{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:06:49Z","timestamp":1790629609228,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T00:00:00Z","timestamp":1533945600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T00:00:00Z","timestamp":1533945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61673143"],"award-info":[{"award-number":["61673143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671187"],"award-info":[{"award-number":["31671187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Postdoctoral Scientific Research Developmental Fund","award":["LBH-Q16166"],"award-info":[{"award-number":["LBH-Q16166"]}]},{"name":"University Nursing Program for Young Scholars with Creative Talents in Heilongjiang Province","award":["UNPYSCT-2017061"],"award-info":[{"award-number":["UNPYSCT-2017061"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Ovarian cancer (OvCa) is one of the most common malignant diseases of the female reproductive system in the world. The majority of OvCa is diagnosed with metastasis in the abdominal cavity. Epithelial-to-mesenchymal transition (EMT) plays a key role in tumor cell metastasis. However, it is still unclear whether long non-coding RNA (lncRNA) is implicated in EMT and influences cell invasion and metastasis in OvCa.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In this study, using bioinformatcis analysis, we constructed a lncRNA-mediated competing endogenous RNA (ceRNA) network for mesenchymal OvCa and identified lncRNA AP000695.4, which we named pro-transition associated RNA (PTAR). PTAR was significantly up-regulated in the mesenchymal subtype samples compared with the epithelial subtype samples from the TCGA OvCa data sets. In addition, our study showed that PTAR expression was positively correlated with the expression level of ZEB1 in the mesenchymal OvCa samples. Meanwhile, we found that silencing miR-101 promoted cell migration, whereas the overexpression of miR-101 suppressed EMT and cell migration in OvCa cell lines through the regulation of ZEB1. Further analysis showed that enhanced expression of PTAR promoted EMT and metastasis through the regulation of miR-101, whereas silencing PTAR led to the attenuation of TGF-\u03b21-induced tumorigenicity in ovarian cancer cells. Mechanistically, we found that PTAR acted as a ceRNA of miR-101, as forced expression of PTAR reduced the expression and activity of miR-101. More importantly, the knockdown of PTAR reduced tumorigenicity and metastasis in vivo.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Taken together, the results from our study highlight a role for the PTAR-miR-101-ZEB1 axis in OvCa, which offers novel strategies for the prevention of metastasis in OvCa.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12943-018-0870-5","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T08:36:14Z","timestamp":1533976574000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":267,"title":["LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression"],"prefix":"10.1186","volume":"17","author":[{"given":"Haihai","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huitong","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5693-4126","authenticated-orcid":false,"given":"Yunyan","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,8,11]]},"reference":[{"key":"870_CR1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7\u201330.","journal-title":"CA Cancer J Clin"},{"key":"870_CR2","doi-asserted-by":"publisher","unstructured":"Rottmann M, Burges A, Mahner S, Anthuber C, Beck T, Grab D, Schnelzer A, Kiechle M, Mayr D, Polcher M, Schubert-Fritschle G, Engel J. Cancer of the ovary, fallopian tube, and peritoneum: a population-based comparison of the prognostic factors and outcomes. J Cancer Res Clin Oncol. 2017; https:\/\/doi.org\/10.1007\/s00432-017-2422-6.","DOI":"10.1007\/s00432-017-2422-6"},{"key":"870_CR3","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3322\/caac.21408","volume":"67","author":"PJ Hoskins","year":"2017","unstructured":"Hoskins PJ, Gotlieb WH. Missed therapeutic and prevention opportunities in women with BRCA-mutated epithelial ovarian cancer and their families due to low referral rates for genetic counseling and BRCA testing: a review of the literature. CA Cancer J Clin. 2017;67:493\u2013506.","journal-title":"CA Cancer J Clin"},{"key":"870_CR4","doi-asserted-by":"publisher","unstructured":"Parida S, Chakraborty S, Maji RK, Ghosh Z. Elucidating the gene regulatory networks modulating cancer stem cells and non-stem cancer cells in high grade serous ovarian cancer. Genomics. 