{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:03:11Z","timestamp":1765040591633,"version":"3.37.3"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,7,16]],"date-time":"2015-07-16T00:00:00Z","timestamp":1437004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG-14249"],"award-info":[{"award-number":["IG-14249"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Lombardy Region Famacovigilanza","award":["ISAV 2011"],"award-info":[{"award-number":["ISAV 2011"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12943-015-0407-0","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T15:42:28Z","timestamp":1436974948000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["BCR\/ABL1 and BCR are under the transcriptional control of the MYC oncogene"],"prefix":"10.1186","volume":"14","author":[{"given":"Nitesh","family":"Sharma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Magistroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocco","family":"Piazza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Citterio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caterina","family":"Mezzatesta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praveen","family":"Khandelwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Pirola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Gambacorti-Passerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,7,16]]},"reference":[{"key":"407_CR1","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/306277a0","volume":"306","author":"CR Bartram","year":"1983","unstructured":"Bartram CR, de Klein A, Hagemeijer A, van Agthoven T, Geurts van Kessel A, Bootsma D, et al. Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1983;306:277\u201380.","journal-title":"Nature"},{"key":"407_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/leu.2010.298","volume":"25","author":"V Grossmann","year":"2011","unstructured":"Grossmann V, Kohlmann A, Zenger M, Schindela S, Eder C, Weissmann S, et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9 % of cases. Leukemia. 2011;25:557\u201360.","journal-title":"Leukemia"},{"key":"407_CR3","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1172\/JCI41246","volume":"120","author":"D Perrotti","year":"2010","unstructured":"Perrotti D, Jamieson C, Goldman J, Skorski T. Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest. 2010;120:2254\u201364.","journal-title":"J Clin Invest"},{"key":"407_CR4","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1038\/sj.emboj.7601485","volume":"26","author":"AM Coluccia","year":"2007","unstructured":"Coluccia AM, Vacca A, Dunach M, Mologni L, Redaelli S, Bustos VH, et al. Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J. 2007;26:1456\u201366.","journal-title":"EMBO J"},{"key":"407_CR5","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1182\/blood-2007-03-078303","volume":"110","author":"JS Chang","year":"2007","unstructured":"Chang JS, Santhanam R, Trotta R, Neviani P, Eiring AM, Briercheck E, et al. High levels of the BCR\/ABL oncoprotein are required for the MAPK-hnRNP-E2 dependent suppression of C\/EBPalpha-driven myeloid differentiation. Blood. 2007;110:994\u20131003.","journal-title":"Blood"},{"key":"407_CR6","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/ng791","volume":"30","author":"D Perrotti","year":"2002","unstructured":"Perrotti D, Cesi V, Trotta R, Guerzoni C, Santilli G, Campbell K, et al. BCR-ABL suppresses C\/EBPalpha expression through inhibitory action of hnRNP E2. Nat Genet. 2002;30:48\u201358.","journal-title":"Nat Genet"},{"key":"407_CR7","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.bjc.6603317","volume":"95","author":"D Perrotti","year":"2006","unstructured":"Perrotti D, Neviani P. ReSETting PP2A tumour suppressor activity in blast crisis and imatinib-resistant chronic myelogenous leukaemia. Br J Cancer. 2006;95:775\u201381.","journal-title":"Br J Cancer"},{"key":"407_CR8","doi-asserted-by":"publisher","first-page":"5411","DOI":"10.1182\/blood-2006-06-032490","volume":"109","author":"H Modi","year":"2007","unstructured":"Modi H, McDonald T, Chu S, Yee JK, Forman SJ, Bhatia R. Role of BCR\/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells. Blood. 2007;109:5411\u201321.","journal-title":"Blood"},{"key":"407_CR9","first-page":"1854","volume":"11","author":"NP Shah","year":"1991","unstructured":"Shah NP, Witte ON, Denny CT. Characterization of the BCR promoter in Philadelphia chromosome-positive and -negative cell lines. Mol Cell Biol. 1991;11:1854\u201360.","journal-title":"Mol Cell Biol"},{"key":"407_CR10","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/leu.2010.101","volume":"24","author":"M Marega","year":"2010","unstructured":"Marega M, Piazza RG, Pirola A, Redaelli S, Mogavero A, Iacobucci I, et al. BCR and BCR-ABL regulation during myeloid differentiation in healthy donors and in chronic phase\/blast crisis CML patients. Leukemia. 