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Herein, this study aimed to investigate the potential impact of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization density and depth on the severity of histological parameters of gastritis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A prospective monocentric study was conducted from December 2019 to July 2022, enrolling patients with confirmed chronic\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection via histopathological evaluation.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization status was detected by immunohistochemical staining, pathological changes of gastric specimens were detected by hematoxylin eosin staining. Epidemiological, endoscopic and histopathological data were collected.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1120 patients with a mean age of 45.8\u00a0years were included. Regardless of the previous history of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      eradication treatment, significant correlations were observed between the density and depth of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization and the intensity of gastritis activity (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Patients with the lowest level of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization density and depth exhibited the highest level of mild activity. In whole participants and anti-\n                      <jats:italic>H. pylori<\/jats:italic>\n                      treatment-naive participants,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization density and depth were markedly correlated with the severity of chronic gastritis and gastric atrophy (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization density (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) and depth (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.047) were significantly associated with ulcer formation in patients naive to any anti-\n                      <jats:italic>H. pylori<\/jats:italic>\n                      treatment. No significant associations were observed between the density and depth of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization and other histopathological findings including lymphadenia, lymphoid follicle formation and dysplasia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      As the density and depth of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      colonization increased, so did the activity and severity of gastritis, along with an elevated risk of ulcer formation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12941-024-00666-7","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T05:02:35Z","timestamp":1705035755000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of Helicobacter pylori colonization density and depth on gastritis severity"],"prefix":"10.1186","volume":"23","author":[{"given":"Jianxiang","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinliang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijie","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,12]]},"reference":[{"key":"666_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","volume":"13","author":"P Correa","year":"2012","unstructured":"Correa P, Piazuelo MB. 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