{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:47:42Z","timestamp":1791380862487,"version":"4.3.3"},"reference-count":57,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Young Talents Program of Sun Yat-sen University Cancer Center","award":["YTP-SYSUCC-0062"],"award-info":[{"award-number":["YTP-SYSUCC-0062"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2021B1515020108"],"award-info":[{"award-number":["2021B1515020108"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2022A1515012430"],"award-info":[{"award-number":["2022A1515012430"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Esophageal Cancer Institute Science and Technology Program","award":["M202206"],"award-info":[{"award-number":["M202206"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372624"],"award-info":[{"award-number":["82372624"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515013102"],"award-info":[{"award-number":["2024A1515013102"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"DOI":"10.1186\/s12943-024-02117-5","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T11:01:55Z","timestamp":1726830115000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["FTO-mediated DSP m6A demethylation promotes an aggressive subtype of growth hormone-secreting pituitary neuroendocrine tumors"],"prefix":"10.1186","volume":"23","author":[{"given":"Yunzhi","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiong","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Depei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanzhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qilin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeming","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekun","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanghao","family":"Yue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jixiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruihong","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixiang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,20]]},"reference":[{"key":"2117_CR1","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1001\/jama.2016.19699","volume":"317","author":"ME Molitch","year":"2017","unstructured":"Molitch ME. Diagnosis and treatment of Pituitary adenomas: a review. JAMA. 2017;317:516\u201324.","journal-title":"JAMA"},{"key":"2117_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11102-020-01091-7","volume":"24","author":"M Fleseriu","year":"2021","unstructured":"Fleseriu M, Biller BMK, Freda PU, Gadelha MR, Giustina A, Katznelson L, Molitch ME, Samson SL, Strasburger CJ, van der Lely AJ, Melmed S. A Pituitary Society update to acromegaly management guidelines. Pituitary. 2021;24:1\u201313.","journal-title":"Pituitary"},{"key":"2117_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41572-019-0071-6","volume":"5","author":"A Colao","year":"2019","unstructured":"Colao A, Grasso LFS, Giustina A, Melmed S, Chanson P, Pereira AM, Pivonello R. Acromegaly. Nat Rev Dis Primers. 2019;5:20.","journal-title":"Nat Rev Dis Primers"},{"key":"2117_CR4","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1159\/000505332","volume":"110","author":"JC Wu","year":"2020","unstructured":"Wu JC, Huang WC, Chang HK, Ko CC, Lirng JF, Chen YC. Natural history of Acromegaly: Incidences, re-operations, cancers, and Mortality Rates in a National Cohort. Neuroendocrinology. 2020;110:977\u201387.","journal-title":"Neuroendocrinology"},{"key":"2117_CR5","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1530\/ERC-16-0553","volume":"24","author":"M Terzolo","year":"2017","unstructured":"Terzolo M, Reimondo G, Berchialla P, Ferrante E, Malchiodi E, De Marinis L, Pivonello R, Grottoli S, Losa M, Cannavo S, et al. Acromegaly is associated with increased cancer risk: a survey in Italy. Endocr Relat Cancer. 