{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T05:23:59Z","timestamp":1731043439886,"version":"3.28.0"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"crossref","award":["JA 1479\/9-1"],"award-info":[{"award-number":["JA 1479\/9-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universit\u00e4tsklinikum D\u00fcsseldorf. Anstalt \u00f6ffentlichen Rechts"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Immunopathology of human tuberculosis (TB)\u00a0in a subgroup of patients is characterized by aberrantly high concentrations of inflammatory cytokines, for example Interleukin (IL)-6. Concomitant (co-)infections by parasites can affect host immunity, but the impact on immunopathology in TB patients is poorly defined. Here we characterized a group of patients with TB ( n\u2009=\u200976) from Ghana with different protozoan and helminth co-infections. Plasma cytokines were measured at the onset of disease and anti-mycobacterial treatment efficacy was monitored during disease course. A subgroup of TB patients had co-infections with protozoan (n\u2009=\u200919) or helminth (n\u2009=\u200916) parasites. Plasma analyses for candidate cytokines identified lower levels of IL-6 in parasite co-infected patients with TB. Moreover, it took less time for co-infected patients to become sputum-negative for <jats:italic>Mycobacterium tuberculosis<\/jats:italic> during treatment. These results indicated an influence of parasite co-infections on immunopathology in TB\u00a0and suggested positive effects on treatment efficacy.<\/jats:p>","DOI":"10.1186\/s12941-024-00756-6","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:01:55Z","timestamp":1730991715000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Concomitant parasite infections influence tuberculosis immunopathology and favor rapid sputum conversion of pulmonary tuberculosis patients"],"prefix":"10.1186","volume":"23","author":[{"given":"Augustine","family":"Yeboah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monikamira","family":"Vivekanandan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Adankwah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorcas O.","family":"Owusu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilfred","family":"Aniagyei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Difery","family":"Minadzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaac","family":"Acheampong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph F.","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Millicent","family":"Lamptey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed K.","family":"Abass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Kumbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francis","family":"Osei-Yeboah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amidu","family":"Gawusu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda Batsa","family":"Debrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Debrah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ertan","family":"Mayatepek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Seyfarth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard O.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Jacobsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,11,7]]},"reference":[{"issue":"9","key":"756_CR1","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/j.it.2016.07.005","volume":"37","author":"S Babu","year":"2016","unstructured":"Babu S, Nutman TB. Helminth-tuberculosis co-infection: an immunologic perspective. Trends Immunol. 2016;37(9):597\u2013607.","journal-title":"Trends Immunol"},{"key":"756_CR2","doi-asserted-by":"publisher","first-page":"2579","DOI":"10.3389\/fimmu.2018.02579","volume":"9","author":"NA Mabbott","year":"2018","unstructured":"Mabbott NA. The influence of parasite infections on host immunity to co-infection with other pathogens. Front Immunol. 2018;9:2579.","journal-title":"Front Immunol"},{"issue":"2","key":"756_CR3","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1462-5822.2005.00653.x","volume":"8","author":"KR Page","year":"2006","unstructured":"Page KR, Scott AL, Manabe YC. The expanding realm of heterologous immunity: friend or foe? Cell Microbiol. 2006;8(2):185\u201396.","journal-title":"Cell Microbiol"},{"issue":"10","key":"756_CR4","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1016\/j.ijpara.2010.05.003","volume":"40","author":"T Supali","year":"2010","unstructured":"Supali T, Verweij JJ, Wiria AE, Djuardi Y, Hamid F, Kaisar MM, Wammes LJ, van Lieshout L, Luty AJ, Sartono E, Yazdanbakhsh M. Polyparasitism and its impact on the immune system. Int J Parasitol. 2010;40(10):1171\u20136.","journal-title":"Int J Parasitol"},{"issue":"6","key":"756_CR5","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1089\/ars.2020.8124","volume":"34","author":"EP Amaral","year":"2021","unstructured":"Amaral EP, Vinhaes CL, Oliveira-de-Souza D, Nogueira B, Akrami KM, Andrade BB. The interplay between systemic inflammation, oxidative stress, and tissue remodeling in tuberculosis. Antioxid Redox Signal. 2021;34(6):471\u201385.","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"756_CR6","doi-asserted-by":"publisher","first-page":"5967","DOI":"10.1172\/JCI140970","volume":"130","author":"C Diorio","year":"2020","unstructured":"Diorio C, Henrickson SE, Vella LA, McNerney KO, Chase J, Burudpakdee C, Lee JH, Jasen C, Balamuth F, Barrett DM, Banwell BL, Bernt KM, Blatz AM, Chiotos K, Fisher BT, Fitzgerald JC, Gerber JS, Gollomp K, Gray C, Grupp SA, Harris RM, Kilbaugh TJ, John ARO, Lambert M, Liebling EJ, Paessler ME, Petrosa W, Phillips C, Reilly AF, Romberg ND, Seif A, Sesok-Pizzini DA, Sullivan KE, Vardaro J, Behrens EM, Teachey DT, Bassiri H. Multisystem inflammatory syndrome in children and COVID-19 are distinct presentations of SARS-CoV-2. J Clin Invest. 