{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:53:30Z","timestamp":1768352010813,"version":"3.49.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T00:00:00Z","timestamp":1433808000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T00:00:00Z","timestamp":1433808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Department of Biotechnology, Government of India","award":["BT\/PR10347, 102\/IFD\/SAN\/PR-1612\/2007 & BT\/PR6198\/Med\/14\/758\/2005"],"award-info":[{"award-number":["BT\/PR10347, 102\/IFD\/SAN\/PR-1612\/2007 & BT\/PR6198\/Med\/14\/758\/2005"]}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12943-015-0385-2","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T00:51:53Z","timestamp":1433724713000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Alterations in microRNAs miR-21 and let-7a correlate with aberrant STAT3 signaling and downstream effects during cervical carcinogenesis"],"prefix":"10.1186","volume":"14","author":[{"given":"Gauri","family":"Shishodia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shirish","family":"Shukla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yogesh","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashank","family":"Masaldan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumita","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Bhambhani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shashi","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ravi","family":"Mehrotra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhudev Chandra","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alok Chandra","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,6,9]]},"reference":[{"key":"385_CR1","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1186\/1476-4598-9-282","volume":"9","author":"S Shukla","year":"2010","unstructured":"Shukla S, Shishodia G, Mahata S, et al. Aberrant expression and constitutive activation of STAT3 in cervical carcinogenesis: implications in high-risk human papillomavirus infection. Mol Cancer. 2010;9:282.","journal-title":"Mol Cancer"},{"key":"385_CR2","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s11010-009-0133-2","volume":"330","author":"RC Sobti","year":"2009","unstructured":"Sobti RC, Singh N, Hussain S, Suri V, Bharti AC, Das BC. Overexpression of STAT3 in HPV-mediated cervical cancer in a north Indian population. Mol Cell Biochem. 2009;330:193\u20139.","journal-title":"Mol Cell Biochem"},{"key":"385_CR3","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/sj.bjc.6603597","volume":"96","author":"CL Chen","year":"2007","unstructured":"Chen CL, Hsieh FC, Lieblein JC, et al. Stat3 activation in human endometrial and cervical cancers. Br J Cancer. 2007;96:591\u20139.","journal-title":"Br J Cancer"},{"key":"385_CR4","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/sj.bjc.6605212","volume":"101","author":"S Takemoto","year":"2009","unstructured":"Takemoto S, Ushijima K, Kawano K, et al. Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma. Br J Cancer. 2009;101:967\u201372.","journal-title":"Br J Cancer"},{"key":"385_CR5","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1002\/mc.20342","volume":"46","author":"DJ Kim","year":"2007","unstructured":"Kim DJ, Chan KS, Sano S, Digiovanni J. Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Mol Carcinog. 2007;46:725\u201331.","journal-title":"Mol Carcinog"},{"key":"385_CR6","doi-asserted-by":"publisher","first-page":"e67849","DOI":"10.1371\/journal.pone.0067849","volume":"8","author":"S Shukla","year":"2013","unstructured":"Shukla S, Mahata S, Shishodia G, et al. Functional regulatory role of STAT3 in HPV16-mediated cervical carcinogenesis. PLoS One. 2013;8:e67849.","journal-title":"PLoS One"},{"key":"385_CR7","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1016\/j.cell.2009.10.014","volume":"139","author":"D Iliopoulos","year":"2009","unstructured":"Iliopoulos D, Hirsch HA, Struhl K. An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell. 2009;139:693\u2013706.","journal-title":"Cell"},{"key":"385_CR8","doi-asserted-by":"publisher","first-page":"ra11","DOI":"10.1126\/scisignal.2004497","volume":"7","author":"M Xiang","year":"2014","unstructured":"Xiang M, Birkbak NJ, Vafaizadeh V, et al. STAT3 Induction of miR-146b Forms a Feedback Loop to Inhibit the NF-kappaB to IL-6 Signaling Axis and STAT3-Driven Cancer Phenotypes. Sci Signal. 