{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T23:14:16Z","timestamp":1794352456262,"version":"4.9.0"},"reference-count":71,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22002096"],"award-info":[{"award-number":["22002096"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heilongjiang Postdoctoral Science Foundation","award":["LBH-223123"],"award-info":[{"award-number":["LBH-223123"]}]},{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["YQ2023H015"],"award-info":[{"award-number":["YQ2023H015"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Research and Development Program of China","award":["2022YFA1205704"],"award-info":[{"award-number":["2022YFA1205704"]}]},{"name":"Fundamental Research Funds for the Provincial Universities of Heilongjiang","award":["2022KYYWF-0298"],"award-info":[{"award-number":["2022KYYWF-0298"]}]},{"name":"Research Fund of the Fourth Affiliated Hospital of Harbin Medical University","award":["HYDSYRCYJ02"],"award-info":[{"award-number":["HYDSYRCYJ02"]}]},{"name":"Research Fund of Chongqing Key Laboratory of Development and Utilization of Genuine Medicine in the Three Gorges Reservoir Area","award":["KFKT2022011"],"award-info":[{"award-number":["KFKT2022011"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2023M730827"],"award-info":[{"award-number":["2023M730827"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"DOI":"10.1186\/s12943-025-02234-9","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T06:38:07Z","timestamp":1737700687000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer"],"prefix":"10.1186","volume":"24","author":[{"given":"Xiang","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailai","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanlong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhai","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manjie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"2234_CR1","doi-asserted-by":"crossref","unstructured":"Siegel RL, Giaquinto AN, Jemal A, Cancer statistics, Cancer JC. 2024 Jan-Feb;74(1):12\u201349. doi: 10.3322\/caac.21820. Epub 2024 Jan 17. Erratum in: CA Cancer J Clin. 2024 Mar-Apr;74(2):203. PMID: 38230766.","DOI":"10.3322\/caac.21820"},{"key":"2234_CR2","doi-asserted-by":"publisher","first-page":"215709","DOI":"10.1016\/j.canlet.2022.215709","volume":"538","author":"A Papachristodoulou","year":"2022","unstructured":"Papachristodoulou A, Abate-Shen C. Precision intervention for prostate cancer: re-evaluating who is at risk. Cancer Lett. 2022;538:215709. https:\/\/doi.org\/10.1016\/j.canlet.2022.215709. Epub 2022 Apr 29. PMID: 35490919; PMCID: PMC9136709.","journal-title":"Cancer Lett"},{"issue":"2","key":"2234_CR3","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.trecan.2020.09.006","volume":"7","author":"G Furesi","year":"2021","unstructured":"Furesi G, Rauner M, Hofbauer LC. Emerging players in prostate Cancer-bone Niche Communication. Trends Cancer. 2021;7(2):112\u201321. https:\/\/doi.org\/10.1016\/j.trecan.2020.09.006. Epub 2020 Oct 24. PMID: 33274720.","journal-title":"Trends Cancer"},{"issue":"3","key":"2234_CR4","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1016\/j.eururo.2017.08.011","volume":"73","author":"T Seisen","year":"2018","unstructured":"Seisen T, Vetterlein MW, Karabon P, Jindal T, Sood A, Nocera L, Nguyen PL, Choueiri TK, Trinh QD, Menon M, Abdollah F. Efficacy of local treatment in prostate Cancer patients with clinically pelvic lymph node-positive disease at initial diagnosis. Eur Urol. 2018;73(3):452\u201361. Epub 2017 Sep 8. PMID: 28890245.","journal-title":"Eur Urol"},{"issue":"10","key":"2234_CR5","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.3390\/ijms20102587","volume":"20","author":"SK Wong","year":"2019","unstructured":"Wong SK, Mohamad NV, Giaze TR, Chin KY, Mohamed N, Ima-Nirwana S. Prostate Cancer and bone metastases: the underlying mechanisms. Int J Mol Sci. 2019;20(10):2587. https:\/\/doi.org\/10.3390\/ijms20102587. PMID: 31137764; PMCID: PMC6567184.","journal-title":"Int J Mol Sci"},{"key":"2234_CR6","doi-asserted-by":"publisher","unstructured":"Petrylak DP, Tangen CM, Hussain MH, Lara PN Jr, Jones JA, Taplin ME, Burch PA, Berry D, Moinpour C, Kohli M, Benson MC, Small EJ, Raghavan D, Crawford ED. Docetaxel and estramustine compared with mitoxantrone and prednisone for advanced refractory prostate cancer. N Engl J Med. 2004;351(15):1513-20. https:\/\/doi.org\/10.1056\/NEJMoa041318. PMID: 15470214.","DOI":"10.1056\/NEJMoa041318"},{"issue":"28","key":"2234_CR7","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1200\/JCO.2016.72.1068","volume":"35","author":"S Oudard","year":"2017","unstructured":"Oudard S, Fizazi K, Sengel\u00f8v L, Daugaard G, Saad F, Hansen S, Hj\u00e4lm-Eriksson M, Jassem J, Thiery-Vuillemin A, Caffo O, Castellano D, Mainwaring PN, Bernard J, Shen L, Chadjaa M, Sartor O. Cabazitaxel Versus Docetaxel as First-Line therapy for patients with metastatic castration-resistant prostate Cancer: a Randomized Phase III Trial-FIRSTANA. J Clin Oncol. 