{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:42:18Z","timestamp":1792788138337,"version":"4.5.0"},"reference-count":601,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Guangdong Basic and Applied Basic Research Foundation","award":["Grant No. 2023A1515111044"],"award-info":[{"award-number":["Grant No. 2023A1515111044"]}]},{"name":"the Guangdong Basic and Applied Basic Research Foundation","award":["Grant No. 2023A1515010156"],"award-info":[{"award-number":["Grant No. 2023A1515010156"]}]},{"name":"the Guangdong Basic and Applied Basic Research Foundation","award":["Grant No.2025B1515020001"],"award-info":[{"award-number":["Grant No.2025B1515020001"]}]},{"name":"the Shenzhen Science and Technology Program","award":["Grant No. RCBS20231211090733052"],"award-info":[{"award-number":["Grant No. RCBS20231211090733052"]}]},{"name":"the Shenzhen Science and Technology Program","award":["Grant No. SGDX20240115111759001"],"award-info":[{"award-number":["Grant No. SGDX20240115111759001"]}]},{"name":"the Shenzhen Science and Technology Program","award":["Grant No. GJHZ20220913142400001"],"award-info":[{"award-number":["Grant No. GJHZ20220913142400001"]}]},{"name":"the Research Start-up Fund of Post-doctoral of SAHSYSU","award":["Grant No. ZSQYRSFPD0067"],"award-info":[{"award-number":["Grant No. ZSQYRSFPD0067"]}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["22477150"],"award-info":[{"award-number":["22477150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32270815"],"award-info":[{"award-number":["32270815"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the National Key Research and Development Program","award":["2023YFF1501203"],"award-info":[{"award-number":["2023YFF1501203"]}]},{"name":"Guangdong Province key field research and development plan","award":["Grant No. 2023B1111040002"],"award-info":[{"award-number":["Grant No. 2023B1111040002"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"DOI":"10.1186\/s12943-025-02414-7","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:03:13Z","timestamp":1760576593000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Targeting metalloptosis in tumor therapy: from molecular mechanisms to application of metal nanoparticles"],"prefix":"10.1186","volume":"24","author":[{"given":"Jinxiang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Yun","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuankai","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danting","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuanwei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leli","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"key":"2414_CR1","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41580-023-00689-6","volume":"25","author":"J Yuan","year":"2024","unstructured":"Yuan J, Ofengeim D. A guide to cell death pathways. Nat Rev Mol Cell Biol. 2024;25:379\u201395.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR2","doi-asserted-by":"crossref","unstructured":"L. Galluzzi, I. Vitale, S.A. Aaronson, J.M. Abrams, D. Adam, P. Agostinis, E.S. Alnemri, L. Altucci, I. Amelio, D.W. Andrews, M. Annicchiarico-Petruzzelli, A.V. Antonov, E. Arama, E.H. Baehrecke, N.A. Barlev, N.G. Bazan, F. Bernassola, M.J.M. Bertrand, K. Bianchi, M.V. Blagosklonny, K. Blomgren, C. Borner, P. Boya, C. Brenner, M. Campanella, E. Candi, D. Carmona-Gutierrez, F. Cecconi, F.K. Chan, N.S. Chandel, E.H. Cheng, J.E. Chipuk, J.A. Cidlowski, A. Ciechanover, G.M. Cohen, M. Conrad, J.R. Cubillos-Ruiz, P.E. Czabotar, V. D'Angiolella, T.M. Dawson, V.L. Dawson, V. De Laurenzi, R. De Maria, K.M. Debatin, R.J. DeBerardinis, M. Deshmukh, N. Di Daniele, F. Di Virgilio, V.M. Dixit, S.J. Dixon, C.S. Duckett, B.D. Dynlacht, W.S. El-Deiry, J.W. Elrod, G.M. Fimia, S. Fulda, A.J. Garcia-Saez, A.D. Garg, C. Garrido, E. Gavathiotis, P. Golstein, E. Gottlieb, D.R. Green, L.A. Greene, H. Gronemeyer, A. Gross, G. Hajnoczky, J.M. Hardwick, I.S. Harris, M.O. Hengartner, C. Hetz, H. Ichijo, M. Jaattela, B. Joseph, P.J. Jost, P.P. Juin, W.J. Kaiser, M. Karin, T. Kaufmann, O. Kepp, A. Kimchi, R.N. Kitsis, D.J. Klionsky, R.A. Knight, S. Kumar, S.W. Lee, J.J. Lemasters, B. Levine, A. Linkermann, S.A. Lipton, R.A. Lockshin, C. Lopez-Otin, S.W. Lowe, T. Luedde, E. Lugli, M. MacFarlane, F. Madeo, M. Malewicz, W. Malorni, G. Manic, J.C. Marine, S.J. Martin, J.C. Martinou, J.P. Medema, P. Mehlen, P. Meier, S. Melino, E.A. Miao, J.D. Molkentin, U.M. Moll, C. Munoz-Pinedo, S. Nagata, G. Nunez, A. Oberst, M. Oren, M. Overholtzer, M. Pagano, T. Panaretakis, M. Pasparakis, J.M. Penninger, D.M. Pereira, S. Pervaiz, M.E. Peter, M. Piacentini, P. Pinton, J.H.M. Prehn, H. Puthalakath, G.A. Rabinovich, M. Rehm, R. Rizzuto, C.M.P. Rodrigues, D.C. Rubinsztein, T. Rudel, K.M. Ryan, E. Sayan, L. Scorrano, F. Shao, Y. Shi, J. Silke, H.U. Simon, A. Sistigu, B.R. Stockwell, A. Strasser, G. Szabadkai, S.W.G. Tait, D. Tang, N. Tavernarakis, A. Thorburn, Y. Tsujimoto, B. Turk, T. Vanden Berghe, P. Vandenabeele, M.G. Vander Heiden, A. Villunger, H.W. Virgin, K.H. Vousden, D. Vucic, E.F. Wagner, H. Walczak, D. Wallach, Y. Wang, J.A. Wells, W. Wood, J. Yuan, Z. Zakeri, B. Zhivotovsky, L. Zitvogel, G. Melino, G. Kroemer. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25:486\u2013541.","DOI":"10.1038\/s41418-017-0012-4"},{"key":"2414_CR3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1038\/s41392-022-01110-y","volume":"7","author":"F Peng","year":"2022","unstructured":"Peng F, Liao M, Qin R, Zhu S, Peng C, Fu L, Chen Y, Han B. Regulated cell death (RCD) in cancer: key pathways and targeted therapies. Signal Transduct Target Ther. 2022;7:286.","journal-title":"Signal Transduct Target Ther"},{"key":"2414_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.cell.2023.11.044","volume":"187","author":"K Newton","year":"2024","unstructured":"Newton K, Strasser A, Kayagaki N, Dixit VM. Cell death. Cell. 2024;187:235\u201356.","journal-title":"Cell"},{"key":"2414_CR5","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/bjc.1972.33","volume":"26","author":"JF Kerr","year":"1972","unstructured":"Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 1972;26:239\u201357.","journal-title":"Br J Cancer"},{"key":"2414_CR6","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/s41580-023-00629-4","volume":"24","author":"PE Czabotar","year":"2023","unstructured":"Czabotar PE, Garcia-Saez AJ. Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nat Rev Mol Cell Biol. 2023;24:732\u201348.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR7","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1111\/febs.14186","volume":"285","author":"A Pena-Blanco","year":"2018","unstructured":"Pena-Blanco A, Garcia-Saez AJ. Bax, bak and beyond - mitochondrial performance in apoptosis. FEBS J. 2018;285:416\u201331.","journal-title":"FEBS J"},{"key":"2414_CR8","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","volume":"21","author":"FJ Bock","year":"2020","unstructured":"Bock FJ, Tait SWG. Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. 2020;21:85\u2013100.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR9","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1016\/j.immuni.2019.05.020","volume":"50","author":"N Van Opdenbosch","year":"2019","unstructured":"Van Opdenbosch N, Lamkanfi M. Caspases in cell death, inflammation, and disease. Immunity. 2019;50:1352\u201364.","journal-title":"Immunity"},{"key":"2414_CR10","doi-asserted-by":"publisher","first-page":"2537","DOI":"10.1038\/s41401-023-01136-0","volume":"44","author":"W Ding","year":"2023","unstructured":"Ding W, Wang JX, Wu JZ, Liu AC, Jiang LL, Zhang HC, Meng Y, Liu BY, Peng GJ, Lou EZ, Mao Q, Zhou H, Tang DL, Chen X, Liu JB, Shi XP. Targeting proteasomal deubiquitinases USP14 and UCHL5 with b-AP15 reduces 5-fluorouracil resistance in colorectal cancer cells. Acta Pharmacol Sin. 2023;44:2537\u201348.","journal-title":"Acta Pharmacol Sin"},{"key":"2414_CR11","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1007\/s11033-018-4258-9","volume":"45","author":"P Majtnerova","year":"2018","unstructured":"Majtnerova P, Rousar T. An overview of apoptosis assays detecting DNA fragmentation. Mol Biol Rep. 2018;45:1469\u201378.","journal-title":"Mol Biol Rep"},{"key":"2414_CR12","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1016\/j.apsb.2024.04.020","volume":"14","author":"X Jin","year":"2024","unstructured":"Jin X, Jin W, Tong L, Zhao J, Zhang L, Lin N. Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer. Acta Pharm Sin B. 2024;14:2815\u201353.","journal-title":"Acta Pharm Sin B"},{"key":"2414_CR13","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41556-023-01091-2","volume":"25","author":"X Liu","year":"2023","unstructured":"Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, Olszewski K, Horbath A, Chen X, Lei G, Mao C, Wu S, Zhuang L, Poyurovsky MV, You M. James, Hart T, Billadeau DD, Chen J, Gan B. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol. 2023;25:404\u201314.","journal-title":"Nat Cell Biol"},{"key":"2414_CR14","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1038\/s41392-022-01046-3","volume":"7","author":"W Gao","year":"2022","unstructured":"Gao W, Wang X, Zhou Y, Wang X, Yu Y. Autophagy, ferroptosis, pyroptosis, and necroptosis in tumor immunotherapy. Signal Transduct Target Ther. 2022;7:196.","journal-title":"Signal Transduct Target Ther"},{"key":"2414_CR15","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41422-019-0164-5","volume":"29","author":"D Tang","year":"2019","unstructured":"Tang D, Kang R, Berghe TV, Vandenabeele P, Kroemer G. The molecular machinery of regulated cell death. Cell Res. 2019;29:347\u201364.","journal-title":"Cell Res"},{"issue":"2023","key":"2414_CR16","volume":"4","author":"ZN Lei","year":"2020","unstructured":"Lei ZN, Tian Q, Teng QX, Wurpel JND, Zeng L, Pan Y, Chen ZS. Understanding and targeting resistance mechanisms in cancer. MedComm. 2020;4: e265.","journal-title":"MedComm"},{"key":"2414_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100916","volume":"66","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wu X, Ren Z, Li Y, Zou W, Chen J, Wang H. Overcoming cancer chemotherapy resistance by the induction of ferroptosis. Drug Resist Updat. 2023;66: 100916.","journal-title":"Drug Resist Updat"},{"key":"2414_CR18","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101018","volume":"72","author":"Y Wang","year":"2024","unstructured":"Wang Y, Chen Y, Zhang J, Yang Y, Fleishman JS, Wang Y, Wang J, Chen J, Li Y, Wang H. Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance. Drug Resist Updat. 2024;72: 101018.","journal-title":"Drug Resist Updat"},{"key":"2414_CR19","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.ccell.2024.03.011","volume":"42","author":"G Lei","year":"2024","unstructured":"Lei G, Zhuang L, Gan B. The roles of ferroptosis in cancer: tumor suppression, tumor microenvironment, and therapeutic interventions. Cancer Cell. 2024;42:513\u201334.","journal-title":"Cancer Cell"},{"issue":"6","key":"2414_CR20","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1021\/acsabm.2c00199","volume":"5","author":"L Zhu","year":"2022","unstructured":"Zhu L, Meng D, Wang X, Chen X. Ferroptosis-driven nanotherapeutics to reverse drug resistance in tumor microenvironment. ACS Appl Bio Mater. 2022;5:2481\u2013506.","journal-title":"ACS Appl Bio Mater"},{"key":"2414_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2024.189124","volume":"1879","author":"M Kciuk","year":"2024","unstructured":"Kciuk M, Gielecinska A, Kaluzinska-Kolat Z, Yahya EB, Kontek R. Ferroptosis and cuproptosis: metal-dependent cell death pathways activated in response to classical chemotherapy - significance for cancer treatment? Biochim Biophys Acta Rev Cancer. 2024;1879: 189124.","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"2414_CR22","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01530-y","volume":"21","author":"C Zhang","year":"2022","unstructured":"Zhang C, Liu X, Jin S, Chen Y, Guo R. Ferroptosis in cancer therapy: a novel approach to reversing drug resistance. Mol Cancer. 2022;21: 47.","journal-title":"Mol Cancer"},{"key":"2414_CR23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/s41419-024-06691-w","volume":"15","author":"QY Zhou","year":"2024","unstructured":"Zhou QY, Ren C, Li JY, Wang L, Duan Y, Yao RQ, Tian YP, Yao YM. The crosstalk between mitochondrial quality control and metal-dependent cell death. Cell Death Dis. 2024;15:299.","journal-title":"Cell Death Dis"},{"key":"2414_CR24","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/s41573-023-00749-8","volume":"22","author":"K Hadian","year":"2023","unstructured":"Hadian K, Stockwell BR. The therapeutic potential of targeting regulated non-apoptotic cell death. Nat Rev Drug Discov. 2023;22:723\u201342.","journal-title":"Nat Rev Drug Discov"},{"key":"2414_CR25","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/s41422-020-00395-4","volume":"30","author":"M Lv","year":"2020","unstructured":"Lv M, Chen M, Zhang R, Zhang W, Wang C, Zhang Y, Wei X, Guan Y, Liu J, Feng K, Jing M, Wang X, Liu YC, Mei Q, Han W, Jiang Z. Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy. Cell Res. 2020;30:966\u201379.","journal-title":"Cell Res"},{"key":"2414_CR26","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/j.jtemb.2018.08.002","volume":"51","author":"N Wiesmann","year":"2019","unstructured":"Wiesmann N, Kluenker M, Demuth P, Brenner W, Tremel W, Brieger J. Zinc overload mediated by zinc oxide nanoparticles as innovative anti-tumor agent. J Trace Elem Med Biol. 2019;51:226\u201334.","journal-title":"J Trace Elem Med Biol"},{"key":"2414_CR27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1039\/C6CS00746E","volume":"47","author":"C Qi","year":"2018","unstructured":"Qi C, Lin J, Fu LH, Huang P. Calcium-based biomaterials for diagnosis, treatment, and theranostics. Chem Soc Rev. 2018;47:357\u2013403.","journal-title":"Chem Soc Rev"},{"key":"2414_CR28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1097\/mm9.0000000000000004","volume":"1","author":"S Wang","year":"2024","unstructured":"Wang S, Ma R, Mei Z, Hou Y. Metalloptosis: metal ions-induced programmed cell death based on nanomaterials for cancer therapy. MedMat. 2024;1:6\u201326.","journal-title":"MedMat"},{"key":"2414_CR29","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","volume":"195","author":"MA Zoroddu","year":"2019","unstructured":"Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi VM. The essential metals for humans: a brief overview. J Inorg Biochem. 2019;195:120\u20139.","journal-title":"J Inorg Biochem"},{"key":"2414_CR30","doi-asserted-by":"publisher","first-page":"4557","DOI":"10.1038\/s41467-020-18425-5","volume":"11","author":"JK Kim","year":"2020","unstructured":"Kim JK, Lee C, Lim SW, Adhikari A, Andring JT, McKenna R, Ghim CM, Kim CU. Elucidating the role of metal ions in carbonic anhydrase catalysis. Nat Commun. 2020;11:4557.","journal-title":"Nat Commun"},{"key":"2414_CR31","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10534-010-9406-1","volume":"24","author":"W Maret","year":"2011","unstructured":"Maret W. Metals on the move: zinc ions in cellular regulation and in the coordination dynamics of zinc proteins. Biometals. 2011;24:411\u20138.","journal-title":"Biometals"},{"key":"2414_CR32","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1039\/C7MT00116A","volume":"9","author":"S Puig","year":"2017","unstructured":"Puig S, Ramos-Alonso L, Romero AM, Martinez-Pastor MT. The elemental role of iron in DNA synthesis and repair. Metallomics. 2017;9:1483\u2013500.","journal-title":"Metallomics"},{"key":"2414_CR33","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1002\/1873-3468.14493","volume":"597","author":"B Giese","year":"2023","unstructured":"Giese B, Karamash M, Fromm KM. Chances and challenges of long-distance electron transfer for cellular redox reactions. FEBS Lett. 2023;597:166\u201373.","journal-title":"FEBS Lett"},{"key":"2414_CR34","doi-asserted-by":"crossref","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, Morrison B 3rd, Stockwell BR. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060\u201372.","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"2414_CR35","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41419-024-06939-5","volume":"15","author":"X An","year":"2024","unstructured":"An X, Yu W, Liu J, Tang D, Yang L, Chen X. Oxidative cell death in cancer: mechanisms and therapeutic opportunities. Cell Death Dis. 2024;15:556.","journal-title":"Cell Death Dis"},{"key":"2414_CR36","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/s41589-022-01249-3","volume":"19","author":"AN von Krusenstiern","year":"2023","unstructured":"von Krusenstiern AN, Robson RN, Qian N, Qiu B, Hu F, Reznik E, Smith N, Zandkarimi F, Estes VM, Dupont M, Hirschhorn T, Shchepinov MS, Min W, Woerpel KA, Stockwell BR. Identification of essential sites of lipid peroxidation in ferroptosis. Nat Chem Biol. 2023;19:719\u201330.","journal-title":"Nat Chem Biol"},{"key":"2414_CR37","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22:266\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR38","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/j.molcel.2022.03.022","volume":"82","author":"D Liang","year":"2022","unstructured":"Liang D, Minikes AM, Jiang X. Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell. 2022;82:2215\u201327.","journal-title":"Mol Cell"},{"key":"2414_CR39","doi-asserted-by":"crossref","unstructured":"Dai E, Chen X, Linkermann A, Jiang X, Kang R, Kagan VE, Bayir H, Yang WS, Garcia-Saez AJ, Ioannou MS, Janowitz T, Ran Q, Gu W, Gan B, Krysko DV, Zhu X, Wang J, Krautwald S, Toyokuni S, Xie Y, Greten FR, Yi Q, Schick J, Liu J, Gabrilovich DI, Liu J, Zeh HJ, Zhang DD, Yang M, Iovanna J, Kopf M, Adolph TE, Chi JT, Li C, Ichijo H, Karin M, Sankaran VG, Zou W, Galluzzi L, Bush AI, Li B, Melino G, Baehrecke EH, Lotze MT, Klionsky DJ, Stockwell BR, Kroemer G, Tang D. A guideline on the molecular ecosystem regulating ferroptosis. Nat Cell Biol. 2024;26:1447\u201357.","DOI":"10.1038\/s41556-024-01360-8"},{"key":"2414_CR40","doi-asserted-by":"crossref","unstructured":"Mao C, Wang M, Zhuang L, Gan B. Metabolic cell death in cancer: Ferroptosis, cuproptosis, disulfidptosis, and beyond. Protein Cell. 2024;15:642\u201360.","DOI":"10.1093\/procel\/pwae003"},{"key":"2414_CR41","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13045-024-01564-3","volume":"17","author":"F Chen","year":"2024","unstructured":"Chen F, Kang R, Tang D, Liu J. Ferroptosis: principles and significance in health and disease. J Hematol Oncol. 2024;17:41.","journal-title":"J Hematol Oncol"},{"key":"2414_CR42","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1126\/science.abf0529","volume":"375","author":"P Tsvetkov","year":"2022","unstructured":"Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M, Rossen J, Joesch-Cohen L, Humeidi R, Spangler RD, Eaton JK, Frenkel E, Kocak M, Corsello SM, Lutsenko S, Kanarek N, Santagata S, Golub TR. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022;375:1254\u201361.","journal-title":"Science"},{"key":"2414_CR43","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nature24637","volume":"551","author":"SW Alvarez","year":"2017","unstructured":"Alvarez SW, Sviderskiy VO, Terzi EM, Papagiannakopoulos T, Moreira AL, Adams S, Sabatini DM, Birsoy K, Possemato R. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis. Nature. 2017;551:639\u201343.","journal-title":"Nature"},{"key":"2414_CR44","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1186\/s12943-023-01732-y","volume":"22","author":"J Xie","year":"2023","unstructured":"Xie J, Yang Y, Gao Y, He J. Cuproptosis: mechanisms and links with cancers. Mol Cancer. 2023;22:46.","journal-title":"Mol Cancer"},{"key":"2414_CR45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109848","author":"W Du","year":"2021","unstructured":"Du W, Gu M, Hu M, Pinchi P, Chen W, Ryan M, Nold T, Bannaga A, Xu H. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 2021;37:109848.","journal-title":"Cell Rep"},{"key":"2414_CR46","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neuro.2017.04.006","volume":"64","author":"PD Blanc","year":"2018","unstructured":"Blanc PD. The early history of manganese and the recognition of its neurotoxicity, 1837\u20131936. Neurotoxicology. 2018;64:5\u201311.","journal-title":"Neurotoxicology"},{"key":"2414_CR47","doi-asserted-by":"crossref","unstructured":"Pajarillo E, Nyarko-Danquah I, Adinew G, Rizor A, Aschner M, Lee E. Neurotoxicity mechanisms of manganese in the central nervous system. Neurotoxicity of metals: old issues and new developments. 2021;5:215\u201338.","DOI":"10.1016\/bs.ant.2020.11.003"},{"key":"2414_CR48","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/nrm1153","volume":"4","author":"R Rudolf","year":"2003","unstructured":"Rudolf R, Mongillo M, Rizzuto R, Pozzan T. Looking forward to seeing calcium. Nat Rev Mol Cell Biol. 2003;4:579\u201386.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2019.102150","volume":"86","author":"E Britti","year":"2020","unstructured":"Britti E, Ros J, Esteras N, Abramov AY. Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death. Cell Calcium. 2020;86: 102150.","journal-title":"Cell Calcium"},{"key":"2414_CR50","doi-asserted-by":"crossref","unstructured":"Fu W, Wang J, Li T, Qiao Y, Zhang Z, Zhang X, He M, Su Y, Zhao Z, Li C, Xiao R, Han Y, Zhang S, Liu Z, Lin J, Chen G, Li Y, Zhong Q. Persistent activation of TRPM4 triggers necrotic cell death characterized by sodium overload. Nat Chem Biol. 2025;21:1238\u201349.","DOI":"10.1038\/s41589-025-01841-3"},{"key":"2414_CR51","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41392-024-01889-y","volume":"9","author":"B Wang","year":"2024","unstructured":"Wang B, Hu S, Teng Y, Chen J, Wang H, Xu Y, Wang K, Xu J, Cheng Y, Gao X. Current advance of nanotechnology in diagnosis and treatment for malignant tumors. Signal Transduct Target Ther. 2024;9:200.","journal-title":"Signal Transduct Target Ther"},{"key":"2414_CR52","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.jconrel.2020.01.008","volume":"319","author":"X Shan","year":"2020","unstructured":"Shan X, Li S, Sun B, Chen Q, Sun J, He Z, Luo C. Ferroptosis-driven nanotherapeutics for cancer treatment. J Control Release. 2020;319:322\u201332.","journal-title":"J Control Release"},{"key":"2414_CR53","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.jconrel.2019.06.017","volume":"307","author":"AI Matos","year":"2019","unstructured":"Matos AI, Carreira B, Peres C, Moura LIF, Conniot J, Fourniols T, Scomparin A, Martinez-Barriocanal A, Arango D, Conde JP, Preat V, Satchi-Fainaro R, Florindo HF. Nanotechnology is an important strategy for combinational innovative chemo-immunotherapies against colorectal cancer. J Control Release. 2019;307:108\u201338.","journal-title":"J Control Release"},{"key":"2414_CR54","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.tips.2017.10.009","volume":"39","author":"Q Chen","year":"2018","unstructured":"Chen Q, Liu G, Liu S, Su H, Wang Y, Li J, Luo C. Remodeling the tumor microenvironment with emerging nanotherapeutics. Trends Pharmacol Sci. 2018;39:59\u201374.","journal-title":"Trends Pharmacol Sci"},{"key":"2414_CR55","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.tips.2014.09.008","volume":"35","author":"C Luo","year":"2014","unstructured":"Luo C, Sun J, Sun B, He Z. Prodrug-based nanoparticulate drug delivery strategies for cancer therapy. Trends Pharmacol Sci. 2014;35:556\u201366.","journal-title":"Trends Pharmacol Sci"},{"key":"2414_CR56","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nrc.2016.108","volume":"17","author":"J Shi","year":"2017","unstructured":"Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017;17:20\u201337.","journal-title":"Nat Rev Cancer"},{"key":"2414_CR57","doi-asserted-by":"publisher","first-page":"19581","DOI":"10.1021\/acsnano.3c07775","volume":"17","author":"W Wang","year":"2023","unstructured":"Wang W, Mo W, Hang Z, Huang Y, Yi H, Sun Z, Lei A. Cuproptosis: harnessing transition metal for cancer therapy. ACS Nano. 2023;17:19581\u201399.","journal-title":"ACS Nano"},{"key":"2414_CR58","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01182-w","author":"T Xu","year":"2022","unstructured":"Xu T, Ma Q, Li Y, Yu Q, Pan P, Zheng Y, Li Z, Xiong X, Hou T, Yu B, Liu H, Sun Y. A small molecule inhibitor of the UBE2F-CRL5 axis induces apoptosis and radiosensitization in lung cancer. Signal Transduct Target Ther. 2022;7:354.","journal-title":"Signal Transduct Target Ther"},{"key":"2414_CR59","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1038\/cr.2016.26","volume":"26","author":"B Xia","year":"2016","unstructured":"Xia B, Fang S, Chen X, Hu H, Chen P, Wang H, Gao Z. MLKL forms cation channels. Cell Res. 2016;26:517\u201328.","journal-title":"Cell Res"},{"key":"2414_CR60","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/biolre\/ioae095","volume":"111","author":"N de Dios","year":"2024","unstructured":"de Dios N, Riedel R, Schanton M, Balestrini P, P\u00e9rez L, P\u00e9rez-P\u00e9rez A, Etcheverry T, Casale R, Farina M, S\u00e1nchez-Margalet V, Maym\u00f3 J, Varone C. Placental apoptosis increased by hypoxia inducible factor-1 stabilization is counteracted by leptin. Biol Reprod. 2024;111:708\u201322.","journal-title":"Biol Reprod"},{"key":"2414_CR61","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jare.2024.04.033","volume":"65","author":"Y Wu","year":"2024","unstructured":"Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z. Sodium citrate targeting Ca2+\/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer. J Adv Res. 2024;65:89\u2013104.","journal-title":"J Adv Res"},{"key":"2414_CR62","doi-asserted-by":"publisher","first-page":"3332","DOI":"10.1182\/blood-2021-148127","volume":"138","author":"BZ Carter","year":"2021","unstructured":"Carter BZ, Tao W, Ostermann LB, Mu-Mosley H, Mak PY, Boettcher S, Nishida Y, Tao R, Lang E, Zhai Y, Yang D, Andreeff M. Co-targeting intrinsic and extrinsic apoptosis to maximize cell death induction in Venetoclax-resistant AML cells. Blood. 2021;138:3332\u20133332.","journal-title":"Blood"},{"key":"2414_CR63","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41568-021-00407-4","volume":"22","author":"ST Diepstraten","year":"2021","unstructured":"Diepstraten ST, Anderson MA, Czabotar PE, Lessene G, Strasser A, Kelly GL. The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs. Nat Rev Cancer. 2021;22:45\u201364.","journal-title":"Nat Rev Cancer"},{"key":"2414_CR64","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0486-y","author":"P Chandler","year":"2016","unstructured":"Chandler P, Kochupurakkal BS, Alam S, Richardson AL, Soybel DI, Kelleher SL. Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer. Mol Cancer. 2016;15:2.","journal-title":"Mol Cancer"},{"key":"2414_CR65","doi-asserted-by":"publisher","first-page":"6914","DOI":"10.1021\/jm049568z","volume":"47","author":"D Cen","year":"2004","unstructured":"Cen D, Brayton D, Shahandeh B, Meyskens FL, Farmer PJ. Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells. J Med Chem. 2004;47:6914\u201320.","journal-title":"J Med Chem"},{"key":"2414_CR66","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1038\/s41418-018-0252-y","volume":"26","author":"D Denton","year":"2018","unstructured":"Denton D, Kumar S. Autophagy-dependent cell death. Cell Death Differ. 2018;26:605\u201316.","journal-title":"Cell Death Differ"},{"key":"2414_CR67","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41565-023-01562-5","volume":"19","author":"X Huang","year":"2024","unstructured":"Huang X, Cao Z, Qian J, Ding T, Wu Y, Zhang H, Zhong S, Wang X, Ren X, Zhang W, Xu Y, Yao G, Wang X, Yang X, Wen L, Zhang Y. Nanoreceptors promote mutant p53 protein degradation by mimicking selective autophagy receptors. Nat Nanotechnol. 2024;19:545\u201353.","journal-title":"Nat Nanotechnol"},{"key":"2414_CR68","doi-asserted-by":"publisher","first-page":"25346","DOI":"10.1002\/anie.202108961","volume":"60","author":"L Chen","year":"2021","unstructured":"Chen L, Li N, Zhang M, Sun M, Bian J, Yang B, Li Z, Wang J, Li F, Shi X, Wang Y, Yuan F, Zou P, Shan C, Wang J. Apex2-based proximity labeling of Atox1 identifies CRIP2 as a nuclear copper-binding protein that regulates autophagy activation. Angew Chem Int Ed. 2021;60:25346\u201355.","journal-title":"Angew Chem Int Ed"},{"key":"2414_CR69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20309-7","author":"H Fang","year":"2021","unstructured":"Fang H, Geng S, Hao M, Chen Q, Liu M, Liu C, Tian Z, Wang C, Takebe T, Guan J-L, Chen Y, Guo Z, He W, Diao J. Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells. Nat Commun. 2021;12:109.","journal-title":"Nat Commun"},{"key":"2414_CR70","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.1016\/j.celrep.2016.07.082","volume":"16","author":"S Missiroli","year":"2016","unstructured":"Missiroli S, Bonora M, Patergnani S, Poletti F, Perrone M, Gaf\u00e0 R, Magri E, Raimondi A, Lanza G, Tacchetti C, Kroemer G, Pandolfi Pier P., Pinton P, Giorgi C. PML at mitochondria-associated membranes is critical for the repression of autophagy and cancer development. Cell Rep. 2016;16:2415\u201327.","journal-title":"Cell Rep"},{"key":"2414_CR71","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1002\/art.42540","volume":"75","author":"H Nakamura","year":"2023","unstructured":"Nakamura H, Tanaka T, Zheng C, Afione SA, Warner BM, Noguchi M, Atsumi T, Chiorini JA. Lysosome-associated membrane protein 3 induces lysosome-dependent cell death by impairing autophagic caspase 8 degradation in the salivary glands of individuals with Sj\u00f6gren\u2019s disease. Arthritis Rheumatol. 2023;75:1586\u201398.","journal-title":"Arthritis Rheumatol"},{"key":"2414_CR72","doi-asserted-by":"crossref","unstructured":"He J, Ma X, Zhang J, Yang Yp, Qin H, Chen H, Wei S, Li F, Wang J, Liang G, Zou Y. Manganese-induced neurological pyroptosis: Unveiling the mechanism through the ROS activaed Caspase-3\/GSDME signaling pathway.\u00a0Food Chem Toxicol. 2024;184:114322.","DOI":"10.1016\/j.fct.2023.114322"},{"key":"2414_CR73","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202215307","author":"B Ding","year":"2023","unstructured":"Ding B, Chen H, Tan J, Meng Q, Zheng P, Ma Pa, Lin J. ZIF\u20108 nanoparticles evoke pyroptosis for high\u2010efficiency cancer immunotherapy. Angew Chem Int Ed Engl. 2023;62:e202215307.","journal-title":"Angew Chem Int Ed Engl"},{"key":"2414_CR74","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202216917","author":"X Su","year":"2023","unstructured":"Su X, Liu B, Wang WJ, Peng K, Liang BB, Zheng Y, Cao Q, Mao ZW. Disruption of zinc homeostasis by a novel platinum(IV)\u2010terthiophene complex for antitumor immunity. Angew Chem Int Ed Engl. 2023;62:e202216917.","journal-title":"Angew Chem Int Ed Engl"},{"key":"2414_CR75","doi-asserted-by":"publisher","first-page":"1237","DOI":"10.1038\/s41401-019-0222-z","volume":"40","author":"P Yu","year":"2019","unstructured":"Yu P, Wang H-Y, Tian M, Li A-X, Chen X-S, Wang X-L, Zhang Y, Cheng Y. Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro. Acta Pharmacol Sin. 2019;40:1237\u201344.","journal-title":"Acta Pharmacol Sin"},{"key":"2414_CR76","doi-asserted-by":"publisher","DOI":"10.26599\/NTM.2022.9130001","author":"Z-J Sun","year":"2022","unstructured":"Sun Z-J, Wang W-D. Evoking pyroptosis with nanomaterials for cancer immunotherapy: current boom and novel outlook. Nano TransMed. 2022;1: e9130001.","journal-title":"Nano TransMed"},{"key":"2414_CR77","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.freeradbiomed.2023.03.020","volume":"202","author":"Q Xiao","year":"2023","unstructured":"Xiao Q, Zhong B, Hou Y, Wang M, Guo B, Lin L, Zhou Y, Chen X. Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction. Free Radic Biol Med. 2023;202:35\u201345.","journal-title":"Free Radic Biol Med"},{"key":"2414_CR78","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0006-291X(03)00618-1","volume":"304","author":"J-S Kim","year":"2003","unstructured":"Kim J-S, He L, Lemasters JJ. Mitochondrial permeability transition: a common pathway to necrosis and apoptosis. Biochem Biophys Res Commun. 2003;304:463\u201370.","journal-title":"Biochem Biophys Res Commun"},{"key":"2414_CR79","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.ccell.2023.03.008","volume":"41","author":"A Mousset","year":"2023","unstructured":"Mousset A, Lecorgne E, Bourget I, Lopez P, Jenovai K, Cherfils-Vicini J, Dominici C, Rios G, Girard-Riboulleau C, Liu B, Spector DL, Ehmsen S, Renault S, Hego C, Mechta-Grigoriou F, Bidard F-C, Terp MG, Egeblad M, Gaggioli C, Albrengues J. Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-\u03b2 activation. Cancer Cell. 2023;41:757-775.e710.","journal-title":"Cancer Cell"},{"key":"2414_CR80","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","volume":"303","author":"V Brinkmann","year":"2004","unstructured":"Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, Weinrauch Y, Zychlinsky A. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532\u20135.","journal-title":"Science"},{"key":"2414_CR81","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101983","author":"M Inoue","year":"2021","unstructured":"Inoue M, Enomoto M, Yoshimura M, Mizowaki T. Pharmacological inhibition of sodium-calcium exchange activates NADPH oxidase and induces infection-independent NETotic cell death. Redox Biol. 2021;43:101983.","journal-title":"Redox Biol"},{"key":"2414_CR82","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.chemosphere.2019.02.035","volume":"223","author":"C. ThankGod Eze","year":"2019","unstructured":"Eze C. ThankGod, Michelangeli F, Otitoloju AA. In\u00a0vitro cyto-toxic assessment of heavy metals and their binary mixtures on mast cell-like, rat basophilic leukemia (RBL-2H3) cells. Chemosphere. 2019;223:686\u201393.","journal-title":"Chemosphere"},{"key":"2414_CR83","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.trecan.2021.09.003","volume":"8","author":"J Yan","year":"2022","unstructured":"Yan J, Wan P, Choksi S, Liu Z-G. Necroptosis and tumor progression. Trends Cancer. 2022;8:21\u20137.","journal-title":"Trends Cancer"},{"key":"2414_CR84","doi-asserted-by":"publisher","first-page":"5266","DOI":"10.7150\/thno.81650","volume":"13","author":"W Feng","year":"2023","unstructured":"Feng W, Shi W, Cui Y, Xu J, Liu S, Gao H, Zhu S, Liu Y, Zhang H. Fe(III)-Shikonin supramolecular nanomedicines as immunogenic cell death stimulants and multifunctional immunoadjuvants for tumor vaccination. Theranostics. 2023;13:5266\u201389.","journal-title":"Theranostics"},{"key":"2414_CR85","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.jconrel.2024.04.042","volume":"370","author":"L Yang","year":"2024","unstructured":"Yang L, Wang Y, Song Y, Li Z, Lei L, Li H, He B, Cao J, Gao H. Metal coordination nanotheranostics mediated by nucleoside metabolic inhibitors potentiate STING pathway activation for cancer metalloimmunotherapy. J Control Release. 2024;370:354\u201366.","journal-title":"J Control Release"},{"key":"2414_CR86","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202205913","author":"AR Lee","year":"2023","unstructured":"Lee AR, Park CY. Orai1 is an entotic Ca2+ channel for non\u2010apoptotic cell death, entosis in cancer development. Adv Sci. 2023;10:e2205913.","journal-title":"Adv Sci"},{"key":"2414_CR87","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14010011","author":"Y Li","year":"2024","unstructured":"Li Y, Wei J, Ye Z, Ji C, Li W, Xu L, Zhou Z. Essential oils from citrus peels promote calcium overload-induced calcicoptosis in U251 cells. Antioxidants. 2024;14:11.","journal-title":"Antioxidants"},{"key":"2414_CR88","doi-asserted-by":"crossref","unstructured":"Zhou M, Boulos JC, Omer EA, Rudbari HA, Schirmeister T, Micale N, Efferth T. Two palladium (II) complexes derived from halogen-substituted Schiff bases and 2-picolylamine induce parthanatos-type cell death in sensitive and multi-drug resistant CCRF-CEM leukemia cells. Eur J Pharmacol. 2023;956:175980.","DOI":"10.1016\/j.ejphar.2023.175980"},{"key":"2414_CR89","doi-asserted-by":"crossref","unstructured":"Li C, Xue Y, Wu J, Zhang L, Yang T, Ai M, Han J, Zheng X, Wang R, Boldogh I, Ba X. MTH1 inhibition synergizes with ROS-inducing agents to trigger cervical cancer cells undergoing parthanatos. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2024;1870:167190.","DOI":"10.1016\/j.bbadis.2024.167190"},{"key":"2414_CR90","doi-asserted-by":"crossref","unstructured":"S. Zhou, J. Liu, A. Wan, Y. Zhang, X. Qi. Epigenetic regulation of diverse cell death modalities in cancer: a focus on pyroptosis, ferroptosis, cuproptosis, and disulfidptosis. J Hematol Oncol. 2024;17:22.","DOI":"10.1186\/s13045-024-01545-6"},{"key":"2414_CR91","doi-asserted-by":"crossref","unstructured":"Anandhan A, Dodson M, Shakya A, Chen J, Liu P, Wei Y, Tan H, Wang Q, Jiang Z, Yang K, Garcia JGN, Chambers SK, Chapman E, Ooi A, Yang-Hartwich Y, Stockwell BR, Zhang DD. NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8. Sci Adv. 2023; 9:eade9585.","DOI":"10.1126\/sciadv.ade9585"},{"key":"2414_CR92","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03482-5","author":"P-H Chen","year":"2021","unstructured":"Chen P-H, Wu J, Xu Y, Ding C-KC, Mestre AA, Lin C-C, Yang W-H, Chi J-T. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021;12:198.","journal-title":"Cell Death Dis"},{"key":"2414_CR93","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1053\/j.gastro.2017.12.004","volume":"154","author":"X Song","year":"2018","unstructured":"Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, Wang P, Ma X, Kroemer G, Bartlett DL, Billiar TR, Lotze MT, Zeh HJ, Kang R, Tang D. JTC801 induces pH-dependent death specifically in cancer cells and slows growth of tumors in mice. Gastroenterology. 2018;154:1480\u201393.","journal-title":"Gastroenterology"},{"key":"2414_CR94","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/s41590-017-0013-y","volume":"19","author":"C Holze","year":"2017","unstructured":"Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A. Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway. Nat Immunol. 2017;19:130\u201340.","journal-title":"Nat Immunol"},{"key":"2414_CR95","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12030678","author":"X Chen","year":"2024","unstructured":"Chen X, Song Y, Chen G, Zhang B, Bai Y, Sun C, Fan D, Chen Z. Circular RNA CircFOXO3 functions as a competitive endogenous RNA for acid-sensing ion channel subunit 1 mediating oxeiptosis in nucleus pulposus. Biomedicines. 2024;12:678.","journal-title":"Biomedicines"},{"key":"2414_CR96","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-03059-2","author":"Y Chen","year":"2024","unstructured":"Chen Y, Tian H, Zhang X, Nice EC, Huang C, Zhang H, Zheng S. Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming. J Nanobiotechnology. 2024;22:801.","journal-title":"J Nanobiotechnology"},{"key":"2414_CR97","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5343","author":"P Li","year":"2024","unstructured":"Li P, Sun Q, Bai S, Wang H, Zhao L. Combination of the cuproptosis inducer disulfiram and anti\u2011PD\u2011L1 abolishes NSCLC resistance by ATP7B to regulate the HIF\u20111 signaling pathway. Int J Mol Med. 2024;53:19.","journal-title":"Int J Mol Med"},{"key":"2414_CR98","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.502","author":"J Xie","year":"2024","unstructured":"Xie J, Deng X, Xie Y, Zhu H, Liu P, Deng W, Ning L, Tang Y, Sun Y, Tang H, Cai M, Xie X, Zou Y. Multi\u2010omics analysis of disulfidptosis regulators and therapeutic potential reveals glycogen synthase 1 as a disulfidptosis triggering target for triple\u2010negative breast cancer. MedComm. 