2014;7:ra11.","journal-title":"Sci Signal"},{"key":"385_CR9","doi-asserted-by":"publisher","first-page":"26167","DOI":"10.1074\/jbc.M113.477950","volume":"288","author":"JM Garner","year":"2013","unstructured":"Garner JM, Fan M, Yang CH, et al. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor kappaB signaling in glioblastoma cancer stem cells regulates the Notch pathway. J Biol Chem. 2013;288:26167\u201376.","journal-title":"J Biol Chem"},{"key":"385_CR10","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.semcancer.2011.12.010","volume":"22","author":"G Kohanbash","year":"2012","unstructured":"Kohanbash G, Okada H. MicroRNAs and STAT interplay. Semin Cancer Biol. 2012;22:70\u20135.","journal-title":"Semin Cancer Biol"},{"key":"385_CR11","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1158\/0008-5472.CAN-09-3289","volume":"70","author":"X Hu","year":"2010","unstructured":"Hu X, Schwarz JK, Lewis Jr JS, et al. A microRNA expression signature for cervical cancer prognosis. Cancer Res. 2010;70:1441\u20138.","journal-title":"Cancer Res"},{"key":"385_CR12","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.1038\/sj.onc.1210919","volume":"27","author":"I Martinez","year":"2008","unstructured":"Martinez I, Gardiner AS, Board KF, Monzon FA, Edwards RP, Khan SA. Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene. 2008;27:2575\u201382.","journal-title":"Oncogene"},{"key":"385_CR13","first-page":"668","volume":"2011","author":"ZM Zheng","year":"1809","unstructured":"Zheng ZM, Wang X. Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta. 1809;2011:668\u201377.","journal-title":"Biochim Biophys Acta"},{"key":"385_CR14","doi-asserted-by":"publisher","first-page":"4113","DOI":"10.1016\/j.febslet.2008.11.011","volume":"582","author":"G Reshmi","year":"2008","unstructured":"Reshmi G, Pillai MR. Beyond HPV: oncomirs as new players in cervical cancer. FEBS Lett. 2008;582:4113\u20136.","journal-title":"FEBS Lett"},{"key":"385_CR15","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1186\/1471-2407-14-996","volume":"14","author":"G Shishodia","year":"2014","unstructured":"Shishodia G, Verma G, Srivastava Y, Mehrotra R, Das BC, Bharti AC. Deregulation of microRNAs Let-7a and miR-21 mediate aberrant STAT3 signaling during human papillomavirus-induced cervical carcinogenesis: role of E6 oncoprotein. BMC Cancer. 2014;14:996.","journal-title":"BMC Cancer"},{"key":"385_CR16","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1182\/blood-2007-03-081133","volume":"110","author":"D Loffler","year":"2007","unstructured":"Loffler D, Brocke-Heidrich K, Pfeifer G, et al. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood. 2007;110:1330\u20133.","journal-title":"Blood"},{"key":"385_CR17","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1038\/sj.onc.1210856","volume":"27","author":"IA Asangani","year":"2008","unstructured":"Asangani IA, Rasheed SA, Nikolova DA, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene. 2008;27:2128\u201336.","journal-title":"Oncogene"},{"key":"385_CR18","doi-asserted-by":"publisher","first-page":"8256","DOI":"10.1074\/jbc.M607712200","volume":"282","author":"F Meng","year":"2007","unstructured":"Meng F, Henson R, Wehbe-Janek H, Smith H, Ueno Y, Patel T. The MicroRNA let-7a modulates interleukin-6-dependent STAT-3 survival signaling in malignant human cholangiocytes. J Biol Chem. 2007;282:8256\u201364.","journal-title":"J Biol Chem"},{"key":"385_CR19","doi-asserted-by":"publisher","first-page":"2799","DOI":"10.1038\/sj.onc.1210083","volume":"26","author":"ML Si","year":"2007","unstructured":"Si ML, Zhu S, Wu H, Lu Z, Wu F, Mo YY. miR-21-mediated tumor growth. Oncogene. 