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Samplings and experiments were acknowledged by the Institutional Review Board of INSERM (Opinion number 12\u2013079, IRB00003888).Human fetal liver (FL) and bone marrow (FBM) samples were collected after pregnancy termination (8-14w and 17-24w of amenorrhea) with informed consent of the parents in accordance to guidelines approved by the French Agence de Biom\u00e9decine (PFS18-009).Allograft bone marrow (ABM) and mobilized peripheral blood (mPB) samples were collected from healthy individuals at Necker Enfants Malades hospital and Centre de Recherche Biologique of H\u00f4pital Saint Louis, Assistance Publique-H\u00f4pitaux de Paris (AP-HP), Paris, France, respectively, with informed consent of the patients and samples were used for research only according to the Material Transfer Agreement VAL 08\/08\u2013081\/01.Mouse experiments: All procedures were done in accordance with the recommendations of the European Community and French Ministry of Agriculture regulations (animal facility registration number: A920322) for the care and use of laboratory animals. Experimental procedures were specifically approved by the local Ethical Committee (CEEA 26: A18_105 and APAFIS #20538\u20132019050710555633). NOD.Cg-<i>Prkdc<\/i><sup><i>scid<\/i><\/sup><i>Il2rg<\/i><sup><i>tm1Wjl<\/i><\/sup>\/SzJ (NSG) and NOD.Cg-<i>Kit<\/i><sup><i>W\u221241J<\/i><\/sup><i>Prkdc<\/i><sup><i>scid<\/i><\/sup><i>Il2rg<\/i><sup><i>tm1Wjl<\/i><\/sup>\/KitW-41\u00a0J (NBSGW) mice were originally obtained from\u00a0the Jackson Laboratory (Bar Harbor, Maine, USA), housed and bred in specific pathogen-free animal facilities (IRCM, CEA, Fontenay-aux-Roses, France). 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