2020;130(11):5967\u201375.","journal-title":"J Clin Invest"},{"key":"756_CR7","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.3389\/fimmu.2020.02037","volume":"11","author":"E Mortaz","year":"2020","unstructured":"Mortaz E, Tabarsi P, Varahram M, Folkerts G, Adcock IM. The immune response and immunopathology of COVID-19. Front Immunol. 2020;11:2037.","journal-title":"Front Immunol"},{"key":"756_CR8","doi-asserted-by":"crossref","unstructured":"Que Y, Hu C, Wan K, Hu P, Wang R, Luo J, Li T, Ping R, Hu Q, Sun Y, Wu X, Tu L, Du Y, Chang C, Xu G. Cytokine release syndrome in COVID-19: a major mechanism of morbidity and mortality. Int Rev Immunol 2021:1\u201314","DOI":"10.1080\/08830185.2021.1884248"},{"issue":"3","key":"756_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1097\/MCP.0000000000000769","volume":"27","author":"M Maeurer","year":"2021","unstructured":"Maeurer M, Ramalho R, Wang FS, Zumla A. Host-directed therapies for COVID-19. 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Cell Mol Immunol. 2021;18(8):2062\u20134.","journal-title":"Cell Mol Immunol"},{"issue":"2","key":"756_CR14","first-page":"62","volume":"5","author":"JJ Ellner","year":"1996","unstructured":"Ellner JJ. Immunosuppression in tuberculosis. Infect Agents Dis. 1996;5(2):62\u201372.","journal-title":"Infect Agents Dis"},{"issue":"9","key":"756_CR15","doi-asserted-by":"publisher","first-page":"e3419","DOI":"10.1093\/cid\/ciaa1104","volume":"73","author":"NP Kumar","year":"2021","unstructured":"Kumar NP, Moideen K, Nancy A, Viswanathan V, Thiruvengadam K, Nair D, Banurekha VV, Sivakumar S, Hissar S, Kornfeld H, Babu S. Plasma chemokines are baseline predictors of unfavorable treatment outcomes in pulmonary tuberculosis. 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J Thorac Dis. 2018;10(9):5246\u201353.","journal-title":"J Thorac Dis"},{"key":"756_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2019.154950","volume":"127","author":"PX Losada","year":"2020","unstructured":"Losada PX, Perdomo-Celis F, Castro M, Salcedo C, Salcedo A, DeLaura I, Lastra G, Narvaez CF. Locally-secreted interleukin-6 is related with radiological severity in smear-negative pulmonary tuberculosis. Cytokine. 2020;127: 154950.","journal-title":"Cytokine"},{"issue":"4","key":"756_CR21","doi-asserted-by":"publisher","first-page":"2100905","DOI":"10.1183\/13993003.00905-2021","volume":"59","author":"AN Gupte","year":"2022","unstructured":"Gupte AN, Kumar P, Araujo-Pereira M, Kulkarni V, Paradkar M, Pradhan N, Menon P, Padmapriyadarsini C, Hanna LE, Yogendra Shivakumar SVB, Rockwood N, Du Bruyn E, Karyakarte R, Gaikwad S, Bollinger R, Golub J, Gupte N, Viswanathan V, Wilkinson RJ, Mave V, Babu S, Kornfeld H, Andrade BB, Gupta A. Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study. Eur Respir J. 2022;59(4):2100905.","journal-title":"Eur Respir J"},{"issue":"1","key":"756_CR22","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s15010-022-01870-3","volume":"51","author":"MM Vivekanandan","year":"2023","unstructured":"Vivekanandan MM, Adankwah E, Aniagyei W, Acheampong I, Yeboah A, Arthur JF, Lamptey MNK, Abass MK, Gawusu A, Kumbel F, Osei-Yeboah F, Debrah LB, Owusu DO, Debrah A, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M. Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients. Infection. 2023;51(1):169\u201379.","journal-title":"Infection"},{"issue":"3","key":"756_CR23","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/cmi.2018.5","volume":"16","author":"K Harling","year":"2019","unstructured":"Harling K, Adankwah E, Guler A, Afum-Adjei Awuah A, Adu-Amoah L, Mayatepek E, Owusu-Dabo E, Nausch N, Jacobsen M. Constitutive STAT3 phosphorylation and IL-6\/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients. Cell Mol Immunol. 2019;16(3):275\u201387.","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"756_CR24","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s15010-023-01977-1","volume":"51","author":"MM Vivekanandan","year":"2023","unstructured":"Vivekanandan MM, Adankwah E, Aniagyei W, Acheampong I, Minadzi D, Yeboah A, Arthur JF, Lamptey M, Abass MK, Kumbel F, Osei-Yeboah F, Gawusu A, Debrah LB, Owusu DO, Debrah A, Mayatepek E, Seyfarth J, Phillips RO, Jacobsen M. Impaired T-cell response to phytohemagglutinin (PHA) in tuberculosis patients is associated with high IL-6 plasma levels and normalizes early during anti-mycobacterial treatment. Infection. 2023;51(4):1013\u201323.","journal-title":"Infection"}],"container-title":["Annals of Clinical Microbiology and Antimicrobials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12941-024-00756-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12941-024-00756-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12941-024-00756-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T15:04:51Z","timestamp":1730991891000},"score":1,"resource":{"primary":{"URL":"https:\/\/ann-clinmicrob.biomedcentral.com\/articles\/10.1186\/s12941-024-00756-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,7]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["756"],"URL":"https:\/\/doi.org\/10.1186\/s12941-024-00756-6","relation":{},"ISSN":["1476-0711"],"issn-type":[{"value":"1476-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,7]]},"assertion":[{"value":"17 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 October 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study received approval from the Committee on Human Research, Publication and Ethics (CHRPE\/AP\/023\/18) at the School of Medicine and Dentistry at the Kwame Nkrumah University of Science and Technology (KNUST) in Kumasi, Ghana. The study was conducted in accordance to the Declaration of Helsinki. All study subjects gave written informed consent for participation and to the publication of the study results prior to recruitment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors have approved the content of the manuscript and consent to its publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"97"}}