{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T12:18:08Z","timestamp":1782908288979,"version":"3.54.5"},"reference-count":86,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["21-ESRE-0028"],"award-info":[{"award-number":["21-ESRE-0028"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["21-ESRE-0028"],"award-info":[{"award-number":["21-ESRE-0028"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-22-CE14-0066 VIVORUSH"],"award-info":[{"award-number":["ANR-22-CE14-0066 VIVORUSH"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007391","name":"Association pour la recherche sur le cancer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006431","name":"Canc\u00e9rop\u00f4le Ile-de-France","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006431","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Elior"},{"name":"European Joint Programme on Rare Diseases (EJPRD) Wilsonmed"},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["ERC-2021-ADG, Grant No. 101052444"],"award-info":[{"award-number":["ERC-2021-ADG, Grant No. 101052444"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ERA4 Health CardInnov Grant Ener-LIGHT"},{"name":"European Union Horizon 2020 research and innovation programmes Oncobiome","award":["825410"],"award-info":[{"award-number":["825410"]}]},{"name":"Prevalung","award":["101095604"],"award-info":[{"award-number":["101095604"]}]},{"name":"Neutrocure","award":["861878"],"award-info":[{"award-number":["861878"]}]},{"name":"Hevolution Network on Senescence in Aging"},{"name":"Institut National du Cancer"},{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018872","name":"Labex Immuno-Oncology","doi-asserted-by":"publisher","award":["ANR-18-IDEX-0001"],"award-info":[{"award-number":["ANR-18-IDEX-0001"]}],"id":[{"id":"10.13039\/501100018872","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cancer Research ASPIRE Award from the Mark Foundation"},{"name":"PAIR-Ob\u00e9sit\u00e9","award":["INCa_1873"],"award-info":[{"award-number":["INCa_1873"]}]},{"DOI":"10.13039\/100015545","name":"Seerave Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015545","id-type":"DOI","asserted-by":"publisher"}]},{"name":"SIRIC Cancer Research and Personalized Medicine"},{"name":"IdEx universit\u00e9 paris cit\u00e9","award":["ANR-18-IDEX-0001"],"award-info":[{"award-number":["ANR-18-IDEX-0001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"DOI":"10.1186\/s12943-024-02189-3","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T02:58:27Z","timestamp":1734663507000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["AI-based classification of anticancer drugs reveals nucleolar condensation as a predictor of immunogenicity"],"prefix":"10.1186","volume":"23","author":[{"given":"Giulia","family":"Cerrato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Petrazzuolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Humeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie Theresa","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abdellatif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Sauvat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"issue":"4","key":"2189_CR1","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/s41590-022-01132-2","volume":"23","author":"G Kroemer","year":"2022","unstructured":"Kroemer G, Galassi C, Zitvogel L, Galluzzi L. Immunogenic cell stress and death. Nat Immunol. 2022;23(4):487\u2013500.","journal-title":"Nat Immunol"},{"issue":"11","key":"2189_CR2","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/s41580-023-00623-w","volume":"24","author":"J Clucas","year":"2023","unstructured":"Clucas J, Meier P. Roles of RIPK1 as a stress sentinel coordinating cell survival and immunogenic cell death. Nat Rev Mol Cell Biol. 2023;24(11):835\u201352.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"2189_CR3","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.trecan.2024.01.013","volume":"10","author":"E Catanzaro","year":"2024","unstructured":"Catanzaro E, Demuynck R, Naessens F, Galluzzi L, Krysko DV. Immunogenicity of ferroptosis in cancer: a matter of context? Trends Cancer. 2024;10(5):407\u201316.","journal-title":"Trends Cancer"},{"issue":"6","key":"2189_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","volume":"23","author":"L Galluzzi","year":"2024","unstructured":"Galluzzi L, Guilbaud E, Schmidt D, Kroemer G, Marincola FM. Targeting immunogenic cell stress and death for cancer therapy. Nat Rev Drug Discov. 2024;23(6):445\u201360.","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"2189_CR5","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.immuni.2015.11.024","volume":"44","author":"C Pfirschke","year":"2016","unstructured":"Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, et al. Immunogenic chemotherapy sensitizes tumors to checkpoint blockade therapy. Immunity. 