2010;24:1445\u20139.","journal-title":"Leukemia"},{"key":"407_CR11","doi-asserted-by":"publisher","first-page":"2955","DOI":"10.1038\/sj.onc.1202750","volume":"18","author":"B Luscher","year":"1999","unstructured":"Luscher B, Larsson LG. The basic region\/helix-loop-helix\/leucine zipper domain of Myc proto-oncoproteins: function and regulation. Oncogene. 1999;18:2955\u201366.","journal-title":"Oncogene"},{"key":"407_CR12","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0092-8674(93)90663-B","volume":"72","author":"B Amati","year":"1993","unstructured":"Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell. 1993;72:233\u201345.","journal-title":"Cell"},{"key":"407_CR13","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/359423a0","volume":"359","author":"B Amati","year":"1992","unstructured":"Amati B, Dalton S, Brooks MW, Littlewood TD, Evan GI, Land H. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max. Nature. 1992;359:423\u20136.","journal-title":"Nature"},{"key":"407_CR14","doi-asserted-by":"publisher","first-page":"7824","DOI":"10.1073\/pnas.79.24.7824","volume":"79","author":"R Dalla-Favera","year":"1982","unstructured":"Dalla-Favera R, Bregni M, Erikson J, Patterson D, Gallo RC, Croce CM. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci U S A. 1982;79:7824\u20137.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"407_CR15","doi-asserted-by":"publisher","first-page":"7842","DOI":"10.1073\/pnas.79.24.7842","volume":"79","author":"BG Neel","year":"1982","unstructured":"Neel BG, Jhanwar SC, Chaganti RS, Hayward WS. Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci U S A. 1982;79:7842\u20136.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"407_CR16","doi-asserted-by":"publisher","first-page":"7837","DOI":"10.1073\/pnas.79.24.7837","volume":"79","author":"R Taub","year":"1982","unstructured":"Taub R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S, et al. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A. 1982;79:7837\u201341.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"407_CR17","doi-asserted-by":"publisher","first-page":"5595","DOI":"10.1038\/sj.onc.1204595","volume":"20","author":"LM Boxer","year":"2001","unstructured":"Boxer LM, Dang CV. Translocations involving c-myc and c-myc function. Oncogene. 2001;20:5595\u2013610.","journal-title":"Oncogene"},{"key":"407_CR18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","volume":"149","author":"CV Dang","year":"2012","unstructured":"Dang CV. MYC on the path to cancer. Cell. 2012;149:22\u201335.","journal-title":"Cell"},{"key":"407_CR19","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/0165-4608(87)90018-5","volume":"27","author":"M Blick","year":"1987","unstructured":"Blick M, Romero P, Talpaz M, Kurzrock R, Shtalrid M, Andersson B, et al. Molecular characteristics of chronic myelogenous leukemia in blast crisis. Cancer Genet Cytogenet. 1987;27:349\u201356.","journal-title":"Cancer Genet Cytogenet"},{"key":"407_CR20","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF02987745","volume":"9","author":"V Gopal","year":"1992","unstructured":"Gopal V, Kadam P, Preisler H, Hulette B, Li YQ, Steele P, et al. Abnormal regulation of the myc gene in myeloid leukemia. Med Oncol Tumor Pharmacother. 1992;9:139\u201347.","journal-title":"Med Oncol Tumor Pharmacother"},{"key":"407_CR21","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/0092-8674(92)90241-4","volume":"70","author":"CL Sawyers","year":"1992","unstructured":"Sawyers CL, Callahan W, Witte ON. Dominant negative MYC blocks transformation by ABL oncogenes. Cell. 1992;70:901\u201310.","journal-title":"Cell"},{"key":"407_CR22","doi-asserted-by":"publisher","first-page":"6151","DOI":"10.1093\/emboj\/16.20.6151","volume":"16","author":"T Skorski","year":"1997","unstructured":"Skorski T, Bellacosa A, Nieborowska-Skorska M, Majewski M, Martinez R, Choi JK, et al. Transformation of hematopoietic cells by BCR\/ABL requires activation of a PI-3k\/Akt-dependent pathway. EMBO J. 1997;16:6151\u201361.","journal-title":"EMBO J"},{"key":"407_CR23","doi-asserted-by":"publisher","first-page":"8905","DOI":"10.1074\/jbc.272.14.8905","volume":"272","author":"MC Birchenall-Roberts","year":"1997","unstructured":"Birchenall-Roberts MC, Yoo YD, Bertolette 3rd DC, Lee KH, Turley JM, Bang OS, et al. The p120-v-Abl protein interacts with E2F-1 and regulates E2F-1 transcriptional activity. J Biol Chem. 1997;272:8905\u201311.","journal-title":"J Biol Chem"},{"key":"407_CR24","first-page":"1499","volume":"9","author":"MJ Stewart","year":"1995","unstructured":"Stewart MJ, Litz-Jackson S, Burgess GS, Williamson EA, Leibowitz DS, Boswell HS. Role for E2F1 in p210 BCR-ABL downstream regulation of c-myc transcription initiation. Studies in murine myeloid cells. Leukemia. 