2024;5:e502.","journal-title":"MedComm"},{"key":"2414_CR99","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1039\/D4CS00930D","volume":"54","author":"YW You","year":"2025","unstructured":"You YW, Guo ZC, Wolter T, Hu QY. Intracellular metal ion-based chemistry for programmed cell death. Chem Soc Rev. 2025;54:1552\u201382.","journal-title":"Chem Soc Rev"},{"key":"2414_CR100","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-024-09910-4","author":"Y Lai","year":"2024","unstructured":"Lai Y, Gao Ff, Ge Rt, Liu R, Ma S, Liu X. Metal ions overloading and cell death. Cell Biol Toxicol. 2024;40:72.","journal-title":"Cell Biol Toxicol"},{"key":"2414_CR101","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Kang R, Kroemer G, Tang D. Broadening horizons: the role of ferroptosis in cancer. Nat Rev Clin Oncol. 2021;18:280\u201396.","journal-title":"Nat Rev Clin Oncol"},{"key":"2414_CR102","doi-asserted-by":"publisher","first-page":"11355","DOI":"10.1021\/acsnano.8b06201","volume":"12","author":"Z Shen","year":"2018","unstructured":"Shen Z, Liu T, Li Y, Lau J, Yang Z, Fan W, Zhou Z, Shi C, Ke C, Bregadze VI, Mandal SK, Liu Y, Li Z, Xue T, Zhu G, Munasinghe J, Niu G, Wu A, Chen X. Fenton-reaction-acceleratable magnetic nanoparticles for ferroptosis therapy of orthotopic brain tumors. ACS Nano. 2018;12:11355\u201365.","journal-title":"ACS Nano"},{"key":"2414_CR103","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/nrc3495","volume":"13","author":"SV Torti","year":"2013","unstructured":"Torti SV, Torti FM. Iron and cancer: more ore to be mined. Nat Rev Cancer. 2013;13:342\u201355.","journal-title":"Nat Rev Cancer"},{"key":"2414_CR104","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1158\/2159-8290.CD-22-0043","volume":"12","author":"N Santana-Codina","year":"2022","unstructured":"Santana-Codina N, Del Rey MQ, Kapner KS, Zhang H, Gikandi A, Malcolm C, Poupault C, Kuljanin M, John KM, Biancur DE, Chen B, Das NK, Lowder KE, Hennessey CJ, Huang W, Yang A, Shah YM, Nowak JA, Aguirre AJ, Mancias JD. NCOA4-mediated ferritinophagy is a pancreatic cancer dependency via maintenance of iron bioavailability for iron-sulfur cluster proteins. Cancer Discov. 2022;12:2180\u201397.","journal-title":"Cancer Discov"},{"key":"2414_CR105","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202051162","volume":"22","author":"J Song","year":"2021","unstructured":"Song J, Liu T, Yin Y, Zhao W, Lin Z, Yin Y, Lu D, You F. The deubiquitinase OTUD1 enhances iron transport and potentiates host antitumor immunity. EMBO Rep. 2021;22: e51162.","journal-title":"EMBO Rep"},{"key":"2414_CR106","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.freeradbiomed.2018.09.014","volume":"133","author":"TM Seibt","year":"2019","unstructured":"Seibt TM, Proneth B, Conrad M. Role of GPX4 in ferroptosis and its pharmacological implication. Free Radic Biol Med. 2019;133:144\u201352.","journal-title":"Free Radic Biol Med"},{"key":"2414_CR107","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1038\/s42255-023-00863-2","volume":"5","author":"T TeSlaa","year":"2023","unstructured":"TeSlaa T, Ralser M, Fan J, Rabinowitz JD. The pentose phosphate pathway in health and disease. Nat Metab. 2023;5:1275\u201389.","journal-title":"Nat Metab"},{"key":"2414_CR108","first-page":"436","volume":"27","author":"A Anandhan","year":"2020","unstructured":"Anandhan A, Dodson M, Schmidlin CJ, Liu P, Zhang DD. Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis, Cell. Chem Biol. 2020;27:436\u201347.","journal-title":"Chem Biol"},{"key":"2414_CR109","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201847563","author":"Y Wang","year":"2019","unstructured":"Wang Y, Yang L, Zhang X, Cui W, Liu Y, Sun QR, He Q, Zhao S, Zhang GA, Wang Y, Chen S. Epigenetic regulation of ferroptosis by H2B monoubiquitination and p53. EMBO Rep. 2019;20:e47563.","journal-title":"EMBO Rep"},{"key":"2414_CR110","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nature14344","volume":"520","author":"L Jiang","year":"2015","unstructured":"Jiang L, Kon N, Li T, Wang S-J, Su T, Hibshoosh H, Baer R, Gu W. Ferroptosis as a p53-mediated activity during tumour suppression. Nature. 2015;520:57\u201362.","journal-title":"Nature"},{"key":"2414_CR111","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1038\/s41556-019-0305-6","volume":"21","author":"B Chu","year":"2019","unstructured":"Chu B, Kon N, Chen D, Li T, Liu T, Jiang L, Song S, Tavana O, Gu W. ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway. Nat Cell Biol. 2019;21:579\u201391.","journal-title":"Nat Cell Biol"},{"key":"2414_CR112","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.tcb.2023.05.003","volume":"33","author":"LE Pope","year":"2023","unstructured":"Pope LE, Dixon SJ. Regulation of ferroptosis by lipid metabolism. Trends Cell Biol. 2023;33:1077\u201387.","journal-title":"Trends Cell Biol"},{"key":"2414_CR113","doi-asserted-by":"crossref","unstructured":"Gao M, Yi J, Zhu J, Minikes AM, Monian P, Thompson CB, Jiang X. Role of Mitochondria in Ferroptosis. Mol Cell. 2019;73:354\u201363.e53.","DOI":"10.1016\/j.molcel.2018.10.042"},{"key":"2414_CR114","doi-asserted-by":"crossref","unstructured":"Yan B, Ai Y, Sun Q, Ma Y, Cao Y, Wang J, Zhang Z, Wang X.\u00a0Membrane damage during ferroptosis is caused by oxidation of phospholipids catalyzed by the oxidoreductases POR and CYB5R1. Mol Cell. 2021;81(2):355\u201369.e10.","DOI":"10.1016\/j.molcel.2020.11.024"},{"key":"2414_CR115","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/s41556-024-01361-7","volume":"26","author":"DD Zhang","year":"2024","unstructured":"Zhang DD. Ironing out the details of ferroptosis. Nat Cell Biol. 2024;26:1386\u201393.","journal-title":"Nat Cell Biol."},{"key":"2414_CR116","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","volume":"15","author":"M Conrad","year":"2019","unstructured":"Conrad M, Pratt DA. The chemical basis of ferroptosis. Nat Chem Biol. 2019;15:1137\u201347.","journal-title":"Nat Chem Biol"},{"key":"2414_CR117","first-page":"1363","volume":"29","author":"H Lee","year":"2022","unstructured":"Lee H, Gan B. Ferroptosis execution: Is it all about ACSL4?, Cell. Chem Biol. 2022;29:1363\u20135.","journal-title":"Chem Biol"},{"key":"2414_CR118","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/cr.2012.70","volume":"22","author":"JM Rodriguez-Vargas","year":"2012","unstructured":"Rodriguez-Vargas JM, Ruiz-Magana MJ, Ruiz-Ruiz C, Majuelos-Melguizo J, Peralta-Leal A, Rodriguez MI, Munoz-Gamez JA, de Almodovar MR, Siles E, Rivas AL, Jaattela M, Oliver FJ. ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy. Cell Res. 2012;22:1181\u201398.","journal-title":"Cell Res"},{"key":"2414_CR119","doi-asserted-by":"publisher","first-page":"e143691","DOI":"10.1172\/JCI143691","volume":"131","author":"R Singhal","year":"2021","unstructured":"Singhal R, Mitta SR, Das NK, Kerk SA, Sajjakulnukit P, Solanki S, Andren A, Kumar R, Olive KP, Banerjee R, Lyssiotis CA, Shah YM. HIF-2alpha activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron. J Clin Invest. 2021;131:e143691.","journal-title":"J Clin Invest."},{"key":"2414_CR120","doi-asserted-by":"crossref","unstructured":"Wang Y, Zhang M, Bi R, Su Y, Quan F, Lin Y, Yue C, Cui X, Zhao Q, Liu S, Yang Y, Zhang D, Cao Q, Gao X. ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury. Redox Biol. 2022;51:102262.","DOI":"10.1016\/j.redox.2022.102262"},{"key":"2414_CR121","doi-asserted-by":"crossref","unstructured":"Wenzel SE, Tyurina YY, Zhao J, St Croix CM, Dar HH, Mao G, Tyurin VA, Anthonymuthu TS, Kapralov AA, Amoscato AA, Mikulska-Ruminska K, Shrivastava IH, Kenny EM, Yang Q, Rosenbaum JC, Sparvero LJ, Emlet DR, Wen X, Minami Y, Qu F, Watkins SC, Holman TR, VanDemark AP, Kellum JA, Bahar I, Bayir H, Kagan VE.\u00a0PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals. Cell. 2017;171:628\u201341.e26.","DOI":"10.1016\/j.cell.2017.09.044"},{"key":"2414_CR122","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.molmed.2023.05.013","volume":"29","author":"W Li","year":"2023","unstructured":"Li W, Liang L, Liu S, Yi H, Zhou Y. FSP1: a key regulator of ferroptosis. Trends Mol Med. 2023;29:753\u201364.","journal-title":"Trends Mol Med"},{"key":"2414_CR123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.115015","volume":"247","author":"Y Gu","year":"2023","unstructured":"Gu Y, Li Y, Wang J, Zhang L, Zhang J, Wang Y. Targeting ferroptosis: Paving new roads for drug design and discovery. Eur J Med Chem. 2023;247: 115015.","journal-title":"Eur J Med Chem"},{"key":"2414_CR124","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12761","volume":"53","author":"Z Ye","year":"2020","unstructured":"Ye Z, Liu W, Zhuo Q, Hu Q, Liu M, Sun Q, Zhang Z, Fan G, Xu W, Ji S, Yu X, Qin Y, Xu X. Ferroptosis: Final destination for cancer? Cell Prolif. 2020;53: e12761.","journal-title":"Cell Prolif"},{"key":"2414_CR125","first-page":"12","volume":"38","author":"P Koppula","year":"2018","unstructured":"Koppula P, Zhang Y, Zhuang L, Gan B. Amino acid transporter SLC7A11\/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond). 2018;38:12.","journal-title":"Cancer Commun (Lond)"},{"key":"2414_CR126","doi-asserted-by":"publisher","first-page":"11455","DOI":"10.1074\/jbc.274.17.11455","volume":"274","author":"H Sato","year":"1999","unstructured":"Sato H, Tamba M, Ishii T, Bannai S. Cloning and expression of a plasma membrane cystine\/glutamate exchange transporter composed of two distinct proteins. J Biol Chem. 1999;274:11455\u20138.","journal-title":"J Biol Chem"},{"key":"2414_CR127","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.niox.2018.05.005","volume":"78","author":"S Kobayashi","year":"2018","unstructured":"Kobayashi S, Hamashima S, Homma T, Sato M, Kusumi R, Bannai S, Fujii J, Sato H. Cystine\/glutamate transporter, system x(c)(-), is involved in nitric oxide production in mouse peritoneal macrophages. Nitric Oxide. 2018;78:32\u201340.","journal-title":"Nitric Oxide"},{"key":"2414_CR128","doi-asserted-by":"crossref","unstructured":"Doll S, Freitas FP, Shah R, Aldrovandi M, da Silva MC, Ingold I, Goya Grocin A, Xavier da Silva TN, Panzilius E, Scheel CH, Mour\u00e3o A, Buday K, Sato M, Wanninger J, Vignane I, Mohana V, Rehberg M, Flatley A, Schepers A, Kurz A, White D, Sauer M, Sattler M, Tate EW, Schmitz W, Schulze A, O'Donnell V, Proneth B, Popowicz GM, Pratt DA, Angeli JPF, Conrad AM. FSP1 is a glutathione-independent ferroptosis suppressor. Nature. 2019;575:693\u201398.","DOI":"10.1038\/s41586-019-1707-0"},{"key":"2414_CR129","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","volume":"575","author":"K Bersuker","year":"2019","unstructured":"Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA. The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis. Nature. 2019;575:688\u201392.","journal-title":"Nature"},{"key":"2414_CR130","doi-asserted-by":"crossref","unstructured":"Capelletti MM, Manceau H, Puy H, Peoc\u2019h K.\u00a0Ferroptosis in liver diseases: an overview.\u00a0Int J of Mol Sci. 2020;21:4908.","DOI":"10.3390\/ijms21144908"},{"key":"2414_CR131","first-page":"133","volume":"16","author":"JW Cheu","year":"2023","unstructured":"Cheu JW, Lee D, Li Q, Goh CC, Bao MH, Yuen VW, Zhang MS, Yang C, Chan CY, Tse AP, Sit GF, Liu CX, Ng IO, Wong CM, Wong CC. Ferroptosis Suppressor Protein 1 Inhibition Promotes Tumor Ferroptosis and Anti-tumor Immune Responses in Liver Cancer, Cell Mol. Gastroenterol Hepatol. 2023;16:133\u201359.","journal-title":"Gastroenterol Hepatol"},{"key":"2414_CR132","doi-asserted-by":"publisher","first-page":"2532","DOI":"10.1007\/s12094-023-03136-2","volume":"25","author":"J Zang","year":"2023","unstructured":"Zang J, Cui M, Xiao L, Zhang J, Jing R. Overexpression of ferroptosis-related genes FSP1 and CISD1 is related to prognosis and tumor immune infiltration in gastric cancer. Clin Transl Oncol. 2023;25:2532\u201344.","journal-title":"Clin Transl Oncol"},{"key":"2414_CR133","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1016\/j.bbrc.2020.01.066","volume":"523","author":"E Dai","year":"2020","unstructured":"Dai E, Zhang W, Cong D, Kang R, Wang J, Tang D. AIFM2 blocks ferroptosis independent of ubiquinol metabolism. Biochem Biophys Res Commun. 2020;523:966\u201371.","journal-title":"Biochem Biophys Res Commun"},{"key":"2414_CR134","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1186\/s12943-024-02088-7","volume":"23","author":"H Wang","year":"2024","unstructured":"Wang H, Fleishman JS, Cheng S, Wang W, Wu F, Wang Y, Wang Y. Epigenetic modification of ferroptosis by non-coding RNAs in cancer drug resistance. Mol Cancer. 2024;23:177.","journal-title":"Mol Cancer"},{"key":"2414_CR135","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","volume":"16","author":"M Soula","year":"2020","unstructured":"Soula M, Weber RA, Zilka O, Alwaseem H, La K, Yen F, Molina H, Garcia-Bermudez J, Pratt DA, Birsoy K. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers. Nat Chem Biol. 2020;16:1351\u201360.","journal-title":"Nat Chem Biol"},{"key":"2414_CR136","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1021\/acscentsci.9b01063","volume":"6","author":"VAN Kraft","year":"2020","unstructured":"Kraft VAN, Bezjian CT, Pfeiffer S, Ringelstetter L, Muller C, Zandkarimi F, Merl-Pham J, Bao X, Anastasov N, Kossl J, Brandner S, Daniels JD, Schmitt-Kopplin P, Hauck SM, Stockwell BR, Hadian K, Schick JA. GTP cyclohydrolase 1\/tetrahydrobiopterin counteract ferroptosis through lipid remodeling. ACS Cent Sci. 2020;6:41\u201353.","journal-title":"ACS Cent Sci"},{"key":"2414_CR137","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/s41418-022-01089-7","volume":"30","author":"D Wang","year":"2023","unstructured":"Wang D, Liang W, Huo D, Wang H, Wang Y, Cong C, Zhang C, Yan S, Gao M, Su X, Tan X, Zhang W, Han L, Zhang D, Feng H. SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1. Cell Death Differ. 2023;30:369\u201382.","journal-title":"Cell Death Differ"},{"key":"2414_CR138","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","volume":"593","author":"C Mao","year":"2021","unstructured":"Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 2021;593:586\u201390.","journal-title":"Nature"},{"key":"2414_CR139","doi-asserted-by":"crossref","unstructured":"Liang D, Feng Y, Zandkarimi F, Wang H, Zhang Z, Kim J, Cai Y, Gu W, Stockwell BR, Jiang X.\u00a0Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones. Cell. 2023;186:2748\u201364.e22.","DOI":"10.1016\/j.cell.2023.05.003"},{"key":"2414_CR140","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nchembio.2239","volume":"13","author":"S Doll","year":"2016","unstructured":"Doll S, Proneth B, Tyurina YY, Panzilius E, Kobayashi S, Ingold I, Irmler M, Beckers J, Aichler M, Walch A, Prokisch H, Tr\u00fcmbach D, Mao G, Qu F, Bayir H, F\u00fcllekrug J, Scheel CH, Wurst W, Schick JA, Kagan VE, Angeli JPF, Conrad M. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2016;13:91\u20138.","journal-title":"Nat Chem Biol"},{"key":"2414_CR141","doi-asserted-by":"crossref","unstructured":"Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B. Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, Chen Z, Atici S, Doll SG, Schaefer EL, Ekpo I, Schmitz W, Horling A, Imming P, Miyamoto S, Wehman AM, Genaro-Mattos TC, Mirnics K, Kumar L, Klein-Seetharaman J, Meierjohann S, Weigand I, Kroiss M. Bornkamm GW, Gomes F, Netto LES, Sathian MB, Konrad DB, Covey DF, Michalke B, Bommert K, Bargou RC, Garcia-Saez A, Pratt DA, Fedorova M, Trumpp A, Conrad M, Friedmann Angeli JP.\u00a07-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature. 2024;626:401\u201310.","DOI":"10.1038\/s41586-023-06878-9"},{"key":"2414_CR142","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1038\/s41586-023-06983-9","volume":"626","author":"Y Li","year":"2024","unstructured":"Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P. 7-dehydrocholesterol dictates ferroptosis sensitivity. Nature. 2024;626:411\u20138.","journal-title":"Nature"},{"key":"2414_CR143","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/s41580-019-0190-7","volume":"21","author":"J Luo","year":"2019","unstructured":"Luo J, Yang H, Song B-L. Mechanisms and regulation of cholesterol homeostasis. Nat Rev Mol Cell Biol. 2019;21:225\u201345.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR144","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/0005-2760(82)90150-3","volume":"710","author":"F Ursini","year":"1982","unstructured":"Ursini F, Maiorino M, Valente M, Ferri L, Gregolin C. Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1982;710:197\u2013211.","journal-title":"Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism"},{"key":"2414_CR145","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.589042","volume":"14","author":"S-Y Zhou","year":"2020","unstructured":"Zhou S-Y, Cui G-Z, Yan X-L, Wang X, Qu Y, Guo Z-N, Jin H. Mechanism of ferroptosis and its relationships with other types of programmed cell death: insights for potential interventions after intracerebral hemorrhage. Front Neurosci. 2020;14: 589042.","journal-title":"Front Neurosci"},{"key":"2414_CR146","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nrm3737","volume":"15","author":"TV Berghe","year":"2014","unstructured":"Berghe TV, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P. Regulated necrosis: the expanding network of non-apoptotic cell death pathways. Nat Rev Mol Cell Biol. 2014;15:135\u201347.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR147","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.molcel.2007.04.021","volume":"26","author":"Y-S Kim","year":"2007","unstructured":"Kim Y-S, Morgan MJ, Choksi S, Liu Z-G. TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death. Mol Cell. 2007;26:675\u201387.","journal-title":"Mol Cell"},{"key":"2414_CR148","first-page":"1","volume":"2020","author":"Q Tian","year":"2020","unstructured":"Tian Q, Qin B, Gu Y, Zhou L, Chen S, Zhang S, Zhang S, Han Q, Liu Y, Wu X, Penna C. ROS-Mediated Necroptosis Is Involved in Iron Overload-Induced Osteoblastic Cell Death. Oxid Med Cell Longev. 2020;2020:1\u201322.","journal-title":"Oxid Med Cell Longev"},{"key":"2414_CR149","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1182\/blood-2011-08-375303","volume":"119","author":"GB Fortes","year":"2012","unstructured":"Fortes GB, Alves LS, de Oliveira R, Dutra FF, Rodrigues D, Fernandez PL, Souto-Padron T, De Rosa MJ, Kelliher M, Golenbock D, Chan FKM, Bozza MT. Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. Blood. 2012;119:2368\u201375.","journal-title":"Blood"},{"key":"2414_CR150","doi-asserted-by":"crossref","unstructured":"Zhou B, Zhang J-y, Liu X-s, Chen H-z, Ai Y-l, Cheng K, Sun R-y, Zhou D, Han J, Wu Q.\u00a0Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018;28:1171\u201385.","DOI":"10.1038\/s41422-018-0090-y"},{"key":"2414_CR151","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1089\/ars.2022.0202","volume":"39","author":"F Chen","year":"2023","unstructured":"Chen F, Cai X, Kang R, Liu J, Tang D. Autophagy-dependent ferroptosis in cancer. Antioxid Redox Signal. 2023;39:79\u2013101.","journal-title":"Antioxid Redox Signal"},{"key":"2414_CR152","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1080\/15548627.2022.2111635","volume":"19","author":"J Liu","year":"2022","unstructured":"Liu J, Liu Y, Wang Y, Li C, Xie Y, Klionsky DJ, Kang R, Tang D. TMEM164 is a new determinant of autophagy-dependent ferroptosis. Autophagy. 2022;19:945\u201356.","journal-title":"Autophagy"},{"key":"2414_CR153","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1080\/15548627.2023.2165323","volume":"19","author":"Q Xue","year":"2023","unstructured":"Xue Q, Yan D, Chen X, Li X, Kang R, Klionsky DJ, Kroemer G, Chen X, Tang D, Liu J. Copper-dependent autophagic degradation of GPX4 drives ferroptosis. Autophagy. 2023;19:1982\u201396.","journal-title":"Autophagy"},{"key":"2414_CR154","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/nchembio727","volume":"1","author":"VE Kagan","year":"2005","unstructured":"Kagan VE, Tyurin VA, Jiang J, Tyurina YY, Ritov VB, Amoscato AA, Osipov AN, Belikova NA, Kapralov AA, Kini V, Vlasova II, Zhao Q, Zou M, Di P, Svistunenko DA, Kurnikov IV, Borisenko GG. Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors. Nat Chem Biol. 2005;1:223\u201332.","journal-title":"Nat Chem Biol"},{"key":"2414_CR155","doi-asserted-by":"crossref","unstructured":"Zhang DD. Thirty years of NRF2: advances and therapeutic challenges.