2016;44(2):343\u201354.","journal-title":"Immunity"},{"issue":"8","key":"2189_CR6","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1038\/s41591-023-02497-z","volume":"29","author":"M Thibaudin","year":"2023","unstructured":"Thibaudin M, Fumet JD, Chibaudel B, Bennouna J, Borg C, Martin-Babau J, et al. First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b\/2 trial. Nat Med. 2023;29(8):2087\u201398.","journal-title":"Nat Med"},{"issue":"10","key":"2189_CR7","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1001\/jamaoncol.2020.3370","volume":"6","author":"K Shitara","year":"2020","unstructured":"Shitara K, Van Cutsem E, Bang YJ, Fuchs C, Wyrwicz L, Lee KW, et al. Efficacy and safety of Pembrolizumab or Pembrolizumab Plus Chemotherapy vs Chemotherapy alone for patients with First-line, Advanced Gastric Cancer: the KEYNOTE-062 phase 3 Randomized Clinical Trial. JAMA Oncol. 2020;6(10):1571\u201380.","journal-title":"JAMA Oncol"},{"issue":"10294","key":"2189_CR8","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0140-6736(21)00797-2","volume":"398","author":"YY Janjigian","year":"2021","unstructured":"Janjigian YY, Shitara K, Moehler M, Garrido M, Salman P, Shen L, et al. First-line nivolumab plus chemotherapy versus chemotherapy alone for advanced gastric, gastro-oesophageal junction, and oesophageal adenocarcinoma (CheckMate 649): a randomised, open-label, phase 3 trial. Lancet. 2021;398(10294):27\u201340.","journal-title":"Lancet"},{"issue":"1","key":"2189_CR9","doi-asserted-by":"publisher","first-page":"2093518","DOI":"10.1080\/2162402X.2022.2093518","volume":"11","author":"P Liu","year":"2022","unstructured":"Liu P, Chen J, Zhao L, Hollebecque A, Kepp O, Zitvogel L, et al. PD-1 blockade synergizes with oxaliplatin-based, but not cisplatin-based, chemotherapy of gastric cancer. Oncoimmunology. 2022;11(1):2093518.","journal-title":"Oncoimmunology"},{"issue":"6","key":"2189_CR10","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1038\/s41591-019-0432-4","volume":"25","author":"L Voorwerk","year":"2019","unstructured":"Voorwerk L, Slagter M, Horlings HM, Sikorska K, van de Vijver KK, de Maaker M, et al. Immune induction strategies in metastatic triple-negative breast cancer to enhance the sensitivity to PD-1 blockade: the TONIC trial. Nat Med. 2019;25(6):920\u20138.","journal-title":"Nat Med"},{"issue":"12","key":"2189_CR11","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1038\/s41591-022-02126-1","volume":"28","author":"AH Rossevold","year":"2022","unstructured":"Rossevold AH, Andresen NK, Bjerre CA, Gilje B, Jakobsen EH, Raj SX, et al. Atezolizumab plus anthracycline-based chemotherapy in metastatic triple-negative breast cancer: the randomized, double-blind phase 2b ALICE trial. Nat Med. 2022;28(12):2573\u201383.","journal-title":"Nat Med"},{"issue":"1","key":"2189_CR12","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41591-023-02677-x","volume":"30","author":"Z Jiang","year":"2024","unstructured":"Jiang Z, Ouyang Q, Sun T, Zhang Q, Teng Y, Cui J, et al. Toripalimab plus nab-paclitaxel in metastatic or recurrent triple-negative breast cancer: a randomized phase 3 trial. Nat Med. 2024;30(1):249\u201356.","journal-title":"Nat Med"},{"key":"2189_CR13","doi-asserted-by":"crossref","unstructured":"Gao J, Xiong A, Liu J, Li X, Wang J, Zhang L et al. PANoptosis: bridging apoptosis, pyroptosis, and necroptosis in cancer progression and treatment. Cancer Gene Ther. 2024;31(7):970\u201383.","DOI":"10.1038\/s41417-024-00765-9"},{"issue":"1","key":"2189_CR14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/nm1523","volume":"13","author":"M Obeid","year":"2007","unstructured":"Obeid M, Tesniere A, Ghiringhelli F, Fimia GM, Apetoh L, Perfettini JL, et al. Calreticulin exposure dictates the immunogenicity of cancer cell death. Nat Med. 2007;13(1):54\u201361.","journal-title":"Nat Med"},{"issue":"6062","key":"2189_CR15","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1126\/science.1208347","volume":"334","author":"M Michaud","year":"2011","unstructured":"Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P, et al. Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science. 2011;334(6062):1573\u20137.","journal-title":"Science"},{"issue":"11","key":"2189_CR16","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1038\/nm.3708","volume":"20","author":"A Sistigu","year":"2014","unstructured":"Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, et al. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. 