1995;9:1499\u2013507.","journal-title":"Leukemia"},{"key":"407_CR25","doi-asserted-by":"publisher","first-page":"7137","DOI":"10.1038\/sj.onc.1205942","volume":"21","author":"S Xie","year":"2002","unstructured":"Xie S, Lin H, Sun T, Arlinghaus RB. Jak2 is involved in c-Myc induction by Bcr-Abl. Oncogene. 2002;21:7137\u201346.","journal-title":"Oncogene"},{"key":"407_CR26","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1182\/blood-2005-09-3732","volume":"107","author":"M Notari","year":"2006","unstructured":"Notari M, Neviani P, Santhanam R, Blaser BW, Chang JS, Galietta A, et al. A MAPK\/HNRPK pathway controls BCR\/ABL oncogenic potential by regulating MYC mRNA translation. Blood. 2006;107:2507\u201316.","journal-title":"Blood"},{"key":"407_CR27","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/S0960-9822(03)00090-3","volume":"13","author":"GM Mahon","year":"2003","unstructured":"Mahon GM, Wang Y, Korus M, Kostenko E, Cheng L, Sun T, et al. The c-Myc Oncoprotein Interacts with Bcr. Curr Biol. 2003;13:437\u201341.","journal-title":"Curr Biol"},{"key":"407_CR28","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0145-2126(97)00006-4","volume":"21","author":"H Handa","year":"1997","unstructured":"Handa H, Hegde UP, Kotelnikov VM, Mundle SD, Dong LM, Burke P, et al. Bcl-2 and c-myc expression, cell cycle kinetics and apoptosis during the progression of chronic myelogenous leukemia from diagnosis to blastic phase. Leuk Res. 1997;21:479\u201389.","journal-title":"Leuk Res"},{"key":"407_CR29","doi-asserted-by":"crossref","unstructured":"Lucas CM, Harris RJ, Giannoudis A, Clark RE. c-Myc inhibition decreases CIP2A and reduces BCR-ABL1 tyrosine kinase activity in chronic myeloid leukemia. Haematologica. 2015.","DOI":"10.3324\/haematol.2014.115691"},{"key":"407_CR30","doi-asserted-by":"publisher","first-page":"7119","DOI":"10.1093\/nar\/18.23.7119","volume":"18","author":"QS Zhu","year":"1990","unstructured":"Zhu QS, Heisterkamp N, Groffen J. Unique organization of the human BCR gene promoter. Nucleic Acids Res. 1990;18:7119\u201325.","journal-title":"Nucleic Acids Res"},{"key":"407_CR31","doi-asserted-by":"publisher","first-page":"17834","DOI":"10.1073\/pnas.0604129103","volume":"103","author":"KI Zeller","year":"2006","unstructured":"Zeller KI, Zhao X, Lee CW, Chiu KP, Yao F, Yustein JT, et al. Global mapping of c-Myc binding sites and target gene networks in human B cells. Proc Natl Acad Sci U S A. 2006;103:17834\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"407_CR32","doi-asserted-by":"publisher","first-page":"8164","DOI":"10.1073\/pnas.1332764100","volume":"100","author":"Z Li","year":"2003","unstructured":"Li Z, Van Calcar S, Qu C, Cavenee WK, Zhang MQ, Ren B. A global transcriptional regulatory role for c-Myc in Burkitt\u2019s lymphoma cells. Proc Natl Acad Sci U S A. 2003;100:8164\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"407_CR33","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1182\/blood.V96.10.3343","volume":"96","author":"MW Deininger","year":"2000","unstructured":"Deininger MW, Goldman JM, Melo JV. The molecular biology of chronic myeloid leukemia. Blood. 2000;96:3343\u201356.","journal-title":"Blood"},{"key":"407_CR34","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1182\/blood.V86.6.2371.bloodjournal8662371","volume":"86","author":"A Gaiger","year":"1995","unstructured":"Gaiger A, Henn T, Horth E, Geissler K, Mitterbauer G, Maier-Dobersberger T, et al. Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression. Blood. 1995;86:2371\u20138.","journal-title":"Blood"},{"key":"407_CR35","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1182\/blood.V87.10.4473.bloodjournal87104473","volume":"87","author":"F Lin","year":"1996","unstructured":"Lin F, van Rhee F, Goldman JM, Cross NC. Kinetics of increasing BCR-ABL transcript numbers in chronic myeloid leukemia patients who relapse after bone marrow transplantation. Blood. 1996;87:4473\u20138.","journal-title":"Blood"},{"key":"407_CR36","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1007\/s002770000169","volume":"79","author":"AH Elmaagacli","year":"2000","unstructured":"Elmaagacli AH, Beelen DW, Opalka B, Seeber S, Schaefer UW. The amount of BCR-ABL fusion transcripts detected by the real-time quantitative polymerase chain reaction method in patients with Philadelphia chromosome positive chronic myeloid leukemia correlates with the disease stage. Ann Hematol. 