{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:14:44Z","timestamp":1794273284050,"version":"4.9.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Key Program for Science and Technology Research and Development","award":["2016YFC0106500"],"award-info":[{"award-number":["2016YFC0106500"]}]},{"name":"National Key Program for Science and Technology Research and Development","award":["2016YFC0106503"],"award-info":[{"award-number":["2016YFC0106503"]}]},{"name":"National Key Program for Science and Technology Research and Development","award":["2016YFC0905902"],"award-info":[{"award-number":["2016YFC0905902"]}]},{"name":"Changjiang Scholars and Innovative Research Team in University","award":["IRT1122"],"award-info":[{"award-number":["IRT1122"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12943-018-0838-5","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T14:26:56Z","timestamp":1526394416000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":181,"title":["Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation"],"prefix":"10.1186","volume":"17","author":[{"given":"Xirui","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruipeng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangchao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihua","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaliang","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangha","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanzheng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiabei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongsen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9000-4344","authenticated-orcid":false,"given":"Lianxin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,5,15]]},"reference":[{"key":"838_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69\u201390.","journal-title":"CA Cancer J Clin"},{"key":"838_CR2","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1053\/j.seminoncol.2012.05.005","volume":"39","author":"S Tanaka","year":"2012","unstructured":"Tanaka S, Arii S. Molecular targeted therapies in hepatocellular carcinoma. Semin Oncol. 2012;39:486\u201392.","journal-title":"Semin Oncol"},{"key":"838_CR3","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nrc2222","volume":"7","author":"JA Menendez","year":"2007","unstructured":"Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer. 2007;7:763\u201377.","journal-title":"Nat Rev Cancer"},{"key":"838_CR4","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.plipres.2013.08.005","volume":"52","author":"N Zaidi","year":"2013","unstructured":"Zaidi N, Lupien L, Kuemmerle NB, Kinlaw WB, Swinnen JV, Smans K. Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids. Prog Lipid Res. 2013;52:585\u20139.","journal-title":"Prog Lipid Res"},{"key":"838_CR5","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1590\/2359-3997000000067","volume":"59","author":"A Bolsoni-Lopes","year":"2015","unstructured":"Bolsoni-Lopes A, Alonso-Vale MI. Lipolysis and lipases in white adipose tissue - an update. Arch Endocrinol Metab. 2015;59:335\u201342.","journal-title":"Arch Endocrinol Metab"},{"key":"838_CR6","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.cell.2009.11.027","volume":"140","author":"DK Nomura","year":"2010","unstructured":"Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF. Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 2010;140:49\u201361.","journal-title":"Cell"},{"key":"838_CR7","doi-asserted-by":"publisher","first-page":"10736","DOI":"10.1074\/jbc.M116.715359","volume":"291","author":"D Rajasekaran","year":"2016","unstructured":"Rajasekaran D, Jariwala N, Mendoza RG, Robertson CL, Akiel MA, Dozmorov M, Fisher PB, Sarkar D. Staphylococcal nuclease and tudor domain containing 1 (SND1 Protein) promotes hepatocarcinogenesis by inhibiting Monoglyceride Lipase (MGLL). J Biol Chem. 2016;291:10736\u201346.","journal-title":"J Biol Chem"},{"key":"838_CR8","doi-asserted-by":"publisher","first-page":"28282","DOI":"10.18632\/oncotarget.5061","volume":"6","author":"R Zagani","year":"2015","unstructured":"Zagani R, El-Assaad W, Gamache I, Teodoro JG. Inhibition of adipose triglyceride lipase (ATGL) by the putative tumor suppressor G0S2 or a small molecule inhibitor attenuates the growth of cancer cells. Oncotarget. 