\u00a0Nat Rev Drug Discov. 2025;24:421\u201344.","DOI":"10.1038\/s41573-025-01145-0"},{"key":"2414_CR156","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.freeradbiomed.2020.08.009","volume":"160","author":"N Li","year":"2020","unstructured":"Li N, Wang W, Zhou H, Wu Q, Duan M, Liu C, Wu H, Deng W, Shen D, Tang Q. Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury. Free Radic Biol Med. 2020;160:303\u201318.","journal-title":"Free Radic Biol Med"},{"key":"2414_CR157","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1126\/science.275.5296.90","volume":"275","author":"H Ichijo","year":"1997","unstructured":"Ichijo H, Nishida E, Irie K, Dijke Pt, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK\/JNK and p38 signaling pathways. Science. 1997;275:90\u20134.","journal-title":"Science"},{"key":"2414_CR158","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.tox.2011.02.010","volume":"283","author":"M Ahamed","year":"2011","unstructured":"Ahamed M, Akhtar MJ, Siddiqui MA, Ahmad J, Musarrat J, Al-Khedhairy AA, AlSalhi MS, Alrokayan SA. Oxidative stress mediated apoptosis induced by nickel ferrite nanoparticles in cultured A549 cells. Toxicology. 2011;283:101\u20138.","journal-title":"Toxicology"},{"key":"2414_CR159","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1182\/blood.V112.11.1872.1872","volume":"112","author":"GC Chan","year":"2008","unstructured":"Chan GC, Ha SY, Cheung YF, Chan S, Yang M. Iron-overload induces apoptosis in cardiomyocytes and hepatocytes via mitochondrial\/caspase-3 pathways. Blood. 2008;112:1872\u20131872.","journal-title":"Blood"},{"key":"2414_CR160","first-page":"370","volume":"21","author":"D Tang","year":"2024","unstructured":"Tang D, Kroemer G, Kang R. Targeting cuproplasia and cuproptosis in cancer, Nature Reviews. Clin Oncol. 2024;21:370\u201388.","journal-title":"Clin Oncol"},{"key":"2414_CR161","doi-asserted-by":"crossref","unstructured":"Cobine PA, Moore SA, Leary SC. Leary, Getting out what you put in: Copper in mitochondria and its impacts on human disease. Biochimica et Biophysica Acta (BBA) - Mol Cell Res. 2021;1868:118867.","DOI":"10.1016\/j.bbamcr.2020.118867"},{"key":"2414_CR162","doi-asserted-by":"crossref","unstructured":"Yu Z, Zhou R, Zhao Y, Pan Y, Liang H, Zhang JS, Tai S, Jin L, Teng CB. Blockage of SLC31A1\u2010dependent copper absorption increases pancreatic cancer cell autophagy to resist cell death. Cell Prolif. 2019;52:e12568.","DOI":"10.1111\/cpr.12568"},{"key":"2414_CR163","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41568-021-00417-2","volume":"22","author":"EJ Ge","year":"2022","unstructured":"Ge EJ, Bush AI, Casini A, Cobine PA, Cross JR, DeNicola GM, Dou QP, Franz KJ, Gohil VM, Gupta S, Kaler SG, Lutsenko S, Mittal V, Petris MJ, Polishchuk R, Ralle M, Schilsky ML, Tonks NK, Vahdat LT, Van Aelst L, Xi D, Yuan P, Brady DC, Chang CJ. Connecting copper and cancer: from transition metal signalling to metalloplasia. Nat Rev Cancer. 2022;22:102\u201313.","journal-title":"Nat Rev Cancer"},{"key":"2414_CR164","doi-asserted-by":"crossref","unstructured":"Kar S, Sen S, Maji S, Saraf D, Ruturaj, Paul R, Dutt S, Mondal B, Rodriguez-Boulan E, Schreiner R, Sengupta D, Gupta A.\u00a0Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1. J Biol Chem. 2022;298:101631.","DOI":"10.1016\/j.jbc.2022.101631"},{"key":"2414_CR165","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12964-024-01726-3","volume":"22","author":"TTT Vo","year":"2024","unstructured":"Vo TTT, Peng T-Y, Nguyen TH, Bui TNH, Wang C-S, Lee W-J, Chen Y-L, Wu Y-C, Lee I-T. The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm. Cell Commun Signal. 2024;22:353.","journal-title":"Cell Commun Signal"},{"key":"2414_CR166","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1038\/s41589-019-0291-9","volume":"15","author":"P Tsvetkov","year":"2019","unstructured":"Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR. Mitochondrial metabolism promotes adaptation to proteotoxic stress. Nat Chem Biol. 2019;15:681\u20139.","journal-title":"Nat Chem Biol"},{"key":"2414_CR167","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1158\/1535-7163.MCT-08-0298","volume":"7","author":"JR Kirshner","year":"2008","unstructured":"Kirshner JR, He S, Balasubramanyam V, Kepros J, Yang CY, Zhang M, Du Z, Barsoum J, Bertin J. Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther. 2008;7:2319\u201327.","journal-title":"Mol Cancer Ther"},{"key":"2414_CR168","doi-asserted-by":"crossref","unstructured":"Oliveri V. Selective targeting of cancer cells by copper ionophores: an overview. Front Mol Biosci. 2022;9:841814.","DOI":"10.3389\/fmolb.2022.841814"},{"key":"2414_CR169","doi-asserted-by":"crossref","unstructured":"Yang C, Li F, Ren Y, Zhang Q, Jiao B, Zhang J, Huang J. Targeting esophageal squamous cell carcinoma by combining copper ionophore disulfiram and JMJD3\/UTX inhibitor GSK J4. Cancers (Basel). 2023;15:5347.","DOI":"10.3390\/cancers15225347"},{"key":"2414_CR170","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nature25016","volume":"552","author":"Z Skrott","year":"2017","unstructured":"Skrott Z, Mistrik M, Andersen KK, Friis S, Majera D, Gursky J, Ozdian T, Bartkova J, Turi Z, Moudry P, Kraus M, Michalova M, Vaclavkova J, Dzubak P, Vrobel I, Pouckova P, Sedlacek J, Miklovicova A, Kutt A, Li J, Mattova J, Driessen C, Dou QP, Olsen J, Hajduch M, Cvek B, Deshaies RJ, Bartek J. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017;552:194\u20139.","journal-title":"Nature"},{"key":"2414_CR171","doi-asserted-by":"publisher","first-page":"6711","DOI":"10.1038\/s41388-019-0915-2","volume":"38","author":"Z Skrott","year":"2019","unstructured":"Skrott Z, Majera D, Gursky J, Buchtova T, Hajduch M, Mistrik M, Bartek J. Disulfiram\u2019s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase. Oncogene. 2019;38:6711\u201322.","journal-title":"Oncogene"},{"key":"2414_CR172","doi-asserted-by":"crossref","unstructured":"Ren X, Li Y, Zhou Y, Hu W, Yang C, Jing Q, Zhou C, Wang X, Hu J, Wang L, Yang J, Wang H, Xu H, Li H, Tong X, Wang Y, Du J. Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram\/copper-induced ferroptosis. Redox Biol. 2021;46:102122.","DOI":"10.1016\/j.redox.2021.102122"},{"key":"2414_CR173","doi-asserted-by":"crossref","unstructured":"Wang W, Lu K, Jiang X, Wei Q, Zhu L, Wang X, Jin H, Feng L. Ferroptosis inducers enhanced cuproptosis induced by copper ionophores in primary liver cancer. J Exp Clin Cancer Res. 2023;42:142.","DOI":"10.1186\/s13046-023-02720-2"},{"key":"2414_CR174","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/s41422-022-00653-7","volume":"32","author":"D Tang","year":"2022","unstructured":"Tang D, Chen X, Kroemer G. Cuproptosis: a copper-triggered modality of mitochondrial cell death. Cell Res. 2022;32:417\u20138.","journal-title":"Cell Res"},{"key":"2414_CR175","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.1038\/bjc.2011.126","volume":"104","author":"NC Yip","year":"2011","unstructured":"Yip NC, Fombon IS, Liu P, Brown S, Kannappan V, Armesilla AL, Xu B, Cassidy J, Darling JL, Wang W. Disulfiram modulated ROS\u2013MAPK and NF\u03baB pathways and targeted breast cancer cells with cancer stem cell-like properties. Br J Cancer. 2011;104:1564\u201374.","journal-title":"Br J Cancer"},{"key":"2414_CR176","doi-asserted-by":"crossref","unstructured":"Liu H, Guo H, Jian Z, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Copper induces oxidative stress and apoptosis in the mouse liver. Oxid Med Cell Longev. 2020;2020:1359164.","DOI":"10.1155\/2020\/1359164"},{"key":"2414_CR177","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.4049\/jimmunol.1700712","volume":"200","author":"N Deigendesch","year":"2018","unstructured":"Deigendesch N, Zychlinsky A, Meissner F. Copper regulates the canonical NLRP3 inflammasome. J Immunol. 2018;200:1607\u201317.","journal-title":"J Immunol"},{"key":"2414_CR178","doi-asserted-by":"crossref","unstructured":"Liu X, Liu H, Wang N, Lai S, Qiu C, Gao S, Huang T, Zhang W. The interactive toxic effect of homocysteine and copper on cardiac microvascular endothelial cells during ischemia-reperfusion injury. Chem Biol Interact.\u00a02025;408:111387.","DOI":"10.1016\/j.cbi.2025.111387"},{"key":"2414_CR179","doi-asserted-by":"publisher","first-page":"12983","DOI":"10.1039\/C9NR03114F","volume":"11","author":"W Chen","year":"2019","unstructured":"Chen W, Wang X, Zhao B, Zhang R, Xie Z, He Y, Chen A, Xie X, Yao K, Zhong M, Yuan M. CuS\u2013MnS2 nano-flowers for magnetic resonance imaging guided photothermal\/photodynamic therapy of ovarian cancer through necroptosis. Nanoscale. 2019;11:12983\u20139.","journal-title":"Nanoscale"},{"key":"2414_CR180","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.tcb.2022.07.004","volume":"33","author":"S Zheng","year":"2023","unstructured":"Zheng S, Wang X, Zhao D, Liu H, Hu Y. Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications. Trends Cell Biol. 2023;33:312\u201323.","journal-title":"Trends Cell Biol"},{"key":"2414_CR181","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1152\/physrev.00006.2016","volume":"96","author":"MJ Berridge","year":"2016","unstructured":"Berridge MJ. The inositol trisphosphate\/calcium signaling pathway in health and disease. Physiol Rev. 2016;96:1261\u201396.","journal-title":"Physiol Rev"},{"key":"2414_CR182","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/j.cell.2007.11.028","volume":"131","author":"DE Clapham","year":"2007","unstructured":"Clapham DE. Calcium signaling. Cell. 2007;131:1047\u201358.","journal-title":"Cell"},{"key":"2414_CR183","doi-asserted-by":"crossref","unstructured":"Stejerean-Todoran I, Gibhardt CS, Bogeski I. Calcium signals as regulators of ferroptosis in cancer. Cell Calcium. 2024;124:102966.","DOI":"10.1016\/j.ceca.2024.102966"},{"key":"2414_CR184","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1007\/s10495-023-01927-0","volume":"29","author":"J Gu","year":"2024","unstructured":"Gu J, Guo C, Ruan J, Li K, Zhou Y, Gong X, Shi H. From ferroptosis to cuproptosis, and calcicoptosis, to find more novel metals-mediated distinct form of regulated cell death. Apoptosis. 2024;29:586\u2013604.","journal-title":"Apoptosis"},{"key":"2414_CR185","doi-asserted-by":"publisher","first-page":"19635","DOI":"10.1073\/pnas.1908998116","volume":"116","author":"C Ge","year":"2019","unstructured":"Ge C, Huang H, Huang F, Yang T, Zhang T, Wu H, Zhou H, Chen Q, Shi Y, Sun Y, Liu L, Wang X, Pearson RB, Cao Y, Kang J, Fu C. Neurokinin-1 receptor is an effective target for treating leukemia by inducing oxidative stress through mitochondrial calcium overload. Proc Natl Acad Sci. 2019;116:19635\u201345.","journal-title":"Proc Natl Acad Sci"},{"key":"2414_CR186","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1038\/s41586-019-1781-3","volume":"576","author":"W Choi","year":"2019","unstructured":"Choi W, Clemente N, Sun W, Du J, L\u00fc W. The structures and gating mechanism of human calcium homeostasis modulator 2. Nature. 2019;576:163\u20137.","journal-title":"Nature"},{"key":"2414_CR187","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.cell.2008.08.006","volume":"135","author":"PB Stathopulos","year":"2008","unstructured":"Stathopulos PB, Zheng L, Li G-Y, Plevin MJ, Ikura M. Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Cell. 2008;135:110\u201322.","journal-title":"Cell"},{"key":"2414_CR188","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1152\/physrev.00020.2014","volume":"95","author":"M Prakriya","year":"2015","unstructured":"Prakriya M, Lewis RS. Store-operated calcium channels. Physiol Rev. 2015;95:1383\u2013436.","journal-title":"Physiol Rev"},{"key":"2414_CR189","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2023.102759","author":"N Dhaouadi","year":"2023","unstructured":"Dhaouadi N, Vitto VAM, Pinton P, Galluzzi L, Marchi S. Ca2+ signaling and cell death. Cell Calcium. 2023;\u00a0113:102759.","journal-title":"Cell Calcium"},{"key":"2414_CR190","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ceca.2011.03.003","volume":"50","author":"B Zhivotovsky","year":"2011","unstructured":"Zhivotovsky B, Orrenius S. Calcium and cell death mechanisms: a perspective from the cell death community. Cell Calcium. 2011;50:211\u201321.","journal-title":"Cell Calcium"},{"key":"2414_CR191","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/s41418-020-00691-x","volume":"28","author":"L Pedrera","year":"2020","unstructured":"Pedrera L, Espiritu RA, Ros U, Weber J, Schmitt A, Stroh J, Hailfinger S, von Karstedt S, Garc\u00eda-S\u00e1ez AJ. Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ. 2020;28:1644\u201357.","journal-title":"Cell Death Differ"},{"key":"2414_CR192","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1083\/jcb.200608035","volume":"175","author":"AL Wozniak","year":"2006","unstructured":"Wozniak AL, Wang X, Stieren ES, Scarbrough SG, Elferink CJ, Boehning D. Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis. J Cell Biol. 2006;175:709\u201314.","journal-title":"J Cell Biol"},{"key":"2414_CR193","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.140","volume":"4","author":"H Akl","year":"2013","unstructured":"Akl H, Monaco G, La Rovere R, Welkenhuyzen K, Kiviluoto S, Vervliet T, Molg\u00f3 J, Distelhorst CW, Missiaen L, Mikoshiba K, Parys JB, De Smedt H, Bultynck G. IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2. Cell Death Dis. 2013;4: e632\u2013e632.","journal-title":"Cell Death Dis"},{"key":"2414_CR194","doi-asserted-by":"crossref","unstructured":"Xue Y, Morris JL, Yang K, Fu Z, Zhu X, Johnson F, Meehan B, Witkowski L, Yasmeen A, Golenar T, Coatham M, Morin G, Monast A, Pilon V, Fiset PO, Jung S, Gonzalez AV, Camilleri-Broet S, Fu L, Postovit L-M, Spicer J, Gotlieb WH, Guiot M-C, Rak J, Park M, Lockwood W, Foulkes WD, Prudent J, Huang S. SMARCA4\/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria. Nat Commun. 2021;12:5404.","DOI":"10.1038\/s41467-021-25260-9"},{"key":"2414_CR195","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1158\/0008-5472.CAN-13-1283","volume":"74","author":"M Nomura","year":"2014","unstructured":"Nomura M, Ueno A, Saga K, Fukuzawa M, Kaneda Y. Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma. Can Res. 2014;74:1056\u201366.","journal-title":"Can Res"},{"key":"2414_CR196","doi-asserted-by":"crossref","unstructured":"Lv Y, Shao G, Zhang Q, Wang X, Meng Y, Wang L, Huang F, Yang T, Jin Y, Fu C. The antimicrobial peptide PFR induces necroptosis mediated by ER stress and elevated cytoplasmic calcium and mitochondrial ROS levels: cooperation with Ara-C to act against acute myeloid leukemia. Signal Transduct Target Ther. 2019;4:38.","DOI":"10.1038\/s41392-019-0073-6"},{"key":"2414_CR197","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.7150\/thno.65716","volume":"12","author":"Z Song","year":"2022","unstructured":"Song Z, Song H, Liu D, Yan B, Wang D, Zhang Y, Zhao X, Tian X, Yan C, Han Y. Overexpression of MFN2 alleviates sorafenib-induced cardiomyocyte necroptosis via the MAM-CaMKII\u03b4 pathway in vitro and in vivo. Theranostics. 2022;12:1267\u201385.","journal-title":"Theranostics"},{"key":"2414_CR198","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1007\/s10517-021-05216-1","volume":"171","author":"B Zhou","year":"2021","unstructured":"Zhou B, Lin Y, Chen S, Cai J, Luo Z, Yu S, Lu J. Activation of Ca2+\/calmodulin-dependent protein kinase II (CaMKII) with lidocaine provokes pyroptosis of glioblastoma cells. Bull Exp Biol Med. 2021;171:297\u2013304.","journal-title":"Bull Exp Biol Med"},{"key":"2414_CR199","doi-asserted-by":"crossref","unstructured":"Y.-X. Hu, X.-S. Han, Q. Jing, Ca(2+) Ion and Autophagy, Autophagy: Biology and Diseases, 2019; pp. 151\u2013166.","DOI":"10.1007\/978-981-15-0602-4_7"},{"key":"2414_CR200","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cmet.2005.06.005","volume":"2","author":"A Woods","year":"2005","unstructured":"Woods A, Dickerson K, Heath R, Hong S-P, Momcilovic M, Johnstone SR, Carlson M, Carling D. Ca2+\/calmodulin-dependent protein kinase kinase-\u03b2 acts upstream of AMP-activated protein kinase in mammalian cells. Cell Metab. 2005;2:21\u201333.","journal-title":"Cell Metab"},{"key":"2414_CR201","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2022.111809","author":"J Peng","year":"2022","unstructured":"Peng J, Peng C, Wang L, Cao H, Xing C, Li G, Hu G, Yang F. Endoplasmic reticulum-mitochondria coupling attenuates vanadium-induced apoptosis via IP3R in duck renal tubular epithelial cells. J Inorg Biochem. 2022;\u00a0232:111809.","journal-title":"J Inorg Biochem"},{"key":"2414_CR202","doi-asserted-by":"crossref","unstructured":"Wang L, Pan Y, Yang F, Guo X, Peng J, Wang X, Fang Y, Chen J, Yi X, Cao H, Hu G. New sight into interaction between endoplasmic reticulum stress and autophagy induced by vanadium in duck renal tubule epithelial cells. Chem Biol Interact. 2022;362:109981.","DOI":"10.1016\/j.cbi.2022.109981"},{"key":"2414_CR203","doi-asserted-by":"crossref","unstructured":"Chen B, Yu P, Chan WN, Xie F, Zhang Y, Liang L, Leung KT, Lo KW, Yu J, Tse GM, Kang W, To KF.\u00a0Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets.\u00a0Signal Transduct Target Ther.\u00a02024;9:6.","DOI":"10.1038\/s41392-023-01679-y"},{"key":"2414_CR204","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1002\/glia.20998","volume":"58","author":"SJ Lee","year":"2010","unstructured":"Lee SJ, Park MH, Kim HJ, Koh JY. Metallothionein-3 regulates lysosomal function in cultured astrocytes under both normal and oxidative conditions. Glia. 2010;58:1186\u201396.","journal-title":"Glia"},{"key":"2414_CR205","doi-asserted-by":"crossref","unstructured":"Lee S-J, Koh J-Y. Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes. Mol Brain. 2010;3:30.","DOI":"10.1186\/1756-6606-3-30"},{"key":"2414_CR206","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1053\/j.gastro.2014.06.024","volume":"147","author":"A Lahiri","year":"2014","unstructured":"Lahiri A, Abraham C. Activation of pattern recognition receptors up-regulates metallothioneins, thereby increasing intracellular accumulation of zinc, autophagy, and bacterial clearance by macrophages. Gastroenterology. 2014;147:835\u201346.","journal-title":"Gastroenterology"},{"key":"2414_CR207","doi-asserted-by":"publisher","first-page":"11780","DOI":"10.1073\/pnas.1323549111","volume":"111","author":"T Miyai","year":"2014","unstructured":"Miyai T, Hojyo S, Ikawa T, Kawamura M, Iri\u00e9 T, Ogura H, Hijikata A, Bin B-H, Yasuda T, Kitamura H, Nakayama M, Ohara O, Yoshida H, Koseki H, Mishima K, Fukada T. Zinc transporter SLC39A10\/ZIP10 facilitates antiapoptotic signaling during early B-cell development. Proc Natl Acad Sci. 2014;111:11780\u20135.","journal-title":"Proc Natl Acad Sci"},{"key":"2414_CR208","doi-asserted-by":"crossref","unstructured":"Leslie TK, James AD, Zaccagna F, Grist JT, Deen S, Kennerley A, Riemer F, Kaggie JD, Gallagher FA, Gilbert FJ, Brackenbury WJ. Sodium homeostasis in the tumour microenvironment. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 2019;1872:188304.\u00a0","DOI":"10.1016\/j.bbcan.2019.07.001"},{"key":"2414_CR209","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1385\/CBB:41:2:233","volume":"41","author":"Y Okada","year":"2004","unstructured":"Okada Y. Ion channels and transporters involved in cell volume regulation and sensor mechanisms. Cell Biochem Biophys. 2004;41:233\u201358.","journal-title":"Cell Biochem Biophys"},{"key":"2414_CR210","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1111\/j.1748-1716.2010.02190.x","volume":"202","author":"EK Hoffmann","year":"2010","unstructured":"Hoffmann EK, Pedersen SF. Cell volume homeostatic mechanisms: effectors and signalling pathways. Acta Physiol. 