2017;24:495\u2013504.","journal-title":"Endocr Relat Cancer"},{"key":"2117_CR6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s12022-022-09703-7","volume":"33","author":"SL Asa","year":"2022","unstructured":"Asa SL, Mete O, Perry A, Osamura RY. Overview of the 2022 WHO classification of Pituitary tumors. Endocr Pathol. 2022;33:6\u201326.","journal-title":"Endocr Pathol"},{"key":"2117_CR7","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nrc3051","volume":"11","author":"RL Dusek","year":"2011","unstructured":"Dusek RL, Attardi LD. Desmosomes: new perpetrators in tumour suppression. Nat Rev Cancer. 2011;11:317\u201323.","journal-title":"Nat Rev Cancer"},{"key":"2117_CR8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nrcardio.2011.173","volume":"9","author":"C Basso","year":"2011","unstructured":"Basso C, Bauce B, Corrado D, Thiene G. Pathophysiology of arrhythmogenic cardiomyopathy. Nat Rev Cardiol. 2011;9:223\u201333.","journal-title":"Nat Rev Cardiol"},{"key":"2117_CR9","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.1210\/en.2016-1841","volume":"158","author":"K Kiseljak-Vassiliades","year":"2017","unstructured":"Kiseljak-Vassiliades K, Mills TS, Zhang Y, Xu M, Lillehei KO, Kleinschmidt-DeMasters BK, Wierman ME. Elucidating the role of the desmosome protein p53 apoptosis effector related to PMP-22 in growth hormone tumors. Endocrinology. 2017;158:1450\u201360.","journal-title":"Endocrinology"},{"key":"2117_CR10","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1126\/science.aay6018","volume":"367","author":"J Liu","year":"2020","unstructured":"Liu J, Dou X, Chen C, Chen C, Liu C, Xu MM, Zhao S, Shen B, Gao Y, Han D, He C. N (6)-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. Science. 2020;367:580\u20136.","journal-title":"Science"},{"key":"2117_CR11","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1126\/science.aau1646","volume":"361","author":"M Frye","year":"2018","unstructured":"Frye M, Harada BT, Behm M, He C. RNA modifications modulate gene expression during development. Science. 2018;361:1346\u20139.","journal-title":"Science"},{"key":"2117_CR12","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/cac2.12458","volume":"43","author":"L Zeng","year":"2023","unstructured":"Zeng L, Huang X, Zhang J, Lin D, Zheng J. Roles and implications of mRNA N(6) -methyladenosine in cancer. Cancer Commun (Lond). 2023;43:729\u201348.","journal-title":"Cancer Commun (Lond)"},{"key":"2117_CR13","doi-asserted-by":"publisher","first-page":"2672","DOI":"10.1038\/s41467-022-30217-7","volume":"13","author":"Y Zou","year":"2022","unstructured":"Zou Y, Zheng S, Xie X, Ye F, Hu X, Tian Z, Yan SM, Yang L, Kong Y, Tang Y, et al. N6-methyladenosine regulated FGFR4 attenuates ferroptotic cell death in recalcitrant HER2-positive breast cancer. Nat Commun. 2022;13:2672.","journal-title":"Nat Commun"},{"key":"2117_CR14","doi-asserted-by":"publisher","first-page":"e1505","DOI":"10.1002\/ctm2.1505","volume":"13","author":"YY Xu","year":"2023","unstructured":"Xu YY, Li T, Shen A, Bao XQ, Lin JF, Guo LZ, Meng Q, Ruan DY, Zhang QH, Zuo ZX, Zeng ZL. FTO up-regulation induced by MYC suppresses tumour progression in Epstein-Barr virus-associated gastric cancer. Clin Transl Med. 2023;13:e1505.","journal-title":"Clin Transl Med"},{"key":"2117_CR15","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41419-022-05391-7","volume":"13","author":"Y Hu","year":"2022","unstructured":"Hu Y, Gao Q, Ma S, Yu P, Ding S, Yao X, Zhang Z, Lu S, Lu M, Zhang J, et al. FMR1 promotes the progression of colorectal cancer cell by stabilizing EGFR mRNA in an m(6)A-dependent manner. Cell Death Dis. 2022;13:941.","journal-title":"Cell Death Dis"},{"key":"2117_CR16","doi-asserted-by":"crossref","unstructured":"Lu W, Yang X, Zhong W, Chen G, Guo X, Ye Q, Xu Y, Qi Z, Ye Y, Zhang J et al. METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2. J Clin Invest 2024, 134.","DOI":"10.1172\/JCI174847"},{"key":"2117_CR17","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1210\/clinem\/dgab652","volume":"107","author":"M Chang","year":"2022","unstructured":"Chang M, Wang Z, Gao J, Yang C, Feng M, Niu Y, Tong WM, Bao X, Wang R. METTL3-mediated RNA m6A hypermethylation promotes tumorigenesis and GH Secretion of Pituitary Somatotroph Adenomas. J Clin Endocrinol Metab. 