2014;20(11):1301\u20139.","journal-title":"Nat Med"},{"issue":"9","key":"2189_CR17","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/nm1622","volume":"13","author":"L Apetoh","year":"2007","unstructured":"Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med. 2007;13(9):1050\u20139.","journal-title":"Nat Med"},{"issue":"6263","key":"2189_CR18","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1126\/science.aad0779","volume":"350","author":"E Vacchelli","year":"2015","unstructured":"Vacchelli E, Ma Y, Baracco EE, Sistigu A, Enot DP, Pietrocola F, et al. Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1. Science. 2015;350(6263):972\u20138.","journal-title":"Science"},{"issue":"12","key":"2189_CR19","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/s41571-020-0413-z","volume":"17","author":"L Galluzzi","year":"2020","unstructured":"Galluzzi L, Humeau J, Buque A, Zitvogel L, Kroemer G. Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors. Nat Rev Clin Oncol. 2020;17(12):725\u201341.","journal-title":"Nat Rev Clin Oncol"},{"issue":"143","key":"2189_CR20","doi-asserted-by":"publisher","first-page":"143ra99","DOI":"10.1126\/scitranslmed.3003807","volume":"4","author":"L Menger","year":"2012","unstructured":"Menger L, Vacchelli E, Adjemian S, Martins I, Ma Y, Shen S, et al. Cardiac glycosides exert anticancer effects by inducing immunogenic cell death. Sci Transl Med. 2012;4(143):143ra99.","journal-title":"Sci Transl Med"},{"key":"2189_CR21","doi-asserted-by":"crossref","unstructured":"Galluzzi L, Vitale I, Warren S, Adjemian S, Agostinis P, Martinez AB et al. Consensus guidelines for the definition, detection and interpretation of immunogenic cell death. J Immunother Cancer. 2020;8(1).","DOI":"10.1136\/jitc-2019-000337corr1"},{"issue":"3","key":"2189_CR22","doi-asserted-by":"publisher","first-page":"e2134","DOI":"10.1038\/cddis.2016.47","volume":"7","author":"H Zhou","year":"2016","unstructured":"Zhou H, Forveille S, Sauvat A, Yamazaki T, Senovilla L, Ma Y, et al. The oncolytic peptide LTX-315 triggers immunogenic cell death. Cell Death Dis. 2016;7(3):e2134.","journal-title":"Cell Death Dis"},{"issue":"11","key":"2189_CR23","doi-asserted-by":"publisher","first-page":"e1656502","DOI":"10.1080\/2162402X.2019.1656502","volume":"8","author":"W Xie","year":"2019","unstructured":"Xie W, Forveille S, Iribarren K, Sauvat A, Senovilla L, Wang Y, et al. Lurbinectedin synergizes with immune checkpoint blockade to generate anticancer immunity. Oncoimmunology. 2019;8(11):e1656502.","journal-title":"Oncoimmunology"},{"issue":"10","key":"2189_CR24","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1158\/1535-7163.MCT-21-0035","volume":"20","author":"R Montes de Oca","year":"2021","unstructured":"Montes de Oca R, Alavi AS, Vitali N, Bhattacharya S, Blackwell C, Patel K, et al. Belantamab Mafodotin (GSK2857916) drives immunogenic cell death and Immune-mediated antitumor responses in vivo. Mol Cancer Ther. 2021;20(10):1941\u201355.","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"2189_CR25","doi-asserted-by":"publisher","first-page":"2290900","DOI":"10.1080\/2162402X.2023.2290900","volume":"13","author":"M Nielsen","year":"2024","unstructured":"Nielsen M, Monberg T, Sundvold V, Albieri B, Hovgaard D, Petersen MM, et al. LTX-315 and adoptive cell therapy using tumor-infiltrating lymphocytes generate tumor specific T cells in patients with metastatic soft tissue sarcoma. Oncoimmunology. 2024;13(1):2290900.","journal-title":"Oncoimmunology"},{"issue":"5","key":"2189_CR26","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1038\/emboj.2009.1","volume":"28","author":"T Panaretakis","year":"2009","unstructured":"Panaretakis T, Kepp O, Brockmeier U, Tesniere A, Bjorklund AC, Chapman DC, et al. Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death. EMBO J. 2009;28(5):578\u201390.","journal-title":"EMBO J"},{"issue":"8","key":"2189_CR27","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/s41418-017-0044-9","volume":"25","author":"L Bezu","year":"2018","unstructured":"Bezu L, Sauvat A, Humeau J, Gomes-da-Silva LC, Iribarren K, Forveille S, et al. eIF2alpha phosphorylation is pathognomonic for immunogenic cell death. Cell Death Differ. 