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Ovarian carcinoma\/carcinosarcoma PDX were generated from patients enrolled in the Australian Ovarian Cancer Study (AOCS) or WEHI Stafford Fox Rare Cancer Program (SFRCP). Informed written consent was obtained from all patients, and all experiments were performed according to human ethics guidelines. Additional ethics approval was obtained from the Human Research Ethics Committees at the Royal Women\u2019s Hospital, the WEHI (HREC #10\/05 and #G16\/02) and QIMR Berghofer (P3456 and P2095). Mouse experiments conducted at FCCC were approved by the Fox Chase Cancer Center Institutional Animal Care and Use Committee (IACUC) and the use of PDX models approved by the Institutional Review Board (IRB).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"K. Nesic reports nonfinancial support from Clovis Oncology during the conduct of the study. O. Kondrashova reports personal fees from XING Technologies outside the submitted work. K. Nesic, C. Vandenberg, M.J. Wakefield, C.L. Scott, K. Shield-Artin, A. Farrell, E. Kyran and H.E. Barker all receive research support outside of this study from Eisai Inc, AstraZeneca, Boehringer Ingelheim and Ideaya Biosciences. N. Traficante reports grants from AstraZeneca Pty Ltd. during the conduct of the study and grants from AstraZeneca Pty Ltd. outside the submitted work. D. Bowtell reports grants from AstraZeneca Pty Ltd. during the conduct of the study and research support grants from AstraZeneca, Roche-Genentech and BeiGene (paid to institution) outside the submitted work; and personal consulting fees from Exo Therapeutics, that are outside the submitted work. Australian Ovarian Cancer Study reports grants from AstraZeneca Pty Ltd. during the conduct of the study and grants from AstraZeneca Pty Ltd. outside the submitted work. There are no other conflicts of interest in relation to the work under consideration for publication, nor other relationships \/ conditions \/ circumstances that present a potential conflict of interest. A. DeFazio reports grants from AstraZeneca outside the submitted work. A. Dobrovic reports grants from National Breast Cancer Foundation of Australia during the conduct of the study. T.C. Harding, K. Lin and T. Kwan were employees of Clovis Oncology. R. Kristeleit reports funding from Clovis Oncology, AstraZeneca, GSK, Pharma&, and was a Co-ordinating Investigator for the ARIEL4 and ATHENA trials. I. McNeish reports advisory boards for Clovis Oncology, AstraZeneca, GSK, OncoC4, Theolytics, Epsila Bio, Duke St Bio, Scancell, Roche, Takeda, and also institutional grant income from AstraZeneca. E.M. Swisher is on the Scientific Advisory Board for Ideaya Biosciences. C.L. Scott reports research support from AstraZeneca Pty Ltd, Boehringer Ingelheim and Eisai Inc, and other support from Clovis Oncology and Sierra Oncology outside the submitted work; and unpaid advisory boards: AstraZeneca, Clovis Oncology, Roche, Eisai, Sierra Oncology, Takeda, MSD. No disclosures were reported by the other authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"158"}}