2017;35(28):3189\u201397. Epub 2017 Jul 28. PMID: 28753384.","journal-title":"J Clin Oncol"},{"issue":"1","key":"2234_CR8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/nrclinonc.2010.136","volume":"8","author":"B Seruga","year":"2011","unstructured":"Seruga B, Ocana A, Tannock IF. Drug resistance in metastatic castration-resistant prostate cancer. Nat Rev Clin Oncol. 2011;8(1):12\u201323. https:\/\/doi.org\/10.1038\/nrclinonc.2010.136. Epub 2010 Sep 21. PMID: 20859283.","journal-title":"Nat Rev Clin Oncol"},{"key":"2234_CR9","doi-asserted-by":"publisher","first-page":"114392","DOI":"10.1016\/j.biopha.2023.114392","volume":"160","author":"M Hashemi","year":"2023","unstructured":"Hashemi M, Zandieh MA, Talebi Y, Rahmanian P, Shafiee SS, Nejad MM, Babaei R, Sadi FH, Rajabi R, Abkenar ZO, Rezaei S, Ren J, Nabavi N, Khorrami R, Rashidi M, Hushmandi K, Entezari M, Taheriazam A. Paclitaxel and docetaxel resistance in prostate cancer: molecular mechanisms and possible therapeutic strategies. Biomed Pharmacother. 2023;160:114392. https:\/\/doi.org\/10.1016\/j.biopha.2023.114392. Epub 2023 Feb 15. PMID: 36804123.","journal-title":"Biomed Pharmacother"},{"key":"2234_CR10","doi-asserted-by":"publisher","unstructured":"Wahl MC, Will CL, L\u00fchrmann R. The spliceosome: design principles of a dynamic RNP machine. Cell. 2009;136(4):701\u2009\u2013\u200918. https:\/\/doi.org\/10.1016\/j.cell.2009.02.009. PMID: 19239890.","DOI":"10.1016\/j.cell.2009.02.009"},{"key":"2234_CR11","doi-asserted-by":"publisher","unstructured":"Wang PL, Bao Y, Yee MC, Barrett SP, Hogan GJ, Olsen MN, Dinneny JR, Brown PO, Salzman J. Circular RNA is expressed across the eukaryotic tree of life. PLoS One. 2014;9(6):e90859. https:\/\/doi.org\/10.1371\/journal.pone.0090859. Erratum in: PLoS One. 2014;9(4):e95116. PMID: 24609083; PMCID: PMC3946582.","DOI":"10.1371\/journal.pone.0090859"},{"issue":"3","key":"2234_CR12","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/s41418-022-00948-7","volume":"29","author":"S Misir","year":"2022","unstructured":"Misir S, Wu N, Yang BB. Specific expression and functions of circular RNAs. Cell Death Differ. 2022;29(3):481\u201391. https:\/\/doi.org\/10.1038\/s41418-022-00948-7. Epub 2022 Feb 15. PMID: 35169296; PMCID: PMC8901656.","journal-title":"Cell Death Differ"},{"issue":"11","key":"2234_CR13","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","volume":"20","author":"LS Kristensen","year":"2019","unstructured":"Kristensen LS, Andersen MS, Stagsted LVW, Ebbesen KK, Hansen TB, Kjems J. The biogenesis, biology and characterization of circular RNAs. Nat Rev Genet. 2019;20(11):675\u201391. https:\/\/doi.org\/10.1038\/s41576-019-0158-7. Epub 2019 Aug 8. PMID: 31395983.","journal-title":"Nat Rev Genet"},{"issue":"1","key":"2234_CR14","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1186\/s12943-019-1002-6","volume":"18","author":"M Su","year":"2019","unstructured":"Su M, Xiao Y, Ma J, Tang Y, Tian B, Zhang Y, Li X, Wu Z, Yang D, Zhou Y, Wang H, Liao Q, Wang W. Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers. Mol Cancer. 2019;18(1):90. https:\/\/doi.org\/10.1186\/s12943-019-1002-6. PMID: 30999909; PMCID: PMC6471953.","journal-title":"Mol Cancer"},{"issue":"1","key":"2234_CR15","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s12943-021-01417-4","volume":"20","author":"L He","year":"2021","unstructured":"He L, Man C, Xiang S, Yao L, Wang X, Fan Y. Circular RNAs\u2019 cap-independent translation protein and its roles in carcinomas. Mol Cancer. 2021;20(1):119. https:\/\/doi.org\/10.1186\/s12943-021-01417-4. PMID: 34526007; PMCID: PMC8442428.","journal-title":"Mol Cancer"},{"issue":"1","key":"2234_CR16","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12943-023-01766-2","volume":"22","author":"ZH Zhang","year":"2023","unstructured":"Zhang ZH, Wang Y, Zhang Y, Zheng SF, Feng T, Tian X, Abudurexiti M, Wang ZD, Zhu WK, Su JQ, Zhang HL, Shi GH, Wang ZL, Cao DL, Ye DW. The function and mechanisms of action of circular RNAs in Urologic Cancer. Mol Cancer. 