{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:51:38Z","timestamp":1793195498388,"version":"4.5.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-ES022968, R01-EB018857"],"award-info":[{"award-number":["R01-ES022968, R01-EB018857"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R15GM122953"],"award-info":[{"award-number":["R15GM122953"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET-1434503"],"award-info":[{"award-number":["CBET-1434503"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM103488"],"award-info":[{"award-number":["GM103488"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12943-017-0633-8","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T03:36:56Z","timestamp":1489462616000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Mesothelin promotes epithelial-to-mesenchymal transition and tumorigenicity of human lung cancer and mesothelioma cells"],"prefix":"10.1186","volume":"16","author":[{"given":"Xiaoqing","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heimo","family":"Riedel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cerasela Zoica","family":"Dinu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yon","family":"Rojanasakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"633_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21332","volume":"66","author":"RL Siegel","year":"2016","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin. 2016;66:7\u201330.","journal-title":"CA Cancer J Clin"},{"key":"633_CR2","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1056\/NEJMra050152","volume":"353","author":"BWS Robinson","year":"2005","unstructured":"Robinson BWS, Lake RA. Advances in malignant mesothelioma. N Engl J Med. 2005;353:1591\u2013603.","journal-title":"N Engl J Med"},{"key":"633_CR3","first-page":"95","volume":"21","author":"DJ Sugarbaker","year":"2009","unstructured":"Sugarbaker DJ. Multimodality management of malignant pleural mesothelioma: Introduction. YSTCS. 2009;21:95\u20136.","journal-title":"YSTCS"},{"key":"633_CR4","unstructured":"Frieden TR, Jaffe HW, Stephens JW, Thacker SB. Morbidity and Mortality Weekly Report Centers for Disease Control and Prevention. MMWR Editorial and Production Staff. MMWR. 2012;61:869\u201388."},{"key":"633_CR5","first-page":"136","volume":"93","author":"K Chang","year":"1996","unstructured":"Chang K, Pastan I. Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Cell Biol. 1996;93:136\u201340.","journal-title":"Cell Biol"},{"key":"633_CR6","first-page":"11531","volume":"96","author":"N Scholler","year":"1999","unstructured":"Scholler N, Fu N, Yang Y, Ye Z, Goodman GE, Hellstrm KE, et al. Soluble member(s) of the mesothelin\u035emegakaryocyte potentiating factor family are detectable in sera from patients with ovarian carcinoma. Med Sci. 1999;96:11531\u20136.","journal-title":"Med Sci"},{"key":"633_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1158\/2159-8290.CD-15-0583","volume":"6","author":"A Morello","year":"2016","unstructured":"Morello A, Sadelain M, Adusumilli PS. Mesothelin-targeted CARs: driving T cells to solid tumors. Cancer Discov. 2016;6:133\u201346.","journal-title":"Cancer Discov"},{"key":"633_CR8","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4137\/BMI.S15245","volume":"9","author":"EB Somers","year":"2014","unstructured":"Somers EB, O\u2019Shannessy DJ. Folate receptor alpha, mesothelin and megakaryocyte potentiating factor as potential serum markers of chronic kidney disease. Biomark Insights. 2014;9:29\u201337.","journal-title":"Biomark Insights"},{"key":"633_CR9","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1158\/1078-0432.CCR-13-1862","volume":"20","author":"SS Kachala","year":"2014","unstructured":"Kachala SS, Bograd AJ, Villena-Vargas J, Suzuki K, Servais EL, Kadota K, et al. Mesothelin overexpression is a marker of tumor aggressiveness and is associated with reduced recurrence-free and overall survival in early-stage lung adenocarcinoma. Clin Cancer Res. 2014;20:1020\u20138.","journal-title":"Clin Cancer Res"},{"key":"633_CR10","doi-asserted-by":"publisher","first-page":"e85935","DOI":"10.1371\/journal.pone.0085935","volume":"9","author":"O Melaiu","year":"2014","unstructured":"Melaiu