{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T07:04:29Z","timestamp":1793430269036,"version":"4.5.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81772514"],"award-info":[{"award-number":["81772514"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009334","name":"Pearl River S and T Nova Program of Guangzhou","doi-asserted-by":"publisher","award":["201806010005"],"award-info":[{"award-number":["201806010005"]}],"id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong","doi-asserted-by":"crossref","award":["S2019B151502046"],"award-info":[{"award-number":["S2019B151502046"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Nature Science Foundation of China","award":["82073381"],"award-info":[{"award-number":["82073381"]}]},{"name":"Nature Science Foundation of China","award":["81725016"],"award-info":[{"award-number":["81725016"]}]},{"name":"Nature Science Foundation of China","award":["81872094"],"award-info":[{"award-number":["81872094"]}]},{"name":"Nature Sicence Foundation of China","award":["81772718"],"award-info":[{"award-number":["81772718"]}]},{"name":"Guangdong Provincial Science and Technology Foundation of China","award":["2017B020227004"],"award-info":[{"award-number":["2017B020227004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns and biological functions of circRNAs in renal cell carcinoma (RCC) remain largely elusive.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Method<\/jats:title>\n                <jats:p>Bioinformatics methods were applied to screen for circRNAs differentially expressed in RCC. Analysis of online circRNAs microarray datasets and our own patient cohort indicated that circSDHC (hsa_circ_0015004) had a potential oncogenic role in RCC. Subsequently, circSDHC expression was measured in RCC tissues and cell lines by qPCR assay, and the prognostic value of circSDHC evaluated. Further, a series of functional in vitro and in vivo experiments were conducted to assess the effects of circSDHC on RCC proliferation and metastasis. RNA pull-down assay, luciferase reporter and fluorescent in situ hybridization assays were used to confirm the interactions between circSDHC, miR-127-3p and its target genes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Clinically, high circSDHC expression was correlated with advanced TNM stage and poor survival in patients with RCC. Further, circSDHC promoted tumor cell proliferation and invasion, both in vivo and in vitro. Analysis of the mechanism underlying the effects of circSDHC in RCC demonstrated that it binds competitively to miR-127-3p and prevents its suppression of a downstream gene, <jats:italic>CDKN3<\/jats:italic>, and the E2F1 pathway, thereby leading to RCC malignant progression. Furthermore, knockdown of circSDHC caused decreased CDKN3 expression and E2F1 pathway inhibition, which could be rescued by treatment with an miR-127-3p inhibitor.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our data indicates, for the first time, an essential role for the circSDHC\/miR-127-3p\/CDKN3\/E2F1 axis in RCC progression. Thus, circSDHC has potential to be a new therapeutic target in patients with RCC.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12943-021-01314-w","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T04:45:08Z","timestamp":1611117908000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3\/E2F1 axis"],"prefix":"10.1186","volume":"20","author":[{"given":"Junjie","family":"Cen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guannan","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhousan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhong","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danlei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3200-173X","authenticated-orcid":false,"given":"Jiaxing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"1314_CR1","doi-asserted-by":"crossref","unstructured":"Scelo G, Larose TL. Epidemiology and Risk Factors for Kidney Cancer. J Clin Oncol. 2018:JCO2018791905.","DOI":"10.1200\/JCO.2018.79.1905"},{"issue":"6","key":"1314_CR2","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1016\/j.eururo.2011.09.001","volume":"60","author":"B Ljungberg","year":"2011","unstructured":"Ljungberg B, et al. Corrigendum to \"the epidemiology of renal cell carcinoma\" [Eur Urol 2011;60:615-21]. Eur Urol. 2011;60(6):1317.","journal-title":"Eur Urol"},{"issue":"4","key":"1314_CR3","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.1016\/S1470-2045(13)70569-2","volume":"15","author":"G De Meerleer","year":"2014","unstructured":"De Meerleer G, et al. Radiotherapy for renal-cell carcinoma. Lancet Oncol. 