2023;22(1):61. https:\/\/doi.org\/10.1186\/s12943-023-01766-2. Erratum in: Mol Cancer. 2023;22(1):73. doi: 10.1186\/s12943-023-01774-2. PMID: 36966306; PMCID: PMC10039696.","journal-title":"Mol Cancer"},{"issue":"6","key":"2234_CR17","doi-asserted-by":"publisher","first-page":"9331","DOI":"10.3390\/ijms15069331","volume":"15","author":"H Suzuki","year":"2014","unstructured":"Suzuki H, Tsukahara T. A view of pre-mRNA splicing from RNase R resistant RNAs. Int J Mol Sci. 2014;15(6):9331\u201342. https:\/\/doi.org\/10.3390\/ijms15069331. PMID: 24865493; PMCID: PMC4100097.","journal-title":"Int J Mol Sci"},{"issue":"3","key":"2234_CR18","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s10555-023-10152-9","volume":"43","author":"Z Zhang","year":"2024","unstructured":"Zhang Z, Gao Z, Fang H, Zhao Y, Xing R. Therapeutic importance and diagnostic function of circRNAs in urological cancers: from metastasis to drug resistance. Cancer Metastasis Rev. 2024;43(3):867\u201388. https:\/\/doi.org\/10.1007\/s10555-023-10152-9. Epub 2024 Jan 22. PMID: 38252399.","journal-title":"Cancer Metastasis Rev"},{"issue":"5","key":"2234_CR19","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41419-021-03743-3","volume":"12","author":"L Verduci","year":"2021","unstructured":"Verduci L, Tarcitano E, Strano S, Yarden Y, Blandino G. CircRNAs: role in human diseases and potential use as biomarkers. Cell Death Dis. 2021;12(5):468. https:\/\/doi.org\/10.1038\/s41419-021-03743-3. PMID: 33976116; PMCID: PMC8113373.","journal-title":"Cell Death Dis"},{"issue":"4","key":"2234_CR20","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22(4):266\u201382. https:\/\/doi.org\/10.1038\/s41580-020-00324-8. Epub 2021 Jan 25. PMID: 33495651; PMCID: PMC8142022.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2234_CR21","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/s41392-024-01769-5","volume":"9","author":"Q Zhou","year":"2024","unstructured":"Zhou Q, Meng Y, Li D, Yao L, Le J, Liu Y, Sun Y, Zeng F, Chen X, Deng G. Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies. Signal Transduct Target Ther. 2024;9(1):55. https:\/\/doi.org\/10.1038\/s41392-024-01769-5. PMID: 38453898; PMCID: PMC10920854.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"2234_CR22","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1186\/s12964-023-01296-w","volume":"21","author":"K Khorsandi","year":"2023","unstructured":"Khorsandi K, Esfahani H, Ghamsari SK, Lakhshehei P. Targeting ferroptosis in melanoma: cancer therapeutics. Cell Commun Signal. 2023;21(1):337. https:\/\/doi.org\/10.1186\/s12964-023-01296-w. PMID: 37996827; PMCID: PMC10666330.","journal-title":"Cell Commun Signal"},{"issue":"3","key":"2234_CR23","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1038\/s41418-022-00941-0","volume":"29","author":"J Chen","year":"2022","unstructured":"Chen J, Li X, Ge C, Min J, Wang F. The multifaceted role of ferroptosis in liver disease. Cell Death Differ. 2022;29(3):467\u201380. https:\/\/doi.org\/10.1038\/s41418-022-00941-0. Epub 2022 Jan 24. PMID: 35075250; PMCID: PMC8901678.","journal-title":"Cell Death Differ"},{"key":"2234_CR24","doi-asserted-by":"publisher","first-page":"860344","DOI":"10.3389\/fcell.2022.860344","volume":"10","author":"R Gu","year":"2022","unstructured":"Gu R, Xia Y, Li P, Zou D, Lu K, Ren L, Zhang H, Sun Z. Ferroptosis and its role in gastric Cancer. Front Cell Dev Biol. 2022;10:860344. https:\/\/doi.org\/10.3389\/fcell.2022.860344. PMID: 35846356; PMCID: PMC9280052.","journal-title":"Front Cell Dev Biol"},{"key":"2234_CR25","doi-asserted-by":"publisher","first-page":"122720","DOI":"10.1016\/j.lfs.2024.122720","volume":"349","author":"C Kapper","year":"2024","unstructured":"Kapper C, Oppelt P, Arbeithuber B, Gyunesh AA, Vilusic I, Stelzl P, Rezk-F\u00fcreder M. Targeting ferroptosis in ovarian cancer: novel strategies to overcome chemotherapy resistance. Life Sci. 2024;349:122720. https:\/\/doi.org\/10.1016\/j.lfs.2024.122720. Epub 2024 May 16. PMID: 38762066.","journal-title":"Life Sci"},{"issue":"10","key":"2234_CR26","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/j.trecan.2021.04.005","volume":"7","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang D. Targeting ferroptosis in pancreatic cancer: a double-edged sword. Trends Cancer. 