O, Stebbing J, Lombardo Y, Bracci E, Uehara N, Bonotti A, et al. MSLN gene silencing has an anti-malignant effect on cell lines overexpressing mesothelin deriving from malignant pleural mesothelioma. PLoS One. 2014;9:e85935.","journal-title":"PLoS One"},{"key":"633_CR11","doi-asserted-by":"publisher","first-page":"e33214","DOI":"10.1371\/journal.pone.0033214","volume":"7","author":"K Wang","year":"2012","unstructured":"Wang K, Bodempudi V, Liu Z, Borrego-Diaz E, Yamoutpoor F, Meyer A, et al. Inhibition of mesothelin as a novel strategy for targeting cancer cells. PLoS One. 2012;7:e33214.","journal-title":"PLoS One"},{"key":"633_CR12","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1158\/1541-7786.MCR-07-0254","volume":"6","author":"N Uehara","year":"2008","unstructured":"Uehara N, Matsuoka Y, Tsubura A. Mesothelin promotes anchorage-independent growth and prevents anoikis via extracellular signal-regulated kinase signaling pathway in human breast cancer cells. Mol Cancer Res. 2008;6:186\u201393.","journal-title":"Mol Cancer Res"},{"key":"633_CR13","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1186\/1476-4598-10-106","volume":"10","author":"U Bharadwaj","year":"2011","unstructured":"Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin confers pancreatic cancer cell resistance to TNF-\u03b1-induced apoptosis through Akt\/PI3K\/NF-\u03baB activation and IL-6\/Mcl-1 overexpression. Mol Cancer. 2011;10:106.","journal-title":"Mol Cancer"},{"key":"633_CR14","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1042\/BJ20082196","volume":"424","author":"M-C Chang","year":"2009","unstructured":"Chang M-C, Chen C-A, Hsieh C-Y, Lee C-N, Su Y-N, Hu Y-H, et al. Mesothelin inhibits paclitaxel-induced apoptosis through the PI3K pathway. Biochem J. 2009;424:449\u201358.","journal-title":"Biochem J"},{"key":"633_CR15","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1038\/nrc822","volume":"2","author":"JP Thiery","year":"2002","unstructured":"Thiery JP. Epithelial\u2013mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2:442\u201354.","journal-title":"Nat Rev Cancer"},{"key":"633_CR16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/ijo.2013.1913","volume":"43","author":"L Lan","year":"2013","unstructured":"Lan L, Luo Y, Cui D, Shi B-Y, Deng W, Huo L-L, et al. Epithelial-mesenchymal transition triggers cancer stem cell generation in human thyroid cancer cells. Int J Oncol. 2013;43:113\u201320.","journal-title":"Int J Oncol"},{"key":"633_CR17","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","volume":"133","author":"SA Mani","year":"2008","unstructured":"Mani SA, Guo W, Liao M-J, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704\u201315.","journal-title":"Cell"},{"key":"633_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/591427","volume":"2011","author":"T Hayashida","year":"2011","unstructured":"Hayashida T, Jinno H, Kitagawa Y, Kitajima M, Hayashida T, Jinno H, et al. Cooperation of cancer stem cell properties and epithelial-mesenchymal transition in the establishment of breast cancer metastasis. J Oncol. 2011;2011:1\u20137.","journal-title":"J Oncol"},{"key":"633_CR19","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.devcel.2008.05.009","volume":"14","author":"J Yang","year":"2008","unstructured":"Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell. 2008;14:818\u201329.","journal-title":"Dev Cell"},{"key":"633_CR20","doi-asserted-by":"publisher","first-page":"10697","DOI":"10.18632\/oncotarget.4037","volume":"6","author":"A Mitra","year":"2015","unstructured":"Mitra A, Mishra L, Li S, Mitra A, Mishra L, Li S. EMT, CTCs and CSCs in tumor relapse and drug-resistance. Oncotarget. 