2015;6:28282\u201395.","journal-title":"Oncotarget"},{"key":"838_CR9","doi-asserted-by":"publisher","first-page":"4020","DOI":"10.1091\/mbc.e10-08-0690","volume":"21","author":"S Souquere","year":"2010","unstructured":"Souquere S, Beauclair G, Harper F, Fox A, Pierron G. Highly ordered spatial organization of the structural long noncoding NEAT1 RNAs within paraspeckle nuclear bodies. Mol Biol Cell. 2010;21:4020\u20137.","journal-title":"Mol Biol Cell"},{"key":"838_CR10","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.18632\/oncotarget.13737","volume":"8","author":"C Yang","year":"2017","unstructured":"Yang C, Li Z, Li Y, Xu R, Wang Y, Tian Y, Chen W. Long non-coding RNA NEAT1 overexpression is associated with poor prognosis in cancer patients: a systematic review and meta-analysis. Oncotarget. 2017;8:2672\u201380.","journal-title":"Oncotarget"},{"key":"838_CR11","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1007\/s13277-015-3843-y","volume":"37","author":"L Zhen","year":"2016","unstructured":"Zhen L, Yun-Hui L, Hong-Yu D, Jun M, Yi-Long Y. Long noncoding RNA NEAT1 promotes glioma pathogenesis by regulating miR-449b-5p\/c-Met axis. Tumour Biol. 2016;37:673\u201383.","journal-title":"Tumour Biol"},{"key":"838_CR12","first-page":"2361","volume":"6","author":"J Cao","year":"2016","unstructured":"Cao J, Zhang Y, Yang J, He S, Li M, Yan S, Chen Y, Qu C, Xu L. NEAT1 regulates pancreatic cancer cell growth, invasion and migration though mircroRNA-335-5p\/c-met axis. Am J Cancer Res. 2016;6:2361\u201374.","journal-title":"Am J Cancer Res"},{"key":"838_CR13","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/ng.3547","volume":"48","author":"A Fujimoto","year":"2016","unstructured":"Fujimoto A, Furuta M, Totoki Y, Tsunoda T, Kato M, Shiraishi Y, Tanaka H, Taniguchi H, Kawakami Y, Ueno M, et al. Whole-genome mutational landscape and characterization of noncoding and structural mutations in liver cancer. Nat Genet. 2016;48:500\u20139.","journal-title":"Nat Genet"},{"key":"838_CR14","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.canlet.2016.05.007","volume":"378","author":"G Yang","year":"2016","unstructured":"Yang G, Liang Y, Zheng T, Song R, Wang J, Shi H, Sun B, Xie C, Li Y, Han J, et al. FCN2 inhibits epithelial-mesenchymal transition-induced metastasis of hepatocellular carcinoma via TGF-beta\/Smad signaling. Cancer Lett. 2016;378:80\u20136.","journal-title":"Cancer Lett"},{"key":"838_CR15","doi-asserted-by":"publisher","first-page":"e179","DOI":"10.1093\/nar\/gni178","volume":"33","author":"C Chen","year":"2005","unstructured":"Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, Barbisin M, Xu NL, Mahuvakar VR, Andersen MR, et al. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 2005;33:e179.","journal-title":"Nucleic Acids Res"},{"key":"838_CR16","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1002\/hep.28781","volume":"64","author":"J Wang","year":"2016","unstructured":"Wang J, Xie C, Pan S, Liang Y, Han J, Lan Y, Sun J, Li K, Sun B, Yang G, et al. N-myc downstream-regulated gene 2 inhibits human cholangiocarcinoma progression and is regulated by leukemia inhibitory factor\/MicroRNA-181c negative feedback pathway. Hepatology. 2016;64:1606\u201322.","journal-title":"Hepatology"},{"key":"838_CR17","doi-asserted-by":"publisher","first-page":"270","DOI":"10.2174\/157339911796397866","volume":"7","author":"P Chakrabarti","year":"2011","unstructured":"Chakrabarti P, Kandror KV. Adipose triglyceride lipase: a new target in the regulation of lipolysis by insulin. Curr Diabetes Rev. 2011;7:270\u20137.","journal-title":"Curr Diabetes Rev"},{"key":"838_CR18","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.cmet.2015.02.004","volume":"21","author":"P Li","year":"2015","unstructured":"Li P, Ruan X, Yang L, Kiesewetter K, Zhao Y, Luo H, Chen Y, Gucek M, Zhu J, Cao H. A liver-enriched long non-coding RNA, lncLSTR, regulates systemic lipid metabolism in mice. Cell Metab. 