2018; https:\/\/doi.org\/10.1016\/j.ygeno.2018.01.006.","DOI":"10.1016\/j.ygeno.2018.01.006"},{"key":"870_CR5","doi-asserted-by":"crossref","first-page":"69538","DOI":"10.18632\/oncotarget.18422","volume":"8","author":"F Ma","year":"2017","unstructured":"Ma F, Li W, Liu C, Yu H, Lei B, Ren Y, Li Z, Pang D, Qian C. MiR-23a promotes TGF-beta1-induced EMT and tumor metastasis in breast cancer cells by directly targeting CDH1 and activating Wnt\/beta-catenin signaling. Oncotarget. 2017;8:69538\u201350.","journal-title":"Oncotarget"},{"key":"870_CR6","doi-asserted-by":"publisher","first-page":"e2872","DOI":"10.1038\/cddis.2017.267","volume":"8","author":"Z Zhao","year":"2017","unstructured":"Zhao Z, Zhou W, Han Y, Peng F, Wang R, Yu R, Wang C, Liang H, Guo Z, Gu Y. EMT-Regulome: a database for EMT-related regulatory interactions, motifs and network. Cell Death Dis. 2017;8:e2872.","journal-title":"Cell Death Dis"},{"key":"870_CR7","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s10555-016-9648-7","volume":"35","author":"CL Chaffer","year":"2016","unstructured":"Chaffer CL, San Juan BP, Lim E, Weinberg RA. EMT, cell plasticity and metastasis. Cancer Metastasis Rev. 2016;35:645\u201354.","journal-title":"Cancer Metastasis Rev"},{"key":"870_CR8","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1158\/0008-5472.CAN-17-0883","volume":"78","author":"P Hou","year":"2018","unstructured":"Hou P, Li L, Chen F, Chen Y, Liu H, Li J, Bai J, Zheng J. PTBP3-mediated regulation of ZEB1 mRNA stability promotes epithelial-mesenchymal transition in breast Cancer. Cancer Res. 2018;78:387\u201398.","journal-title":"Cancer Res"},{"key":"870_CR9","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1038\/bjc.2017.265","volume":"117","author":"Y Chen","year":"2017","unstructured":"Chen Y, Wang DD, Wu YP, Su D, Zhou TY, Gai RH, Fu YY, Zheng L, He QJ, Zhu H, Yang B. MDM2 promotes epithelial-mesenchymal transition and metastasis of ovarian cancer SKOV3 cells. Br J Cancer. 2017;117:1192\u2013201.","journal-title":"Br J Cancer"},{"key":"870_CR10","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1152\/physrev.00041.2015","volume":"96","author":"J Beermann","year":"2016","unstructured":"Beermann J, Piccoli MT, Viereck J, Thum T. Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches. Physiol Rev. 2016;96:1297\u2013325.","journal-title":"Physiol Rev"},{"key":"870_CR11","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.canlet.2018.01.053","volume":"419","author":"DH Bach","year":"2018","unstructured":"Bach DH, Lee SK. Long noncoding RNAs in cancer cells. Cancer Lett. 2018;419:152\u201366.","journal-title":"Cancer Lett"},{"key":"870_CR12","doi-asserted-by":"publisher","unstructured":"Tan X, Banerjee P, Liu X, Yu J, Gibbons DL, Wu P, Scott KL, Diao L, Zheng X, Wang J, Jalali A, Suraokar M, Fujimoto J, Behrens C, Liu CG, Creighton CJ, Wistuba II, Kurie JM. The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest. 2018; https:\/\/doi.org\/10.1172\/JCI97225.","DOI":"10.1172\/JCI97225"},{"key":"870_CR13","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.canlet.2016.09.034","volume":"383","author":"L Chang","year":"2016","unstructured":"Chang L, Yuan Y, Li C, Guo T, Qi H, Xiao Y, Dong X, Liu Z, Liu Q. Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma. Cancer Lett. 2016;383:183\u201394.","journal-title":"Cancer Lett"},{"key":"870_CR14","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1038\/leu.2016.296","volume":"31","author":"S Manier","year":"2017","unstructured":"Manier S, Powers JT, Sacco A, Glavey SV, Huynh D, Reagan MR, Salem KZ, Moschetta M, Shi J, Mishima Y, Roche-Lestienne C, Leleu X, Roccaro AM, Daley GQ, Ghobrial IM. The LIN28B\/let-7 axis is a novel therapeutic pathway in multiple myeloma. Leukemia. 