{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:24:53Z","timestamp":1789428293139,"version":"build-2803163510"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Key projects of Henan Science and Technology Department","award":["232102311115"],"award-info":[{"award-number":["232102311115"]}]},{"name":"Key projects of Henan Science and Technology Department","award":["242102311032"],"award-info":[{"award-number":["242102311032"]}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan","doi-asserted-by":"crossref","award":["232300420050"],"award-info":[{"award-number":["232300420050"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key R&D Program of China","award":["2021YFA0909600"],"award-info":[{"award-number":["2021YFA0909600"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"DOI":"10.1186\/s12943-024-02067-y","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:07:24Z","timestamp":1722409644000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Targeting DKK1 enhances the antitumor activity of paclitaxel and alleviates chemotherapy-induced peripheral neuropathy in breast cancer"],"prefix":"10.1186","volume":"23","author":[{"given":"Hong-Xiang","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Tian","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Jin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-Qing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Na","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Li","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Jiang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song-Qiang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"2067_CR1","doi-asserted-by":"publisher","first-page":"114458","DOI":"10.1016\/j.biopha.2023.114458","volume":"161","author":"J Skubn\u00edk","year":"2023","unstructured":"Skubn\u00edk J, Pavl\u00edckov\u00e1 VS, Ruml T, Rimpelov\u00e1 S. Autophagy in cancer resistance to paclitaxel: development of combination strategies. Biomed Pharmacother. 2023;161:114458.","journal-title":"Biomed Pharmacother"},{"issue":"3","key":"2067_CR2","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1056\/NEJMoa2202809","volume":"387","author":"J Cortes","year":"2022","unstructured":"Cortes J, Rugo HS, Cescon DW, Im SA, Yusof MM, Gallardo C, Lipatov O, Barrios CH, Perez-Garcia J, Iwata H, et al. Pembrolizumab plus chemotherapy in advanced triple-negative breast cancer. New Engl J Med. 2022;387(3):217\u201326.","journal-title":"New Engl J Med"},{"key":"2067_CR3","doi-asserted-by":"crossref","unstructured":"Pusztai L, Yau C, Wolf DM, Han HS, Du LL, Wallace AM, String-Reasor E, Boughey JC, Chien AJ, Elias AD, et al. Durvalumab with olaparib and paclitaxel for high-risk HER2-negative stage II\/III breast cancer: results from the adaptively randomized I-SPY2 trial. Cancer Cell. 2021;39(7):989-+.","DOI":"10.1016\/j.ccell.2021.05.009"},{"issue":"1","key":"2067_CR4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S1470-2045(19)30689-8","volume":"21","author":"P Schmid","year":"2020","unstructured":"Schmid P, Rugo HS, Adams S, Schneeweiss A, Barrios CH, Iwata H, Di\u00e9ras V, Henschel V, Molinero L, Chui SY, et al. Atezolizumab plus nab-paclitaxel as first-line treatment for unresectable, locally advanced or metastatic triple-negative breast cancer (IMpassion130): updated efficacy results from a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2020;21(1):44\u201359.","journal-title":"Lancet Oncol"},{"issue":"10","key":"2067_CR5","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1080\/0284186X.2021.1954241","volume":"60","author":"CJC Vermeer","year":"2021","unstructured":"Vermeer CJC, Hiensch AE, Cleenewerk L, May AM, Eijkelkamp N. Neuro-immune interactions in paclitaxel-induced peripheral neuropathy. Acta Oncol. 2021;60(10):1369\u201382.","journal-title":"Acta Oncol"},{"issue":"12","key":"2067_CR6","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/nrneurol.2014.211","volume":"10","author":"M Sisignano","year":"2014","unstructured":"Sisignano M, Baron R, Scholich K, Geisslinger G. Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain. Nat Rev Neurol. 