2015;21:455\u201367.","journal-title":"Cell Metab"},{"key":"838_CR19","doi-asserted-by":"publisher","unstructured":"Zhao Z, Bai J, Wu A, Wang Y, Zhang J, Wang Z, Li Y, Xu J, Li X. Co-LncRNA: investigating the lncRNA combinatorial effects in GO annotations and KEGG pathways based on human RNA-Seq data. Database (Oxford). 2015. https:\/\/doi.org\/10.1093\/database\/bav082 .","DOI":"10.1093\/database\/bav082"},{"key":"838_CR20","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1002\/hep.27893","volume":"63","author":"SX Yuan","year":"2016","unstructured":"Yuan SX, Wang J, Yang F, Tao QF, Zhang J, Wang LL, Yang Y, Liu H, Wang ZG, Xu QG, et al. Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1. Hepatology. 2016;63:499\u2013511.","journal-title":"Hepatology"},{"key":"838_CR21","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1038\/nm.4135","volume":"22","author":"C Adriaens","year":"2016","unstructured":"Adriaens C, Standaert L, Barra J, Latil M, Verfaillie A, Kalev P, Boeckx B, Wijnhoven PW, Radaelli E, Vermi W, et al. p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity. Nat Med. 2016;22:861\u20138.","journal-title":"Nat Med"},{"key":"838_CR22","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1038\/leu.2015.119","volume":"29","author":"CJ Blume","year":"2015","unstructured":"Blume CJ, Hotz-Wagenblatt A, Hullein J, Sellner L, Jethwa A, Stolz T, Slabicki M, Lee K, Sharathchandra A, Benner A, et al. p53-dependent non-coding RNA networks in chronic lymphocytic leukemia. Leukemia. 2015;29:2015\u201323.","journal-title":"Leukemia"},{"key":"838_CR23","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.tibs.2015.03.001","volume":"40","author":"S Guil","year":"2015","unstructured":"Guil S, Esteller M. RNA-RNA interactions in gene regulation: the coding and noncoding players. Trends Biochem Sci. 2015;40:248\u201356.","journal-title":"Trends Biochem Sci"},{"key":"838_CR24","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.canlet.2016.08.029","volume":"382","author":"J Lv","year":"2016","unstructured":"Lv J, Fan HX, Zhao XP, Lv P, Fan JY, Zhang Y, Liu M, Tang H. Long non-coding RNA Unigene56159 promotes epithelial-mesenchymal transition by acting as a ceRNA of miR-140-5p in hepatocellular carcinoma cells. Cancer Lett. 2016;382:166\u201375.","journal-title":"Cancer Lett"},{"key":"838_CR25","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s13238-013-3001-5","volume":"4","author":"H Liang","year":"2013","unstructured":"Liang H, Zhang J, Zen K, Zhang CY, Chen X. Nuclear microRNAs and their unconventional role in regulating non-coding RNAs. Protein Cell. 2013;4:325\u201330.","journal-title":"Protein Cell"},{"key":"838_CR26","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1038\/srep02535","volume":"3","author":"E Leucci","year":"2013","unstructured":"Leucci E, Patella F, Waage J, Holmstrom K, Lindow M, Porse B, Kauppinen S, Lund AH. microRNA-9 targets the long non-coding RNA MALAT1 for degradation in the nucleus. Sci Rep. 2013;3:2535.","journal-title":"Sci Rep"},{"key":"838_CR27","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/nature11066","volume":"485","author":"SM Jeon","year":"2012","unstructured":"Jeon SM, Chandel NS, Hay N. AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress. Nature. 2012;485:661\u20135.","journal-title":"Nature"},{"key":"838_CR28","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1194\/jlr.M039867","volume":"55","author":"KT Ong","year":"2014","unstructured":"Ong KT, Mashek MT, Davidson NO, Mashek DG. Hepatic ATGL mediates PPAR-alpha signaling and fatty acid channeling through an L-FABP independent mechanism. J Lipid Res. 2014;55:808\u201315.","journal-title":"J Lipid Res"},{"key":"838_CR29","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3945\/an.111.001602","volume":"3","author":"A Georgiadi","year":"2012","unstructured":"Georgiadi A, Kersten S. Mechanisms of gene regulation by fatty acids. Adv Nutr. 2012;3:127\u201334.","journal-title":"Adv Nutr"},{"key":"838_CR30","doi-asserted-by":"publisher","first-page":"4238","DOI":"10.1128\/MCB.00317-07","volume":"27","author":"YM Shah","year":"2007","unstructured":"Shah YM, Morimura