2017;31:853\u201360.","journal-title":"Leukemia"},{"key":"870_CR15","doi-asserted-by":"publisher","first-page":"3845","DOI":"10.1093\/nar\/gkw099","volume":"44","author":"B Busch","year":"2016","unstructured":"Busch B, Bley N, Muller S, Glass M, Misiak D, Lederer M, Vetter M, Strauss HG, Thomssen C, Huttelmaier S. The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family. Nucleic Acids Res. 2016;44:3845\u201364.","journal-title":"Nucleic Acids Res"},{"key":"870_CR16","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1053\/j.gastro.2013.10.009","volume":"146","author":"V Haselmann","year":"2014","unstructured":"Haselmann V, Kurz A, Bertsch U, Hubner S, Olempska-Muller M, Fritsch J, Hasler R, Pickl A, Fritsche H, Annewanter F, Engler C, Fleig B, Bernt A, Roder C, Schmidt H, Gelhaus C, Hauser C, Egberts JH, Heneweer C, Rohde AM, Boger C, Knippschild U, Rocken C, Adam D, Walczak H, Schutze S, Janssen O, Wulczyn FG, Wajant H, Kalthoff H, Trauzold A. Nuclear death receptor TRAIL-R2 inhibits maturation of let-7 and promotes proliferation of pancreatic and other tumor cells. Gastroenterology. 2014;146:278\u201390.","journal-title":"Gastroenterology"},{"key":"870_CR17","doi-asserted-by":"publisher","first-page":"e2569","DOI":"10.1038\/cddis.2016.438","volume":"8","author":"F Peng","year":"2017","unstructured":"Peng F, Li TT, Wang KL, Xiao GQ, Wang JH, Zhao HD, Kang ZJ, Fan WJ, Zhu LL, Li M, Cui B, Zheng FM, Wang HJ, Lam EW, Wang B, Xu J, Liu Q. H19\/let-7\/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance. Cell Death Dis. 2017;8:e2569.","journal-title":"Cell Death Dis"},{"key":"870_CR18","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12943-017-0709-5","volume":"16","author":"DD Wu","year":"2017","unstructured":"Wu DD, Chen X, Sun KX, Wang LL, Chen S, Zhao Y. Role of the lncRNA ABHD11-AS1 in the tumorigenesis and progression of epithelial ovarian cancer through targeted regulation of RhoC. Mol Cancer. 2017;16:138.","journal-title":"Mol Cancer"},{"key":"870_CR19","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.canlet.2018.01.036","volume":"418","author":"C Li","year":"2018","unstructured":"Li C, Wan L, Liu Z, Xu G, Wang S, Su Z, Zhang Y, Zhang C, Liu X, Lei Z, Zhang HT. Long non-coding RNA XIST promotes TGF-beta-induced epithelial-mesenchymal transition by regulating miR-367\/141-ZEB2 axis in non-small-cell lung cancer. Cancer Lett. 2018;418:185\u201395.","journal-title":"Cancer Lett"},{"key":"870_CR20","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.ccr.2012.12.020","volume":"23","author":"D Yang","year":"2013","unstructured":"Yang D, Sun Y, Hu L, Zheng H, Ji P, Pecot CV, Zhao Y, Reynolds S, Cheng H, Rupaimoole R, Cogdell D, Nykter M, Broaddus R, Rodriguez-Aguayo C, Lopez-Berestein G, Liu J, Shmulevich I, Sood AK, Chen K, Zhang W. Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell. 2013;23:186\u201399.","journal-title":"Cancer Cell"},{"key":"870_CR21","doi-asserted-by":"publisher","first-page":"3728","DOI":"10.1158\/0008-5472.CAN-15-0273","volume":"75","author":"J Li","year":"2015","unstructured":"Li J, Han L, Roebuck P, Diao L, Liu L, Yuan Y, Weinstein JN, Liang H. TANRIC: an interactive open platform to explore the function of lncRNAs in Cancer. Cancer Res. 2015;75:3728\u201337.","journal-title":"Cancer Res"},{"key":"870_CR22","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jns.2017.07.009","volume":"380","author":"M Wallesch","year":"2017","unstructured":"Wallesch M, Pachow D, Blucher C, Firsching R, Warnke JP, Braunsdorf WEK, Kirches E, Mawrin C. Altered expression of E-Cadherin-related transcription factors indicates partial epithelial-mesenchymal transition in aggressive meningiomas. J Neurol Sci. 2017;380:112\u201321.","journal-title":"J Neurol Sci"},{"key":"870_CR23","doi-asserted-by":"publisher","first-page":"2021","DOI":"10.3892\/or.2014.3106","volume":"31","author":"F Guo","year":"2014","unstructured":"Guo F, Cogdell D, Hu L, Yang D, Sood AK, Xue F, Zhang W. MiR-101 suppresses the epithelial-to-mesenchymal transition by targeting ZEB1 and ZEB2 in ovarian carcinoma. Oncol Rep. 2014;31:2021\u20138.","journal-title":"Oncol Rep"},{"key":"870_CR24","doi-asserted-by":"crossref","first-page":"91530","DOI":"10.18632\/oncotarget.21069","volume":"8","author":"N Li","year":"2017","unstructured":"Li N, Wang L, Tan G, Guo Z, Liu L, Yang M, He J. MicroRNA-218 inhibits proliferation and invasion in ovarian cancer by targeting Runx2. Oncotarget. 