2018;25(8):1375\u201393.","journal-title":"Cell Death Differ"},{"issue":"7","key":"2189_CR28","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1158\/0008-5472.CAN-15-1142","volume":"76","author":"J Fucikova","year":"2016","unstructured":"Fucikova J, Becht E, Iribarren K, Goc J, Remark R, Damotte D, et al. Calreticulin expression in human non-small cell lung cancers correlates with increased Accumulation of Antitumor Immune Cells and favorable prognosis. Cancer Res. 2016;76(7):1746\u201356.","journal-title":"Cancer Res"},{"key":"2189_CR29","doi-asserted-by":"publisher","first-page":"104371","DOI":"10.1016\/j.compbiomed.2021.104371","volume":"133","author":"A Sauvat","year":"2021","unstructured":"Sauvat A, Cerrato G, Humeau J, Leduc M, Kepp O, Kroemer G. High-throughput label-free detection of DNA-to-RNA transcription inhibition using brightfield microscopy and deep neural networks. Comput Biol Med. 2021;133:104371.","journal-title":"Comput Biol Med"},{"issue":"5","key":"2189_CR30","doi-asserted-by":"publisher","first-page":"e11622","DOI":"10.15252\/emmm.201911622","volume":"12","author":"J Humeau","year":"2020","unstructured":"Humeau J, Sauvat A, Cerrato G, Xie W, Loos F, Iannantuoni F, et al. Inhibition of transcription by dactinomycin reveals a new characteristic of immunogenic cell stress. EMBO Mol Med. 2020;12(5):e11622.","journal-title":"EMBO Mol Med"},{"issue":"9","key":"2189_CR31","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1038\/nprot.2016.105","volume":"11","author":"MA Bray","year":"2016","unstructured":"Bray MA, Singh S, Han H, Davis CT, Borgeson B, Hartland C, et al. Cell painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes. Nat Protoc. 2016;11(9):1757\u201374.","journal-title":"Nat Protoc"},{"issue":"9","key":"2189_CR32","doi-asserted-by":"publisher","first-page":"e955691","DOI":"10.4161\/21624011.2014.955691","volume":"3","author":"O Kepp","year":"2014","unstructured":"Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology. 2014;3(9):e955691.","journal-title":"Oncoimmunology"},{"issue":"13","key":"2189_CR33","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1091\/mbc.E20-03-0187","volume":"31","author":"Y Nagao","year":"2020","unstructured":"Nagao Y, Sakamoto M, Chinen T, Okada Y, Takao D. Robust classification of cell cycle phase and biological feature extraction by image-based deep learning. Mol Biol Cell. 2020;31(13):1346\u201354.","journal-title":"Mol Biol Cell"},{"issue":"2","key":"2189_CR34","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s11263-019-01228-7","volume":"128","author":"RR Selvaraju","year":"2020","unstructured":"Selvaraju RR, Cogswell M, Das A, Vedantam R, Parikh D, Batra D. Grad-CAM: visual explanations from deep networks via gradient-based localization. Int J Comput Vision. 2020;128(2):336\u201359.","journal-title":"Int J Comput Vision"},{"issue":"12","key":"2189_CR35","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1084\/jem.20050915","volume":"202","author":"N Casares","year":"2005","unstructured":"Casares N, Pequignot MO, Tesniere A, Ghiringhelli F, Roux S, Chaput N, et al. Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death. J Exp Med. 2005;202(12):1691\u2013701.","journal-title":"J Exp Med"},{"issue":"41","key":"2189_CR36","doi-asserted-by":"publisher","first-page":"15779","DOI":"10.1073\/pnas.0808480105","volume":"105","author":"CY Jao","year":"2008","unstructured":"Jao CY, Salic A. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008;105(41):15779\u201384.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"2189_CR37","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.ccr.2013.12.009","volume":"25","author":"K Peltonen","year":"2014","unstructured":"Peltonen K, Colis L, Liu H, Trivedi R, Moubarek MS, Moore HM, et al. A targeting modality for destruction of RNA polymerase I that possesses anticancer activity. Cancer Cell. 2014;25(1):77\u201390.","journal-title":"Cancer Cell"},{"key":"2189_CR38","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.compbiomed.2019.02.024","volume":"107","author":"A Sauvat","year":"2019","unstructured":"Sauvat A, Leduc M, Muller K, Kepp O, Kroemer G. ColocalizR: an open-source application for cell-based high-throughput colocalization analysis. Comput Biol Med. 2019;107:227\u201334.","journal-title":"Comput Biol Med"},{"key":"2189_CR39","doi-asserted-by":"crossref","unstructured":"Yakimovich A, Witte R, Andriasyan V, Georgi F, Greber UF. Label-Free Digital Holo-Tomographic Microscopy reveals Virus-Induced Cytopathic effects in live cells. mSphere. 2018;3(6).","DOI":"10.1128\/mSphereDirect.00599-18"},{"key":"2189_CR40","doi-asserted-by":"crossref","unstructured":"Barsanti L, Birindelli L, Sbrana F, Lombardi G, Gualtieri P. Advanced Microscopy Techniques for Molecular Biophysics. Int J Mol Sci. 2023;24(12).","DOI":"10.3390\/ijms24129973"},{"issue":"9","key":"2189_CR41","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.1038\/cdd.2008.67","volume":"15","author":"T Panaretakis","year":"2008","unstructured":"Panaretakis T, Joza N, Modjtahedi N, Tesniere A, Vitale I, Durchschlag M, et al. The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death. Cell Death Differ. 2008;15(9):1499\u2013509.","journal-title":"Cell Death Differ"},{"issue":"26","key":"2189_CR42","doi-asserted-by":"publisher","first-page":"15182","DOI":"10.1073\/pnas.1922072117","volume":"117","author":"X Qiao","year":"2020","unstructured":"Qiao X, van der Zanden SY, Wander DPA, Borras DM, Song JY, Li X, et al. Uncoupling DNA damage from chromatin damage to detoxify doxorubicin. Proc Natl Acad Sci U S A. 2020;117(26):15182\u201392.