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The collection of these samples was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou University of Chinese Medicine, and all patients provided informed consent to participate in this study (Ethics Review No. K-2024-036).This study and included experimental procedures were approved by the Experimental Animal Ethics Committee of Guangzhou University of Chinese Medicine. All animal housing and experiments were conducted in strict accordance with the institutional guidelines of laboratory animals (Ethics Review No. 20230319001, No. 20240508008, No. 20240508008, No. 20241009011).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"32"}}