2007;26:2799\u2013803.","journal-title":"Oncogene"},{"key":"385_CR20","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/cr.2008.24","volume":"18","author":"S Zhu","year":"2008","unstructured":"Zhu S, Wu H, Wu F, Nie D, Sheng S, Mo YY. MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Cell Res. 2008;18:350\u20139.","journal-title":"Cell Res"},{"key":"385_CR21","first-page":"248","volume":"2012","author":"T Yao","year":"1822","unstructured":"Yao T, Lin Z. MiR-21 is involved in cervical squamous cell tumorigenesis and regulates CCL20. Biochim Biophys Acta. 1822;2012:248\u201360.","journal-title":"Biochim Biophys Acta"},{"key":"385_CR22","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.bbrc.2009.08.044","volume":"388","author":"Q Yao","year":"2009","unstructured":"Yao Q, Xu H, Zhang QQ, Zhou H, Qu LH. MicroRNA-21 promotes cell proliferation and down-regulates the expression of programmed cell death 4 (PDCD4) in HeLa cervical carcinoma cells. Biochem Biophys Res Commun. 2009;388:539\u201342.","journal-title":"Biochem Biophys Res Commun"},{"key":"385_CR23","doi-asserted-by":"publisher","first-page":"e2557","DOI":"10.1371\/journal.pone.0002557","volume":"3","author":"X Wang","year":"2008","unstructured":"Wang X, Tang S, Le SY, et al. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One. 2008;3:e2557.","journal-title":"PLoS One"},{"key":"385_CR24","doi-asserted-by":"publisher","first-page":"6031","DOI":"10.1158\/0008-5472.CAN-06-0561","volume":"67","author":"WO Lui","year":"2007","unstructured":"Lui WO, Pourmand N, Patterson BK, Fire A. Patterns of known and novel small RNAs in human cervical cancer. Cancer Res. 2007;67:6031\u201343.","journal-title":"Cancer Res"},{"key":"385_CR25","doi-asserted-by":"publisher","first-page":"e28423","DOI":"10.1371\/journal.pone.0028423","volume":"6","author":"G Deftereos","year":"2011","unstructured":"Deftereos G, Corrie SR, Feng Q, et al. Expression of mir-21 and mir-143 in cervical specimens ranging from histologically normal through to invasive cervical cancer. PLoS One. 2011;6:e28423.","journal-title":"PLoS One"},{"key":"385_CR26","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jhep.2009.12.043","volume":"53","author":"Y Wang","year":"2010","unstructured":"Wang Y, Lu Y, Toh ST, et al. Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. J Hepatol. 2010;53:57\u201366.","journal-title":"J Hepatol"},{"key":"385_CR27","first-page":"383","volume":"4","author":"HC Jeong","year":"2011","unstructured":"Jeong HC, Kim EK, Lee JH, Lee JM, Yoo HN, Kim JK. Aberrant expression of let-7a miRNA in the blood of non-small cell lung cancer patients. Mol Med Report. 2011;4:383\u20137.","journal-title":"Mol Med Report"},{"key":"385_CR28","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1073\/pnas.0307323101","volume":"101","author":"GA Calin","year":"2004","unstructured":"Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci U S A. 2004;101:2999\u20133004.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"385_CR29","doi-asserted-by":"publisher","first-page":"5665","DOI":"10.1158\/1078-0432.CCR-06-2491","volume":"13","author":"D Germain","year":"2007","unstructured":"Germain D, Frank DA. Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy. Clin Cancer Res. 2007;13:5665\u20139.","journal-title":"Clin Cancer Res"},{"key":"385_CR30","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1126\/science.1136319","volume":"315","author":"R Triboulet","year":"2007","unstructured":"Triboulet R, Mari B, Lin YL, et al. Suppression of microRNA-silencing pathway by HIV-1 during virus replication. Science. 