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2189_CR43","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/onc.2009.356","volume":"29","author":"A Tesniere","year":"2010","unstructured":"Tesniere A, Schlemmer F, Boige V, Kepp O, Martins I, Ghiringhelli F, et al. Immunogenic death of colon cancer cells treated with oxaliplatin. Oncogene. 2010;29(4):482\u201391.","journal-title":"Oncogene"},{"issue":"6716","key":"2189_CR44","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/16729","volume":"397","author":"HP Harding","year":"1999","unstructured":"Harding HP, Zhang Y, Ron D. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature. 1999;397(6716):271\u20134.","journal-title":"Nature"},{"issue":"2","key":"2189_CR45","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1172\/JCI94586","volume":"128","author":"DMS Hossain","year":"2018","unstructured":"Hossain DMS, Javaid S, Cai M, Zhang C, Sawant A, Hinton M, et al. Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression. J Clin Invest. 2018;128(2):644\u201354.","journal-title":"J Clin Invest"},{"issue":"14","key":"2189_CR46","doi-asserted-by":"publisher","first-page":"3913","DOI":"10.1158\/0008-5472.CAN-14-0247","volume":"74","author":"MD Hall","year":"2014","unstructured":"Hall MD, Telma KA, Chang KE, Lee TD, Madigan JP, Lloyd JR, et al. Say no to DMSO: dimethylsulfoxide inactivates cisplatin, carboplatin, and other platinum complexes. Cancer Res. 2014;74(14):3913\u201322.","journal-title":"Cancer Res"},{"key":"2189_CR47","doi-asserted-by":"publisher","first-page":"106556","DOI":"10.1016\/j.phrs.2022.106556","volume":"187","author":"X Chang","year":"2023","unstructured":"Chang X, Bian M, Liu L, Yang J, Yang Z, Wang Z, et al. Induction of immunogenic cell death by novel platinum-based anticancer agents. Pharmacol Res. 2023;187:106556.","journal-title":"Pharmacol Res"},{"issue":"2","key":"2189_CR48","doi-asserted-by":"publisher","first-page":"101393","DOI":"10.1016\/j.xcrm.2024.101393","volume":"5","author":"MD Galsky","year":"2024","unstructured":"Galsky MD, Guan X, Rishipathak D, Rapaport AS, Shehata HM, Banchereau R, et al. Immunomodulatory effects and improved outcomes with cisplatin- versus carboplatin-based chemotherapy plus atezolizumab in urothelial cancer. Cell Rep Med. 2024;5(2):101393.","journal-title":"Cell Rep Med"},{"issue":"4","key":"2189_CR49","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nm.4291","volume":"23","author":"PM Bruno","year":"2017","unstructured":"Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, et al. A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress. Nat Med. 2017;23(4):461\u201371.","journal-title":"Nat Med"},{"key":"2189_CR50","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1038\/ncomms2921","volume":"4","author":"B Pang","year":"2013","unstructured":"Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, et al. Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908.","journal-title":"Nat Commun"},{"key":"2189_CR51","doi-asserted-by":"crossref","unstructured":"Gujar S, Pol JG, Kumar V, Lizarralde-Guerrero M, Konda P, Kroemer G et al. Tutorial: design, production and testing of oncolytic viruses for cancer immunotherapy. Nat Protoc. 2024;19(9):2540\u2013570","DOI":"10.1038\/s41596-024-00985-1"},{"issue":"5","key":"2189_CR52","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1016\/j.coi.2008.05.007","volume":"20","author":"A Tesniere","year":"2008","unstructured":"Tesniere A, Apetoh L, Ghiringhelli F, Joza N, Panaretakis T, Kepp O, et al. Immunogenic cancer cell death: a key-lock paradigm. Curr Opin Immunol. 2008;20(5):504\u201311.","journal-title":"Curr Opin Immunol"},{"issue":"8","key":"2189_CR53","doi-asserted-by":"publisher","first-page":"1606665","DOI":"10.1080\/2162402X.2019.1606665","volume":"8","author":"O Kepp","year":"2019","unstructured":"Kepp O, Sauvat A, Leduc M, Forveille S, Liu P, Zhao L, et al. A fluorescent biosensor-based platform for the discovery of immunogenic cancer cell death inducers. Oncoimmunology. 2019;8(8):1606665.","journal-title":"Oncoimmunology"},{"key":"2189_CR54","doi-asserted-by":"crossref","unstructured":"Alzeibak R, Mishchenko TA, Shilyagina NY, Balalaeva IV, Vedunova MV, Krysko DV. Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future. J Immunother Cancer. 2021;9(1).","DOI":"10.1136\/jitc-2020-001926"},{"issue":"1","key":"2189_CR55","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF01315177","volume":"71","author":"S Kyriakidis","year":"1982","unstructured":"Kyriakidis S, Stevely WS. The effect of herpesvirus infection on ribosomal RNA synthesis and on nucleolar size and number in HeLa cells. Arch Virol. 