K, Yang Q, Tanabe T, Takagi M, Gonzalez FJ. Peroxisome proliferator-activated receptor alpha regulates a microRNA-mediated signaling cascade responsible for hepatocellular proliferation. Mol Cell Biol. 2007;27:4238\u201347.","journal-title":"Mol Cell Biol"},{"key":"838_CR31","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.juro.2009.08.115","volume":"183","author":"SF Shariat","year":"2010","unstructured":"Shariat SF, Chade DC, Karakiewicz PI, Ashfaq R, Isbarn H, Fradet Y, Bastian PJ, Nielsen ME, Capitanio U, Jeldres C, et al. Combination of multiple molecular markers can improve prognostication in patients with locally advanced and lymph node positive bladder cancer. J Urol. 2010;183:68\u201375.","journal-title":"J Urol"},{"key":"838_CR32","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/nature17674","volume":"534","author":"T Sallam","year":"2016","unstructured":"Sallam T, Jones MC, Gilliland T, Zhang L, Wu X, Eskin A, Sandhu J, Casero D, Vallim TQ, Hong C, et al. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. Nature. 2016;534:124\u20138.","journal-title":"Nature"},{"key":"838_CR33","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3390\/genes5041050","volume":"5","author":"DR Cooper","year":"2014","unstructured":"Cooper DR, Carter G, Li P, Patel R, Watson JE, Patel NA. Long non-coding RNA NEAT1 associates with SRp40 to temporally regulate PPARgamma2 splicing during adipogenesis in 3T3-L1 cells. Genes (Basel). 2014;5:1050\u201363.","journal-title":"Genes (Basel)"},{"key":"838_CR34","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.cmet.2013.08.002","volume":"18","author":"DW Lamming","year":"2013","unstructured":"Lamming DW, Sabatini DM. A central role for mTOR in lipid homeostasis. Cell Metab. 2013;18:465\u20139.","journal-title":"Cell Metab"},{"key":"838_CR35","doi-asserted-by":"publisher","first-page":"386","DOI":"10.2174\/1389557510909030386","volume":"9","author":"M Wojcik","year":"2009","unstructured":"Wojcik M, Mac-Marcjanek K, Wozniak LA. Physiological and pathophysiological functions of SIRT1. Mini Rev Med Chem. 2009;9:386\u201394.","journal-title":"Mini Rev Med Chem"},{"key":"838_CR36","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1002\/cbf.1596","volume":"27","author":"X Chen","year":"2009","unstructured":"Chen X, Xun K, Chen L, Wang Y. TNF-alpha, a potent lipid metabolism regulator. Cell Biochem Funct. 2009;27:407\u201316.","journal-title":"Cell Biochem Funct"},{"key":"838_CR37","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1016\/j.bbalip.2017.07.007","volume":"1862","author":"MA de la Rosa Rodriguez","year":"2017","unstructured":"de la Rosa Rodriguez MA, Kersten S. Regulation of lipid droplet-associated proteins by peroxisome proliferator-activated receptors. Biochim Biophys Acta. 2017;1862:1212\u201320.","journal-title":"Biochim Biophys Acta"},{"key":"838_CR38","doi-asserted-by":"publisher","first-page":"4482","DOI":"10.1038\/onc.2014.378","volume":"34","author":"H Choudhry","year":"2015","unstructured":"Choudhry H, Albukhari A, Morotti M, Haider S, Moralli D, Smythies J, Schodel J, Green CM, Camps C, Buffa F, et al. Tumor hypoxia induces nuclear paraspeckle formation through HIF-2alpha dependent transcriptional activation of NEAT1 leading to cancer cell survival. Oncogene. 2015;34:4482\u201390.","journal-title":"Oncogene"},{"key":"838_CR39","first-page":"11","volume":"10","author":"H Ke","year":"2016","unstructured":"Ke H, Zhao L, Feng X, Xu H, Zou L, Yang Q, Su X, Peng L, Jiao B. NEAT1 is required for survival of breast cancer cells through FUS and miR-548. Gene Regul Syst Bio. 2016;10:11\u20137.","journal-title":"Gene Regul Syst Bio"},{"key":"838_CR40","doi-asserted-by":"publisher","first-page":"5383","DOI":"10.1038\/ncomms6383","volume":"5","author":"D Chakravarty","year":"2014","unstructured":"Chakravarty D, Sboner A, Nair SS, Giannopoulou E, Li R, Hennig S, Mosquera JM, Pauwels J, Park K, Kossai M, et al. The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun. 2014;5:5383.","journal-title":"Nat Commun"},{"key":"838_CR41","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12943-017-0674-z","volume":"16","author":"J Jen","year":"2017","unstructured":"Jen J, Tang YA, Lu YH, Lin CC, Lai WW, Wang YC. Oct4 transcriptionally regulates the expression of long non-coding RNAs NEAT1 and MALAT1 to promote lung cancer progression. Mol Cancer. 