2014;10(12):694\u2013707.","journal-title":"Nat Rev Neurol"},{"key":"2067_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.canlet.2020.03.031","volume":"482","author":"N Jaschke","year":"2020","unstructured":"Jaschke N, Hofbauer LC, G\u00f6bel A, Rachner TD. Evolving functions of Dickkopf-1 in cancer and immunity. Cancer Lett. 2020;482:1\u20137.","journal-title":"Cancer Lett"},{"issue":"12","key":"2067_CR8","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1158\/2326-6066.CIR-22-0218","volume":"10","author":"T Shi","year":"2022","unstructured":"Shi T, Zhang YP, Wang Y, Song XR, Wang HB, Zhou XY, Liang KJ, Luo YT, Che KY, Wang X, et al. DKK1 promotes tumor immune evasion and impedes anti-PD-1 treatment by inducing immunosuppressive macrophages in gastric cancer. Cancer Immunol Res. 2022;10(12):1506\u201324.","journal-title":"Cancer Immunol Res"},{"issue":"8","key":"2067_CR9","doi-asserted-by":"publisher","first-page":"e001498","DOI":"10.1136\/jitc-2020-001498","volume":"9","author":"Q Sui","year":"2021","unstructured":"Sui Q, Liu D, Jiang W. Dickkopf 1 impairs the tumor response to PD-1 blockade by inactivating CD8+ T cells in deficient mismatch repair colorectal cancer. J Immunother Cancer. 2021;9(8):e001498.","journal-title":"J Immunother Cancer"},{"issue":"13","key":"2067_CR10","doi-asserted-by":"publisher","first-page":"5326","DOI":"10.1158\/0008-5472.CAN-09-3879","volume":"70","author":"N Sato","year":"2010","unstructured":"Sato N, Yamabuki T, Takano A, Koinuma J, Aragaki M, Masuda K, Ishikawa N, Kohno N, Ito H, Miyamoto M, et al. Wnt inhibitor Dickkopf-1 as a target for passive cancer immunotherapy. Can Res. 2010;70(13):5326\u201336.","journal-title":"Can Res"},{"issue":"12","key":"2067_CR11","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.3390\/biom10121630","volume":"10","author":"MP Srikanth","year":"2020","unstructured":"Srikanth MP, Feldman RA. Elevated Dkk1 mediates downregulation of the canonical Wnt pathway and lysosomal loss in an iPSC model of neuronopathic gaucher disease. Biomolecules. 2020;10(12):1630.","journal-title":"Biomolecules"},{"issue":"657","key":"2067_CR12","doi-asserted-by":"publisher","first-page":"eabb5727","DOI":"10.1126\/scisignal.abb5727","volume":"13","author":"J Niu","year":"2020","unstructured":"Niu J, Li W, Liang C, Wang X, Yao X, Yang RH, Zhang ZS, Liu HF, Liu FY, Pei SH, et al. EGF promotes transcription in hepatocellular carcinoma by enhancing the phosphorylation and acetylation of histone H3. Sci Signal. 2020;13(657):eabb5727.","journal-title":"Sci Signal"},{"issue":"6","key":"2067_CR13","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1097\/j.pain.0000000000001831","volume":"161","author":"LH Chen","year":"2020","unstructured":"Chen LH, Yeh YM, Chen YF, Hsu YH, Wang HH, Lin PC, Chang LY, Lin CCK, Chang MS, Shen MR. Targeting interleukin-20 alleviates paclitaxel-induced peripheral neuropathy. Pain. 2020;161(6):1237\u201354.","journal-title":"Pain"},{"key":"2067_CR14","doi-asserted-by":"publisher","first-page":"175288","DOI":"10.1016\/j.ejphar.2022.175288","volume":"933","author":"YH Xu","year":"2022","unstructured":"Xu YH, Jiang ZS, Chen XW. Mechanisms underlying paclitaxel-induced neuropathic pain: channels, inflammation and immune regulations. Eur J Pharmacol. 2022;933:175288.","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"2067_CR15","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1158\/1535-7163.MCT-21-0273","volume":"20","author":"SJ Klempner","year":"2021","unstructured":"Klempner SJ, Bendell JC, Villaflor VM, Tenner LL, Stein SM, Rottman JB, Naik GS, Sirard CA, Kagey MH, Chaney MF, et al. Safety, efficacy, and biomarker results from a phase Ib study of the anti-DKK1 antibody DKN-01 in combination with pembrolizumab in advanced esophagogastric cancers. Mol Cancer Ther. 2021;20(11):2240\u20139.","journal-title":"Mol Cancer Ther"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-024-02067-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-024-02067-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-024-02067-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:12:49Z","timestamp":1722409969000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-024-02067-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2067"],"URL":"https:\/\/doi.org\/10.1186\/s12943-024-02067-y","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"23 June 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All human tissues were collected from The First Affiliated Hospital of Henan University. Written informed consent was obtained from each patient. The study was approved by the Ethics Committee of Henan University. All animal procedures were conducted strictly following the protocols approved by the Institutional Animal Care and Use Committee at Henan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"152"}}