1982;71(1):79\u201383.","journal-title":"Arch Virol"},{"issue":"1","key":"2189_CR56","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/0041-008X(84)90038-3","volume":"76","author":"RE Dudley","year":"1984","unstructured":"Dudley RE, Svoboda DJ, Klaassen CD. Time course of cadmium-induced ultrastructural changes in rat liver. Toxicol Appl Pharmacol. 1984;76(1):150\u201360.","journal-title":"Toxicol Appl Pharmacol"},{"issue":"3","key":"2189_CR57","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/BF00691320","volume":"55","author":"LW Jenkins","year":"1981","unstructured":"Jenkins LW, Povlishock JT, Lewelt W, Miller JD, Becker DP. The role of postischemic recirculation in the development of ischemic neuronal injury following complete cerebral ischemia. Acta Neuropathol. 1981;55(3):205\u201320.","journal-title":"Acta Neuropathol"},{"issue":"4","key":"2189_CR58","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/S0040-8166(98)80054-2","volume":"30","author":"MR Nassiri","year":"1998","unstructured":"Nassiri MR, Gilloteaux J, Taichman RS, Drach JC. Ultrastructural aspects of cytomegalovirus-infected fibroblastic stromal cells of human bone marrow. Tissue Cell. 1998;30(4):398\u2013406.","journal-title":"Tissue Cell"},{"issue":"1","key":"2189_CR59","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10495-005-3347-0","volume":"11","author":"R Ortiz","year":"2006","unstructured":"Ortiz R, Echeverria OM, Salgado R, Escobar ML, Vazquez-Nin GH. Fine structural and cytochemical analysis of the processes of cell death of oocytes in atretic follicles in new born and prepubertal rats. Apoptosis. 2006;11(1):25\u201337.","journal-title":"Apoptosis"},{"issue":"21","key":"2189_CR60","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1016\/j.cub.2017.09.028","volume":"27","author":"AI de Los Santos-Velazquez","year":"2017","unstructured":"de Los Santos-Velazquez AI, de Oya IG, Manzano-Lopez J, Monje-Casas F. Late rDNA condensation ensures timely Cdc14 release and coordination of Mitotic Exit Signaling with Nucleolar Segregation. Curr Biol. 2017;27(21):3248\u201363. e5.","journal-title":"Curr Biol"},{"issue":"22","key":"2189_CR61","doi-asserted-by":"publisher","first-page":"R1220","DOI":"10.1016\/j.cub.2017.10.016","volume":"27","author":"A Clemente-Blanco","year":"2017","unstructured":"Clemente-Blanco A. Nucleolar condensation: a new mechanism to Control Mitotic exit. Curr Biol. 2017;27(22):R1220\u20132.","journal-title":"Curr Biol"},{"issue":"1","key":"2189_CR62","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1111\/j.1768-322X.1984.tb00199.x","volume":"48","author":"N Crozet","year":"1983","unstructured":"Crozet N. Effects of actinomycin D and cycloheximide on the nucleolar ultrastructure of porcine oocytes. Biol Cell. 1983;48(1):25\u20139.","journal-title":"Biol Cell"},{"issue":"1","key":"2189_CR63","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1262\/jrd.11-134A","volume":"58","author":"M Jitsukawa","year":"2012","unstructured":"Jitsukawa M, Kyogoku H, Ogushi S, Miyano T. Effects of proteasome inhibitors on the nucleolar size of porcine oocytes. J Reprod Dev. 2012;58(1):162\u20136.","journal-title":"J Reprod Dev"},{"issue":"1","key":"2189_CR64","doi-asserted-by":"publisher","first-page":"13972","DOI":"10.1038\/s41598-022-17923-4","volume":"12","author":"L Snyers","year":"2022","unstructured":"Snyers L, Laffer S, Lohnert R, Weipoltshammer K, Schofer C. CX-5461 causes nucleolar compaction, alteration of peri- and intranucleolar chromatin arrangement, an increase in both heterochromatin and DNA damage response. Sci Rep. 2022;12(1):13972.","journal-title":"Sci Rep"},{"issue":"2","key":"2189_CR65","first-page":"54","volume":"3","author":"DV Dzidziguri","year":"1994","unstructured":"Dzidziguri DV, Chelidze PV, Zarandia MA, Cherkezia EC, Tumanishvili GD. Transcriptional activity and ultrastructure of morphologically different types of nucleoli isolated from hepatocytes of normal and hepatectomized rats. Epithel Cell Biol. 1994;3(2):54\u201360.","journal-title":"Epithel Cell Biol"},{"issue":"4","key":"2189_CR66","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1016\/S0002-9440(10)62523-0","volume":"159","author":"K Nakamoto","year":"2001","unstructured":"Nakamoto K, Ito A, Watabe K, Koma Y, Asada H, Yoshikawa K, et al. Increased expression of a nucleolar Nop5\/Sik family member in metastatic melanoma cells: evidence for its role in nucleolar sizing and function. Am J Pathol. 