2017;16:104.","journal-title":"Mol Cancer"},{"key":"838_CR42","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1186\/1471-2407-14-693","volume":"14","author":"C Zeng","year":"2014","unstructured":"Zeng C, Xu Y, Xu L, Yu X, Cheng J, Yang L, Chen S, Li Y. Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells. BMC Cancer. 2014;14:693.","journal-title":"BMC Cancer"},{"key":"838_CR43","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1101\/gad.284661.116","volume":"31","author":"SS Mello","year":"2017","unstructured":"Mello SS, Sinow C, Raj N, Mazur PK, Bieging-Rolett K, Broz DK, Imam JFC, Vogel H, Wood LD, Sage J, et al. Neat1 is a p53-inducible lincRNA essential for transformation suppression. Genes Dev. 2017;31:1095\u2013108.","journal-title":"Genes Dev"},{"key":"838_CR44","doi-asserted-by":"publisher","first-page":"2785","DOI":"10.1002\/ijc.30689","volume":"140","author":"M Idogawa","year":"2017","unstructured":"Idogawa M, Ohashi T, Sasaki Y, Nakase H, Tokino T. Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function. Int J Cancer. 2017;140:2785\u201391.","journal-title":"Int J Cancer"},{"key":"838_CR45","doi-asserted-by":"publisher","first-page":"4983","DOI":"10.3892\/ol.2017.6769","volume":"14","author":"J Zhang","year":"2017","unstructured":"Zhang J, Li Y, Dong M, Wu D. Long non-coding RNA NEAT1 regulates E2F3 expression by competitively binding to miR-377 in non-small cell lung cancer. Oncol Lett. 2017;14:4983\u20138.","journal-title":"Oncol Lett"},{"key":"838_CR46","doi-asserted-by":"publisher","unstructured":"Jiang X, Zhou Y, Sun AJ, Xue JL. NEAT1 contributes to breast cancer progression through modulating miR-448 and ZEB1. J Cell Physiol. 2018. https:\/\/doi.org\/10.1002\/jcp.26470 .","DOI":"10.1002\/jcp.26470"},{"key":"838_CR47","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s12253-016-0172-4","volume":"23","author":"W Peng","year":"2017","unstructured":"Peng W, Wang Z, Fan H. LncRNA NEAT1 impacts cell proliferation and apoptosis of colorectal cancer via regulation of Akt signaling. Pathol Oncol Res. 2017;23:651\u20136.","journal-title":"Pathol Oncol Res"},{"key":"838_CR48","doi-asserted-by":"publisher","first-page":"418","DOI":"10.2337\/db14-0325","volume":"64","author":"SA Khan","year":"2015","unstructured":"Khan SA, Sathyanarayan A, Mashek MT, Ong KT, Wollaston-Hayden EE, Mashek DG. ATGL-catalyzed lipolysis regulates SIRT1 to control PGC-1alpha\/PPAR-alpha signaling. Diabetes. 2015;64:418\u201326.","journal-title":"Diabetes"},{"key":"838_CR49","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1152\/physrev.00025.2005","volume":"86","author":"B Desvergne","year":"2006","unstructured":"Desvergne B, Michalik L, Wahli W. Transcriptional regulation of metabolism. Physiol Rev. 2006;86:465\u2013514.","journal-title":"Physiol Rev"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-018-0838-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12943-018-0838-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-018-0838-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:54:31Z","timestamp":1604278471000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-018-0838-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,15]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["838"],"URL":"https:\/\/doi.org\/10.1186\/s12943-018-0838-5","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,15]]},"assertion":[{"value":"20 August 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"HCC tissue and paired normal adjacent tissue samples were acquired from patients undergoing a surgical procedure at the First Affiliated Hospital of Harbin Medical University (Harbin, China).Patient consent was obtained prior to the initiation of the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"We have obtained consents to publish this paper from all the participants of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"90"}}