2014;15(4):e170\u20137.","journal-title":"Lancet Oncol"},{"issue":"4","key":"1314_CR4","doi-asserted-by":"publisher","first-page":"4010","DOI":"10.3390\/cancers3044010","volume":"3","author":"AI Blanco","year":"2011","unstructured":"Blanco AI, Teh BS, Amato RJ. Role of radiation therapy in the management of renal cell cancer. Cancers (Basel). 2011;3(4):4010\u201323.","journal-title":"Cancers (Basel)"},{"issue":"3","key":"1314_CR5","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s00428-014-1546-1","volume":"464","author":"H Moch","year":"2014","unstructured":"Moch H, et al. Biomarkers in renal cancer. Virchows Arch. 2014;464(3):359\u201365.","journal-title":"Virchows Arch"},{"issue":"2","key":"1314_CR6","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.canlet.2015.06.003","volume":"365","author":"S Qu","year":"2015","unstructured":"Qu S, et al. Circular RNA: a new star of noncoding RNAs. Cancer Lett. 2015;365(2):141\u20138.","journal-title":"Cancer Lett"},{"issue":"5720","key":"1314_CR7","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/280339a0","volume":"280","author":"MT Hsu","year":"1979","unstructured":"Hsu MT, Coca-Prados M. Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells. Nature. 1979;280(5720):339\u201340.","journal-title":"Nature"},{"issue":"1","key":"1314_CR8","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1096\/fasebj.7.1.7678559","volume":"7","author":"C Cocquerelle","year":"1993","unstructured":"Cocquerelle C, et al. Mis-splicing yields circular RNA molecules. FASEB J. 1993;7(1):155\u201360.","journal-title":"FASEB J"},{"issue":"7441","key":"1314_CR9","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature11928","volume":"495","author":"S Memczak","year":"2013","unstructured":"Memczak S, et al. Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 2013;495(7441):333\u20138.","journal-title":"Nature"},{"key":"1314_CR10","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.gde.2017.11.007","volume":"48","author":"IL Patop","year":"2018","unstructured":"Patop, I.L. And S. Kadener. circRNAs in Cancer. Curr Opin Genet Dev, 2018. 48: p. 121\u2013127.","journal-title":"Curr Opin Genet Dev"},{"issue":"6","key":"1314_CR11","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1016\/j.cell.2015.02.014","volume":"160","author":"SJ Conn","year":"2015","unstructured":"Conn SJ, et al. The RNA binding protein quaking regulates formation of circRNAs. Cell. 2015;160(6):1125\u201334.","journal-title":"Cell"},{"issue":"5\u20136","key":"1314_CR12","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ygeno.2017.06.005","volume":"109","author":"S Huang","year":"2017","unstructured":"Huang S, et al. The emerging role of circular RNAs in transcriptome regulation. Genomics. 2017;109(5\u20136):401\u20137.","journal-title":"Genomics"},{"issue":"1","key":"1314_CR13","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/s12943-019-1120-1","volume":"19","author":"J He","year":"2020","unstructured":"He J, et al. Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas. Mol Cancer. 2020;19(1):17.","journal-title":"Mol Cancer"},{"issue":"7","key":"1314_CR14","doi-asserted-by":"publisher","first-page":"10646","DOI":"10.1002\/jcp.27744","volume":"234","author":"Y Xiong","year":"2019","unstructured":"Xiong Y, Zhang J, Song C. CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR-138-5p in renal carcinoma. J Cell Physiol. 2019;234(7):10646\u201354.","journal-title":"J Cell Physiol"},{"issue":"7","key":"1314_CR15","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1111\/jcmm.12999","volume":"21","author":"X Chen","year":"2017","unstructured":"Chen X, et al. Heterogeneous nuclear ribonucleoprotein K is associated with poor prognosis and regulates proliferation and apoptosis in bladder cancer. J Cell Mol Med. 2017;21(7):1266\u201379.","journal-title":"J Cell Mol Med"},{"issue":"2","key":"1314_CR16","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1172\/JCI96218","volume":"128","author":"W He","year":"2018","unstructured":"He W, et al. Long noncoding RNA BLACAT2 promotes bladder cancer-associated lymphangiogenesis and lymphatic metastasis. J Clin Invest. 2018;128(2):861\u201375.","journal-title":"J Clin Invest"},{"issue":"7441","key":"1314_CR17","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1038\/nature11993","volume":"495","author":"TB Hansen","year":"2013","unstructured":"Hansen TB, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384\u20138.","journal-title":"Nature"},{"issue":"7","key":"1314_CR18","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1002\/gcc.21957","volume":"51","author":"O Slaby","year":"2012","unstructured":"Slaby O, et al. Identification of MicroRNAs associated with early relapse after nephrectomy in renal cell carcinoma patients. Genes Chromos Cancer. 