2021;7(10):891\u2013901. https:\/\/doi.org\/10.1016\/j.trecan.2021.04.005. Epub 2021 May 20. PMID: 34023326.","journal-title":"Trends Cancer"},{"issue":"1","key":"2234_CR27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s40364-020-00230-3","volume":"8","author":"Z Li","year":"2020","unstructured":"Li Z, Chen L, Chen C, Zhou Y, Hu D, Yang J, Chen Y, Zhuo W, Mao M, Zhang X, Xu L, Wang L, Zhou J. Targeting ferroptosis in breast cancer. Biomark Res. 2020;8(1):58. https:\/\/doi.org\/10.1186\/s40364-020-00230-3. PMID: 33292585; PMCID: PMC7643412.","journal-title":"Biomark Res"},{"issue":"8","key":"2234_CR28","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1038\/s41416-023-02149-6","volume":"128","author":"H Yan","year":"2023","unstructured":"Yan H, Talty R, Aladelokun O, Bosenberg M, Johnson CH. Ferroptosis in colorectal cancer: a future target? Br J Cancer. 2023;128(8):1439\u201351. https:\/\/doi.org\/10.1038\/s41416-023-02149-6. Epub 2023 Jan 26. PMID: 36703079; PMCID: PMC10070248.","journal-title":"Br J Cancer"},{"issue":"6","key":"2234_CR29","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/ame2.12365","volume":"6","author":"R Liu","year":"2023","unstructured":"Liu R, Zhou Y, Cao Y. CircRNA and ferroptosis in human disease: insights for new treatments. Anim Model Exp Med. 2023;6(6):508\u201317. https:\/\/doi.org\/10.1002\/ame2.12365. Epub 2023 Dec 13. PMID: 38093404; PMCID: PMC10757220.","journal-title":"Anim Model Exp Med"},{"issue":"6","key":"2234_CR30","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1038\/s41418-022-00998-x","volume":"29","author":"A Balihodzic","year":"2022","unstructured":"Balihodzic A, Prinz F, Dengler MA, Calin GA, Jost PJ, Pichler M. Non-coding RNAs and ferroptosis: potential implications for cancer therapy. Cell Death Differ. 2022;29(6):1094\u2013106. https:\/\/doi.org\/10.1038\/s41418-022-00998-x. Epub 2022 Apr 14. PMID: 35422492; PMCID: PMC9177660.","journal-title":"Cell Death Differ"},{"issue":"1","key":"2234_CR31","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1186\/s12943-024-02030-x","volume":"23","author":"XY Zhang","year":"2024","unstructured":"Zhang XY, Li SS, Gu YR, Xiao LX, Ma XY, Chen XR, Wang JL, Liao CH, Lin BL, Huang YH, Lian YF. CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p\/NUPR1\/FTH1 axis. Mol Cancer. 2024;23(1):113. https:\/\/doi.org\/10.1186\/s12943-024-02030-x. PMID: 38802795; PMCID: PMC11131253.","journal-title":"Mol Cancer"},{"issue":"36","key":"2234_CR32","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1038\/s41388-024-03116-y","volume":"43","author":"J Hu","year":"2024","unstructured":"Hu J, Li X, Xu K, Chen J, Zong S, Zhang H, Li H, Zhang G, Guo Z, Zhao X, Jiang Y, Jing Z. CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A. Oncogene. 2024;43(36):2679\u201395. https:\/\/doi.org\/10.1038\/s41388-024-03116-y. Epub 2024 Aug 4. PMID: 39098847.","journal-title":"Oncogene"},{"key":"2234_CR33","doi-asserted-by":"crossref","unstructured":"Liu M, Wang QSJ, Yang BB,Ding X. Circbank: a comprehensive database for circRNA with standard nomenclature.RNA Biol.2019;16(7):899\u2013905.doi:10.1080\/15476286.2019.1600395.Epub 2019 Apr 25.PMID:31023147;PMCID:PMC6546381.","DOI":"10.1080\/15476286.2019.1600395"},{"issue":"D1","key":"2234_CR34","doi-asserted-by":"publisher","first-page":"D127","DOI":"10.1093\/nar\/gkz757","volume":"48","author":"Y Chen","year":"2020","unstructured":"Chen Y, Wang X. miRDB: an online database for prediction of functional microRNA targets. Nucleic Acids Res. 2020;48(D1):D127\u201331. https:\/\/doi.org\/10.1093\/nar\/gkz757. PMID: 31504780; PMCID: PMC6943051.","journal-title":"Nucleic Acids Res"},{"issue":"6472","key":"2234_CR35","doi-asserted-by":"publisher","first-page":"eaav1741","DOI":"10.1126\/science.aav1741","volume":"366","author":"SE McGeary","year":"2019","unstructured":"McGeary SE, Lin KS, Shi CY, Pham TM, Bisaria N, Kelley GM, Bartel DP. The biochemical basis of microRNA targeting efficacy. Science. 2019;366(6472):eaav1741. https:\/\/doi.org\/10.1126\/science.aav1741. Epub 2019 Dec 5. PMID: 31806698; PMCID: PMC7051167.","journal-title":"Science"},{"issue":"12","key":"2234_CR36","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1002\/cac2.12217","volume":"41","author":"Y Luo","year":"2021","unstructured":"Luo Y, Vlaeminck-Guillem V, Teinturier R, Abou Ziki R, Bertolino P, Le Romancer M, Zhang CX. The scaffold protein menin is essential for activating the MYC locus and MYC-mediated androgen receptor transcription in androgen receptor-dependent prostate cancer cells. Cancer Commun (Lond). 