{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:15:55Z","timestamp":1793643355649,"version":"4.5.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Ann Clin Microbiol Antimicrob"],"DOI":"10.1186\/s12941-025-00794-8","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T13:57:11Z","timestamp":1745589431000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Is neutropenia still the main risk factor for invasive aspergillosis? A contemporary university hospital retrospective cohort of invasive aspergillosis in neutropenic and non-neutropenic patients"],"prefix":"10.1186","volume":"24","author":[{"given":"Andrea","family":"Guti\u00e9rrez-Villanueva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Diego-Yag\u00fce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Guti\u00e9rrez-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Garc\u00eda-Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Guti\u00e9rrez-Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rom\u00e1n","family":"Fern\u00e1ndez-Guiti\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Castilla-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Bermejo-Moreno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Miguel-Onta\u00f1on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Calder\u00f3n-Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Callejas-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"D\u00edaz-de Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"de la Fuente-Moral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"M\u00fa\u00f1ez-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarela","family":"Garc\u00eda-Masedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"S\u00e1nchez-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Ramos-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Fern\u00e1ndez-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"issue":"4","key":"794_CR1","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/ciw326","volume":"63","author":"TF Patterson","year":"2016","unstructured":"Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, et al. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63(4):e1-60.","journal-title":"Clin Infect Dis"},{"issue":"2","key":"794_CR2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.riam.2022.04.002","volume":"39","author":"M Fernandez-Pittol","year":"2022","unstructured":"Fernandez-Pittol M, Alejo-Cancho I, Rubio-Garc\u00eda E, Cardozo C, Puerta-Alcalde P, Moreno-Garc\u00eda E, et al. Aspergillosis by cryptic Aspergillus species: a case series and review of the literature. Rev Iberoam Micol. 2022;39(2):44\u20139.","journal-title":"Rev Iberoam Micol"},{"issue":"11","key":"794_CR3","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.3390\/pathogens12111305","volume":"12","author":"MA De Francesco","year":"2023","unstructured":"De Francesco MA. Drug-resistant Aspergillus spp.: a literature review of its resistance mechanisms and its prevalence in Europe. Pathogens. 2023;12(11):1305.","journal-title":"Pathogens"},{"issue":"4","key":"794_CR4","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s00134-024-07341-7","volume":"50","author":"M Bassetti","year":"2024","unstructured":"Bassetti M, Giacobbe DR, Agvald-Ohman C, Akova M, Alastruey-Izquierdo A, Arikan-Akdagli S, et al. Invasive fungal diseases in adult patients in intensive care unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM. Intensive Care Med abril de. 2024;50(4):502\u201315.","journal-title":"Intensive Care Med abril de"},{"issue":"2","key":"794_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s12281-023-00459-z","volume":"17","author":"D Bosetti","year":"2023","unstructured":"Bosetti D, Neofytos D. Invasive aspergillosis and the impact of azole-resistance. Curr Fungal Infect Rep. 2023;17(2):77\u201386.","journal-title":"Curr Fungal Infect Rep"},{"issue":"Suppl 1","key":"794_CR6","first-page":"56","volume":"29","author":"MI Tejeda","year":"2016","unstructured":"Tejeda MI, Salso S, Barber\u00e1n J. Invasive pulmonary aspergillosis in non-neutropenic patients. Rev Espanola Quimioter Publicacion Of Soc Espanola Quimioter. 2016;29(Suppl 1):56\u20138.","journal-title":"Rev Espanola Quimioter Publicacion Of Soc Espanola Quimioter."},{"key":"794_CR7","doi-asserted-by":"publisher","first-page":"1256158","DOI":"10.3389\/fcimb.2024.1256158","volume":"14","author":"A Azim","year":"2024","unstructured":"Azim A, Ahmed A. Diagnosis and management of invasive fungal diseases in non-neutropenic ICU patients, with focus on candidiasis and aspergillosis: a comprehensive review. Front Cell Infect Microbiol. 