2022;107:136\u201349.","journal-title":"J Clin Endocrinol Metab"},{"key":"2117_CR18","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1038\/s41388-022-02186-0","volume":"41","author":"W Zhang","year":"2022","unstructured":"Zhang W, Chen S, Du Q, Bian P, Chen Y, Liu Z, Zheng J, Sai K, Mou Y, Chen Z, et al. CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1. Oncogene. 2022;41:1550\u201362.","journal-title":"Oncogene"},{"key":"2117_CR19","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1210\/jc.2018-01851","volume":"104","author":"Q Du","year":"2019","unstructured":"Du Q, Hu B, Feng Y, Wang Z, Wang X, Zhu D, Zhu Y, Jiang X, Wang H. circOMA1-Mediated mir-145-5p suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1. J Clin Endocrinol Metab. 2019;104:2419\u201334.","journal-title":"J Clin Endocrinol Metab"},{"key":"2117_CR20","doi-asserted-by":"publisher","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","volume":"34","author":"S Chen","year":"2018","unstructured":"Chen S, Zhou Y, Chen Y, Gu J. Fastp: an ultra-fast all-in-one FASTQ preprocessor. Bioinformatics. 2018;34:i884\u201390.","journal-title":"Bioinformatics"},{"key":"2117_CR21","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1093\/bioinformatics\/btac025","volume":"38","author":"X Bao","year":"2022","unstructured":"Bao X, Zhu K, Liu X, Chen Z, Luo Z, Zhao Q, Ren J, Zuo Z. MeRIPseqPipe: an integrated analysis pipeline for MeRIP-seq data based on Nextflow. Bioinformatics. 2022;38:2054\u20136.","journal-title":"Bioinformatics"},{"key":"2117_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M, Gingeras TR. STAR: ultrafast universal RNA-seq aligner. Bioinformatics. 2013;29:15\u201321.","journal-title":"Bioinformatics"},{"key":"2117_CR23","doi-asserted-by":"publisher","first-page":"R137","DOI":"10.1186\/gb-2008-9-9-r137","volume":"9","author":"Y Zhang","year":"2008","unstructured":"Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W, Liu XS. Model-based analysis of ChIP-Seq (MACS). Genome Biol. 2008;9:R137.","journal-title":"Genome Biol"},{"key":"2117_CR24","doi-asserted-by":"publisher","first-page":"i378","DOI":"10.1093\/bioinformatics\/btw281","volume":"32","author":"X Cui","year":"2016","unstructured":"Cui X, Meng J, Zhang S, Chen Y, Huang Y. A novel algorithm for calling mRNA m6A peaks by modeling biological variances in MeRIP-seq data. Bioinformatics. 2016;32:i378\u201385.","journal-title":"Bioinformatics"},{"key":"2117_CR25","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841\u20132.","journal-title":"Bioinformatics"},{"key":"2117_CR26","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","volume":"30","author":"Y Liao","year":"2014","unstructured":"Liao Y, Smyth GK, Shi W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 2014;30:923\u201330.","journal-title":"Bioinformatics"},{"key":"2117_CR27","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","volume":"15","author":"MI Love","year":"2014","unstructured":"Love MI, Huber W, Anders S. Moderated estimation of Fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15:550.","journal-title":"Genome Biol"},{"key":"2117_CR28","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.molcel.2010.05.004","volume":"38","author":"S Heinz","year":"2010","unstructured":"Heinz S, Benner C, Spann N, Bertolino E, Lin YC, Laslo P, Cheng JX, Murre C, Singh H, Glass CK. Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol Cell. 2010;38:576\u201389.","journal-title":"Mol Cell"},{"key":"2117_CR29","doi-asserted-by":"publisher","first-page":"100934","DOI":"10.1016\/j.xcrm.2023.100934","volume":"4","author":"Q Zhang","year":"2023","unstructured":"Zhang Q, Yao B, Long X, Chen Z, He M, Wu Y, Qiao N, Ma Z, Ye Z, Zhang Y, et al. Single-cell sequencing identifies differentiation-related markers for molecular classification and recurrence prediction of PitNET. Cell Rep Med. 2023;4:100934.","journal-title":"Cell Rep Med"},{"key":"2117_CR30","doi-asserted-by":"crossref","unstructured":"Cui R, Duan H, Hu W, Li C, Zhong S, Liang L, Chen S, Hu H, He Z, Wang Z et al. Establishment of human pituitary neuroendocrine tumor derived Organoid and its pilot application for drug screening. J Clin Endocrinol Metab 2024.","DOI":"10.1210\/clinem\/dgae228"},{"key":"2117_CR31","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1016\/j.cell.2012.05.003","volume":"149","author":"KD Meyer","year":"2012","unstructured":"Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3\u2019 UTRs and near stop codons. Cell. 2012;149:1635\u201346.","journal-title":"Cell"},{"key":"2117_CR32","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.3171\/2023.3.JNS221949","volume":"139","author":"K Asmaro","year":"2023","unstructured":"Asmaro K, Zhang M, Rodrigues AJ, Mohyeldin A, Vigo V, Nernekli K, Vogel H, Born DE, Katznelson L, Fernandez-Miranda JC. Cytodifferentiation of pituitary tumors influences pathogenesis and cavernous sinus invasion. J Neurosurg. 2023;139:1216\u201324.","journal-title":"J Neurosurg"},{"key":"2117_CR33","doi-asserted-by":"crossref","unstructured":"Sokol E. Structure of Desmosomes. In Autoimmune Bullous Diseases: Text and Review. Edited by Horv\u00e1th B. Cham: Springer International Publishing; 2022: 61\u201364.","DOI":"10.1007\/978-3-030-91557-5_7"},{"key":"2117_CR34","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1093\/nar\/gkw104","volume":"44","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Zeng P, Li YH, Zhang Z, Cui Q. SRAMP: prediction of mammalian N6-methyladenosine (m6A) sites based on sequence-derived features. Nucleic Acids Res. 2016;44:e91.","journal-title":"Nucleic Acids Res"},{"key":"2117_CR35","doi-asserted-by":"publisher","first-page":"D1405","DOI":"10.1093\/nar\/gkaa811","volume":"49","author":"X Luo","year":"2021","unstructured":"Luo X, Li H, Liang J, Zhao Q, Xie Y, Ren J, Zuo Z. RMVar: an updated database of functional variants involved in RNA modifications. Nucleic Acids Res. 2021;49:D1405\u201312.","journal-title":"Nucleic Acids Res"},{"key":"2117_CR36","doi-asserted-by":"publisher","first-page":"D139","DOI":"10.1093\/nar\/gkx895","volume":"46","author":"Y Zheng","year":"2018","unstructured":"Zheng Y, Nie P, Peng D, He Z, Liu M, Xie Y, Miao Y, Zuo Z, Ren J. m6AVar: a database of functional variants involved in m6A modification. Nucleic Acids Res. 2018;46:D139\u201345.","journal-title":"Nucleic Acids Res"},{"key":"2117_CR37","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41583-021-00432-0","volume":"22","author":"JD Richter","year":"2021","unstructured":"Richter JD, Zhao X. The molecular biology of FMRP: new insights into fragile X syndrome. Nat Rev Neurosci. 2021;22:209\u201322.","journal-title":"Nat Rev Neurosci"},{"key":"2117_CR38","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1210\/me.2014-1332","volume":"29","author":"W Xiong","year":"2015","unstructured":"Xiong W, Knox AJ, Xu M, Kiseljak-Vassiliades K, Colgan SP, Brodsky KS, Kleinschmidt-Demasters BK, Lillehei KO, Wierman ME. Mammalian Ste20-like kinase 4 promotes pituitary cell proliferation and survival under hypoxia. Mol Endocrinol. 2015;29:460\u201372.","journal-title":"Mol Endocrinol"},{"key":"2117_CR39","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1227\/01.NEU.0000083604.09901.F6","volume":"53","author":"RA Kristof","year":"2003","unstructured":"Kristof RA, Aliashkevich AF, Hans V, Haun D, Meyer B, Thees C, Schramm J. The regional oxygen saturation of pituitary adenomas is lower than that of the pituitary gland: microspectrophotometric study with potential clinical implications. Neurosurgery. 