2017;8:91530\u201341.","journal-title":"Oncotarget"},{"key":"870_CR25","doi-asserted-by":"publisher","first-page":"1258","DOI":"10.1002\/2211-5463.12257","volume":"7","author":"Y Xu","year":"2017","unstructured":"Xu Y, Xu L, Zheng J, Geng L, Zhao S. MiR-101 inhibits ovarian carcinogenesis by repressing the expression of brain-derived neurotrophic factor. FEBS Open Bio. 2017;7:1258\u201366.","journal-title":"FEBS Open Bio"},{"key":"870_CR26","first-page":"20263","volume":"8","author":"HB Zheng","year":"2015","unstructured":"Zheng HB, Zheng XG, Liu BP. miRNA-101 inhibits ovarian cancer cells proliferation and invasion by down-regulating expression of SOCS-2. Int J Clin Exp Med. 2015;8:20263\u201370.","journal-title":"Int J Clin Exp Med"},{"key":"870_CR27","doi-asserted-by":"crossref","unstructured":"Liu G, Yang D, Rupaimoole R, Pecot CV, Sun Y, Mangala LS, Li X, Ji P, Cogdell D, Hu L, Wang Y, Rodriguez-Aguayo C, Lopez-Berestein G, Shmulevich I, De Cecco L, Chen K, Mezzanzanica D, Xue F, Sood AK, Zhang W. Augmentation of response to chemotherapy by microRNA-506 through regulation of RAD51 in serous ovarian cancers. J Natl Cancer Inst. 2015;107","DOI":"10.1093\/jnci\/djv108"},{"key":"870_CR28","doi-asserted-by":"publisher","first-page":"4836","DOI":"10.7150\/thno.20942","volume":"7","author":"DL Chen","year":"2017","unstructured":"Chen DL, Lu YX, Zhang JX, Wei XL, Wang F, Zeng ZL, Pan ZZ, Yuan YF, Wang FH, Pelicano H, Chiao PJ, Huang P, Xie D, Li YH, Ju HQ, Xu RH. Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression. Theranostics. 2017;7:4836\u201349.","journal-title":"Theranostics"},{"key":"870_CR29","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.15252\/embr.201744147","volume":"18","author":"XS Wu","year":"2017","unstructured":"Wu XS, Wang F, Li HF, Hu YP, Jiang L, Zhang F, Li ML, Wang XA, Jin YP, Zhang YJ, Lu W, Wu WG, Shu YJ, Weng H, Cao Y, Bao RF, Liang HB, Wang Z, Zhang YC, Gong W, Zheng L, Sun SH, Liu YB. LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis. EMBO Rep. 2017;18:1837\u201353.","journal-title":"EMBO Rep"},{"key":"870_CR30","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12943-017-0685-9","volume":"16","author":"W Lu","year":"2017","unstructured":"Lu W, Zhang H, Niu Y, Wu Y, Sun W, Li H, Kong J, Ding K, Shen HM, Wu H, Xia D. Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p. Mol Cancer. 2017;16:118.","journal-title":"Mol Cancer"},{"key":"870_CR31","doi-asserted-by":"crossref","first-page":"38005","DOI":"10.18632\/oncotarget.5357","volume":"6","author":"H Xiao","year":"2015","unstructured":"Xiao H, Tang K, Liu P, Chen K, Hu J, Zeng J, Xiao W, Yu G, Yao W, Zhou H, Li H, Pan Y, Li A, Ye Z, Wang J, Xu H, Huang Q. LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma. Oncotarget. 2015;6:38005\u201315.","journal-title":"Oncotarget"}],"updated-by":[{"DOI":"10.1186\/s12943-021-01344-4","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T00:00:00Z","timestamp":1617926400000}}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-018-0870-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12943-018-0870-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-018-0870-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T04:03:45Z","timestamp":1617941025000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-018-0870-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,11]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["870"],"URL":"https:\/\/doi.org\/10.1186\/s12943-018-0870-5","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s12943-021-01344-4","asserted-by":"object"}]},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,11]]},"assertion":[{"value":"17 May 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1186\/s12943-021-01344-4","URL":"https:\/\/doi.org\/10.1186\/s12943-021-01344-4","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All experiments were approved by the Ethics Committee of Harbin Medical University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All authors give consent for the publication of the manuscript in <i>Molecular Cancer<\/i>.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Publisher\u2019s Note"}}],"article-number":"119"}}