2024;14:1256158.","journal-title":"Front Cell Infect Microbiol"},{"issue":"1","key":"794_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s40121-017-0183-9","volume":"7","author":"M Bassetti","year":"2018","unstructured":"Bassetti M, Peghin M, Vena A. Challenges and solution of invasive aspergillosis in non-neutropenic patients: a review. Infect Dis Ther marzo de. 2018;7(1):17\u201327.","journal-title":"Infect Dis Ther marzo de"},{"issue":"5","key":"794_CR9","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1086\/505870","volume":"43","author":"A Cornillet","year":"2006","unstructured":"Cornillet A, Camus C, Nimubona S, Gandemer V, Tattevin P, Belleguic C, et al. Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey. Clin Infect Dis. 2006;43(5):577\u201384.","journal-title":"Clin Infect Dis"},{"key":"794_CR10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01630-21","author":"R Yamamuro","year":"2022","unstructured":"Yamamuro R, Kimura M, Asano-Mori Y, Abe M, Nakamura S, Umeyama T, et al. Clinical and microbiological characteristics of proven invasive aspergillosis due to rare\/cryptic species in allogeneic hematopoietic stem cell transplant recipients. Antimicrob Agents Chemother. 2022. https:\/\/doi.org\/10.1128\/AAC.01630-21.","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"794_CR11","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1093\/cid\/ciz1008","volume":"71","author":"JP Donnelly","year":"2020","unstructured":"Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, et al. Revision and update of the consensus definitions of invasive fungal disease from the European Organization for research and treatment of cancer and the mycoses study group education and research consortium. Clin Infect Dis. 2020;71(6):1367\u201376.","journal-title":"Clin Infect Dis"},{"issue":"6","key":"794_CR12","doi-asserted-by":"publisher","first-page":"e149","DOI":"10.1016\/S1473-3099(20)30847-1","volume":"21","author":"P Koehler","year":"2021","unstructured":"Koehler P, Bassetti M, Chakrabarti A, Chen SCA, Colombo AL, Hoenigl M, et al. Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM\/ISHAM consensus criteria for research and clinical guidance. Lancet Infect Dis. 2021;21(6):e149\u201362.","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"794_CR13","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1186\/s12879-017-2307-y","volume":"17","author":"L Huang","year":"2017","unstructured":"Huang L, He H, Jin J, Zhan Q. Is Bulpa criteria suitable for the diagnosis of probable invasive pulmonary Aspergillosis in critically ill patients with chronic obstructive pulmonary disease? A comparative study with EORTC\/ MSG and ICU criteria. BMC Infect Dis. 2017;17(1):209.","journal-title":"BMC Infect Dis"},{"issue":"10","key":"794_CR14","first-page":"1631","volume":"224","author":"F Lamoth","year":"2021","unstructured":"Lamoth F, Lewis RE, Walsh TJ, Kontoyiannis DP. Navigating the uncertainties of COVID-19-associated aspergillosis: a comparison with influenza-associated aspergillosis. J Infect Dis. 2021;224(10):1631\u201340.","journal-title":"J Infect Dis"},{"issue":"7","key":"794_CR15","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S2213-2600(21)00138-7","volume":"9","author":"FL Van De Veerdonk","year":"2021","unstructured":"Van De Veerdonk FL, Br\u00fcggemann RJM, Vos S, De Hertogh G, Wauters J, Reijers MHE, et al. COVID-19-associated Aspergillus tracheobronchitis: the interplay between viral tropism, host defence, and fungal invasion. Lancet Respir Med. 2021;9(7):795\u2013802.","journal-title":"Lancet Respir Med"},{"issue":"1","key":"794_CR16","doi-asserted-by":"publisher","first-page":"e0009421","DOI":"10.1128\/CMR.00094-21","volume":"35","author":"F Salazar","year":"2022","unstructured":"Salazar F, Bignell E, Brown GD, Cook PC, Warris A. Pathogenesis of respiratory viral and fungal coinfections. Clin Microbiol Rev. 2022;35(1):e0009421.","journal-title":"Clin Microbiol Rev"},{"issue":"2","key":"794_CR17","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3390\/jof8020161","volume":"8","author":"J Calder\u00f3n-Parra","year":"2022","unstructured":"Calder\u00f3n-Parra J, Moreno-Torres V, Mills-Sanchez P, Tejado-Bravo S, Romero-S\u00e1nchez I, Balandin-Moreno B, et al. Association of COVID-19-associated pulmonary aspergillosis with cytomegalovirus replication: a case-control study. J Fungi Basel Switz. 