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This study aims to characterize endometrial microbiota in RIF patients with CE and assess its implications for reproductive outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In this prospective study, we enrolled RIF patients both with and without CE. Endometrial and cervical samples were collected for 16\u00a0S rRNA gene sequencing. Microbiota composition was compared between groups using diversity indices, phylum, and genus-level analysis. Canonical correlation analysis (CCA) and Spearman\u2019s correlation coefficients were used to assess relationships between CE, reproductive outcomes, and microbiota. Predictive functional profiling was performed to evaluate metabolic pathways associated with CE.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Endometrial microbiota in CE patients exhibited greater diversity and evenness compared to non-CE patients. Principal coordinates analysis (PCoA) revealed distinct clustering between CE and non-CE groups. Linear discriminant analysis (LDA) identified <jats:italic>Proteobacteria<\/jats:italic>, <jats:italic>Aminicenantales<\/jats:italic>, and <jats:italic>Chloroflexaceae<\/jats:italic> as characteristic of CE, while <jats:italic>Lactobacillus<\/jats:italic>, <jats:italic>Acinetobacter<\/jats:italic>, <jats:italic>Herbaspirillum<\/jats:italic>, <jats:italic>Ralstonia<\/jats:italic>, <jats:italic>Shewanela<\/jats:italic>, and <jats:italic>Micrococcaceae<\/jats:italic> were associated with non-CE. CCA demonstrated associations between CE, adverse reproductive outcomes, and specific bacterial taxa. Microbial metabolic pathways significantly differed between CE and non-CE groups, with enrichment in pathways related to cofactors, vitamins, secondary metabolites, and the immune system in CE patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>RIF patients with CE exhibit distinct endometrial microbiota compositions associated with adverse reproductive outcomes. The increased microbial diversity and altered metabolic pathways in CE suggest a potential correlation with reproductive outcomes, although further studies are necessary to elucidate the causal relationship between microbiota alterations and fertility. Modulating the endometrial microbiome may represent a novel therapeutic strategy to improve IVF outcomes in patients with CE.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12941-024-00710-6","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T16:02:03Z","timestamp":1717084923000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Chronic endometritis and the endometrial microbiota: implications for reproductive success in patients with recurrent implantation failure"],"prefix":"10.1186","volume":"23","author":[{"given":"Hong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"710_CR1","doi-asserted-by":"publisher","first-page":"1061766","DOI":"10.3389\/fendo.2022.1061766","volume":"13","author":"J Ma","year":"2022","unstructured":"Ma J, Gao W, Li D. 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