2012;51(7):707\u201316.","journal-title":"Genes Chromos Cancer"},{"issue":"W1","key":"1314_CR19","doi-asserted-by":"publisher","first-page":"W98","DOI":"10.1093\/nar\/gkx247","volume":"45","author":"Z Tang","year":"2017","unstructured":"Tang Z, et al. GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses. Nucleic Acids Res. 2017;45(W1):W98\u2013W102.","journal-title":"Nucleic Acids Res"},{"issue":"43","key":"1314_CR20","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A. 2005;102(43):15545\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"1314_CR21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/ng1180","volume":"34","author":"VK Mootha","year":"2003","unstructured":"Mootha VK, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet. 2003;34(3):267\u201373.","journal-title":"Nat Genet"},{"issue":"24","key":"1314_CR22","doi-asserted-by":"publisher","first-page":"11897","DOI":"10.1158\/0008-5472.CAN-06-2497","volume":"66","author":"JN Davis","year":"2006","unstructured":"Davis JN, et al. Elevated E2F1 inhibits transcription of the androgen receptor in metastatic hormone-resistant prostate cancer. Cancer Res. 2006;66(24):11897\u2013906.","journal-title":"Cancer Res"},{"issue":"16","key":"1314_CR23","doi-asserted-by":"publisher","first-page":"2660","DOI":"10.1200\/JCO.2009.25.0977","volume":"28","author":"JS Lee","year":"2010","unstructured":"Lee JS, et al. Expression signature of E2F1 and its associated genes predict superficial to invasive progression of bladder tumors. J Clin Oncol. 2010;28(16):2660\u20137.","journal-title":"J Clin Oncol"},{"issue":"4","key":"1314_CR24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.4161\/cbt.3.4.733","volume":"3","author":"M Iwamoto","year":"2004","unstructured":"Iwamoto M, et al. Overexpression of E2F-1 in lung and liver metastases of human colon cancer is associated with gene amplification. Cancer Biol Ther. 2004;3(4):395\u20139.","journal-title":"Cancer Biol Ther"},{"issue":"2","key":"1314_CR25","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/jnci\/djp458","volume":"102","author":"V Alla","year":"2010","unstructured":"Alla V, et al. E2F1 in melanoma progression and metastasis. J Natl Cancer Inst. 2010;102(2):127\u201333.","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"1314_CR26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073436","volume":"8","author":"X Ma","year":"2013","unstructured":"Ma X, et al. Overexpression of E2F1 promotes tumor malignancy and correlates with TNM stages in clear cell renal cell carcinoma. PLoS One. 2013;8(9):e73436.","journal-title":"PLoS One"},{"issue":"2","key":"1314_CR27","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/cas.14261","volume":"111","author":"Z Chen","year":"2020","unstructured":"Chen Z, et al. Circular RNA hsa_circ_001895 serves as a sponge of microRNA-296-5p to promote clear cell renal cell carcinoma progression by regulating SOX12. Cancer Sci. 2020;111(2):713\u201326.","journal-title":"Cancer Sci"},{"issue":"2","key":"1314_CR28","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1177\/1724600819842279","volume":"34","author":"Y Huang","year":"2019","unstructured":"Huang Y, et al. Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinoma. Int J Biol Markers. 2019;34(2):176\u201383.","journal-title":"Int J Biol Markers"},{"issue":"24","key":"1314_CR29","doi-asserted-by":"publisher","first-page":"6319","DOI":"10.1158\/1078-0432.CCR-18-1270","volume":"24","author":"X Chen","year":"2018","unstructured":"Chen X, et al. PRMT5 circular RNA promotes metastasis of Urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-Mesenchymal transition. Clin Cancer Res. 2018;24(24):6319\u201330.","journal-title":"Clin Cancer Res"},{"issue":"1","key":"1314_CR30","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s12943-019-1040-0","volume":"18","author":"Q Lu","year":"2019","unstructured":"Lu Q, et al. Circular RNA circSLC8A1 acts as a sponge of miR-130b\/miR-494 in suppressing bladder cancer progression via regulating PTEN. Mol Cancer. 2019;18(1):111.","journal-title":"Mol Cancer"},{"issue":"1","key":"1314_CR31","doi-asserted-by":"publisher","first-page":"3200","DOI":"10.1038\/s41467-019-11162-4","volume":"10","author":"Z Cheng","year":"2019","unstructured":"Cheng Z, et al. circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1. Nat Commun. 