2003;53:880\u20135. discussion 885\u2013886.","journal-title":"Neurosurgery"},{"key":"2117_CR40","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1385\/EP:11:3:215","volume":"11","author":"S Vidal","year":"2000","unstructured":"Vidal S, Scheithauer BW, Kovacs K. Vascularity in Nontumorous Human pituitaries and Incidental Microadenomas: a morphometric study. Endocr Pathol. 2000;11:215\u201327.","journal-title":"Endocr Pathol"},{"key":"2117_CR41","first-page":"679","volume":"18","author":"S Vidal","year":"2003","unstructured":"Vidal S, Horvath E, Kovacs K, Kuroki T, Lloyd RV, Scheithauer BW. Expression of hypoxia-inducible factor-1alpha (HIF-1alpha) in pituitary tumours. Histol Histopathol. 2003;18:679\u201386.","journal-title":"Histol Histopathol"},{"key":"2117_CR42","doi-asserted-by":"publisher","first-page":"2386","DOI":"10.1172\/JCI119779","volume":"100","author":"I Shimon","year":"1997","unstructured":"Shimon I, Yan X, Taylor JE, Weiss MH, Culler MD, Melmed S. Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors. J Clin Invest. 1997;100:2386\u201392.","journal-title":"J Clin Invest"},{"key":"2117_CR43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0739-7240(95)00059-3","volume":"13","author":"CK Tuggle","year":"1996","unstructured":"Tuggle CK, Trenkle A. Control of growth hormone synthesis. Domest Anim Endocrinol. 1996;13:1\u201333.","journal-title":"Domest Anim Endocrinol"},{"key":"2117_CR44","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1159\/000185471","volume":"47","author":"J Bertherat","year":"1997","unstructured":"Bertherat J. Nuclear effects of the cAMP pathway activation in somatotrophs. Horm Res. 1997;47:245\u201350.","journal-title":"Horm Res"},{"key":"2117_CR45","first-page":"35","volume":"50","author":"KE Mayo","year":"1995","unstructured":"Mayo KE, Godfrey PA, Suhr ST, Kulik DJ, Rahal JO. Growth hormone-releasing hormone: synthesis and signaling. Recent Prog Horm Res. 1995;50:35\u201373.","journal-title":"Recent Prog Horm Res"},{"key":"2117_CR46","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1210\/jcem-71-6-1421","volume":"71","author":"A Spada","year":"1990","unstructured":"Spada A, Arosio M, Bochicchio D, Bazzoni N, Vallar L, Bassetti M, Faglia G. Clinical, biochemical, and morphological correlates in patients bearing growth hormone-secreting pituitary tumors with or without constitutively active adenylyl cyclase. J Clin Endocrinol Metab. 1990;71:1421\u20136.","journal-title":"J Clin Endocrinol Metab"},{"key":"2117_CR47","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1530\/EJE-10-0586","volume":"163","author":"Y Bakhtiar","year":"2010","unstructured":"Bakhtiar Y, Hirano H, Arita K, Yunoue S, Fujio S, Tominaga A, Sakoguchi T, Sugiyama K, Kurisu K, Yasufuku-Takano J, Takano K. Relationship between cytokeratin staining patterns and clinico-pathological features in somatotropinomae. Eur J Endocrinol. 2010;163:531\u20139.","journal-title":"Eur J Endocrinol"},{"key":"2117_CR48","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1111\/j.1365-2265.2011.04163.x","volume":"76","author":"SL Fougner","year":"2012","unstructured":"Fougner SL, Casar-Borota O, Heck A, Berg JP, Bollerslev J. Adenoma granulation pattern correlates with clinical variables and effect of somatostatin analogue treatment in a large series of patients with acromegaly. Clin Endocrinol (Oxf). 2012;76:96\u2013102.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2117_CR49","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1530\/EJE-12-0864","volume":"168","author":"S Larkin","year":"2013","unstructured":"Larkin S, Reddy R, Karavitaki N, Cudlip S, Wass J, Ansorge O. Granulation pattern, but not GSP or GHR mutation, is associated with clinical characteristics in somatostatin-naive patients with somatotroph adenomas. Eur J Endocrinol. 