective study of 77 nonduplicated CRAB isolates was conducted. The carbapenem resistance and virulence genes were characterized by polymerase chain reaction (PCR) and gel electrophoresis. In the present study,\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    mainly came from the intensive care unit and was mostly isolated from sputum samples. The carbapenem resistant rate of\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    in 2018\u20132020 increased significantly compared with that in 2016\u20132017. All isolates had carbapenem resistant genes. They were highly resistant to a variety of antibiotics but were relatively sensitive to fluoroquinolones and tetracyclines.\n                    <jats:italic>bla<\/jats:italic>\n                    VIM and\n                    <jats:italic>bla<\/jats:italic>\n                    OXA-23 were detected in all isolates, whereas\n                    <jats:italic>bla<\/jats:italic>\n                    OXA-51,\n                    <jats:italic>bla<\/jats:italic>\n                    IMP and\n                    <jats:italic>bla<\/jats:italic>\n                    NDM were present in 98.70%, 67.53% and 31.17% of isolates, respectively. Notably, 1 isolate\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    was identified as multidrug-resistant\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    (MDR-AB), and 76 other extensively drug-resistance (XDR) isolates were also detected. Virulence genes were present in 100% of all isolates, including genes in the iron acquisition system (basJ), secretion systems (ompA, plcD), quorum sensing system (abaI) and biofilm formation (csuA). adeH, pgaA, and ptk were present in 98.70%, 98.70% and 94.80% of isolates, respectively. CRAB, which is prevalent in east China, carries a large number of drug resistance and virulence genes. Fluoroquinolones and tetracyclines may be effective antibiotics for the treatment of CRAB infection in children. An in-depth understanding of the resistance and virulence of CRAB is conducive to timely guiding empirical drug use and controlling infection.\n                  <\/jats:p>","DOI":"10.1186\/s12941-022-00536-0","type":"journal-article","created":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T13:13:54Z","timestamp":1667654034000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Insight into carbapenem resistance and virulence of Acinetobacter baumannii from a children\u2019s medical centre in eastern China"],"prefix":"10.1186","volume":"21","author":[{"given":"Yunfen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzhen","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"issue":"1","key":"536_CR1","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.clinthera.2011.11.023","volume":"34","author":"X Bertrand","year":"2012","unstructured":"Bertrand X, Dowzicky MJ. 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