2015;6:10697\u2013711.","journal-title":"Oncotarget"},{"key":"633_CR21","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1083\/jcb.113.1.173","volume":"113","author":"UH Frixen","year":"1991","unstructured":"Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, et al. E-Cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol. 1991;113:173\u201385.","journal-title":"J Cell Biol"},{"key":"633_CR22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/809259","volume":"2011","author":"G Sowa","year":"2011","unstructured":"Sowa G, Sowa G. Novel insights into the role of caveolin-2 in cell- and tissue-specific signaling and function. Biochem Res. 2011;2011:1\u20139.","journal-title":"Biochem Res"},{"key":"633_CR23","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.ccr.2013.08.018","volume":"24","author":"J Caramel","year":"2013","unstructured":"Caramel J, Papadogeorgakis E, Hill L, Browne GJ, Richard G, Wierinckx A, et al. A switch in the expression of embryonic EMT-inducers drives the development of malignant melanoma. Cancer Cell. 2013;24:466\u201380.","journal-title":"Cancer Cell"},{"key":"633_CR24","doi-asserted-by":"publisher","first-page":"6958","DOI":"10.1038\/onc.2008.346","volume":"27","author":"G Moreno-Bueno","year":"2008","unstructured":"Moreno-Bueno G, Portillo F, Cano A. Transcriptional regulation of cell polarity in EMT and cancer. Oncogene. 2008;27:6958\u201369.","journal-title":"Oncogene"},{"key":"633_CR25","doi-asserted-by":"publisher","first-page":"2462","DOI":"10.18632\/oncotarget.1578","volume":"4","author":"S-Y Liu","year":"2013","unstructured":"Liu S-Y, Zheng P-S. High aldehyde dehydrogenase activity identifies cancer stem cells in human cervical cancer. Oncotarget. 2013;4:2462\u201375.","journal-title":"Oncotarget"},{"key":"633_CR26","doi-asserted-by":"publisher","first-page":"3579","DOI":"10.1158\/0008-5472.CAN-13-3456","volume":"74","author":"D Raha","year":"2014","unstructured":"Raha D, Wilson TR, Peng J, Peterson D, Yue P, Evangelista M, et al. The cancer stem cell marker aldehyde dehydrogenase is required to maintain a drug-tolerant tumor cell subpopulation. Cancer Res. 2014;74:3579\u201390.","journal-title":"Cancer Res"},{"key":"633_CR27","doi-asserted-by":"publisher","first-page":"2902","DOI":"10.1128\/MCB.20.8.2902-2906.2000","volume":"20","author":"TK Bera","year":"2000","unstructured":"Bera TK, Pastan I. Mesothelin is not required for normal mouse development or reproduction. Mol Cell Biol. 2000;20:2902\u20136.","journal-title":"Mol Cell Biol"},{"key":"633_CR28","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1093\/carcin\/bgr075","volume":"32","author":"U Bharadwaj","year":"2011","unstructured":"Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin overexpression promotes autocrine IL-6\/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis. 2011;32:1013\u201324.","journal-title":"Carcinogenesis"},{"key":"633_CR29","doi-asserted-by":"publisher","first-page":"2478","DOI":"10.1158\/1078-0432.CCR-11-2614","volume":"1","author":"EL Servais","year":"2012","unstructured":"Servais EL, Colovos C, Rodriguez L, Bograd AJ, Nitadori J, Sima C, et al. Mesothelin overexpression promotes mesothelioma cell invasion and MMP-9 secretion in an orthotopic mouse model and in epithelioid pleural mesothelioma patients. Clin Cancer Res. 2012;1:2478\u201389.","journal-title":"Clin Cancer Res"},{"issue":"R59","key":"633_CR30","first-page":"1","volume":"13","author":"G Kallergi","year":"2011","unstructured":"Kallergi G, Papadaki MA, Politaki E, Mavroudis D, Georgoulias V, Agelaki S. Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients. Breast Cancer Res. 2011;13(R59):1\u201311.","journal-title":"Breast Cancer Res"},{"key":"633_CR31","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1158\/1535-7163.MCT-12-0460","volume":"11","author":"A Giordano","year":"2012","unstructured":"Giordano A, Gao H, Anfossi S, Cohen E, Mego M, Lee B-N, et al. Molecular medicine in practice epithelial\u2013mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. Cancer Ther. 2012;11:2526\u201334.","journal-title":"Cancer Ther"},{"key":"633_CR32","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1126\/science.1228522","volume":"339","author":"M Yu","year":"2013","unstructured":"Yu M, Bardia A, Wittner BS, Stott SL, Smas ME, Ting DT, et al. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science. 2013;339:580\u20134.","journal-title":"Science"},{"key":"633_CR33","doi-asserted-by":"publisher","first-page":"15449","DOI":"10.1073\/pnas.1004900107","volume":"107","author":"JH Taube","year":"2010","unstructured":"Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin- low and metaplastic breast cancer subtypes. Proc Natl Acad Sci USA. 2010;107:15449\u201354.","journal-title":"Proc Natl Acad Sci USA"},{"key":"633_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep18772","volume":"6","author":"C Morata-Tarifa","year":"2016","unstructured":"Morata-Tarifa C, Jim\u00e9nez G, Garc\u00eda MA, Entrena JM, Gri\u00f1\u00e1n-Lis\u00f3n C, Aguilera M, et al. Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells. Sci Rep. 2016;6:1\u201313. e18772.","journal-title":"Sci Rep"},{"key":"633_CR35","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.cell.2011.11.025","volume":"148","author":"AD Rhim","year":"2012","unstructured":"Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, Mccallister F, et al. EMT and dissemination precede pancreatic tumor formation. Cell. 2012;148:349\u201361.","journal-title":"Cell"},{"key":"633_CR36","doi-asserted-by":"publisher","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","volume":"65","author":"F Van Roy","year":"2008","unstructured":"Van Roy F, Berx G. The cell-cell adhesion molecule E-cadherin: Introduction to E-cadherin. Cell Mol Life Sci. 2008;65:3756\u201388.","journal-title":"Cell Mol Life Sci"},{"key":"633_CR37","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1152\/physrev.00019.2012","volume":"93","author":"D G\u00fcnzel","year":"2013","unstructured":"G\u00fcnzel D, Yu ASL. Claudins and the modulation of tight junction permeability. Physiol Rev. 2013;93:525\u201369.","journal-title":"Physiol Rev"},{"key":"633_CR38","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.devcel.2009.12.008","volume":"18","author":"D Du","year":"2010","unstructured":"Du D, Xu F, Yu L, Zhang C, Lu X, Yuan H, et al. The tight junction protein, occludin, regulates the directional migration of epithelial cells. Dev Cell. 2010;18:52\u201363.","journal-title":"Dev Cell"},{"key":"633_CR39","doi-asserted-by":"publisher","first-page":"723","DOI":"10.3892\/ijmm_00000519","volume":"26","author":"TA Martin","year":"2010","unstructured":"Martin TA, Mansel RE, Jiang WG. Loss of occludin leads to the progression of human breast cancer. Int J Mol Med. 2010;26:723\u201334.","journal-title":"Int J Mol Med"},{"key":"633_CR40","first-page":"1","volume":"4","author":"Je","year":"2013","unstructured":"Je. The role of transcription factor TWIST in cancer cells. J Genet Syndr Gene Ther. 2013;4:1\u20137.","journal-title":"J Genet Syndr Gene Ther"},{"key":"633_CR41","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1242\/dev.01907","volume":"132","author":"A Barrallo-Gimeno","year":"2005","unstructured":"Barrallo-Gimeno A, Angela NM. The snail genes as inducers of cell movement and survival: implication in development and cancer. Development. 2005;132:3151\u201361.","journal-title":"Development"},{"key":"633_CR42","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/nrm3758","volume":"15","author":"S Lamouille","year":"2014","unstructured":"Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial\u2013mesenchymal transition. Nat Rev Mol Cell Biol. 2014;15:178\u201396.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"633_CR43","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2009.11.007","volume":"139","author":"JP Thiery","year":"2009","unstructured":"Thiery JP, Acloque H, Huang RYJ, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871\u201390.","journal-title":"Cell"},{"key":"633_CR44","doi-asserted-by":"publisher","first-page":"3645","DOI":"10.1158\/0008-5472.CAN-07-2938","volume":"68","author":"TT Onder","year":"2008","unstructured":"Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 2008;68:3645\u201354.","journal-title":"Cancer Res"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-017-0633-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12943-017-0633-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-017-0633-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T07:31:28Z","timestamp":1589527888000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-017-0633-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["633"],"URL":"https:\/\/doi.org\/10.1186\/s12943-017-0633-8","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"7 September 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 March 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"63"}}