2001;159(4):1363\u201374.","journal-title":"Am J Pathol"},{"issue":"7807","key":"2189_CR67","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41586-020-2256-2","volume":"581","author":"JA Riback","year":"2020","unstructured":"Riback JA, Zhu L, Ferrolino MC, Tolbert M, Mitrea DM, Sanders DW, et al. Composition-dependent thermodynamics of intracellular phase separation. Nature. 2020;581(7807):209\u201314.","journal-title":"Nature"},{"issue":"1","key":"2189_CR68","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1261\/rna.078997.121","volume":"28","author":"PA Sharp","year":"2022","unstructured":"Sharp PA, Chakraborty AK, Henninger JE, Young RA. RNA in formation and regulation of transcriptional condensates. RNA. 2022;28(1):52\u20137.","journal-title":"RNA"},{"key":"2189_CR69","doi-asserted-by":"crossref","unstructured":"Mokin YI, Gavrilova AA, Fefilova AS, Kuznetsova IM, Turoverov KK, Uversky VN et al. Nucleolar- and nuclear-stress-Induced Membrane-less organelles: a Proteome Analysis through the prism of liquid-liquid phase separation. Int J Mol Sci. 2023;24(13).","DOI":"10.3390\/ijms241311007"},{"issue":"23","key":"2189_CR70","doi-asserted-by":"publisher","first-page":"e2316734121","DOI":"10.1073\/pnas.2316734121","volume":"121","author":"M Bokros","year":"2024","unstructured":"Bokros M, Balukoff NC, Grunfeld A, Sebastiao M, Beurel E, Bourgault S, et al. RNA tailing machinery drives amyloidogenic phase transition. Proc Natl Acad Sci U S A. 2024;121(23):e2316734121.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"2189_CR71","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1042\/BCJ20200847","volume":"478","author":"E Kim","year":"2021","unstructured":"Kim E, Kwon I. Phase transition of fibrillarin LC domain regulates localization and protein interaction of fibrillarin. Biochem J. 2021;478(4):799\u2013810.","journal-title":"Biochem J"},{"issue":"7948","key":"2189_CR72","first-page":"564","volume":"614","author":"MA Mensah","year":"2023","unstructured":"Mensah MA, Niskanen H, Magalhaes AP, Basu S, Kircher M, Sczakiel HL, et al. Aberrant phase separation and nucleolar dysfunction in rare genetic diseases. Nature. 2023;614(7948):564\u201371.","journal-title":"Nature"},{"key":"2189_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.redox.2017.08.003","volume":"14","author":"J Deng","year":"2018","unstructured":"Deng J, Zhong YF, Wu YP, Luo Z, Sun YM, Wang GE, et al. Carnosine attenuates cyclophosphamide-induced bone marrow suppression by reducing oxidative DNA damage. Redox Biol. 2018;14:1\u20136.","journal-title":"Redox Biol"},{"issue":"7","key":"2189_CR74","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/s41419-020-02774-6","volume":"11","author":"O Makarevich","year":"2020","unstructured":"Makarevich O, Sabirzhanov B, Aubrecht TG, Glaser EP, Polster BM, Henry RJ, et al. Mithramycin selectively attenuates DNA-damage-induced neuronal cell death. Cell Death Dis. 2020;11(7):587.","journal-title":"Cell Death Dis"},{"issue":"9","key":"2189_CR75","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1038\/nrc3342","volume":"12","author":"P Bouwman","year":"2012","unstructured":"Bouwman P, Jonkers J. The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance. Nat Rev Cancer. 2012;12(9):587\u201398.","journal-title":"Nat Rev Cancer"},{"key":"2189_CR76","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev-med-081313-121208","volume":"66","author":"M Goldstein","year":"2015","unstructured":"Goldstein M, Kastan MB. The DNA damage response: implications for tumor responses to radiation and chemotherapy. Annu Rev Med. 2015;66:129\u201343.","journal-title":"Annu Rev Med"},{"issue":"29","key":"2189_CR77","doi-asserted-by":"publisher","first-page":"e2205166119","DOI":"10.1073\/pnas.2205166119","volume":"119","author":"M Locatelli","year":"2022","unstructured":"Locatelli M, Lawrimore J, Lin H, Sanaullah S, Seitz C, Segall D, et al. DNA damage reduces heterogeneity and coherence of chromatin motions. Proc Natl Acad Sci U S A. 2022;119(29):e2205166119.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2189_CR78","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/bs.mcb.2022.01.003","volume":"172","author":"L Bezu","year":"2022","unstructured":"Bezu L, Humeau J, Leduc M, Pan H, Kroemer G, Kepp O. Assessment of eIF2alpha phosphorylation during immunogenic cell death. Methods Cell Biol. 2022;172:83\u201398.","journal-title":"Methods Cell Biol"},{"key":"2189_CR79","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/bs.mcb.2021.12.026","volume":"172","author":"G Cerrato","year":"2022","unstructured":"Cerrato G, Humeau J, Sauvat A, Kepp O, Kroemer G. Assessment of transcription inhibition as a characteristic of immunogenic cell death. Methods Cell Biol. 2022;172:67\u201382.","journal-title":"Methods Cell Biol"},{"issue":"2","key":"2189_CR80","doi-asserted-by":"publisher","first-page":"100488","DOI":"10.1016\/j.xpro.2021.100488","volume":"2","author":"A Sato","year":"2021","unstructured":"Sato A, Buque A, Yamazaki T, Bloy N, Petroni G, Galluzzi L. Immunofluorescence microscopy-based assessment of cytosolic DNA accumulation in mammalian cells. STAR Protoc. 