2010;202:465\u201385.","journal-title":"Acta Physiol"},{"key":"2414_CR211","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904058","author":"W Jiang","year":"2019","unstructured":"Jiang W, Yin L, Chen H, Paschall AV, Zhang L, Fu W, Zhang W, Todd T, Yu KS, Zhou S, Zhen Z, Butler M, Yao L, Zhang F, Shen Y, Li Z, Yin A, Yin H, Wang X, Avci FY, Yu X, Xie J. NaCl nanoparticles as a cancer therapeutic. Adv Mater. 2019;\u00a031:e1904058.","journal-title":"Adv Mater"},{"key":"2414_CR212","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.jhazmat.2012.11.040","volume":"244\u2013245","author":"M Yeganeh","year":"2013","unstructured":"Yeganeh M, Afyuni M, Khoshgoftarmanesh A-H, Khodakarami L, Amini M, Soffyanian A-R, Schulin R. Mapping of human health risks arising from soil nickel and mercury contamination. J Hazard Mater. 2013;244\u2013245:225\u201339.","journal-title":"J Hazard Mater"},{"key":"2414_CR213","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1002\/pro.3836","volume":"29","author":"M Alfano","year":"2020","unstructured":"Alfano M, Cavazza C. Structure, function, and biosynthesis of nickel-dependent enzymes. Protein Sci. 2020;29:1071\u201389.","journal-title":"Protein Sci"},{"key":"2414_CR214","doi-asserted-by":"crossref","unstructured":"Guo H, Liu H, Jian Z, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L, He R, Tang H. Immunotoxicity of nickel: pathological and toxicological effects. Ecotoxicol Environ Saf. 2020;203:111006.","DOI":"10.1016\/j.ecoenv.2020.111006"},{"key":"2414_CR215","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/17435390.2022.2030821","volume":"16","author":"O Germande","year":"2022","unstructured":"Germande O, Baudrimont M, Beaufils F, Freund-Michel V, Ducret T, Quignard J-F, Errera M-H, Lacomme S, Gontier E, Mornet S, Bejko M, Muller B, Marthan R, Guibert C, Deweirdt J, Baudrimont I. NiONPs-induced alteration in calcium signaling and mitochondrial function in pulmonary artery endothelial cells involves oxidative stress and TRPV4 channels disruption. Nanotoxicology. 2022;16:29\u201351.","journal-title":"Nanotoxicology"},{"key":"2414_CR216","doi-asserted-by":"crossref","unstructured":"Di Bucchianico S, Gliga AR, \u00c5kerlund E, Skoglund S, Wallinder IO, Fadeel B, Karlsson HL. Calcium-dependent cyto- and genotoxicity of nickel metal and nickel oxide nanoparticles in human lung cells. Part Fibre Toxicol. 2018;15:32.","DOI":"10.1186\/s12989-018-0268-y"},{"key":"2414_CR217","doi-asserted-by":"publisher","first-page":"1","DOI":"10.13075\/ijomeh.1896.01814","volume":"35","author":"M Alfhili","year":"2022","unstructured":"Alfhili M, Alamri H, Alsughayyir J, Basudan A. Induction of hemolysis and eryptosis by occupational pollutant nickel chloride is mediated through calcium influx and p38 MAP kinase signaling. Int J Occup Med Environ Health. 2022;35:1\u201311.","journal-title":"Int J Occup Med Environ Health"},{"key":"2414_CR218","doi-asserted-by":"crossref","unstructured":"Wang Y, Wang S-Y, Jia L, Zhang L, Ba J-C, Han D, Yu C-P, Wu Y-H. Nickel-refining fumes induced DNA damage and apoptosis of NIH\/3T3 cells via oxidative stress. Int J Environ Res Public Health. 2016;13:629.","DOI":"10.3390\/ijerph13070629"},{"key":"2414_CR219","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.etap.2016.01.005","volume":"42","author":"Y-J Lee","year":"2016","unstructured":"Lee Y-J, Lim S-S, Baek BJ, An J-M, Nam H-S, Woo K-M, Cho M-K, Kim S-H, Lee S-H. Nickel(II)-induced nasal epithelial toxicity and oxidative mitochondrial damage. Environ Toxicol Pharmacol. 2016;42:76\u201384.","journal-title":"Environ Toxicol Pharmacol"},{"key":"2414_CR220","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1021\/tx9003193","volume":"23","author":"J Pan","year":"2010","unstructured":"Pan J, Chang Q, Wang X, Son Y, Zhang Z, Chen G, Luo J, Bi Y, Chen F, Shi X. Reactive oxygen species-activated Akt\/ASK1\/p38 signaling pathway in nickel compound-induced apoptosis in BEAS 2B cells. Chem Res Toxicol. 2010;23:568\u201377.","journal-title":"Chem Res Toxicol"},{"key":"2414_CR221","doi-asserted-by":"crossref","unstructured":"Zhang X, Xu L, Ma W, Shi B, Liu Q, Song Y, Fang C, Liu P, Qiao S, Cai J, Zhang Z. N-acetyl-L-cysteine alleviated the oxidative stress-induced inflammation and necroptosis caused by excessive NiCl2 in primary spleen lymphocytes. Front Immunol. 2023;14:1146645.","DOI":"10.3389\/fimmu.2023.1146645"},{"key":"2414_CR222","doi-asserted-by":"crossref","unstructured":"Yin H, Zuo Z, Yang Z, Guo H, Fang J, Cui H, Ouyang P, Chen X, Chen J, Geng Y, Chen Z, Huang C, Zhu Y. Nickel induces autophagy via PI3K\/AKT\/mTOR and AMPK pathways in mouse kidney. Ecotoxicol Environ Saf. 2021;223:112583.","DOI":"10.1016\/j.ecoenv.2021.112583"},{"key":"2414_CR223","doi-asserted-by":"crossref","unstructured":"Zhang T, Wang Y, Yao W, Chen Y, Zhang D, Gao Y, Jin S, Li L, Yang S, Wu Y. Metformin antagonizes nickel-refining fumes-induced cell pyroptosis via Nrf2\/GOLPH3 pathway in vitro and in vivo. Ecotoxicol Environ Saf. 2022;247:114233.","DOI":"10.1016\/j.ecoenv.2022.114233"},{"key":"2414_CR224","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.1007\/s00204-021-03106-z","volume":"95","author":"S Probst","year":"2021","unstructured":"Probst S, Fels J, Scharner B, Wolff NA, Roussa E, van Swelm RPL, Lee W-K, Th\u00e9venod F. Role of hepcidin in oxidative stress and cell death of cultured mouse renal collecting duct cells: protection against iron and sensitization to cadmium. Arch Toxicol. 2021;95:2719\u201335.","journal-title":"Arch Toxicol"},{"key":"2414_CR225","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.tiv.2016.09.014","volume":"37","author":"S Nemmiche","year":"2016","unstructured":"Nemmiche S, Guiraud P. Cadmium-induced oxidative damages in the human BJAB cells correlate with changes in intracellular trace elements levels and zinc transporters expression. Toxicol In Vitro. 2016;37:169\u201377.","journal-title":"Toxicol In Vitro"},{"key":"2414_CR226","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1007\/s12011-022-03170-1","volume":"201","author":"Z Hu","year":"2022","unstructured":"Hu Z, Nie G, Luo J, Hu R, Li G, Hu G, Zhang C. Molybdenum and cadmium co-induce pyroptosis via inhibiting Nrf2-mediated antioxidant defense response in the brain of ducks. Biol Trace Elem Res. 2022;201:874\u201387.","journal-title":"Biol Trace Elem Res"},{"key":"2414_CR227","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1016\/j.tiv.2008.04.021","volume":"22","author":"T Kusakabe","year":"2008","unstructured":"Kusakabe T, Nakajima K, Nakazato K, Suzuki K, Takada H, Satoh T, Oikawa M, Arakawa K, Nagamine T. Changes of heavy metal, metallothionein and heat shock proteins in Sertoli cells induced by cadmium exposure. Toxicol In Vitro. 2008;22:1469\u201375.","journal-title":"Toxicol In Vitro"},{"key":"2414_CR228","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.freeradbiomed.2021.09.008","volume":"175","author":"C Zhao","year":"2021","unstructured":"Zhao C, Yu D, He Z, Bao L, Feng L, Chen L, Liu Z, Hu X, Zhang N, Wang T, Fu Y. Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells. Free Radic Biol Med. 2021;175:236\u201348.","journal-title":"Free Radic Biol Med"},{"key":"2414_CR229","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1002\/tox.23376","volume":"37","author":"R Hao","year":"2021","unstructured":"Hao R, Ge J, Song X, Li F, Sun-Waterhouse D, Li D. Cadmium induces ferroptosis and apoptosis by modulating miR-34a-5p\/Sirt1axis in PC12 cells. Environ Toxicol. 2021;37:41\u201351.","journal-title":"Environ Toxicol"},{"key":"2414_CR230","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.157819","author":"H Hong","year":"2022","unstructured":"Hong H, Lin X, Xu Y, Tong T, Zhang J, He H, Yang L, Lu Y, Zhou Z. Cadmium induces ferroptosis mediated inflammation by activating Gpx4\/Ager\/p65 axis in pancreatic \u03b2-cells. Sci Total Environ. 2022;\u00a0849:157819.","journal-title":"Sci Total Environ"},{"key":"2414_CR231","doi-asserted-by":"crossref","unstructured":"He Z, Shen P, Feng L, Hao H, He Y, Fan G, Liu Z, Zhu K, Wang Y, Zhang N, Hu X, Fu Y, Wu J. Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis. Ecotoxicol Environ Saf. 2022;245:114123.","DOI":"10.1016\/j.ecoenv.2022.114123"},{"key":"2414_CR232","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1002\/tox.23740","volume":"38","author":"L Wang","year":"2023","unstructured":"Wang L, Yang F, Hu M, Chen G, Wang Y, Xue H, Fu D, Bai H, Hu G, Cao H. GPX4 utilization by selenium is required to alleviate cadmium-induced ferroptosis and pyroptosis in sheep kidney. Environ Toxicol. 2023;38:962\u201374.","journal-title":"Environ Toxicol"},{"key":"2414_CR233","doi-asserted-by":"crossref","unstructured":"Wang Y, Wu J, Zhang M, OuYang H, Li M, Jia D, Wang R, Zhou W, Liu H, Hu Y, Yao Y, Liu Y, Ji Y. Cadmium exposure during puberty damages testicular development and spermatogenesis via ferroptosis caused by intracellular iron overload and oxidative stress in mice. Environ Pollut. 2023;325:121434.","DOI":"10.1016\/j.envpol.2023.121434"},{"key":"2414_CR234","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1016\/j.neuro.2007.04.004","volume":"28","author":"Q Wang","year":"2007","unstructured":"Wang Q, Luo W, Zhang W, Dai Z, Chen Y, Chen J. Iron supplementation protects against lead-induced apoptosis through MAPK pathway in weanling rat cortex. Neurotoxicology. 2007;28:850\u20139.","journal-title":"Neurotoxicology"},{"key":"2414_CR235","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainres.2018.02.014","volume":"1686","author":"SM Nam","year":"2018","unstructured":"Nam SM, Chang B-J, Kim J-H, Nahm S-S, Lee J-H. Ascorbic acid ameliorates lead-induced apoptosis in the cerebellar cortex of developing rats. Brain Res. 2018;1686:10\u20138.","journal-title":"Brain Res"},{"key":"2414_CR236","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1007\/s12011-017-1097-9","volume":"182","author":"X Wang","year":"2017","unstructured":"Wang X, An Y, Jiao W, Zhang Z, Han H, Gu X, Teng X. Selenium protects against lead-induced apoptosis via endoplasmic reticulum stress in chicken kidneys. Biol Trace Elem Res. 2017;182:354\u201363.","journal-title":"Biol Trace Elem Res"},{"key":"2414_CR237","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.ceca.2013.07.003","volume":"54","author":"G Kovacs","year":"2013","unstructured":"Kovacs G, Montalbetti N, Franz M-C, Graeter S, Simonin A, Hediger MA. Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity. Cell Calcium. 2013;54:276\u201386.","journal-title":"Cell Calcium"},{"key":"2414_CR238","doi-asserted-by":"crossref","unstructured":"Gu J, Dai S, Liu Y, Liu H, Zhang Y, Ji X, Yu F, Zhou Y, Chen L, Tse WKF, Wong CKC, Chen B, Shi H. Activation of Ca2+-sensing receptor as a protective pathway to reduce cadmium-induced cytotoxicity in renal proximal tubular cells. Sci Rep. 2018;8:1092.","DOI":"10.1038\/s41598-018-19327-9"},{"key":"2414_CR239","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1093\/toxsci\/kfz089","volume":"170","author":"J Gu","year":"2019","unstructured":"Gu J, Wang Y, Liu Y, Shi M, Yin L, Hou Y, Zhou Y, Chu Wong CK, Chen D, Guo Z, Shi H. Inhibition of autophagy alleviates cadmium-induced mouse spleen and human B cells apoptosis. Toxicol Sci. 2019;170:109\u201322.","journal-title":"Toxicol Sci"},{"key":"2414_CR240","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1159\/000431032","volume":"38","author":"X Zhou","year":"2015","unstructured":"Zhou X, Hao W, Shi H, Hou Y, Xu Q. Calcium homeostasis disruption - a bridge connecting cadmium-induced apoptosis. Autophagy and tumorigenesis. Oncol Res Treat. 2015;38:311\u20135.","journal-title":"Oncol Res Treat"},{"key":"2414_CR241","doi-asserted-by":"crossref","unstructured":"Li Z-c, Wang L-l, Zhao Y-s, Peng D-j, Chen J, Jiang S-y, Zhao L, Aschner M, Li S-j, Jiang Y-m. Sodium para-aminosalicylic acid ameliorates lead-induced hippocampal neuronal apoptosis by suppressing the activation of the IP3R-Ca2+-ASK1-p38 signaling pathway. Ecotoxicol Environ Saf. 2022;241:113829.","DOI":"10.1016\/j.ecoenv.2022.113829"},{"key":"2414_CR242","doi-asserted-by":"publisher","first-page":"39702","DOI":"10.1074\/jbc.M007369200","volume":"275","author":"M Li","year":"2000","unstructured":"Li M, Kondo T, Zhao Q-L, Li F-J, Tanabe K, Arai Y, Zhou Z-C, Kasuya M. Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria- dependent pathways. J Biol Chem. 2000;275:39702\u20139.","journal-title":"J Biol Chem"},{"key":"2414_CR243","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.tox.2015.04.015","volume":"333","author":"H Wang","year":"2015","unstructured":"Wang H, Wang Z-K, Jiao P, Zhou X-P, Yang D-B, Wang Z-Y, Wang L. Redistribution of subcellular calcium and its effect on apoptosis in primary cultures of rat proximal tubular cells exposed to lead. Toxicology. 2015;333:137\u201346.","journal-title":"Toxicology"},{"key":"2414_CR244","doi-asserted-by":"crossref","unstructured":"Li K, Guo C, Ruan J, Ning B, Wong CK-C, Shi H, Gu J. Cadmium disrupted ER Ca2+ homeostasis by inhibiting SERCA2 expression and activity to induce apoptosis in renal proximal tubular cells. Int J Mol Sci. 2023;24:5979.","DOI":"10.3390\/ijms24065979"},{"key":"2414_CR245","doi-asserted-by":"crossref","unstructured":"Kong A, Zhang Y, Ning B, Li K, Ren Z, Dai S, Chen D, Zhou Y, Gu J, Shi H. Cadmium induces triglyceride levels via microsomal triglyceride transfer protein (MTTP) accumulation caused by lysosomal deacidification regulated by endoplasmic reticulum (ER) Ca2+ homeostasis. Chemico-Biological Interactions. 2021;348:109649.","DOI":"10.1016\/j.cbi.2021.109649"},{"key":"2414_CR246","doi-asserted-by":"publisher","first-page":"5187","DOI":"10.2147\/IJN.S382928","volume":"17","author":"X Zhao","year":"2022","unstructured":"Zhao X, Wang Y, Zhu TT, Wu HL, Leng DY, Qin ZG, Li Y, Wu DM. Mesoporous calcium-silicate nanoparticles loaded with Prussian blue promotes Enterococcus faecalis ferroptosis-like death by regulating bacterial redox pathway ROS\/GSH. Int J Nanomed. 2022;17:5187\u2013205.","journal-title":"Int J Nanomed"},{"key":"2414_CR247","doi-asserted-by":"crossref","unstructured":"Zhao L, Gui Y, Cai J, Deng X. Biometallic ions and derivatives: a new direction for cancer immunotherapy. Mol Cancer. 2025;24:17.","DOI":"10.1186\/s12943-025-02225-w"},{"key":"2414_CR248","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.scib.2023.02.027","volume":"68","author":"J-L Liang","year":"2023","unstructured":"Liang J-L, Jin X-K, Zhang S-M, Huang Q-X, Ji P, Deng X-C, Cheng S-X, Chen W-H, Zhang X-Z. Specific activation of cGAS-STING pathway by nanotherapeutics-mediated ferroptosis evoked endogenous signaling for boosting systemic tumor immunotherapy. Sci Bull. 2023;68:622\u201336.","journal-title":"Sci Bull"},{"key":"2414_CR249","doi-asserted-by":"publisher","first-page":"41140","DOI":"10.1021\/acsami.9b16617","volume":"11","author":"P Wang","year":"2019","unstructured":"Wang P, Liang C, Zhu J, Yang N, Jiao A, Wang W, Song X, Dong X. Manganese-based nanoplatform as metal ion-enhanced ROS generator for combined chemodynamic\/photodynamic therapy. ACS Appl Mater Interfaces. 2019;11:41140\u20137.","journal-title":"ACS Appl Mater Interfaces"},{"key":"2414_CR250","doi-asserted-by":"crossref","unstructured":"Du Q, Luo Y, Xu L, Du C, Zhang W, Xu J, Liu Y, Liu B, Chen S, Wang Y, Wang Z, Ran H, Wang J, Guo D. Smart responsive Fe\/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation. J Nanobiotechnol. 2024;22:95.","DOI":"10.1186\/s12951-024-02354-2"},{"key":"2414_CR251","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1042\/CS20120086","volume":"123","author":"I Federica","year":"2012","unstructured":"Federica I, Wolf V. Trapani, Magnesium and its transporters in cancer: a novel paradigm in tumour development. Clin Sci. 2012;123:417\u201327.","journal-title":"Clin Sci"},{"key":"2414_CR252","doi-asserted-by":"crossref","unstructured":"Tang J, Su Q, Guo Z, Zhou J, Zheng F, Yu G, Shao W, Hu H, Wu S, Li H. N6-methyladenosine(m6A) demethylase FTO regulates cellular apoptosis following cobalt-induced oxidative stress. Environ Pollut. 2022;297:118749.","DOI":"10.1016\/j.envpol.2021.118749"},{"key":"2414_CR253","doi-asserted-by":"publisher","first-page":"4952","DOI":"10.1039\/D3DT04045C","volume":"53","author":"B Deka","year":"2024","unstructured":"Deka B, Sarkar T, Bhattacharyya A, Butcher RJ, Banerjee S, Deka S, Saikia KK, Hussain A. Synthesis, characterization, and cancer cell-selective cytotoxicity of mixed-ligand cobalt(III) complexes of 8-hydroxyquinolines and phenanthroline bases. Dalton Trans. 2024;53:4952\u201361.","journal-title":"Dalton Trans"},{"key":"2414_CR254","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1016\/j.biocel.2008.07.012","volume":"41","author":"V Battaglia","year":"2009","unstructured":"Battaglia V, Compagnone A, Bandino A, Bragadin M, Rossi CA, Zanetti F, Colombatto S, Grillo MA, Toninello A. Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeability transition and intrinsic apoptosis in hepatocyte primary cultures. Int J Biochem Cell Biol. 2009;41:586\u201394.","journal-title":"Int J Biochem Cell Biol"},{"key":"2414_CR255","doi-asserted-by":"crossref","unstructured":"Ratinaud MH. The cell death response to the ROS inducer, cobalt chloride, in neuroblastoma cell lines according to p53 status. Int J Oncol. 2011;39:601\u20139.","DOI":"10.3892\/ijo.2011.1083"},{"key":"2414_CR256","doi-asserted-by":"publisher","first-page":"5262","DOI":"10.1096\/fj.201902191RR","volume":"34","author":"G Gupta","year":"2020","unstructured":"Gupta G, Gliga A, Hedberg J, Serra A, Greco D, Odnevall Wallinder I, Fadeel B. Cobalt nanoparticles trigger ferroptosis\u2010like cell death (oxytosis) in neuronal cells: potential implications for neurodegenerative disease. FASEB J. 2020;34:5262\u201381.","journal-title":"FASEB J"},{"key":"2414_CR257","doi-asserted-by":"crossref","unstructured":"Edwards KC, Kim H, Ferguson R, Lockart MM, Vincent JB. Significance of conformation changes during the binding and release of chromium(III) from human serum transferrin. J Inorg Biochem. 2020;206:111040.","DOI":"10.1016\/j.jinorgbio.2020.111040"},{"key":"2414_CR258","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1002\/tox.23713","volume":"38","author":"R Zhuge","year":"2022","unstructured":"Zhuge R, Li Z, He C, Ma W, Yan J, Xue Q, Wang R, Liu Y, Lu R, Du H, Yin F, Guo L. Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT\/mTOR pathway in rats. Environ Toxicol. 2022;38:289\u201399.","journal-title":"Environ Toxicol"},{"key":"2414_CR259","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1016\/j.freeradbiomed.2010.09.020","volume":"49","author":"CR Myers","year":"2010","unstructured":"Myers CR, Antholine WE, Myers JM. The pro-oxidant chromium(VI) inhibits mitochondrial complex I, complex II, and aconitase in the bronchial epithelium: EPR markers for Fe\u2013S proteins. Free Radic Biol Med. 2010;49:1903\u201315.","journal-title":"Free Radic Biol Med"},{"key":"2414_CR260","doi-asserted-by":"crossref","unstructured":"Xu Y, Yang W, Han Y, Bian K, Zeng W, Hao L, Wang H, Cheng Y, Wang P, Zhang B. Biomimetic molybdenum sulfide\u2010catalyzed tumor ferroptosis and bioimaging. Small. 2023;19:e2207544.","DOI":"10.1002\/smll.202207544"},{"key":"2414_CR261","doi-asserted-by":"crossref","unstructured":"Thorndyke MP, Guimaraes O, Kistner MJ, Wagner JJ, Engle TE. Influence of molybdenum in drinking water or feed on copper metabolism in cattle-A review. Animals. 2021;11:2083.","DOI":"10.3390\/ani11072083"},{"key":"2414_CR262","doi-asserted-by":"crossref","unstructured":"Cai SH, Zhang BH, Huang CJ, Deng YJ, Wang CG, Yang YK, Xiang ZC, Ni Y, Wang Z, Wang LX, Zhang BH, Guo XT, He J, Ma K, Yu ZT. CTRP6 protects against ferroptosis to drive lung cancer progression and metastasis by destabilizing SOCS2 and augmenting the xCT\/GPX4 pathway. Cancer Lett. 2023;579:216465.","DOI":"10.1016\/j.canlet.2023.216465"},{"key":"2414_CR263","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/s41589-020-0472-6","volume":"16","author":"YL Zou","year":"2020","unstructured":"Zou YL, Li HX, Graham ET, Deik AA, Eaton JK, Wang WY, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL. Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis. Nat Chem Biol. 2020;16:302.","journal-title":"Nat Chem Biol"},{"key":"2414_CR264","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/cr.2016.95","volume":"26","author":"MH Gao","year":"2016","unstructured":"Gao MH, Monian P, Pan QH, Zhang W, Xiang J, Jiang XJ. Ferroptosis is an autophagic cell death process. Cell Res. 2016;26:1021\u201332.","journal-title":"Cell Res"},{"key":"2414_CR265","doi-asserted-by":"publisher","first-page":"1171","DOI":"10.1038\/s41422-018-0090-y","volume":"28","author":"B Zhou","year":"2018","unstructured":"Zhou B, Zhang JY, Liu XS, Chen HZ, Ai YL, Cheng K, Sun RY, Zhou DW, Han JH, Wu Q. Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis. Cell Res. 2018;28:1171\u201385.","journal-title":"Cell Res"},{"key":"2414_CR266","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nature22393","volume":"547","author":"YP Wang","year":"2017","unstructured":"Wang YP, Gao WQ, Shi XY, Ding JJ, Liu W, He HB, Wang K, Shao F. Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin. Nature. 2017;547:99.","journal-title":"Nature"},{"key":"2414_CR267","doi-asserted-by":"crossref","unstructured":"Miller ZA, Mueller A, Kim T, Jolivert JF, Ma RZ, Muthuswami S, Park A, McMahon DB, Nead KT, Carey RM, Lee RJ. Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14. Cell Rep. 2023;42:113437.","DOI":"10.1016\/j.celrep.2023.113437"},{"key":"2414_CR268","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/sj.cdd.4401375","volume":"11","author":"K Vanoverberghe","year":"2004","unstructured":"Vanoverberghe K, Vanden Abeele F, Mariot P, Lepage G, Roudbaraki M, Bonnal JL, Mauroy B, Shuba Y, Skryma R, Prevarskaya N. Ca homeostasis and apoptotic resistance of neuroendocrine-differentiated prostate cancer cells. Cell Death Differ. 2004;11:321\u201330.","journal-title":"Cell Death Differ"},{"key":"2414_CR269","doi-asserted-by":"crossref","unstructured":"Yuan R, Zhao W, Wang Q-Q, He J, Han S, Gao H, Feng Y, Yang S. Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4\/NLRP3\/GSDMD-dependent pyroptosis. Pharmacol Res. 2021;170:105748.","DOI":"10.1016\/j.phrs.2021.105748"},{"key":"2414_CR270","doi-asserted-by":"crossref","unstructured":"Yang Y, Yang J, Zhu N, Qiu H, Feng W, Chen Y, Chen X, Chen Y, Zheng W, Liang M, Lin T, Yu J, Guo Z. Tumor-targeting hydroxyapatite nanoparticles for remodeling tumor immune microenvironment (TIME) by activating mitoDNA-pyroptosis pathway in cancer. J Nanobiotechnol. 2023;21:470.","DOI":"10.1186\/s12951-023-02231-4"},{"key":"2414_CR271","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1080\/15548627.2021.1954348","volume":"18","author":"Q Zhan","year":"2021","unstructured":"Zhan Q, Jeon J, Li Y, Huang Y, Xiong J, Wang Q, Xu T-L, Li Y, Ji F-H, Du G, Zhu MX. CAMK2\/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy. 2021;18:726\u201344.","journal-title":"Autophagy"},{"key":"2414_CR272","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nm.4017","volume":"22","author":"T Zhang","year":"2016","unstructured":"Zhang T, Zhang Y, Cui M, Jin L, Wang Y, Lv F, Liu Y, Zheng W, Shang H, Zhang J, Zhang M, Wu H, Guo J, Zhang X, Hu X, Cao C-M, Xiao R-P. CaMKII is a RIP3 substrate mediating ischemia- and oxidative stress\u2013induced myocardial necroptosis. Nat Med. 2016;22:175\u201382.","journal-title":"Nat Med"},{"key":"2414_CR273","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.cell.2017.03.020","volume":"169","author":"Y-N Gong","year":"2017","unstructured":"Gong Y-N, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR. ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences. Cell. 2017;169:286-300.e216.","journal-title":"Cell"},{"key":"2414_CR274","doi-asserted-by":"crossref","unstructured":"Lu X, Chen X, Lin C, Yi Y, Zhao S, Zhu B, Deng W, Wang X, Xie Z, Rao S, Ni Z, You T, Li L, Huang Y, Xue X, Yu Y, Sun W, Shen X. Elesclomol loaded copper oxide nanoplatform triggers cuproptosis to enhance antitumor immunotherapy. Adv Sci. 2024;11:e2309984.","DOI":"10.1002\/advs.202309984"},{"key":"2414_CR275","doi-asserted-by":"crossref","unstructured":"Wang C-P, Zhang L, Zhu M-J. Copper overload promotes \u03b2-amyloid induced NLRP3\/caspase-1\/GSDMD-mediated pyroptosis in Alzheimer\u2019s disease. J Integr Neurosci. 2024;23:194.","DOI":"10.31083\/j.jin2310194"},{"key":"2414_CR276","doi-asserted-by":"crossref","unstructured":"Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC. Copper is an essential regulator of the autophagic kinases ULK1\/2 to drive lung adenocarcinoma.\u00a0Nat Cell Biol. 2020;22:412\u201324.","DOI":"10.1038\/s41556-020-0481-4"},{"key":"2414_CR277","doi-asserted-by":"publisher","first-page":"12858","DOI":"10.1039\/C9NR01277J","volume":"11","author":"P Ruenraroengsak","year":"2019","unstructured":"Ruenraroengsak P, Kiryushko D, Theodorou IG, Klosowski MM, Taylor ER, Niriella T, Palmieri C, Yag\u00fce E, Ryan MP, Coombes RC, Xie F, Porter AE. Frizzled-7-targeted delivery of zinc oxide nanoparticles to drug-resistant breast cancer cells. Nanoscale. 2019;11:12858\u201370.","journal-title":"Nanoscale"},{"key":"2414_CR278","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0486-y","volume":"15","author":"P Chandler","year":"2016","unstructured":"Chandler P, Kochupurakkal BS, Alam S, Richardson AL, Soybel DI, Kelleher SL. Subtype-specific accumulation of intracellular zinc pools is associated with the malignant phenotype in breast cancer. Mol Cancer. 2016;15: 2.","journal-title":"Mol Cancer"},{"key":"2414_CR279","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109848","volume":"37","author":"W Du","year":"2021","unstructured":"Du W, Gu M, Hu M, Pinchi P, Chen W, Ryan M, Nold T, Bannaga A, Xu H. Lysosomal Zn(2+) release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 2021;37: 109848.","journal-title":"Cell Rep"},{"key":"2414_CR280","doi-asserted-by":"publisher","first-page":"161","DOI":"10.2478\/s11756-019-00325-9","volume":"75","author":"M Farasat","year":"2020","unstructured":"Farasat M, Niazvand F, Khorsandi L. Zinc oxide nanoparticles induce necroptosis and inhibit autophagy in MCF-7 human breast cancer cells. Biologia. 2020;75:161\u201374.","journal-title":"Biologia"},{"key":"2414_CR281","doi-asserted-by":"crossref","unstructured":"Chen PH, Wu JL, Xu YT, Ding CKC, Mestre AA, Lin CC, Yang WH, Chi JT. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021;12:198.","DOI":"10.1038\/s41419-021-03482-5"},{"key":"2414_CR282","doi-asserted-by":"crossref","unstructured":"Zheng P, Ding BB, Zhu GQ, Wang M, Li CX, Lin J. Biodegradable hydrogen peroxide nanogenerator for controllable cancer immunotherapy via modulating cell death pathway from apoptosis to pyroptosis. Chem Eng J. 2022;450:137967.","DOI":"10.1016\/j.cej.2022.137967"},{"key":"2414_CR283","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1007\/s11064-024-04101-3","volume":"49","author":"X Wu","year":"2024","unstructured":"Wu X, Shi M, Chen Y, Lian Y, Fang S, Zhang H. Effect and mechanism of LIN28 on ferroptosis in Mg2+-free rat hippocampal neuron model of epilepsy. Neurochem Res. 2024;49:1655\u201364.","journal-title":"Neurochem Res"},{"key":"2414_CR284","doi-asserted-by":"crossref","unstructured":"Hoggard NK, Yuan S, Szczepaniak MR, Turner MM, Kantake N, Lo C, LaRussa ZD, Song J, Daniels NA, Young JA, Echols JB, Iii BEH, Bergmeier SC, Chen X, Rosol TJ.\u00a0Progression of bone-metastatic prostate cancer in a mouse model treated with a novel pan-class I GLUT inhibitor (DRB18).\u00a0J Cancer Metastasis Treat. 2025;11:5.","DOI":"10.20517\/2394-4722.2024.105"},{"key":"2414_CR285","doi-asserted-by":"crossref","unstructured":"Liang Y, Yang Q. The role of circular RNAs in glucose metabolic reprogramming: impact on cancer progression and therapeutic implications in breast cancer.\u00a0J Cancer Metastasis Treat. 2025;11:3.","DOI":"10.20517\/2394-4722.2024.93"},{"key":"2414_CR286","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.phrs.2016.12.001","volume":"115","author":"L Fouani","year":"2017","unstructured":"Fouani L, Menezes SV, Paulson M, Richardson DR, Kovacevic Z. Metals and metastasis: exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents. Pharmacol Res. 2017;115:275\u201387.","journal-title":"Pharmacol Res"},{"key":"2414_CR287","doi-asserted-by":"publisher","DOI":"10.1002\/cplu.202300624","author":"Y Yang","year":"2024","unstructured":"Yang Y, Fan H, Guo Z. Modulation of metal homeostasis for cancer therapy. ChemPlusChem. 2024;\u00a089:e202300624.","journal-title":"ChemPlusChem"},{"key":"2414_CR288","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1021\/acschembio.1c00122","volume":"16","author":"U Abbasi","year":"2021","unstructured":"Abbasi U, Abbina S, Gill A, Takuechi LE, Kizhakkedathu JN. Role of iron in the molecular pathogenesis of diseases and therapeutic opportunities. ACS Chem Biol. 2021;16:945\u201372.","journal-title":"ACS Chem Biol"},{"key":"2414_CR289","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nrd.2016.248","volume":"16","author":"BJ Crielaard","year":"2017","unstructured":"Crielaard BJ, Lammers T, Rivella S. Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017;16:400\u201323.","journal-title":"Nat Rev Drug Discov"},{"key":"2414_CR290","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41580-023-00648-1","volume":"25","author":"B Galy","year":"2023","unstructured":"Galy B, Conrad M, Muckenthaler M. Mechanisms controlling cellular and systemic iron homeostasis. Nat Rev Mol Cell Biol. 2023;25:133\u201355.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2414_CR291","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1158\/0008-5472.CAN-20-2017","volume":"80","author":"SV Torti","year":"2020","unstructured":"Torti SV, Torti FM. Iron and cancer: 2020 vision. Cancer Res. 2020;80:5435\u201348.","journal-title":"Cancer Res"},{"key":"2414_CR292","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.ijbiomac.2021.09.188","volume":"192","author":"L-L Chen","year":"2021","unstructured":"Chen L-L, Wang W-J. P53 regulates lipid metabolism in cancer. Int J Biol Macromol. 2021;192:45\u201354.","journal-title":"Int J Biol Macromol"},{"key":"2414_CR293","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS, Cheah JH, Clemons PA, Shamji AF, Clish CB. Regulation of ferroptotic cancer cell death by GPX4. Cell. 2014;156:317\u201331.","journal-title":"Cell"},{"key":"2414_CR294","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1111\/jcmm.13008","volume":"21","author":"H Yu","year":"2017","unstructured":"Yu H, Guo P, Xie X, Wang Y, Chen G. Ferroptosis, a new form of cell death, and its relationships with tumourous diseases. J Cell Mol Med. 2017;21:648\u201357.","journal-title":"J Cell Mol Med"},{"key":"2414_CR295","doi-asserted-by":"crossref","unstructured":"Battaglia AM, Sacco A, Vecchio E, Scicchitano S, Petriaggi L, Giorgio E, Bulotta S, Levi S, Faniello CM, Biamonte F, Costanzo F. Iron affects the sphere-forming ability of ovarian cancer cells in non-adherent culture conditions. Front Cell Dev Biol. 2023;11:1272667.","DOI":"10.3389\/fcell.2023.1272667"},{"key":"2414_CR296","doi-asserted-by":"crossref","unstructured":"Moloney JN, Cotter TG.\u00a0ROS signalling in the biology of cancer.\u00a0Semin Cell Dev Biol. 2018;80:50\u201364.","DOI":"10.1016\/j.semcdb.2017.05.023"},{"key":"2414_CR297","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","volume":"22","author":"EC Cheung","year":"2022","unstructured":"Cheung EC, Vousden KH. The role of ROS in tumour development and progression. Nat Rev Cancer. 2022;22:280\u201397.","journal-title":"Nat Rev Cancer"},{"key":"2414_CR298","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/mc.22474","volume":"56","author":"AL Greenshields","year":"2017","unstructured":"Greenshields AL, Shepherd TG, Hoskin DW. Contribution of reactive oxygen species to ovarian cancer cell growth arrest and killing by the anti-malarial drug artesunate. Mol Carcinog. 2017;56:75\u201393.","journal-title":"Mol Carcinog"},{"key":"2414_CR299","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/jgh.16402","volume":"39","author":"X Dong","year":"2024","unstructured":"Dong X, Chen X, Zhao Y, Wu Q, Ren Y. CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR-1276\/SLC7A11 axis. J Gastroenterol Hepatol. 2024;39:121\u201332.","journal-title":"J Gastroenterol Hepatol"},{"key":"2414_CR300","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41586-020-2623-z","volume":"585","author":"JM Ubellacker","year":"2020","unstructured":"Ubellacker JM, Tasdogan A, Ramesh V, Shen B, Mitchell EC, Martin-Sandoval MS, Gu Z, McCormick ML, Durham AB, Spitz DR. Lymph protects metastasizing melanoma cells from ferroptosis. Nature. 2020;585:113\u20138.","journal-title":"Nature"},{"key":"2414_CR301","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.7150\/ijbs.69454","volume":"18","author":"G Huang","year":"2022","unstructured":"Huang G, Xiang Z, Wu H, He Q, Dou R, Lin Z, Yang C, Huang S, Song J, Di Z. The lncRNA BDNF-AS\/WDR5\/FBXW7 axis mediates ferroptosis in gastric cancer peritoneal metastasis by regulating VDAC3 ubiquitination. Int J Biol Sci. 2022;18:1415.","journal-title":"Int J Biol Sci"},{"key":"2414_CR302","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25354-4","volume":"12","author":"W Liu","year":"2021","unstructured":"Liu W, Chakraborty B, Safi R, Kazmin D, Chang C-Y, McDonnell DP. Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. Nat Commun. 2021;12: 5103.","journal-title":"Nat Commun"},{"key":"2414_CR303","doi-asserted-by":"publisher","first-page":"3920664","DOI":"10.1155\/2022\/3920664","volume":"2022","author":"D Guan","year":"2022","unstructured":"Guan D, Zhou W, Wei H, Wang T, Zheng K, Yang C, Feng R, Xu R, Fu Y, Li C. Ferritinophagy-Mediated Ferroptosis and Activation of Keap1\/Nrf2\/HO-1 Pathway Were Conducive to EMT Inhibition of Gastric Cancer Cells in Action of 2, 2\u2032-Di-pyridineketone Hydrazone Dithiocarbamate Butyric Acid Ester. Oxid Med Cell Longev. 2022;2022:3920664.","journal-title":"Oxid Med Cell Longev"},{"key":"2414_CR304","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115730","author":"X Zhang","year":"2023","unstructured":"Zhang X, Tao T, Qiu Y, Guo X, Zhu X, Zhou X. Copper-mediated novel cell death pathway in tumor cells and implications for innovative cancer therapies. Biomed Pharmacother. 2023;168:115730.","journal-title":"Biomed Pharmacother"},{"key":"2414_CR305","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17549-y","author":"L Aubert","year":"2020","unstructured":"Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP. Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer. Nat Commun. 2020;11:3701.","journal-title":"Nat Commun"},{"key":"2414_CR306","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1002\/ijc.31991","volume":"144","author":"AP Fang","year":"2019","unstructured":"Fang AP, Chen PY, Wang XY, Liu ZY, Zhang DM, Luo Y, Liao GC, Long JA, Zhong RH, Zhou ZG, Xu YJ, Xu XJ, Ling WH, Chen MS, Zhang YJ, Zhu HL. Serum copper and zinc levels at diagnosis and hepatocellular carcinoma survival in the Guangdong Liver Cancer Cohort. Int J Cancer. 2019;144:2823\u201332.","journal-title":"Int J Cancer"},{"key":"2414_CR307","doi-asserted-by":"publisher","first-page":"4863","DOI":"10.1177\/0300060518798507","volume":"46","author":"X Zhang","year":"2018","unstructured":"Zhang X, Yang Q. Association between serum copper levels and lung cancer risk: a meta-analysis. J Int Med Res. 2018;46:4863\u201373.","journal-title":"J Int Med Res"},{"key":"2414_CR308","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1209156","author":"X Tang","year":"2023","unstructured":"Tang X, Yan Z, Miao Y, Ha W, Li Z, Yang L, Mi D. Copper in cancer: from limiting nutrient to therapeutic target. Front Oncol. 2023;13:1209156.","journal-title":"Front Oncol"},{"key":"2414_CR309","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27559-z","author":"D Ramchandani","year":"2021","unstructured":"Ramchandani D, Berisa M, Tavarez DA, Li Z, Miele M, Bai Y, Lee SB, Ban Y, Dephoure N, Hendrickson RC, Cloonan SM, Gao D, Cross JR, Vahdat LT, Mittal V. Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis. Nat Commun. 2021;12:7311.","journal-title":"Nat Commun"},{"key":"2414_CR310","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtemb.2004.02.004","volume":"18","author":"A Nasulewicz","year":"2004","unstructured":"Nasulewicz A, Mazur A, Opolski A. Role of copper in tumour angiogenesis\u2014clinical implications. J Trace Elem Med Biol. 2004;18:1\u20138.","journal-title":"J Trace Elem Med Biol"},{"key":"2414_CR311","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1039\/C8MT00280K","volume":"11","author":"Z Wu","year":"2019","unstructured":"Wu Z, Zhang W, Kang YJ. Copper affects the binding of HIF-1\u03b1 to the critical motifs of its target genes. Metallomics. 2019;11:429\u201338.","journal-title":"Metallomics"},{"key":"2414_CR312","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/549412","volume":"2015","author":"A Zimna","year":"2015","unstructured":"Zimna A, Kurpisz M. Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies. Biomed Res Int. 2015;2015: 549412.","journal-title":"Biomed Res Int"},{"key":"2414_CR313","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1007\/s10495-023-01845-1","volume":"28","author":"J Lu","year":"2023","unstructured":"Lu J, Ling X, Sun Y, Liu L, Liu L, Wang X, Lu C, Ren C, Han X, Yu Z. FDX1 enhances endometriosis cell cuproptosis via G6PD-mediated redox homeostasis. Apoptosis. 2023;28:1128\u201340.","journal-title":"Apoptosis"},{"key":"2414_CR314","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.abb.2006.08.016","volume":"454","author":"PL Walter","year":"2006","unstructured":"Walter PL, Kampk\u00f6tter A, Eckers A, Barthel A, Schmoll D, Sies H, Klotz L-O. Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions. Arch Biochem Biophys. 2006;454:107\u201313.","journal-title":"Arch Biochem Biophys"},{"key":"2414_CR315","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11050659","author":"S Baldari","year":"2019","unstructured":"Baldari S, Di Rocco G, Heffern MC, Su TA, Chang CJ, Toietta G. Effects of copper chelation on BRAFV600E positive colon carcinoma cells. Cancers (Basel). 2019;11:659.","journal-title":"Cancers (Basel)"},{"key":"2414_CR316","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.canep.2010.06.004","volume":"35","author":"Y Jin","year":"2011","unstructured":"Jin Y, Zhang C, Xu H, Xue S, Wang Y, Hou Y, Kong Y, Xu Y. Combined effects of serum trace metals and polymorphisms of CYP1A1 or GSTM1 on non-small cell lung cancer: a hospital based case\u2013control study in China. Cancer Epidemiol. 2011;35:182\u20137.","journal-title":"Cancer Epidemiol"},{"key":"2414_CR317","doi-asserted-by":"crossref","unstructured":"Pavithra V, Sathisha T, Kasturi K, Mallika DS, Amos SJ, Ragunatha S. Serum levels of metal ions in female patients with breast cancer. Journal of clinical and diagnostic research: JCDR. 2015;9: BC25.","DOI":"10.7860\/JCDR\/2015\/11627.5476"},{"key":"2414_CR318","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1385\/BTER:114:1:41","volume":"114","author":"X Zuo","year":"2006","unstructured":"Zuo X, Chen J, Zhou X, Li X, Mei G. Levels of selenium, zinc, copper, and antioxidant enzyme activity in patients with leukemia. Biol Trace Elem Res. 2006;114:41\u201353.","journal-title":"Biol Trace Elem Res"},{"key":"2414_CR319","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1159\/000499261","volume":"14","author":"SA Saleh","year":"2020","unstructured":"Saleh SA, Adly HM, Abdelkhaliq AA, Nassir AM. Serum levels of selenium, zinc, copper, manganese, and iron in prostate cancer patients. Curr Urol. 2020;14:44\u20139.","journal-title":"Curr Urol"},{"key":"2414_CR320","doi-asserted-by":"publisher","first-page":"3594","DOI":"10.3390\/cancers12123594","volume":"12","author":"P Leli\u00e8vre","year":"2020","unstructured":"Leli\u00e8vre P, Sancey L, Coll J-L, Deniaud A, Busser B. The multifaceted roles of copper in cancer: a trace metal element with dysregulated metabolism, but also a target or a bullet for therapy. Cancers (Basel). 