2021;41(12):1427\u201330. Epub 2021 Dec 1. PMID: 34850609; PMCID: PMC8696212.","journal-title":"Cancer Commun (Lond)"},{"issue":"4","key":"2234_CR37","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/j.cell.2018.12.021","volume":"176","author":"JN Vo","year":"2019","unstructured":"Vo JN, Cieslik M, Zhang Y, Shukla S, Xiao L, Zhang Y, Wu YM, Dhanasekaran SM, Engelke CG, Cao X, Robinson DR, Nesvizhskii AI, Chinnaiyan AM. The Landscape of circular RNA in Cancer. Cell. 2019;176(4):869\u2013e88113. https:\/\/doi.org\/10.1016\/j.cell.2018.12.021. PMID: 30735636; PMCID: PMC6601354.","journal-title":"Cell"},{"key":"2234_CR38","doi-asserted-by":"publisher","unstructured":"Robinson D, Van Allen EM, Wu YM, Schultz N, Lonigro RJ, Mosquera JM, Montgomery B, Taplin ME, Pritchard CC, Attard G, Beltran H, Abida W, Bradley RK, Vinson J, Cao X, Vats P, Kunju LP, Hussain M, Feng FY, Tomlins SA, Cooney KA, Smith DC, Brennan C, Siddiqui J, Mehra R, Chen Y, Rathkopf DE, Morris MJ, Solomon SB, Durack JC, Reuter VE, Gopalan A, Gao J, Loda M, Lis RT, Bowden M, Balk SP, Gaviola G, Sougnez C, Gupta M, Yu EY, Mostaghel EA, Cheng HH, Mulcahy H, True LD, Plymate SR, Dvinge H, Ferraldeschi R, Flohr P, Miranda S, Zafeiriou Z, Tunariu N, Mateo J, Perez-Lopez R, Demichelis F, Robinson BD, Schiffman M, Nanus DM, Tagawa ST, Sigaras A, Eng KW, Elemento O, Sboner A, Heath EI, Scher HI, Pienta KJ, Kantoff P, de Bono JS, Rubin MA, Nelson PS, Garraway LA, Sawyers CL, Chinnaiyan AM. Integrative clinical genomics of advanced prostate cancer. Cell. 2015;161(5):1215\u20131228. https:\/\/doi.org\/10.1016\/j.cell.2015.05.001. Erratum in: Cell. 2015;162(2):454. PMID: 26000489; PMCID: PMC4484602.","DOI":"10.1016\/j.cell.2015.05.001"},{"key":"2234_CR39","doi-asserted-by":"publisher","first-page":"892","DOI":"10.3389\/fgene.2020.00892","volume":"11","author":"YP Wu","year":"2020","unstructured":"Wu YP, Lin XD, Chen SH, Ke ZB, Lin F, Chen DN, Xue XY, Wei Y, Zheng QS, Wen YA, Xu N. Identification of prostate Cancer-related circular RNA through Bioinformatics Analysis. Front Genet. 2020;11:892. https:\/\/doi.org\/10.3389\/fgene.2020.00892. PMID: 32922436; PMCID: PMC7457069.","journal-title":"Front Genet"},{"key":"2234_CR40","doi-asserted-by":"publisher","first-page":"8060389","DOI":"10.1155\/2021\/8060389","volume":"2021","author":"G Luo","year":"2021","unstructured":"Luo G, Li G, Wan Z, Zhang Y, Liu D, Guo Y. circITGA7 acts as a mir-370-3p sponge to suppress the proliferation of prostate Cancer. J Oncol. 2021;2021:8060389. https:\/\/doi.org\/10.1155\/2021\/8060389. PMID: 35003259; PMCID: PMC8741341.","journal-title":"J Oncol"},{"issue":"5","key":"2234_CR41","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1016\/j.tibs.2015.03.001","volume":"40","author":"S Guil","year":"2015","unstructured":"Guil S, Esteller M. RNA-RNA interactions in gene regulation: the coding and noncoding players. Trends Biochem Sci. 2015;40(5):248\u201356. https:\/\/doi.org\/10.1016\/j.tibs.2015.03.001. Epub 2015 Mar 25. PMID: 25818326.","journal-title":"Trends Biochem Sci"},{"key":"2234_CR42","doi-asserted-by":"publisher","unstructured":"Meister G, Landthaler M, Patkaniowska A, Dorsett Y, Teng G, Tuschl T. Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAs. Mol Cell. 2004;15(2):185\u2009\u2013\u200997. https:\/\/doi.org\/10.1016\/j.molcel.2004.07.007. PMID: 15260970.","DOI":"10.1016\/j.molcel.2004.07.007"},{"issue":"1","key":"2234_CR43","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/cdd.2014.112","volume":"22","author":"A Wilczynska","year":"2015","unstructured":"Wilczynska A, Bushell M. The complexity of miRNA-mediated repression. Cell Death Differ. 2015;22(1):22\u201333. https:\/\/doi.org\/10.1038\/cdd.2014.112. Epub 2014 Sep 5. PMID: 25190144; PMCID: PMC4262769.","journal-title":"Cell Death Differ"},{"key":"2234_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev-nutr-071813-105541","volume":"34","author":"TJ Grevengoed","year":"2014","unstructured":"Grevengoed TJ, Klett EL, Coleman RA. Acyl-CoA metabolism and partitioning. Annu Rev Nutr. 2014;34:1\u201330. https:\/\/doi.org\/10.1146\/annurev-nutr-071813-105541. Epub 2014 Apr 10. PMID: 24819326; PMCID: PMC5881898.","journal-title":"Annu Rev Nutr"},{"key":"2234_CR45","doi-asserted-by":"publisher","unstructured":"Faergeman NJ, Knudsen J. Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling. Biochem J. 1997;323 (Pt 1)(Pt 1):1\u201312. https:\/\/doi.org\/10.1042\/bj3230001. PMID: 9173866; PMCID: PMC1218279.","DOI":"10.1042\/bj3230001"},{"issue":"10","key":"2234_CR46","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1038\/s41388-021-01667-y","volume":"40","author":"Y Ma","year":"2021","unstructured":"Ma Y, Zha J, Yang X, Li Q, Zhang Q, Yin A, Beharry Z, Huang H, Huang J, Bartlett M, Ye K, Yin H, Cai H. Long-chain fatty acyl-CoA synthetase 1 promotes prostate cancer progression by elevation of lipogenesis and fatty acid beta-oxidation. Oncogene. 