2022;8(2):161.","journal-title":"J Fungi Basel Switz"},{"issue":"8","key":"794_CR18","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1080\/07853890.2018.1518581","volume":"50","author":"D Dandachi","year":"2018","unstructured":"Dandachi D, Wilson Dib R, Fern\u00e1ndez-Cruz A, Jiang Y, Chaftari AM, Hachem R, et al. Invasive pulmonary aspergillosis in patients with solid tumours: risk factors and predictors of clinical outcomes. Ann Med. 2018;50(8):713\u201320.","journal-title":"Ann Med"},{"issue":"4","key":"794_CR19","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.jinf.2014.03.018","volume":"69","author":"M Peghin","year":"2014","unstructured":"Peghin M, Ruiz-Camps I, Garcia-Vidal C, Cervera C, Andreu J, Martin M, et al. Unusual forms of subacute invasive pulmonary aspergillosis in patients with solid tumors. J Infect. 2014;69(4):387\u201395.","journal-title":"J Infect"},{"issue":"6","key":"794_CR20","doi-asserted-by":"publisher","first-page":"576","DOI":"10.3390\/jof8060576","volume":"8","author":"P Gonz\u00e1lez-Garc\u00eda","year":"2022","unstructured":"Gonz\u00e1lez-Garc\u00eda P, Alonso-Sard\u00f3n M, Rodr\u00edguez-Alonso B, Almeida H, Romero-Alegr\u00eda \u00c1, Vega-Rodr\u00edguez VJ, et al. How has the aspergillosis case fatality rate changed over the last two decades in Spain? J Fungi Basel Switz. 2022;8(6):576.","journal-title":"J Fungi Basel Switz"},{"issue":"3","key":"794_CR21","doi-asserted-by":"publisher","first-page":"myad021","DOI":"10.1093\/mmy\/myad021","volume":"61","author":"P Monz\u00f3-Gallo","year":"2023","unstructured":"Monz\u00f3-Gallo P, Chumbita M, Lopera C, Aiello TF, Peyrony O, Bodro M, et al. Real-life epidemiology and current outcomes of hospitalized adults with invasive fungal infections. Med Mycol. 2023;61(3):myad021.","journal-title":"Med Mycol"},{"issue":"1","key":"794_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3390\/microorganisms12010117","volume":"12","author":"G Mori","year":"2024","unstructured":"Mori G, Diotallevi S, Farina F, Lolatto R, Galli L, Chiurlo M, et al. High-risk neutropenic fever and invasive fungal diseases in patients with hematological malignancies. Microorganisms. 2024;12(1):117.","journal-title":"Microorganisms"},{"issue":"11","key":"794_CR23","doi-asserted-by":"publisher","first-page":"1657","DOI":"10.3324\/haematol.2013.094359","volume":"98","author":"M Nucci","year":"2013","unstructured":"Nucci M, Nou\u00e9r SA, Cappone D, Anaissie E. Early diagnosis of invasive pulmonary aspergillosis in hematologic patients: an opportunity to improve the outcome. Haematologica. 2013;98(11):1657\u201360.","journal-title":"Haematologica"},{"key":"794_CR24","doi-asserted-by":"publisher","first-page":"109042","DOI":"10.1016\/j.ejrad.2020.109042","volume":"131","author":"N Yanagawa","year":"2020","unstructured":"Yanagawa N, Sakai F, Doki N, Sekiya N. CT of invasive pulmonary aspergillosis (IPA) in cases with hematologic malignancy: comparison of CT features in the group classified by the severity of neutropenia and underlying disease. Eur J Radiol. 2020;131:109042.","journal-title":"Eur J Radiol"},{"issue":"4","key":"794_CR25","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s15010-022-01960-2","volume":"51","author":"A Otu","year":"2023","unstructured":"Otu A, Kosmidis C, Mathioudakis AG, Ibe C, Denning DW. The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease. Infection. 2023;51(4):813\u201329.","journal-title":"Infection"},{"issue":"8","key":"794_CR26","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1182\/blood-2011-04-351601","volume":"119","author":"A Bergeron","year":"2012","unstructured":"Bergeron A, Porcher R, Sulahian A, de Bazelaire C, Chagnon K, Raffoux E, et al. The strategy for the diagnosis of invasive pulmonary aspergillosis should depend on both the underlying condition and the leukocyte count of patients with hematologic malignancies. Blood. 2012;119(8):1831\u20137 (quiz 1956).","journal-title":"Blood"},{"issue":"7","key":"794_CR27","doi-asserted-by":"publisher","first-page":"2153","DOI":"10.1128\/JCM.00345-17","volume":"55","author":"W Zhou","year":"2017","unstructured":"Zhou W, Li H, Zhang Y, Huang M, He Q, Li P, et al. Diagnostic value of galactomannan antigen test in serum and bronchoalveolar lavage fluid samples from patients with nonneutropenic invasive pulmonary aspergillosis. J Clin Microbiol. 2017;55(7):2153\u201361.","journal-title":"J Clin Microbiol"},{"issue":"4","key":"794_CR28","doi-asserted-by":"publisher","first-page":"115274","DOI":"10.1016\/j.diagmicrobio.2020.115274","volume":"99","author":"Z Wu","year":"2021","unstructured":"Wu Z, Wang L, Tan L, Wu J, Chen Z, Hu M. Diagnostic value of galactomannan in serum and bronchoalveolar lavage fluid for invasive pulmonary aspergillosis in non-neutropenic patients. Diagn Microbiol Infect Dis. 2021;99(4):115274.","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"2","key":"794_CR29","doi-asserted-by":"publisher","first-page":"e13701","DOI":"10.1111\/myc.13701","volume":"67","author":"I Guti\u00e9rrez-Mart\u00edn","year":"2024","unstructured":"Guti\u00e9rrez-Mart\u00edn I, Garc\u00eda-Prieto S, Vel\u00e1squez K, Guti\u00e9rrez-Abreu EV, Diego-Yag\u00fce I, Calder\u00f3n-Parra J, et al. Usefulness of 18 F-FDG PET-CT for the management of invasive fungal infections: a retrospective cohort from a tertiary university hospital. Mycoses. 