2020;12:3594.","journal-title":"Cancers (Basel)"},{"key":"2414_CR321","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/s41556-020-0481-4","volume":"22","author":"T Tsang","year":"2020","unstructured":"Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC. Copper is an essential regulator of the autophagic kinases ULK1\/2 to drive lung adenocarcinoma. Nat Cell Biol. 2020;22:412\u201324.","journal-title":"Nat Cell Biol"},{"key":"2414_CR322","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1038\/s41467-020-14698-y","volume":"11","author":"Y Liao","year":"2020","unstructured":"Liao Y, Zhao J, Bulek K, Tang F, Chen X, Cai G, Jia S, Fox PL, Huang E, Pizarro TT. Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nat Commun. 2020;11:900.","journal-title":"Nat Commun"},{"key":"2414_CR323","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1038\/s41575-021-00486-6","volume":"18","author":"X Chen","year":"2021","unstructured":"Chen X, Zeh HJ, Kang R, Kroemer G, Tang D. Cell death in pancreatic cancer: from pathogenesis to therapy. Nat Rev Gastroenterol Hepatol. 2021;18:804\u201323.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2414_CR324","doi-asserted-by":"publisher","first-page":"3363","DOI":"10.3390\/ijms21093363","volume":"21","author":"P Ghosh","year":"2020","unstructured":"Ghosh P, Vidal C, Dey S, Zhang L. Mitochondria targeting as an effective strategy for cancer therapy. Int J Mol Sci. 2020;21:3363.","journal-title":"Int J Mol Sci"},{"key":"2414_CR325","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.03.42","author":"D Yu","year":"2020","unstructured":"Yu D, Liu C, Guo L. Mitochondrial metabolism and cancer metastasis. Ann Transl Med. 2020;8:904.","journal-title":"Ann Transl Med"},{"key":"2414_CR326","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.925618","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zeng X, Wu Y, Liu Y, Zhang X, Song Z. Cuproptosis-related risk score predicts prognosis and characterizes the tumor microenvironment in hepatocellular carcinoma. Front Immunol. 2022;13:925618.","journal-title":"Front Immunol"},{"key":"2414_CR327","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.925743","volume":"12","author":"J Li","year":"2022","unstructured":"Li J, Chen S, Liao Y, Wang H, Zhou D, Zhang B. Arecoline is associated with inhibition of cuproptosis and proliferation of cancer-associated fibroblasts in oral squamous cell carcinoma: a potential mechanism for tumor metastasis. Front Oncol. 2022;12: 925743.","journal-title":"Front Oncol"},{"key":"2414_CR328","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12943-019-1019-x","volume":"18","author":"J Hu","year":"2019","unstructured":"Hu J, Wang W, Lan X, Zeng Z, Liang Y, Yan Y, Song F, Wang F, Zhu X, Liao W. CAfs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer. Mol Cancer. 2019;18:1\u201315.","journal-title":"Mol Cancer"},{"key":"2414_CR329","doi-asserted-by":"publisher","first-page":"4720","DOI":"10.3390\/cancers13184720","volume":"13","author":"PJ Asif","year":"2021","unstructured":"Asif PJ, Longobardi C, Hahne M, Medema JP. The role of cancer-associated fibroblasts in cancer invasion and metastasis. Cancers. 2021;13:4720.","journal-title":"Cancers"},{"key":"2414_CR330","doi-asserted-by":"publisher","first-page":"ra56","DOI":"10.1126\/scisignal.2004870","volume":"7","author":"G MacDonald","year":"2014","unstructured":"MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Doelemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D. Memo is a copper-dependent redox protein with an essential role in migration and metastasis. Sci Signal. 2014;7:ra56\u2013ra56.","journal-title":"Sci Signal"},{"key":"2414_CR331","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2206905119","volume":"119","author":"X Zhang","year":"2022","unstructured":"Zhang X, Walke GR, Horvath I, Kumar R, Blockhuys S, Holgersson S, Walton PH, Wittung-Stafshede P. Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro. Proc Natl Acad Sci. 2022;119: e2206905119.","journal-title":"Proc Natl Acad Sci"},{"key":"2414_CR332","doi-asserted-by":"publisher","first-page":"871","DOI":"10.3390\/ijms18040871","volume":"18","author":"S Blockhuys","year":"2017","unstructured":"Blockhuys S, Wittung-Stafshede P. Roles of copper-binding proteins in breast cancer. Int J Mol Sci. 2017;18:871.","journal-title":"Int J Mol Sci"},{"key":"2414_CR333","doi-asserted-by":"publisher","first-page":"6836","DOI":"10.1073\/pnas.1817473116","volume":"116","author":"V Shanbhag","year":"2019","unstructured":"Shanbhag V, Jasmer-McDonald K, Zhu S, Martin AL, Gudekar N, Khan A, Ladomersky E, Singh K, Weisman GA, Petris MJ. ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis. Proc Natl Acad Sci. 2019;116:6836\u201341.","journal-title":"Proc Natl Acad Sci"},{"key":"2414_CR334","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216157","volume":"561","author":"X Wang","year":"2023","unstructured":"Wang X, Zhou M, Liu Y, Si Z. Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies. Cancer Lett. 2023;561: 216157.","journal-title":"Cancer Lett"},{"key":"2414_CR335","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/nrc.2017.51","volume":"17","author":"M De Palma","year":"2017","unstructured":"De Palma M, Biziato D, Petrova TV. Microenvironmental regulation of tumour angiogenesis. Nat Rev Cancer. 2017;17:457\u201374.","journal-title":"Nat Rev Cancer"},{"key":"2414_CR336","first-page":"218","volume":"3","author":"F Runa","year":"2017","unstructured":"Runa F, Hamalian S, Meade K, Shisgal P, Gray PC, Kelber JA. Tumor Microenvironment Heterogeneity: Challenges and Opportunities, Current. Mol Biol Rep. 2017;3:218\u201329.","journal-title":"Mol Biol Rep"},{"key":"2414_CR337","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107753","author":"Y Xiao","year":"2021","unstructured":"Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021;221:107753.","journal-title":"Pharmacol Ther"},{"key":"2414_CR338","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01771-z","author":"F Shen","year":"2023","unstructured":"Shen F, Fang Y, Wu Y, Zhou M, Shen J, Fan X. Metal ions and nanometallic materials in antitumor immunity: function, application, and perspective. J Nanobiotechnology. 2023;21:20.","journal-title":"J Nanobiotechnology"},{"key":"2414_CR339","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1987636","author":"W Song","year":"2021","unstructured":"Song W, Ren J, Xiang R, Kong C, Fu T. Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer. Oncoimmunology. 2021;10:1987636.","journal-title":"Oncoimmunology"},{"key":"2414_CR340","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.626812","author":"W Liang","year":"2021","unstructured":"Liang W, Ferrara N. Iron metabolism in the tumor microenvironment: contributions of innate immune cells. Front Immunol. 2021;11:626812.","journal-title":"Front Immunol"},{"key":"2414_CR341","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-024-03329-x","author":"R Yu","year":"2024","unstructured":"Yu R, Hang Y, Tsai H-i, Wang D, Zhu H. Iron metabolism: backfire of cancer cell stemness and therapeutic modalities. Cancer Cell Int. 2024;24:157.","journal-title":"Cancer Cell Int"},{"key":"2414_CR342","doi-asserted-by":"publisher","DOI":"10.3390\/cells10020303","author":"A Sacco","year":"2021","unstructured":"Sacco A, Battaglia AM, Botta C, Aversa I, Mancuso S, Costanzo F, Biamonte F. Iron metabolism in the tumor microenvironment\u2014implications for anti-cancer immune response. Cells. 2021;10:303.","journal-title":"Cells"},{"key":"2414_CR343","doi-asserted-by":"publisher","first-page":"1545","DOI":"10.1007\/s13402-023-00828-3","volume":"46","author":"D Est\u00eav\u00e3o","year":"2023","unstructured":"Est\u00eav\u00e3o D, da Cruz-Ribeiro M, Cardoso AP, Costa \u00c2M, Oliveira MJ, Duarte TL, da Cruz TB. Iron metabolism in colorectal cancer: a balancing act. Cell Oncol. 2023;46:1545\u201358.","journal-title":"Cell Oncol"},{"key":"2414_CR344","doi-asserted-by":"crossref","unstructured":"D. Vela, Iron in the Tumor Microenvironment, Tumor Microenvironment2020, pp. 39\u201351.","DOI":"10.1007\/978-3-030-43093-1_3"},{"key":"2414_CR345","doi-asserted-by":"publisher","first-page":"4089","DOI":"10.1038\/onc.2017.11","volume":"36","author":"D Basuli","year":"2017","unstructured":"Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017;36:4089\u201399.","journal-title":"Oncogene"},{"key":"2414_CR346","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17804-1","author":"C Raggi","year":"2017","unstructured":"Raggi C, Gammella E, Correnti M, Buratti P, Forti E, Andersen JB, Alpini G, Glaser S, Alvaro D, Invernizzi P, Cairo G, Recalcati S. Dysregulation of iron metabolism in cholangiocarcinoma stem-like cells. Sci Rep. 2017;7:17667.","journal-title":"Sci Rep"},{"key":"2414_CR347","doi-asserted-by":"publisher","first-page":"4013","DOI":"10.1038\/s41388-018-0243-y","volume":"37","author":"N Blanchette-Farra","year":"2018","unstructured":"Blanchette-Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, Claffey KP, Torti FM, Torti SV. Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer. Oncogene. 2018;37:4013\u201332.","journal-title":"Oncogene"},{"key":"2414_CR348","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.7150\/ijbs.74985","volume":"19","author":"Y Lv","year":"2023","unstructured":"Lv Y, Tang W, Xu Y, Chang W, Zhang Z, Lin Q, Ji M, Feng Q, He G, Xu J. Apolipoprotein L3 enhances CD8+ T cell antitumor immunity of colorectal cancer by promoting LDHA-mediated ferroptosis. Int J Biol Sci. 2023;19:1284\u201398.","journal-title":"Int J Biol Sci"},{"key":"2414_CR349","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.ccell.2022.02.003","volume":"40","author":"P Liao","year":"2022","unstructured":"Liao P, Wang W, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK, Kennedy PD, Gij\u00f3n M, Shah YM, Zou W. CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022;40:365-378.e366.","journal-title":"Cancer Cell"},{"key":"2414_CR350","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.cmet.2021.02.015","volume":"33","author":"X Ma","year":"2021","unstructured":"Ma X, Xiao L, Liu L, Ye L, Su P, Bi E, Wang Q, Yang M, Qian J, Yi Q. CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability. Cell Metab. 2021;33:1001-1012.e1005.","journal-title":"Cell Metab"},{"key":"2414_CR351","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/s41589-019-0462-8","volume":"16","author":"AA Kapralov","year":"2020","unstructured":"Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St. Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16:278\u201390.","journal-title":"Nat Chem Biol"},{"key":"2414_CR352","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1158\/0008-5472.CAN-24-1941","volume":"85","author":"W Zeng","year":"2025","unstructured":"Zeng W, Zhang R, Huang P, Chen M, Chen H, Zeng X, Liu J, Zhang J, Huang D, Lao L. Ferroptotic neutrophils induce immunosuppression and chemoresistance in breast cancer. Can Res. 2025;85:477\u201396.","journal-title":"Can Res"},{"key":"2414_CR353","doi-asserted-by":"crossref","unstructured":"Zhao Y, Liu Z, Liu G, Zhang Y, Liu S, Gan D, Chang W, Peng X, Sung ES, Gilbert K, Zhu Y, Wang X, Zeng Z, Baldwin H, Ren G, Weaver J, Huron A, Mayberry T, Wang Q, Wang Y, Diaz-Rubio ME, Su X, Stack MS, Zhang S, Lu X, Sheldon RD, Li J, Zhang C, Wan J, Lu X. Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1. Cell Metab. 2023;35:1688\u20131703.e10.","DOI":"10.1016\/j.cmet.2023.09.004"},{"key":"2414_CR354","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41586-022-05443-0","volume":"612","author":"R Kim","year":"2022","unstructured":"Kim R, Hashimoto A, Markosyan N, Tyurin VA, Tyurina YY, Kar G, Fu S, Sehgal M, Garcia-Gerique L, Kossenkov A. Ferroptosis of tumour neutrophils causes immune suppression in cancer. Nature. 2022;612:338\u201346.","journal-title":"Nature"},{"key":"2414_CR355","doi-asserted-by":"crossref","unstructured":"Poznanski SM, Singh K, Ritchie TM, Aguiar JA, Fan IY, Portillo AL, Rojas EA, Vahedi F, El-Sayes A, Xing S.\u00a0Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment. Cell Metabolism. 2021;33(6):1205\u201320.e5.","DOI":"10.1016\/j.cmet.2021.03.023"},{"key":"2414_CR356","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.molmed.2021.06.014","volume":"27","author":"H Xu","year":"2021","unstructured":"Xu H, Ye D, Ren M, Zhang H, Bi F. Ferroptosis in the tumor microenvironment: perspectives for immunotherapy. Trends Mol Med. 2021;27:856\u201367.","journal-title":"Trends Mol Med"},{"key":"2414_CR357","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nature10189","volume":"475","author":"GM DeNicola","year":"2011","unstructured":"DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011;475:106\u20139.","journal-title":"Nature"},{"key":"2414_CR358","first-page":"1569","volume":"9","author":"M Jiang","year":"2020","unstructured":"Jiang M, Qiao M, Zhao C, Deng J, Li X, Zhou C. Targeting ferroptosis for cancer therapy: exploring novel strategies from its mechanisms and role in cancers, Translational Lung. Can Res. 2020;9:1569\u201384.","journal-title":"Can Res"},{"key":"2414_CR359","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2023.106808","author":"L Li","year":"2024","unstructured":"Li L, Shi J, Liu W, Luo Y, Gao S, Liu J-X. Copper overload induces apoptosis and impaired proliferation of T cell in zebrafish. Aquat Toxicol. 2024;267:106808.","journal-title":"Aquat Toxicol"},{"key":"2414_CR360","doi-asserted-by":"crossref","unstructured":"Solier S, M\u00fcller S, Ca\u00f1eque T, Versini A, Mansart A, Sindikubwabo F, Baron L, Emam L, Gestraud P, Panto\u0219 GD, Gandon V, Gaillet C, Wu T-D, Dingli F, Loew D, Baulande S, Durand S, Sencio V, Robil C, Trottein F, P\u00e9ricat D, N\u00e4ser E, Cougoule C, Meunier E, B\u00e8gue A-L, Salmon H, Manel N, Puisieux A, Watson S, Dawson MA, Servant N, Kroemer G, Annane D, Rodriguez R. A druggable copper-signalling pathway that drives inflammation. Nature. 2023;617:386\u201394.","DOI":"10.1038\/s41586-023-06017-4"},{"key":"2414_CR361","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","volume":"38","author":"JD Hayes","year":"2020","unstructured":"Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative Stress in Cancer. Cancer Cell. 2020;38:167\u201397.","journal-title":"Cancer Cell"},{"key":"2414_CR362","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.925618","volume":"13","author":"Z Zhang","year":"2022","unstructured":"Zhang Z, Zeng X, Wu Y, Liu Y, Zhang X, Song Z. Cuproptosis-related risk score predicts prognosis and characterizes the tumor microenvironment in hepatocellular carcinoma. Front Immunol. 2022;13: 925618.","journal-title":"Front Immunol"},{"key":"2414_CR363","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13045-020-00946-7","volume":"13","author":"R Tang","year":"2020","unstructured":"Tang R, Xu J, Zhang B, Liu J, Liang C, Hua J, Meng Q, Yu X, Shi S. Ferroptosis, necroptosis, and pyroptosis in anticancer immunity. J Hematol Oncol. 2020;13:1\u201318.","journal-title":"J Hematol Oncol"},{"key":"2414_CR364","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.922780","volume":"13","author":"S Sha","year":"2022","unstructured":"Sha S, Si L, Wu X, Chen Y, Xiong H, Xu Y, Liu W, Mei H, Wang T, Li M. Prognostic analysis of cuproptosis-related gene in triple-negative breast cancer. Front Immunol. 2022;13: 922780.","journal-title":"Front Immunol"},{"key":"2414_CR365","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/s12957-022-02727-7","volume":"20","author":"F Wang","year":"2022","unstructured":"Wang F, Lin H, Su Q, Li C. Cuproptosis-related lncRNA predict prognosis and immune response of lung adenocarcinoma. World J Surg Oncol. 2022;20:275.","journal-title":"World J Surg Oncol"},{"key":"2414_CR366","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.930041","author":"H Lv","year":"2022","unstructured":"Lv H, Liu X, Zeng X, Liu Y, Zhang C, Zhang Q, Xu J. Comprehensive analysis of cuproptosis-related genes in immune infiltration and prognosis in melanoma. Front Pharmacol. 2022;13:930041.","journal-title":"Front Pharmacol"},{"key":"2414_CR367","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01164-5","volume":"8","author":"R Jiang","year":"2022","unstructured":"Jiang R, Huan Y, Li Y, Gao X, Sun Q, Zhang F, Jiang T. Transcriptional and genetic alterations of cuproptosis-related genes correlated to malignancy and immune-infiltrate of esophageal carcinoma. Cell Death Discov. 2022;8: 370.","journal-title":"Cell Death Discov"},{"key":"2414_CR368","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1002\/jcb.29911","volume":"122","author":"R Takemoto","year":"2021","unstructured":"Takemoto R, Kamiya T, Atobe T, Hara H, Adachi T. Regulation of lysyl oxidase expression in THP-1 cell-derived M2-like macrophages. J Cell Biochem. 2021;122:777\u201386.","journal-title":"J Cell Biochem"},{"key":"2414_CR369","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.933241","volume":"13","author":"Z Cai","year":"2022","unstructured":"Cai Z, He Ye, Yu Z, Hu J, Xiao Z, Zu X, Li Z, Li H. Cuproptosis-related modification patterns depict the tumor microenvironment, precision immunotherapy, and prognosis of kidney renal clear cell carcinoma. Front Immunol. 2022;13: 933241.","journal-title":"Front Immunol"},{"key":"2414_CR370","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1146\/annurev-nutr-122019-120635","volume":"41","author":"I Wessels","year":"2021","unstructured":"Wessels I, Fischer HJ, Rink L. Dietary and physiological effects of Zinc on the immune system. Annu Rev Nutr. 2021;41:133\u201375.","journal-title":"Annu Rev Nutr"},{"key":"2414_CR371","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/ijc.34679","volume":"154","author":"M Bendellaa","year":"2023","unstructured":"Bendellaa M, Leli\u00e8vre P, Coll JL, Sancey L, Deniaud A, Busser B. Roles of zinc in cancers: from altered metabolism to therapeutic applications. Int J Cancer. 2023;154:7\u201320.","journal-title":"Int J Cancer"},{"key":"2414_CR372","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2021.126864","author":"B Rolles","year":"2021","unstructured":"Rolles B, Maywald M, Rink L. Intracellular zinc during cell activation and zinc deficiency. J Trace Elem Med Biol. 2021;68:126864.","journal-title":"J Trace Elem Med Biol"},{"key":"2414_CR373","doi-asserted-by":"publisher","first-page":"2210","DOI":"10.31635\/ccschem.023.202303514","volume":"6","author":"Y Yang","year":"2024","unstructured":"Yang Y, Fan H, Xu X, Yao S, Yu W, Guo Z. Zinc ion-induced immune responses in antitumor immunotherapy. CCS Chem. 2024;6:2210\u201329.","journal-title":"CCS Chem"},{"key":"2414_CR374","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1056\/NEJMra1510603","volume":"390","author":"RM Touyz","year":"2024","unstructured":"Touyz RM, Ingelfinger JR, de Baaij JHF, Hoenderop JGJ. Magnesium Disorders. N Engl J Med. 2024;390:1998\u20132009.","journal-title":"N Engl J Med"},{"key":"2414_CR375","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.bbadis.2004.08.003","volume":"1739","author":"A Nasulewicz","year":"2004","unstructured":"Nasulewicz A, Wietrzyk J, Wolf FI, Dzimira S, Madej J, Maier JAM, Rayssiguier Y, Mazur A, Opolski A. Magnesium deficiency inhibits primary tumor growth but favors metastasis in mice. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2004;1739:26\u201332.","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"2414_CR376","doi-asserted-by":"crossref","unstructured":"J. L\u00f6tscher, A.-A. Mart\u00ed i L\u00edndez, N. Kirchhammer, E. Cribioli, G.M.P. Giordano Attianese, M.P. Trefny, M. Lenz, S.I. Rothschild, P. Strati, M. K\u00fcnzli, C. Lotter, S.H. Schenk, P. Dehio, J. L\u00f6liger, L. Litzler, D. Schreiner, V. Koch, N. Page, D. Lee, J. Gr\u00e4hlert, D. Kuzmin, A.