2021;40(10):1806\u201320. https:\/\/doi.org\/10.1038\/s41388-021-01667-y. Epub 2021 Feb 9. PMID: 33564069; PMCID: PMC8842993.","journal-title":"Oncogene"},{"issue":"6","key":"2234_CR47","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1016\/j.asjsur.2022.12.077","volume":"46","author":"X Shi","year":"2023","unstructured":"Shi X, Feng D, Han P, Wei W. Ferroptosis-related ACSL3 and ACTC1 predict metastasis-free survival for prostate cancer patients undergoing radical radiotherapy. Asian J Surg. 2023;46(6):2489\u201390. https:\/\/doi.org\/10.1016\/j.asjsur.2022.12.077. Epub 2022 Dec 26. PMID: 36577584.","journal-title":"Asian J Surg"},{"issue":"10","key":"2234_CR48","doi-asserted-by":"publisher","first-page":"e166647","DOI":"10.1172\/JCI166647","volume":"133","author":"ME Wang","year":"2023","unstructured":"Wang ME, Chen J, Lu Y, Bawcom AR, Wu J, Ou J, Asara JM, Armstrong AJ, Wang Q, Li L, Wang Y, Huang J, Chen M. RB1-deficient prostate tumor growth and metastasis are vulnerable to ferroptosis induction via the E2F\/ACSL4 axis. J Clin Invest. 2023;133(10):e166647. https:\/\/doi.org\/10.1172\/JCI166647. PMID: 36928314; PMCID: PMC10178842.","journal-title":"J Clin Invest"},{"issue":"23","key":"2234_CR49","doi-asserted-by":"publisher","first-page":"5896","DOI":"10.3390\/cancers14235896","volume":"14","author":"Y Yang","year":"2022","unstructured":"Yang Y, Zhu T, Wang X, Xiong F, Hu Z, Qiao X, Yuan X, Wang D. ACSL3 and ACSL4, distinct roles in Ferroptosis and cancers. Cancers (Basel). 2022;14(23):5896. https:\/\/doi.org\/10.3390\/cancers14235896. PMID: 36497375; PMCID: PMC9739553.","journal-title":"Cancers (Basel)"},{"key":"2234_CR50","doi-asserted-by":"publisher","unstructured":"Dagher R, Li N, Abraham S, Rahman A, Sridhara R, Pazdur R. Approval summary: Docetaxel in combination with prednisone for the treatment of androgen-independent hormone-refractory prostate cancer. Clin Cancer Res. 2004;10(24):8147-51. https:\/\/doi.org\/10.1158\/1078-0432.CCR-04-1402. PMID: 15623588.","DOI":"10.1158\/1078-0432.CCR-04-1402"},{"issue":"10","key":"2234_CR51","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.1021\/nn900918w","volume":"3","author":"T Xia","year":"2009","unstructured":"Xia T, Kovochich M, Liong M, Meng H, Kabehie S, George S, Zink JI, Nel AE. Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. ACS Nano. 2009;3(10):3273\u201386. https:\/\/doi.org\/10.1021\/nn900918w. PMID: 19739605; PMCID: PMC3900639.","journal-title":"ACS Nano"},{"issue":"1","key":"2234_CR52","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s10585-022-10197-0","volume":"40","author":"Y Wang","year":"2023","unstructured":"Wang Y, Zhang M, Zhang L, Zhou M, Wang E. Nanoparticles loaded with circ_0086375 for suppressing the tumorigenesis of pancreatic cancer by targeting the miR-646\/SLC4A4 axis. Clin Exp Metastasis. 2023;40(1):53\u201367. https:\/\/doi.org\/10.1007\/s10585-022-10197-0. Epub 2022 Dec 7. PMID: 36479657.","journal-title":"Clin Exp Metastasis"},{"issue":"11","key":"2234_CR53","doi-asserted-by":"publisher","first-page":"e2307809121","DOI":"10.1073\/pnas.2307809121","volume":"121","author":"N Nabar","year":"2024","unstructured":"Nabar N, Dacoba TG, Covarrubias G, Romero-Cruz D, Hammond PT. Electrostatic adsorption of polyanions onto lipid nanoparticles controls uptake, trafficking, and transfection of RNA and DNA therapies. Proc Natl Acad Sci U S A. 2024;121(11):e2307809121. https:\/\/doi.org\/10.1073\/pnas.2307809121. Epub 2024 Mar 4. PMID: 38437543; PMCID: PMC10945854.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2234_CR54","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.biomaterials.2016.10.035","volume":"113","author":"L Giraud","year":"2017","unstructured":"Giraud L, Viricel W, Leblond J, Giasson S. Single stranded siRNA complexation through non-electrostatic interactions. Biomaterials. 2017;113:230\u201342. https:\/\/doi.org\/10.1016\/j.biomaterials.2016.10.035. Epub 2016 Oct 29. PMID: 27825070.","journal-title":"Biomaterials"},{"key":"2234_CR55","doi-asserted-by":"publisher","unstructured":"Vidallon MLP, Liu H, Lu Z, Acter S, Song Y, Baldwin C, Teo BM, Bishop AI, Tabor RF, Peter K, de Campo L, Wang X. Polydopamine Nanobowl-Armoured Perfluorocarbon Emulsions: Tracking Thermal- and Photothermal-Induced Phase Change through Neutron Scattering. Small. 