2013;168:491\u20139.","journal-title":"Eur J Endocrinol"},{"key":"2117_CR50","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/340692a0","volume":"340","author":"CA Landis","year":"1989","unstructured":"Landis CA, Masters SB, Spada A, Pace AM, Bourne HR, Vallar L. GTPase inhibiting mutations activate the alpha chain of gs and stimulate adenylyl cyclase in human pituitary tumours. Nature. 1989;340:692\u20136.","journal-title":"Nature"},{"key":"2117_CR51","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1097\/00006123-199308000-00003","volume":"33","author":"EF Adams","year":"1993","unstructured":"Adams EF, Brockmeier S, Friedmann E, Roth M, Buchfelder M, Fahlbusch R. Clinical and biochemical characteristics of acromegalic patients harboring gsp-positive and gsp-negative pituitary tumors. Neurosurgery. 1993;33:198\u2013203. discussion 203.","journal-title":"Neurosurgery"},{"key":"2117_CR52","doi-asserted-by":"publisher","first-page":"7505","DOI":"10.1158\/0008-5472.CAN-07-0219","volume":"67","author":"SL Asa","year":"2007","unstructured":"Asa SL, Digiovanni R, Jiang J, Ward ML, Loesch K, Yamada S, Sano T, Yoshimoto K, Frank SJ, Ezzat S. A growth hormone receptor mutation impairs growth hormone autofeedback signaling in pituitary tumors. Cancer Res. 2007;67:7505\u201311.","journal-title":"Cancer Res"},{"key":"2117_CR53","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1046\/j.1365-2265.2003.01851.x","volume":"59","author":"B Kola","year":"2003","unstructured":"Kola B, Korbonits M, Diaz-Cano S, Kaltsas G, Morris DG, Jordan S, Metherell L, Powell M, Czirjak S, Arnaldi G, et al. Reduced expression of the growth hormone and type 1 insulin-like growth factor receptors in human somatotroph tumours and an analysis of possible mutations of the growth hormone receptor. Clin Endocrinol (Oxf). 2003;59:328\u201338.","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2117_CR54","first-page":"179","volume":"39","author":"G Di Bella","year":"2018","unstructured":"Di Bella G, Colori B, Scanferlato R. The over-expression of GH\/GHR in tumour tissues with respect to healthy ones confirms its oncogenic role and the consequent oncosuppressor role of its physiological inhibitor, somatostatin: a review of the literature. Neuro Endocrinol Lett. 2018;39:179\u201388.","journal-title":"Neuro Endocrinol Lett"},{"key":"2117_CR55","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/s41574-022-00702-6","volume":"18","author":"JJ Kopchick","year":"2022","unstructured":"Kopchick JJ, Basu R, Berryman DE, Jorgensen JOL, Johannsson G, Puri V. Covert actions of growth hormone: fibrosis, cardiovascular diseases and cancer. Nat Rev Endocrinol. 2022;18:558\u201373.","journal-title":"Nat Rev Endocrinol"},{"key":"2117_CR56","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrendo.2010.171","volume":"7","author":"PE Clayton","year":"2011","unstructured":"Clayton PE, Banerjee I, Murray PG, Renehan AG. Growth hormone, the insulin-like growth factor axis, insulin and cancer risk. Nat Rev Endocrinol. 2011;7:11\u201324.","journal-title":"Nat Rev Endocrinol"},{"key":"2117_CR57","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1210\/er.2018-00166","volume":"40","author":"CL Boguszewski","year":"2019","unstructured":"Boguszewski CL, Boguszewski M. Growth hormone\u2019s links to Cancer. Endocr Rev. 2019;40:558\u201374.","journal-title":"Endocr Rev"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-024-02117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-024-02117-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-024-02117-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T11:03:08Z","timestamp":1726830188000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-024-02117-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":57,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2117"],"URL":"https:\/\/doi.org\/10.1186\/s12943-024-02117-5","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]},"assertion":[{"value":"9 July 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"205"}}