2007;315:1579\u201382.","journal-title":"Science"},{"key":"385_CR31","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1158\/0008-5472.CAN-10-2193","volume":"71","author":"N Schroer","year":"2011","unstructured":"Schroer N, Pahne J, Walch B, Wickenhauser C, Smola S. Molecular pathobiology of human cervical high-grade lesions: paracrine STAT3 activation in tumor-instructed myeloid cells drives local MMP-9 expression. Cancer Res. 2011;71:87\u201397.","journal-title":"Cancer Res"},{"key":"385_CR32","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1593\/neo.06820","volume":"9","author":"SA Tsareva","year":"2007","unstructured":"Tsareva SA, Moriggl R, Corvinus FM, et al. Signal transducer and activator of transcription 3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia. 2007;9:279\u201391.","journal-title":"Neoplasia"},{"key":"385_CR33","doi-asserted-by":"publisher","first-page":"2296","DOI":"10.1002\/1529-0131(200110)44:10<2296::AID-ART392>3.0.CO;2-9","volume":"44","author":"JB Catterall","year":"2001","unstructured":"Catterall JB, Carrere S, Koshy PJ, et al. Synergistic induction of matrix metalloproteinase 1 by interleukin-1alpha and oncostatin M in human chondrocytes involves signal transducer and activator of transcription and activator protein 1 transcription factors via a novel mechanism. Arthritis Rheum. 2001;44:2296\u2013310.","journal-title":"Arthritis Rheum"},{"key":"385_CR34","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1432-1033.1996.0056t.x","volume":"241","author":"P Gatsios","year":"1996","unstructured":"Gatsios P, Haubeck HD, Van de Leur E, et al. Oncostatin M differentially regulates tissue inhibitors of metalloproteinases TIMP-1 and TIMP-3 gene expression in human synovial lining cells. Eur J Biochem. 1996;241:56\u201363.","journal-title":"Eur J Biochem"},{"key":"385_CR35","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1074\/jbc.272.2.1188","volume":"272","author":"E Korzus","year":"1997","unstructured":"Korzus E, Nagase H, Rydell R, Travis J. The mitogen-activated protein kinase and JAK-STAT signaling pathways are required for an oncostatin M-responsive element-mediated activation of matrix metalloproteinase 1 gene expression. J Biol Chem. 1997;272:1188\u201396.","journal-title":"J Biol Chem"},{"key":"385_CR36","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/jmv.1890360402","volume":"36","author":"BC Das","year":"1992","unstructured":"Das BC, Sharma JK, Gopalkrishna V, et al. A high frequency of human papillomavirus DNA sequences in cervical carcinomas of Indian women as revealed by Southern blot hybridization and polymerase chain reaction. J Med Virol. 1992;36:239\u201345.","journal-title":"J Med Virol"},{"key":"385_CR37","first-page":"531","volume":"139","author":"S Shukla","year":"2014","unstructured":"Shukla S, Mahata S, Shishodia G, et al. Physical state & copy number of high risk human papillomavirus type 16 DNA in progression of cervical cancer. Indian J Med Res. 2014;139:531\u201343.","journal-title":"Indian J Med Res"},{"key":"385_CR38","doi-asserted-by":"publisher","first-page":"2840","DOI":"10.1002\/ijc.22262","volume":"119","author":"A Mishra","year":"2006","unstructured":"Mishra A, Bharti AC, Varghese P, Saluja D, Das BC. Differential expression and activation of NF-kappaB family proteins during oral carcinogenesis: Role of high risk human papillomavirus infection. Int J Cancer. 2006;119:2840\u201350.","journal-title":"Int J Cancer"},{"key":"385_CR39","doi-asserted-by":"publisher","first-page":"14313","DOI":"10.1074\/jbc.270.24.14313","volume":"270","author":"SS Apte","year":"1995","unstructured":"Apte SS, Olsen BR, Murphy G. The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene family. J Biol Chem. 1995;270:14313\u20138.","journal-title":"J Biol Chem"},{"key":"385_CR40","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.fertnstert.2012.10.004","volume":"99","author":"P Suman","year":"2013","unstructured":"Suman P, Shembekar N, Gupta SK. Leukemia inhibitory factor increases the invasiveness of trophoblastic cells through integrated increase in the expression of adhesion molecules and pappalysin 1 with a concomitant decrease in the expression of tissue inhibitor of matrix metalloproteinases. Fertil Steril. 