2024;67(2):e13701.","journal-title":"Mycoses"},{"issue":"2","key":"794_CR30","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3390\/microorganisms12020307","volume":"12","author":"A Guti\u00e9rrez-Villanueva","year":"2024","unstructured":"Guti\u00e9rrez-Villanueva A, Quintana-Reyes C, de Antonio EM, Rodr\u00edguez-Alfonso B, Vel\u00e1squez K, de la Iglesia A, et al. Usefulness of 18F-FDG PET-CT in the management of febrile neutropenia: a retrospective cohort from a Tertiary University Hospital and a systematic review. Microorganisms. 2024;12(2):307.","journal-title":"Microorganisms."},{"issue":"6","key":"794_CR31","doi-asserted-by":"publisher","first-page":"e074240","DOI":"10.1136\/bmjopen-2023-074240","volume":"13","author":"A Guti\u00e9rrez","year":"2023","unstructured":"Guti\u00e9rrez A, Rodriguez B, Velasquez K, Guti\u00e9rrez I, Garc\u00eda S, M\u00fa\u00f1ez E, et al. Determining the usefulness of systematic 18F-FDG PET\/CT for the management of invasive fungal infection (PETIFI project): a prospective national multicentre cohort study protocol. BMJ Open. 2023;13(6):e074240.","journal-title":"BMJ Open"},{"key":"794_CR32","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-024-02236-7","author":"P Monzo-Gallo","year":"2024","unstructured":"Monzo-Gallo P, Alastruey-Izquierdo A, Chumbita M, Aiello TF, Gallardo-Pizarro A, Peyrony O, et al. Report of three azole-resistant Aspergillus fumigatus cases with TR34\/L98H mutation in hematological patients in Barcelona, Spain. Infection. 2024. https:\/\/doi.org\/10.1007\/s15010-024-02236-7.","journal-title":"Infection"},{"issue":"3","key":"794_CR33","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/jof5030067","volume":"5","author":"DZP Friedman","year":"2019","unstructured":"Friedman DZP, Schwartz IS. Emerging fungal infections: new patients, new patterns, and new pathogens. J Fungi. 2019;5(3):67.","journal-title":"J Fungi"},{"issue":"7","key":"794_CR34","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.3201\/eid2607.200088","volume":"26","author":"PPA Lestrade","year":"2020","unstructured":"Lestrade PPA, Buil JB, van der Beek MT, Kuijper EJ, van Dijk K, Kampinga GA, et al. Paradoxal trends in azole-resistant aspergillus fumigatus in a National Multicenter Surveillance Program, the Netherlands, 2013\u20132018. Emerg Infect Dis. 2020;26(7):1447\u201355.","journal-title":"Emerg Infect Dis"},{"issue":"4","key":"794_CR35","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1111\/myc.13426","volume":"65","author":"M Risum","year":"2022","unstructured":"Risum M, Hare RK, Gertsen JB, Kristensen L, Rosenvinge FS, Sulim S, et al. Azole resistance in Aspergillus fumigatus. The first 2-year\u2019s Data from the Danish National Surveillance Study, 2018\u20132020. Mycoses. 2022;65(4):419\u201328.","journal-title":"Mycoses"},{"issue":"1","key":"794_CR36","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jinf.2023.05.005","volume":"87","author":"P Puerta-Alcalde","year":"2023","unstructured":"Puerta-Alcalde P, Monz\u00f3-Gallo P, Aguilar-Guisado M, Ramos JC, Laporte-Amarg\u00f3s J, Machado M, et al. Breakthrough invasive fungal infection among patients with haematologic malignancies: a national, prospective, and multicentre study. J Infect. 2023;87(1):46\u201353.","journal-title":"J Infect"}],"container-title":["Annals of Clinical Microbiology and Antimicrobials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12941-025-00794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12941-025-00794-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12941-025-00794-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T13:57:12Z","timestamp":1745589432000},"score":1,"resource":{"primary":{"URL":"https:\/\/ann-clinmicrob.biomedcentral.com\/articles\/10.1186\/s12941-025-00794-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,25]]},"references-count":36,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["794"],"URL":"https:\/\/doi.org\/10.1186\/s12941-025-00794-8","relation":{},"ISSN":["1476-0711"],"issn-type":[{"value":"1476-0711","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,25]]},"assertion":[{"value":"15 January 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study has been approved by the Ethical Research Committee of the Puerta de Hierro-Majadahonda Hospital (PI 156\/24).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"28"}}