2024 Nov 10:e2406019. https:\/\/doi.org\/10.1002\/smll.202406019. Epub ahead of print. PMID: 39523733.","DOI":"10.1002\/smll.202406019"},{"issue":"Pt B","key":"2234_CR56","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.jcis.2024.10.118","volume":"679","author":"Y Gong","year":"2025","unstructured":"Gong Y, Zhang H, Lu M, Sun J, Jia Y, Yang Y, Liu X, Yin B, Zhou Y, Ling Y. Tuning the Fe-Gd nanoparticles co-functionalized mesoporous carbon from sphere to nanobowl for advanced bioapplications. J Colloid Interface Sci. 2025;679(Pt B):412\u201321. Epub 2024 Oct 22. PMID: 39461130.","journal-title":"J Colloid Interface Sci"},{"key":"2234_CR57","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1756-8722-5-35","volume":"5","author":"X Huang","year":"2012","unstructured":"Huang X, Chau CH, Figg WD. Challenges to improved therapeutics for metastatic castrate resistant prostate cancer: from recent successes and failures. J Hematol Oncol. 2012;5:35. https:\/\/doi.org\/10.1186\/1756-8722-5-35. PMID: 22747660; PMCID: PMC3425086.","journal-title":"J Hematol Oncol"},{"issue":"6","key":"2234_CR58","doi-asserted-by":"publisher","first-page":"e17120","DOI":"10.1016\/j.heliyon.2023.e17120","volume":"9","author":"Y Feng","year":"2023","unstructured":"Feng Y, Xia S, Hui J, Xu Y, Circular RNA. circBNC2 facilitates glycolysis and stemness of hepatocellular carcinoma through the miR-217\/high mobility group AT-hook 2 (HMGA2) axis. Heliyon. 2023;9(6):e17120. https:\/\/doi.org\/10.1016\/j.heliyon.2023.e17120. PMID: 37360090; PMCID: PMC10285170.","journal-title":"Heliyon"},{"issue":"1","key":"2234_CR59","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13048-022-01025-w","volume":"15","author":"T Liu","year":"2022","unstructured":"Liu T, Yuan L, Zou X, Circular RNA. circBNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p\/ FBXW7 axis. J Ovarian Res. 2022;15(1):95. https:\/\/doi.org\/10.1186\/s13048-022-01025-w. PMID: 35965327; PMCID: PMC9377053.","journal-title":"J Ovarian Res"},{"issue":"7","key":"2234_CR60","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1038\/s41419-023-05930-w","volume":"14","author":"Z Chen","year":"2023","unstructured":"Chen Z, Wang W, Abdul Razak SR, Han T, Ahmad NH, Li X. Ferroptosis as a potential target for cancer therapy. Cell Death Dis. 2023;14(7):460. https:\/\/doi.org\/10.1038\/s41419-023-05930-w. PMID: 37488128; PMCID: PMC10366218.","journal-title":"Cell Death Dis"},{"key":"2234_CR61","doi-asserted-by":"publisher","first-page":"547","DOI":"10.3389\/fonc.2018.00547","volume":"8","author":"D Vela","year":"2018","unstructured":"Vela D. Iron metabolism in prostate Cancer; from Basic Science to New Therapeutic Strategies. Front Oncol. 2018;8:547. https:\/\/doi.org\/10.3389\/fonc.2018.00547. PMID: 30538952; PMCID: PMC6277552.","journal-title":"Front Oncol"},{"issue":"1","key":"2234_CR62","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/s41420-023-01383-4","volume":"9","author":"F Maccarinelli","year":"2023","unstructured":"Maccarinelli F, Coltrini D, Mussi S, Bugatti M, Turati M, Chiodelli P, Giacomini A, De Cillis F, Cattane N, Cattaneo A, Ligresti A, Asperti M, Poli M, Vermi W, Presta M, Ronca R. Iron supplementation enhances RSL3-induced ferroptosis to treat na\u00efve and prevent castration-resistant prostate cancer. Cell Death Discov. 2023;9(1):81. https:\/\/doi.org\/10.1038\/s41420-023-01383-4. PMID: 36872341; PMCID: PMC9986230.","journal-title":"Cell Death Discov"},{"issue":"1","key":"2234_CR63","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/s41391-022-00583-w","volume":"26","author":"Y Wang","year":"2023","unstructured":"Wang Y, Ma Y, Jiang K. The role of ferroptosis in prostate cancer: a novel therapeutic strategy. Prostate Cancer Prostatic Dis. 2023;26(1):25\u20139. https:\/\/doi.org\/10.1038\/s41391-022-00583-w. Epub 2022 Sep 2. PMID: 36056183; PMCID: PMC10023567.","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"3","key":"2234_CR64","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","volume":"478","author":"H Yuan","year":"2016","unstructured":"Yuan H, Li X, Zhang X, Kang R, Tang D. Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem Biophys Res Commun. 2016;478(3):1338\u201343. https:\/\/doi.org\/10.1016\/j.bbrc.2016.08.124. Epub 2016 Aug 23. PMID: 27565726.