2013;99:533\u201342.","journal-title":"Fertil Steril"},{"key":"385_CR41","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.humpath.2014.11.003","volume":"46","author":"A Ghosh","year":"2015","unstructured":"Ghosh A, Pechota A, Coleman D, Upchurch Jr GR, Eliason JL. Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak\/Stat pathway. Hum Pathol. 2015;46:284\u201394.","journal-title":"Hum Pathol"},{"key":"385_CR42","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3892\/mmr_00000170","volume":"2","author":"G Xu","year":"2009","unstructured":"Xu G, Zhang C, Zhang J. Dominant negative STAT3 suppresses the growth and invasion capability of human lung cancer cells. Mol Med Rep. 2009;2:819\u201324.","journal-title":"Mol Med Rep"},{"key":"385_CR43","doi-asserted-by":"publisher","first-page":"e0115919","DOI":"10.1371\/journal.pone.0115919","volume":"10","author":"SE Martin Del Campo","year":"2015","unstructured":"Martin Del Campo SE, Latchana N, Levine KM, et al. MiR-21 Enhances Melanoma Invasiveness via Inhibition of Tissue Inhibitor of Metalloproteinases 3 Expression: In Vivo Effects of MiR-21 Inhibitor. PLoS One. 2015;10:e0115919.","journal-title":"PLoS One"},{"key":"385_CR44","doi-asserted-by":"publisher","first-page":"5369","DOI":"10.1128\/MCB.00479-08","volume":"28","author":"G Gabriely","year":"2008","unstructured":"Gabriely G, Wurdinger T, Kesari S, et al. MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators. Mol Cell Biol. 2008;28:5369\u201380.","journal-title":"Mol Cell Biol"},{"key":"385_CR45","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1111\/j.1525-1438.2006.00569.x","volume":"16","author":"MT El-Mansi","year":"2006","unstructured":"El-Mansi MT, Williams AR. Evaluation of PTEN expression in cervical adenocarcinoma by tissue microarray. Int J Gynecol Cancer. 2006;16:1254\u201360.","journal-title":"Int J Gynecol Cancer"},{"key":"385_CR46","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/jso.20493","volume":"93","author":"JS Lee","year":"2006","unstructured":"Lee JS, Choi YD, Lee JH, et al. Expression of PTEN in the progression of cervical neoplasia and its relation to tumor behavior and angiogenesis in invasive squamous cell carcinoma. J Surg Oncol. 2006;93:233\u201340.","journal-title":"J Surg Oncol"},{"key":"385_CR47","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.canlet.2006.05.013","volume":"247","author":"Z Zhang","year":"2007","unstructured":"Zhang Z, Joh K, Yatsuki H, et al. Retinoic acid receptor beta2 is epigenetically silenced either by DNA methylation or repressive histone modifications at the promoter in cervical cancer cells. Cancer Lett. 2007;247:318\u201327.","journal-title":"Cancer Lett"},{"key":"385_CR48","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1099\/0022-1317-83-7-1651","volume":"83","author":"S Sun","year":"2002","unstructured":"Sun S, Steinberg BM. PTEN is a negative regulator of STAT3 activation in human papillomavirus-infected cells. J Gen Virol. 2002;83:1651\u20138.","journal-title":"J Gen Virol"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-015-0385-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-015-0385-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-015-0385-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-015-0385-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:55:14Z","timestamp":1630594514000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-015-0385-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,9]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["385"],"URL":"https:\/\/doi.org\/10.1186\/s12943-015-0385-2","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,9]]},"assertion":[{"value":"25 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"116"}}