2019;10(1):3200.","journal-title":"Nat Commun"},{"issue":"1","key":"1314_CR32","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s12943-019-1025-z","volume":"18","author":"W Dong","year":"2019","unstructured":"Dong W, et al. Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626\/EYA4 axis. Mol Cancer. 2019;18(1):95.","journal-title":"Mol Cancer"},{"key":"1314_CR33","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/cancers11122019","volume":"11","author":"J Fellenberg","year":"2019","unstructured":"Fellenberg J, et al. Tumor Suppressor Function of miR-127-3p and miR-376a-3p in Osteosarcoma Cells. Cancers (Basel). 2019;11:12.","journal-title":"Cancers (Basel)"},{"issue":"2","key":"1314_CR34","first-page":"630","volume":"23","author":"L Ji","year":"2019","unstructured":"Ji L, et al. MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2019;23(2):630\u201340.","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"3","key":"1314_CR35","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1002\/1873-3468.13624","volume":"594","author":"J Fan","year":"2020","unstructured":"Fan J, et al. Transcriptional downregulation of miR-127-3p by CTCF promotes prostate cancer bone metastasis by targeting PSMB5. FEBS Lett. 2020;594(3):466\u201376.","journal-title":"FEBS Lett"},{"issue":"5233","key":"1314_CR36","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1126\/science.270.5233.90","volume":"270","author":"RY Poon","year":"1995","unstructured":"Poon RY, Hunter T. Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. Science. 1995;270(5233):90\u20133.","journal-title":"Science"},{"key":"1314_CR37","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1016\/j.biopha.2017.11.112","volume":"96","author":"C Yu","year":"2017","unstructured":"Yu C, et al. Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling. Biomed Pharmacother. 2017;96:1109\u201318.","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"1314_CR38","doi-asserted-by":"publisher","first-page":"721","DOI":"10.3727\/096504016X14772375848616","volume":"25","author":"Y Li","year":"2017","unstructured":"Li Y, et al. Knockdown of Cyclin-dependent kinase inhibitor 3 inhibits proliferation and invasion in human gastric Cancer cells. Oncol Res. 2017;25(5):721\u201331.","journal-title":"Oncol Res"},{"issue":"10","key":"1314_CR39","doi-asserted-by":"publisher","first-page":"992","DOI":"10.7150\/ijms.25065","volume":"15","author":"SL Chang","year":"2018","unstructured":"Chang SL, et al. CDKN3 expression is an independent prognostic factor and associated with advanced tumor stage in nasopharyngeal carcinoma. Int J Med Sci. 2018;15(10):992\u20138.","journal-title":"Int J Med Sci"},{"key":"1314_CR40","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.2147\/CMAR.S193793","volume":"11","author":"J Wang","year":"2019","unstructured":"Wang J, et al. CDKN3 promotes tumor progression and confers cisplatin resistance via RAD51 in esophageal cancer. Cancer Manag Res. 2019;11:3253\u201364.","journal-title":"Cancer Manag Res"},{"issue":"1","key":"1314_CR41","first-page":"542","volume":"19","author":"H Yu","year":"2020","unstructured":"Yu H, et al. CDKN3 promotes cell proliferation, invasion and migration by activating the AKT signaling pathway in esophageal squamous cell carcinoma. Oncol Lett. 2020;19(1):542\u20138.","journal-title":"Oncol Lett"},{"issue":"5","key":"1314_CR42","first-page":"4535","volume":"8","author":"LP Zhang","year":"2015","unstructured":"Zhang LP, et al. CDKN3 knockdown reduces cell proliferation, invasion and promotes apoptosis in human ovarian cancer. Int J Clin Exp Pathol. 2015;8(5):4535\u201344.","journal-title":"Int J Clin Exp Pathol"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-021-01314-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12943-021-01314-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-021-01314-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T04:45:33Z","timestamp":1611117933000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-021-01314-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,20]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1314"],"URL":"https:\/\/doi.org\/10.1186\/s12943-021-01314-w","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,20]]},"assertion":[{"value":"9 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study was approved by the Medical Ethics Committee of the First Affiliated Hospital of Sun Yat-sen University.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"19"}}