2000;79:424\u201331.","journal-title":"Ann Hematol"},{"key":"407_CR37","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1182\/blood.V88.3.1005.1005","volume":"88","author":"T Skorski","year":"1996","unstructured":"Skorski T, Nieborowska-Skorska M, Wlodarski P, Zon G, Iozzo RV, Calabretta B. Antisense oligodeoxynucleotide combination therapy of primary chronic myelogenous leukemia blast crisis in SCID mice. Blood. 1996;88:1005\u201312.","journal-title":"Blood"},{"key":"407_CR38","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.1182\/blood-2003-12-4111","volume":"103","author":"B Calabretta","year":"2004","unstructured":"Calabretta B, Perrotti D. The biology of CML blast crisis. Blood. 2004;103:4010\u201322.","journal-title":"Blood"},{"key":"407_CR39","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1056\/NEJMoa040258","volume":"351","author":"CH Jamieson","year":"2004","unstructured":"Jamieson CH, Ailles LE, Dylla SJ, Muijtjens M, Jones C, Zehnder JL, et al. Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML. N Engl J Med. 2004;351:657\u201367.","journal-title":"N Engl J Med"},{"key":"407_CR40","doi-asserted-by":"publisher","first-page":"D142","DOI":"10.1093\/nar\/gkt997","volume":"42","author":"A Mathelier","year":"2013","unstructured":"Mathelier A, Zhao X, Zhang AW, Parcy F, Worsley-Hunt R, Arenillas DJ, et al. JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles. Nucleic Acids Res. 2013;42:D142\u2013147.","journal-title":"Nucleic Acids Res"},{"key":"407_CR41","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1593\/neo.121784","volume":"15","author":"R Piazza","year":"2013","unstructured":"Piazza R, Magistroni V, Mogavero A, Andreoni F, Ambrogio C, Chiarle R, et al. Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2\/SIN3a deacetylating complex. Neoplasia. 2013;15:511\u201322.","journal-title":"Neoplasia"},{"key":"407_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0028162","volume":"6","author":"V Magistroni","year":"2011","unstructured":"Magistroni V, Mologni L, Sanselicio S, Reid JF, Redaelli S, Piazza R, et al. ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells. PLoS One. 2011;6, e28162.","journal-title":"PLoS One"},{"key":"407_CR43","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1038\/sj.leu.2403136","volume":"17","author":"E Beillard","year":"2003","unstructured":"Beillard E, Pallisgaard N, van der Velden VH, Bi W, Dee R, van der Schoot E, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using \u2018real-time\u2019 quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - a Europe against cancer program. Leukemia. 2003;17:2474\u201386.","journal-title":"Leukemia"},{"key":"407_CR44","doi-asserted-by":"publisher","first-page":"3157","DOI":"10.1038\/emboj.2009.254","volume":"28","author":"CH Lin","year":"2009","unstructured":"Lin CH, Jackson AL, Guo J, Linsley PS, Eisenman RN. Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J. 2009;28:3157\u201370.","journal-title":"EMBO J"},{"key":"407_CR45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042883","volume":"7","author":"Q Wang","year":"2012","unstructured":"Wang Q, Yang L, Alexander C, Temple S. The niche factor syndecan-1 regulates the maintenance and proliferation of neural progenitor cells during mammalian cortical development. PLoS One. 2012;7, e42883.","journal-title":"PLoS One"},{"key":"407_CR46","doi-asserted-by":"publisher","first-page":"6464","DOI":"10.1128\/MCB.25.15.6464-6474.2005","volume":"25","author":"JS Boehm","year":"2005","unstructured":"Boehm JS, Hession MT, Bulmer SE, Hahn WC. Transformation of human and murine fibroblasts without viral oncoproteins. Mol Cell Biol. 2005;25:6464\u201374.","journal-title":"Mol Cell Biol"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-015-0407-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12943-015-0407-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-015-0407-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-015-0407-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T03:58:45Z","timestamp":1652846325000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-015-0407-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,16]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["407"],"URL":"https:\/\/doi.org\/10.1186\/s12943-015-0407-0","relation":{},"ISSN":["1476-4598"],"issn-type":[{"type":"electronic","value":"1476-4598"}],"subject":[],"published":{"date-parts":[[2015,7,16]]},"assertion":[{"value":"28 April 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"132"}}