{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:41:48Z","timestamp":1791931308444,"version":"4.3.4"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p><jats:italic>Edwardsiella tarda<\/jats:italic> is a member of Enterobacteriaceae isolated from freshwater and sea. <jats:italic>E. tarda<\/jats:italic> infection in humans commonly causes gastroenteritis, but rarely causes bacteremia. However, few studies have described the clinical features of <jats:italic>E. tarda<\/jats:italic> bacteremia (ETB); therefore, we conducted a case review in our hospital.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We conducted a single-center, retrospective descriptive study using electronic medical records. Patient and microbial features were extracted and evaluated for 30- and 90-day mortality rates.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>From April 2005 to April 2022, the total set of blood cultures positive for any microorganisms was 9368, 38 of which were positive for <jats:italic>E. tarda<\/jats:italic>. Underlying cancer was observed in 65.8% of patients. The most common source of bacteremia was cholangitis, followed by cholecystitis, and endoscopic or surgical drainage was performed in almost all cases. Diarrhea was observed in only one patient, and there were no cases in which gastroenteritis was the source of bacteremia. All cases, except for one, were susceptible to all \u03b2-lactams, such as ampicillin. The 30- and 90-day overall mortality rates were 8.6% (3\/35) and 25.8% (8\/31). Of these, 75% patients died because of cancer progression after successful ETB treatment.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>ETB may occur in patients with malignant underlying conditions. Biliary tract infections are common in ETB cases, whereas gastroenteritis may be an atypical cause of bacteremia. This study suggests that although the mortality rate for ETB at 30\u00a0day was low, it increased at 90\u00a0day as a result of the development of unfavorable underlying conditions.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12941-022-00548-w","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T17:04:53Z","timestamp":1670432693000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Characteristics and prognosis of patients with Edwardsiella tarda bacteremia at a single institution, Japan, 2005\u20132022"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0980-609X","authenticated-orcid":false,"given":"Kohei","family":"Hasegawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murata","family":"Kenya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"issue":"4","key":"548_CR1","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1093\/clinids\/17.4.742","volume":"17","author":"JM Janda","year":"1993","unstructured":"Janda JM, Abbott SL. Infections associated with the genus Edwardsiella: the role of Edwardsiella tarda in human disease. Clin Infect Dis. 1993;17(4):742\u20138.","journal-title":"Clin Infect Dis"},{"issue":"10","key":"548_CR2","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1086\/320152","volume":"32","author":"EM Slaven","year":"2001","unstructured":"Slaven EM, Lopez FA, Hart SM, Sanders CV. Myonecrosis caused by Edwardsiella tarda: a case report and case series of extraintestinal E. tarda infections. Clin Infect Dis. 2001;32(10):1430\u20133.","journal-title":"Clin Infect Dis"},{"issue":"1","key":"548_CR3","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12941-018-0273-x","volume":"17","author":"KF Ebisawa","year":"2018","unstructured":"Ebisawa KF, Nishimura S, Yamamoto S, Ohji G, Iwata K. Mycotic aneurysm caused by Edwardsiella tarda successfully treated with stenting and suppressive antibiotic therapy: a case report and systematic review. 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A rare but fatal water- and foodborne infection: review of the literature and clinical cases from a single centre. Can J Infect Dis Med Microbiol. 2015;26(6):313\u20138.","journal-title":"Can J Infect Dis Med Microbiol."},{"issue":"11","key":"548_CR7","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","volume":"47","author":"L Evans","year":"2021","unstructured":"Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021;47(11):1181\u2013247.","journal-title":"Intensive Care Med"},{"issue":"5","key":"548_CR8","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","volume":"40","author":"ME Charlson","year":"1987","unstructured":"Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373\u201383.","journal-title":"J Chronic Dis"},{"issue":"8","key":"548_CR9","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1128\/AAC.45.8.2245-2255.2001","volume":"45","author":"I Stock","year":"2001","unstructured":"Stock I, Wiedemann B. Natural antibiotic susceptibilities of Edwardsiella tarda, E. ictaluri, and E. hoshinae. Antimicrob Agents Chemother. 2001;45(8):2245\u201355.","journal-title":"Antimicrob Agents Chemother"},{"issue":"5","key":"548_CR10","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1128\/AAC.4.5.521","volume":"4","author":"T Muyembe","year":"1973","unstructured":"Muyembe T, Vandepitte J, Desmyter J. Natural colistin resistance in Edwardsiella tarda. 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Arch Microbiol. 2021;203(1):219\u201331.","journal-title":"Arch Microbiol"}],"container-title":["Annals of Clinical Microbiology and Antimicrobials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12941-022-00548-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12941-022-00548-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12941-022-00548-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T17:09:02Z","timestamp":1670432942000},"score":1,"resource":{"primary":{"URL":"https:\/\/ann-clinmicrob.biomedcentral.com\/articles\/10.1186\/s12941-022-00548-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["548"],"URL":"https:\/\/doi.org\/10.1186\/s12941-022-00548-w","relation":{},"ISSN":["1476-0711"],"issn-type":[{"value":"1476-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"29 June 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 December 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study protocol was approved by the ethics committee of our institution, Sakai City Medical Hospital (No. 22\u2013284).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Informed consent was waived because of the retrospective nature of this study, and ethical considerations for the use of clinical information were based on the institutional opt-out policy ().","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"None declared.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"56"}}