2021;2(2):100488.","journal-title":"STAR Protoc"},{"issue":"7","key":"2189_CR81","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1093\/bioinformatics\/btq046","volume":"26","author":"G Pau","year":"2010","unstructured":"Pau G, Fuchs F, Sklyar O, Boutros M, Huber W. EBImage\u2013an R package for image processing with applications to cellular phenotypes. Bioinformatics. 2010;26(7):979\u201381.","journal-title":"Bioinformatics"},{"issue":"6","key":"2189_CR82","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1109\/TSMC.1973.4309314","volume":"SMC\u20133","author":"RM Haralick","year":"1973","unstructured":"Haralick RM, Shanmugam K, Dinstein I. Textural features for image classification. IEEE Trans Syst Man Cybernetics. 1973;SMC\u20133(6):610\u201321.","journal-title":"IEEE Trans Syst Man Cybernetics"},{"key":"2189_CR83","unstructured":"Goodfellow IJ, Pouget-Abadie J, Mirza M, Xu B, Warde-Farley D, Ozair S et al. Generative Adversarial Networks. arXiv [statML]. 2014."},{"issue":"25","key":"2189_CR84","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1161\/CIRCULATIONAHA.122.059863","volume":"145","author":"M Abdellatif","year":"2022","unstructured":"Abdellatif M, Trummer-Herbst V, Heberle AM, Humnig A, Pendl T, Durand S, et al. Fine-tuning Cardiac insulin-like Growth factor 1 receptor signaling to Promote Health and Longevity. Circulation. 2022;145(25):1853\u201366.","journal-title":"Circulation"},{"key":"2189_CR85","doi-asserted-by":"crossref","unstructured":"Ribeiro MT, Singh S, Guestrin C. Why should I trust you? Explaining the predictions of any classifier. arXiv [csLG]; 2016.","DOI":"10.18653\/v1\/N16-3020"},{"issue":"9","key":"2189_CR86","doi-asserted-by":"publisher","first-page":"e1462431","DOI":"10.1080\/2162402X.2018.1462431","volume":"7","author":"DP Enot","year":"2018","unstructured":"Enot DP, Vacchelli E, Jacquelot N, Zitvogel L, Kroemer G. TumGrowth: an open-access web tool for the statistical analysis of tumor growth curves. Oncoimmunology. 2018;7(9):e1462431.","journal-title":"Oncoimmunology"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-024-02189-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-024-02189-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-024-02189-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T05:00:03Z","timestamp":1734670803000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-024-02189-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":86,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2189"],"URL":"https:\/\/doi.org\/10.1186\/s12943-024-02189-3","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"assertion":[{"value":"4 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments followed the EU Directive 63\/2010 and were conducted under the protocol no. 2023120514306594, approved by the Ethical Committee of Gustave Roussy Cancer Campus (CEEA IRCIV\/IGR no. 26, registered at the French Ministry of Research) and by the national agency Bundesministerium f\u00fcr Wissenschaft, Forschung und Wirtschaft, BMWFW, Austria under the protocols no. BMWFW-2020-0.824.559 and BMWFW-2024-0.697.697).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"GK has been holding research contracts with Daiichi Sankyo, Eleor, Kaleido, Lytix Pharma, PharmaMar, Osasuna Therapeutics, Samsara Therapeutics, Sanofi, Sutro, Tollys, and Vascage. GK is on the Board of Directors of the Bristol Myers Squibb Foundation France. GK is a scientific co-founder of everImmune, Osasuna Therapeutics, Samsara Therapeutics and Therafast Bio. GK is in the scientific advisory boards of Hevolution, Institut Servier, Longevity Vision Funds and Rejuveron Life Sciences. GK is the inventor of patents covering therapeutic targeting of aging, cancer, cystic fibrosis and metabolic disorders. GK\u2019s wife, Laurence Zitvogel, has held research contracts with Glaxo Smyth Kline, Incyte, Lytix, Kaleido, Innovate Pharma, Daiichi Sankyo, Pilege, Merus, Transgene, 9\u00a0m, Tusk and Roche, was on the on the Board of Directors of Transgene, is a cofounder of everImmune, and holds patents covering the treatment of cancer and the therapeutic manipulation of the microbiota. GK\u2019s brother, Romano Kroemer, was an employee of Sanofi and now consults for Boehringer-Ingelheim. The funders had no role in the design of the study; in the writing of the manuscript, or in the decision to publish the results. No disclosures were reported by the other authors.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"275"}}