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2234_CR65","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1158\/1541-7786.MCR-20-0379","volume":"19","author":"Y Ma","year":"2021","unstructured":"Ma Y, Zhang X, Alsaidan OA, Yang X, Sulejmani E, Zha J, Beharry Z, Huang H, Bartlett M, Lewis Z, Cai H. Long-chain Acyl-CoA synthetase 4-Mediated fatty acid metabolism sustains androgen receptor pathway-independent prostate Cancer. Mol Cancer Res. 2021;19(1):124\u201335. https:\/\/doi.org\/10.1158\/1541-7786.MCR-20-0379. Epub 2020 Oct 19. PMID: 33077484; PMCID: PMC7785683.","journal-title":"Mol Cancer Res"},{"issue":"11","key":"2234_CR66","doi-asserted-by":"publisher","first-page":"e144351","DOI":"10.1172\/jci.insight.144351","volume":"6","author":"RF Fernandez","year":"2021","unstructured":"Fernandez RF, Pereyra AS, Diaz V, Wilson ES, Litwa KA, Mart\u00ednez-Gardeazabal J, Jackson SN, Brenna JT, Hermann BP, Eells JB, Ellis JM. Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging. JCI Insight. 2021;6(11):e144351. https:\/\/doi.org\/10.1172\/jci.insight.144351. PMID: 34100386; PMCID: PMC8262339.","journal-title":"JCI Insight"},{"issue":"49","key":"2234_CR67","doi-asserted-by":"publisher","first-page":"12525","DOI":"10.1073\/pnas.1807958115","volume":"115","author":"RF Fernandez","year":"2018","unstructured":"Fernandez RF, Kim SQ, Zhao Y, Foguth RM, Weera MM, Counihan JL, Nomura DK, Chester JA, Cannon JR, Ellis JM. Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain. Proc Natl Acad Sci U S A. 2018;115(49):12525\u201330. https:\/\/doi.org\/10.1073\/pnas.1807958115. Epub 2018 Nov 6. PMID: 30401738; PMCID: PMC6298081.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2234_CR68","doi-asserted-by":"publisher","first-page":"e0155660","DOI":"10.1371\/journal.pone.0155660","volume":"11","author":"WC Chen","year":"2016","unstructured":"Chen WC, Wang CY, Hung YH, Weng TY, Yen MC, Lai MD. Systematic analysis of Gene expression alterations and clinical outcomes for long-chain acyl-coenzyme A synthetase family in Cancer. PLoS ONE. 2016;11(5):e0155660. https:\/\/doi.org\/10.1371\/journal.pone.0155660. PMID: 27171439; PMCID: PMC4865206.","journal-title":"PLoS ONE"},{"issue":"16","key":"2234_CR69","doi-asserted-by":"publisher","first-page":"4067","DOI":"10.3390\/ijms20164067","volume":"20","author":"A Angius","year":"2019","unstructured":"Angius A, Uva P, Pira G, Muroni MR, Sotgiu G, Saderi L, Uleri E, Caocci M, Ibba G, Cesaraccio MR, Serra C, Carru C, Manca A, Sanges F, Porcu A, Dolei A, Scanu AM, Rocca PC, De Miglio MR. Integrated Analysis of miRNA and mRNA endorses a twenty miRNAs signature for colorectal carcinoma. Int J Mol Sci. 2019;20(16):4067. https:\/\/doi.org\/10.3390\/ijms20164067. PMID: 31434359; PMCID: PMC6720928.","journal-title":"Int J Mol Sci"},{"key":"2234_CR70","doi-asserted-by":"crossref","unstructured":"Liu CX, Chen LL. Circular RNAs: Characterization, cellular roles, and applications. Cell. 2022;185(12):2016\u20132034. doi: 10.1016\/j.cell.2022.04.021. Epub 2022 May 17. Erratum in: Cell. 2022;185(13):2390. PMID: 35584701.","DOI":"10.1016\/j.cell.2022.04.021"},{"issue":"Pt 1","key":"2234_CR71","doi-asserted-by":"publisher","first-page":"116526","DOI":"10.1016\/j.envres.2023.116526","volume":"236","author":"R Malekzadeh","year":"2023","unstructured":"Malekzadeh R, Mortezazadeh T, Abdulsahib WK, Babaye Abdollahi B, Hamblin MR, Mansoori B, Alsaikhan F, Zeng B. Nanoarchitecture-based photothermal ablation of cancer: a systematic review. Environ Res. 2023;236(Pt 1):116526. https:\/\/doi.org\/10.1016\/j.envres.2023.116526. Epub 2023 Jul 22. PMID: 37487920.","journal-title":"Environ Res"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-025-02234-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-025-02234-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-025-02234-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T06:38:23Z","timestamp":1737700703000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02234-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2234"],"URL":"https:\/\/doi.org\/10.1186\/s12943-025-02234-9","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"assertion":[{"value":"24 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study involving human participants was reviewed and approved by the Ethics Committee of the Fourth Affiliated Hospital of Harbin Medical University (approval number 2021-WZYSLLSC-31) and was conducted in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Patients\/participants provided written informed consent for their participation in this study. All animal experiments were performed in accordance with the Guide for the Care and Use of Laboratory Animals (NIH publication No. 85\u2009\u2212\u200923, revised 1985) and were approved by the Institutional Animal Care and Use Committee of Harbin Medical University (2022-SCILLSC-30).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"29"}}