-V. Burgener, D. Merkler, M. Pless, M.L. Balmer, W. Reith, J. Huwyler, M. Irving, C.G. King, A. Zippelius, C. Hess. Magnesium sensing via LFA-1 regulates CD8+ T cell effector function. Cell. 2022;185:585\u2013602.e29.","DOI":"10.1016\/j.cell.2021.12.039"},{"key":"2414_CR377","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216511","author":"S Sun","year":"2024","unstructured":"Sun S, Xu H, Zhao W, Li Q, Yuan Y, Zhang G, Li S, Wang B, Zhang W, Gao X, Zheng J, Zhang Q. PA suppresses antitumor immunity of T cells by disturbing mitochondrial activity through Akt\/mTOR-mediated Ca2+ flux. Cancer Lett. 2024;581:216511.","journal-title":"Cancer Lett"},{"key":"2414_CR378","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-022-01661-w","author":"H Hu","year":"2022","unstructured":"Hu H, Xu Q, Mo Z, Hu X, He Q, Zhang Z, Xu Z. New anti-cancer explorations based on metal ions. J Nanobiotechnology. 2022;\u00a020:457.","journal-title":"J Nanobiotechnology"},{"key":"2414_CR379","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104234","author":"X Wang","year":"2020","unstructured":"Wang X, Chen F, Gou S. Combination of DN604 with gemcitabine led to cell apoptosis and cell motility inhibition via p38 MAPK signaling pathway in NSCLC. Bioorg Chem. 2020;104:104234.","journal-title":"Bioorg Chem"},{"key":"2414_CR380","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2024.103259","author":"Y Wang","year":"2024","unstructured":"Wang Y, Yan D, Liu J, Tang D, Chen X. Protein modification and degradation in ferroptosis. Redox Biol. 2024;75:103259.","journal-title":"Redox Biol"},{"key":"2414_CR381","doi-asserted-by":"crossref","unstructured":"An X, Yu W, Liu J, Tang D, Yang L, Chen X. Chen, Oxidative cell death in cancer: mechanisms and therapeutic opportunities. Cell Death Dis. 2024;15:556.","DOI":"10.1038\/s41419-024-06939-5"},{"key":"2414_CR382","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1089\/ars.2024.0608","volume":"41","author":"TA Muluh","year":"2024","unstructured":"Muluh TA, Fu Q, Ai X, Wang C, Chen W, Zheng X, Wang W, Wang M, Shu X-S, Ying Y. Targeting ferroptosis as an advance strategy in cancer therapy. Antioxid Redox Signal. 2024;41:616\u201336.","journal-title":"Antioxid Redox Signal"},{"key":"2414_CR383","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101057","author":"J Liang","year":"2024","unstructured":"Liang J, Bi G, Huang Y, Zhao G, Sui Q, Zhang H, Bian Y, Yin J, Wang Q, Chen Z, Zhan C. MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinoma. Drug Resist Updat. 2024;73:101057.","journal-title":"Drug Resist Updat"},{"key":"2414_CR384","doi-asserted-by":"publisher","unstructured":"D. Calhoon, L. Sang, F. Ji, D. Bezwada, S.-C. Hsu, F. Cai, N. Kim, A. Basu, R. Wu, A. Pimentel, B. Brooks, K. La, A. Paulina Serrano, D.L. Cassidy, L. Cai, V. Toffessi-Tcheuyap, M.E. Moussa, W. Uritboonthai, L.T. Hoang, M. Kolli, B. Jackson, V. Margulis, G. Siuzdak, J. Brugarolas, I. Corbin, D.A. Pratt, R.J. Weiss, R.J. DeBerardinis, K. Birsoy, J. Garcia-Bermudez, Glycosaminoglycan-driven lipoprotein uptake protects tumours from ferroptosis. Nature. 2025. https:\/\/doi.org\/10.1038\/s41586-025-09162-0.","DOI":"10.1038\/s41586-025-09162-0"},{"key":"2414_CR385","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216515","author":"W Li","year":"2024","unstructured":"Li W, Shen Y, Yang C, Ye F, Liang Y, Cheng Z, Ou Y, Chen W, Chen Z, Zou L, Liu Y, Hu Y, Yan X, Jiang H. Identification of a novel ferroptosis-inducing micropeptide in bladder cancer. Cancer Lett. 2024;582:216515.","journal-title":"Cancer Lett"},{"key":"2414_CR386","doi-asserted-by":"publisher","DOI":"10.53388\/TMR20230618001","author":"Y-Y Cao","year":"2023","unstructured":"Cao Y-Y, Guo K, Qian L-C, Daniels MJ, Tian Y, Li Y, Song L-N, Wang Z-Q, Ren S. Dihydroartemisinin induces ferroptosis in pancreatic cancer cells by the regulation of survival prediction-related genes. Tradit Med Res. 2023;8:67.","journal-title":"Tradit Med Res"},{"key":"2414_CR387","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","volume":"12","author":"P Koppula","year":"2021","unstructured":"Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12:599\u2013620.","journal-title":"Protein Cell"},{"key":"2414_CR388","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S1535-6108(03)00050-3","volume":"3","author":"S Dolma","year":"2003","unstructured":"Dolma S, Lessnick SL, Hahn WC, Stockwell BR. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell. 2003;3:285\u201396.","journal-title":"Cancer Cell"},{"key":"2414_CR389","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1038\/nature05859","volume":"447","author":"N Yagoda","year":"2007","unstructured":"Yagoda N, von Rechenberg M, Zaganjor E, Bauer AJ, Yang WS, Fridman DJ, Wolpaw AJ, Smukste I, Peltier JM, Boniface JJ, Smith R, Lessnick SL, Sahasrabudhe S, Stockwell BR. RAS\u2013RAF\u2013MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature. 2007;447:865\u20139.","journal-title":"Nature"},{"key":"2414_CR390","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177652","author":"M Zhong","year":"2025","unstructured":"Zhong M, Zhong S, Qiu K, Peng X, Liu X, Sui S, Dai Z, Wang X, Nie D, Yu Z, Yu Q, Chen C, Li Y, Zeng C. Synergistic effects of BET inhibitors and ferroptosis inducers via targeted inhibition of the BRD4\/c-Myc\/NRF2 pathway in AML. Eur J Pharmacol. 2025;998:177652.","journal-title":"Eur J Pharmacol"},{"key":"2414_CR391","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2025.1532097","author":"AM Battaglia","year":"2025","unstructured":"Battaglia AM, Sacco A, Giorgio E, Petriaggi L, Elzanowska J, Cruz AR, Rocha L, Pereira CE, Moraes M.C. Strano, Palazzo L, Vitis C. De, Costa-Silva B, Biamonte F. Expulsion of iron-rich ferritin via CD63-mediated exosome drives ferroptosis resistance in ovarian cancer cells. Front Cell Dev Biol. 2025;13:1532097.","journal-title":"Front Cell Dev Biol"},{"key":"2414_CR392","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1158\/0008-5472.CAN-20-3477","volume":"81","author":"A Ghoochani","year":"2021","unstructured":"Ghoochani A, Hsu E-C, Aslan M, Rice MA, Nguyen HM, Brooks JD, Corey E, Paulmurugan R, Stoyanova T. Ferroptosis inducers are a novel therapeutic approach for advanced prostate cancer. Can Res. 2021;81:1583\u201394.","journal-title":"Can Res"},{"key":"2414_CR393","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.100985","author":"J Wang","year":"2023","unstructured":"Wang J, Zeng L, Wu N, Liang Y, Jin J, Fan M, Lai X, Chen Z-S, Pan Y, Zeng F, Deng F. Inhibition of phosphoglycerate dehydrogenase induces ferroptosis and overcomes enzalutamide resistance in castration-resistant prostate cancer cells. Drug Resist Updat. 2023;70:100985.","journal-title":"Drug Resist Updat"},{"key":"2414_CR394","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1002\/1878-0261.12936","volume":"15","author":"M Liu","year":"2021","unstructured":"Liu M, Fan Y, Li D, Han B, Meng Y, Chen F, Liu T, Song Z, Han Y, Huang L, Chang Y, Cao P, Nakai A, Tan K. Ferroptosis inducer erastin sensitizes NSCLC cells to celastrol through activation of the ROS\u2013mitochondrial fission\u2013mitophagy axis. Mol Oncol. 2021;15:2084\u2013105.","journal-title":"Mol Oncol"},{"key":"2414_CR395","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbrc.2021.06.088","volume":"569","author":"Z Liang","year":"2021","unstructured":"Liang Z, Zhao W, Li X, Wang L, Meng L, Yu R. Cisplatin synergizes with PRLX93936 to induce ferroptosis in non-small cell lung cancer cells. Biochem Biophys Res Commun. 2021;569:79\u201385.","journal-title":"Biochem Biophys Res Commun"},{"key":"2414_CR396","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2023.122411","volume":"339","author":"T Takatani-Nakase","year":"2024","unstructured":"Takatani-Nakase T, Ikushima C, Sakitani M, Nakase I. Regulatory network of ferroptosis and autophagy by targeting oxidative stress defense using sulfasalazine in triple-negative breast cancer. Life Sci. 2024;339: 122411.","journal-title":"Life Sci"},{"key":"2414_CR397","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1038\/s41388-024-02949-x","volume":"43","author":"W Xie","year":"2024","unstructured":"Xie W, Wang J, Tian S, Zhao H, Cao L, Liang Z, Yang J, Zhao Y, Wang B, Jiang F. RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis. Oncogene. 2024;43:1463\u201375.","journal-title":"Oncogene"},{"key":"2414_CR398","doi-asserted-by":"crossref","unstructured":"Yin Lb, Li Zw, Wang Jl, Wang L, Hou L, Hu Sy, Chen H, Luo P, Cui Xb, Zhu Jl. Sulfasalazine inhibits esophageal cancer cell proliferation by mediating ferroptosis.\u00a0Chem Biol Drug Design. 2023;102:730\u20137.","DOI":"10.1111\/cbdd.14281"},{"key":"2414_CR399","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.3390\/cancers15082363","volume":"15","author":"L Kerkhove","year":"2023","unstructured":"Kerkhove L, Geirnaert F, Rifi AL, Law KL, Guti\u00e9rrez A, Oudaert I, Corbet C, Gevaert T, Dufait I, De Ridder M. Repurposing sulfasalazine as a radiosensitizer in hypoxic human colorectal cancer. Cancers. 2023;15:2363.","journal-title":"Cancers"},{"key":"2414_CR400","doi-asserted-by":"publisher","first-page":"45","DOI":"10.31083\/j.fbl2901045","volume":"29","author":"C Yang","year":"2024","unstructured":"Yang C, Dong Q, Bao H, Ge Y, Xu Z, Li J, Jiang X, Xu Y, Zhong X. Ferroptosis: new strategies and ideas for the treatment of pancreatic ductal adenocarcinoma. Frontiers in Bioscience-Landmark. 2024;29:45.","journal-title":"Frontiers in Bioscience-Landmark"},{"key":"2414_CR401","doi-asserted-by":"publisher","first-page":"196","DOI":"10.3390\/antiox13020196","volume":"13","author":"J Campos","year":"2024","unstructured":"Campos J, Gleitze S, Hidalgo C, N\u00fa\u00f1ez MT. IP3R-mediated calcium release promotes ferroptotic death in SH-SY5Y neuroblastoma cells. Antioxidants. 2024;13:196.","journal-title":"Antioxidants"},{"key":"2414_CR402","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01854-2","volume":"10","author":"E Panczyszyn","year":"2024","unstructured":"Panczyszyn E, Saverio V, Monzani R, Gagliardi M, Petrovic J, Stojkovska J, Collavin L, Corazzari M. FSP1 is a predictive biomarker of osteosarcoma cells\u2019 susceptibility to ferroptotic cell death and a potential therapeutic target. Cell Death Discov. 2024;10: 87.","journal-title":"Cell Death Discov"},{"key":"2414_CR403","doi-asserted-by":"publisher","first-page":"8872","DOI":"10.1038\/s41598-023-35978-9","volume":"13","author":"J-W Kim","year":"2023","unstructured":"Kim J-W, Min DW, Kim D, Kim J, Kim MJ, Lim H, Lee J-Y. GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis. Sci Rep. 2023;13:8872.","journal-title":"Sci Rep"},{"key":"2414_CR404","doi-asserted-by":"crossref","unstructured":"Habermann KJ, Gr\u00fcnewald L, Van Wijk S, Fulda S. Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death. Cell Death Dis. 2017;8:e3067.","DOI":"10.1038\/cddis.2017.412"},{"key":"2414_CR405","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06042-1","volume":"14","author":"SY Park","year":"2023","unstructured":"Park SY, Jeong KJ, Poire A, Zhang D, Tsang YH, Blucher AS, Mills GB. Irreversible HER2 inhibitors overcome resistance to the RSL3 ferroptosis inducer in non-HER2 amplified luminal breast cancer. Cell Death Dis. 2023;14: 532.","journal-title":"Cell Death Dis"},{"key":"2414_CR406","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01383-4","volume":"9","author":"F Maccarinelli","year":"2023","unstructured":"Maccarinelli F, Coltrini D, Mussi S, Bugatti M, Turati M, Chiodelli P, Giacomini A, De Cillis F, Cattane N, Cattaneo A. Iron supplementation enhances RSL3-induced ferroptosis to treat na\u00efve and prevent castration-resistant prostate cancer. Cell Death Discov. 2023;9: 81.","journal-title":"Cell Death Discov"},{"key":"2414_CR407","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01382-z","volume":"22","author":"S Peng","year":"2024","unstructured":"Peng S, Chen G, Yu KN, Feng Y, Zhao L, Yang M, Cao W, Almahi WAA, Sun M, Xu Y, Zhao Y, Cheng C, Zhu F, Han W. Synergism of non-thermal plasma and low concentration RSL3 triggers ferroptosis via promoting xCT lysosomal degradation through ROS\/AMPK\/mTOR axis in lung cancer cells. Cell Commun Signal. 2024;22: 112.","journal-title":"Cell Commun Signal"},{"key":"2414_CR408","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","volume":"8","author":"S Sun","year":"2023","unstructured":"Sun S, Shen J, Jiang J, Wang F, Min J. Targeting ferroptosis opens new avenues for the development of novel therapeutics. Signal Transduct Target Ther. 2023;8:372.","journal-title":"Signal Transduct Target Ther"},{"key":"2414_CR409","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.116110","volume":"265","author":"H Song","year":"2024","unstructured":"Song H, Liang J, Guo Y, Liu Y, Sa K, Yan G, Xu W, Xu W, Chen L, Li H. A potent GPX4 degrader to induce ferroptosis in HT1080 cells. Eur J Med Chem. 2024;265: 116110.","journal-title":"Eur J Med Chem"},{"key":"2414_CR410","doi-asserted-by":"crossref","unstructured":"Liu J, Tang D, Kang R. Targeting GPX4 in ferroptosis and cancer: chemical strategies and challenges. Trends Pharmacol Sci. 2024;45:666\u201370","DOI":"10.1016\/j.tips.2024.05.006"},{"key":"2414_CR411","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s12032-023-02130-6","volume":"40","author":"M Golbashirzadeh","year":"2023","unstructured":"Golbashirzadeh M, Heidari HR, Aghamolayi AA, Fattahi Y, Talebi M, Khosroushahi AY. In vitro siRNA-mediated GPX4 and AKT1 silencing in oxaliplatin resistance cancer cells induces ferroptosis and apoptosis. Med Oncol. 2023;40:279.","journal-title":"Med Oncol"},{"key":"2414_CR412","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124582","volume":"664","author":"L Shu","year":"2024","unstructured":"Shu L, Luo P, Chen Q, Liu J, Huang Y, Wu C, Pan X, Huang Z. Fibroin nanodisruptor with ferroptosis-autophagy synergism is potent for lung cancer treatment. Int J Pharm. 2024;664: 124582.","journal-title":"Int J Pharm"},{"key":"2414_CR413","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.4251\/wjgo.v16.i5.2018","volume":"16","author":"L Wang","year":"2024","unstructured":"Wang L, Gong WH. Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis. World J Gastrointest Oncol. 2024;16:2018\u201337.","journal-title":"World J Gastrointest Oncol"},{"key":"2414_CR414","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101413","volume":"30","author":"T-C Chen","year":"2020","unstructured":"Chen T-C, Chuang J-Y, Ko C-Y, Kao T-J, Yang P-Y, Yu C-H, Liu M-S, Hu S-L, Tsai Y-T, Chan H. AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis. Redox Biol. 2020;30: 101413.","journal-title":"Redox Biol"},{"key":"2414_CR415","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1111\/1759-7714.13904","volume":"12","author":"X Tang","year":"2021","unstructured":"Tang X, Ding H, Liang M, Chen X, Yan Y, Wan N, Chen Q, Zhang J, Cao J. Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy. Thorac Cancer. 2021;12:1219\u201330.","journal-title":"Thorac Cancer"},{"key":"2414_CR416","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00432-024-05878-0","volume":"150","author":"Y Jiang","year":"2024","unstructured":"Jiang Y, Hui D, Pan Z, Yu Y, Liu L, Yu X, Wu C, Sun M. Curcumin promotes ferroptosis in hepatocellular carcinoma via upregulation of ACSL4. J Cancer Res Clin Oncol. 2024;150:429.","journal-title":"J Cancer Res Clin Oncol"},{"key":"2414_CR417","doi-asserted-by":"publisher","first-page":"1207496","DOI":"10.3389\/fphar.2023.1207496","volume":"14","author":"L Guo","year":"2023","unstructured":"Guo L, Hu C, Yao M, Han G. Mechanism of sorafenib resistance associated with ferroptosis in HCC. Front Pharmacol. 2023;14:1207496.","journal-title":"Front Pharmacol"},{"key":"2414_CR418","first-page":"323","volume":"19","author":"Y Li","year":"2020","unstructured":"Li Y, Yan H, Xu X, Liu H, Wu C, Zhao L. Erastin\/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2\/xCT pathway. Oncol Lett. 2020;19:323\u201333.","journal-title":"Oncol Lett"},{"key":"2414_CR419","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s13046-024-03061-4","volume":"43","author":"J Li","year":"2024","unstructured":"Li J, Li Y, Wang D, Liao R, Wu Z. PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1\/miR-195-5p axis-dependent manner in hepatocellular carcinoma. Journal of experimental & clinical cancer research\u202f: CR. 2024;43:143.","journal-title":"Journal of experimental & clinical cancer research : CR"},{"key":"2414_CR420","doi-asserted-by":"publisher","first-page":"7706","DOI":"10.3390\/ijms24097706","volume":"24","author":"I-C Su","year":"2023","unstructured":"Su I-C, Su Y-K, Setiawan SA, Yadav VK, Fong I-H, Yeh C-T, Lin C-M, Liu H-W. NADPH oxidase subunit CYBB confers chemotherapy and ferroptosis resistance in mesenchymal glioblastoma via nrf2\/SOD2 modulation. Int J Mol Sci. 2023;24:7706.","journal-title":"Int J Mol Sci"},{"key":"2414_CR421","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.7150\/jca.83355","volume":"14","author":"Y Xiong","year":"2023","unstructured":"Xiong Y, Liu T, Chen J. Anisomycin has the potential to induce human ovarian cancer stem cell ferroptosis by influencing glutathione metabolism and autophagy signal transduction pathways. J Cancer. 2023;14:1202\u201315.","journal-title":"J Cancer"},{"key":"2414_CR422","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-41490-x","volume":"13","author":"Y Huang","year":"2023","unstructured":"Huang Y, Yang W, Yang L, Wang T, Li C, Yu J, Zhang P, Yin Y, Li R, Tao K. Nrf2 inhibition increases sensitivity to chemotherapy of colorectal cancer by promoting ferroptosis and pyroptosis. Sci Rep. 2023;13: 14359.","journal-title":"Sci Rep"},{"key":"2414_CR423","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114866","volume":"163","author":"AM Posadino","year":"2023","unstructured":"Posadino AM, Giordo R, Pintus G, Mohammed SA, Orhan IE, Fokou PVT, Sharopov F, Adetunji CO, Gulsunoglu-Konuskan Z, Ydyrys A. Medicinal and mechanistic overview of artemisinin in the treatment of human diseases. Biomed Pharmacother. 2023;163: 114866.","journal-title":"Biomed Pharmacother"},{"key":"2414_CR424","doi-asserted-by":"publisher","first-page":"9106","DOI":"10.1021\/acsanm.4c00548","volume":"7","author":"J Shao","year":"2024","unstructured":"Shao J, Zhang J, Xue K, An Y, Wang Y, Zhang Z, Liu D, Tang Q. Upconversion dihydroartemisinin-loaded nanocomposites for NIR-enhanced ferroptosis of glioblastoma cells. ACS Appl Nano Mater. 2024;7:9106\u201315.","journal-title":"ACS Appl Nano Mater"},{"key":"2414_CR425","doi-asserted-by":"publisher","first-page":"67","DOI":"10.53388\/TMR20230618001","volume":"8","author":"K Guo","year":"2023","unstructured":"Guo K, Cao Y, Qian L, Daniels M, Tian Y, Li Y, Song L, Wang Z, Ren S. Dihydroartemisinin induces ferroptosis in pancreatic cancer cells by the regulation of survival prediction-related genes. Tradit Med Res. 2023;8:67.","journal-title":"Tradit Med Res"},{"key":"2414_CR426","doi-asserted-by":"publisher","DOI":"10.1016\/j.neo.2024.100991","volume":"51","author":"L Ni","year":"2024","unstructured":"Ni L, Zhu X, Zhao Q, Shen Y, Tao L, Zhang J, Lin H, Zhuge W, Cho Y-C, Cui R. Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways. Neoplasia. 2024;51: 100991.","journal-title":"Neoplasia"},{"key":"2414_CR427","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1038\/s12276-023-01079-w","volume":"55","author":"M Xiao","year":"2023","unstructured":"Xiao M, Xu J, Wang W, Zhang B, Liu J, Li J, Xu H, Zhao Y, Yu X, Shi S. Functional significance of cholesterol metabolism in cancer: from threat to treatment. Exp Mol Med. 2023;55:1982\u201395.","journal-title":"Exp Mol Med"},{"key":"2414_CR428","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113244","volume":"142","author":"Y Ning","year":"2024","unstructured":"Ning Y, Fang S, Zhang R, Fang J, Lin K, Ding Y, Nie H, Zhou J, Zhao Q, Ke H. Simvastatin induces ferroptosis and activates anti-tumor immunity to sensitize anti-PD-1 immunotherapy in microsatellite stable gastric cancer. Int Immunopharmacol. 2024;142: 113244.","journal-title":"Int Immunopharmacol"},{"key":"2414_CR429","doi-asserted-by":"publisher","first-page":"1491802","DOI":"10.3389\/fphar.2024.1491802","volume":"15","author":"Q Li","year":"2024","unstructured":"Li Q, Tong Y, Chen J, Xie T. Targeting programmed cell death via active ingredients from natural plants: a promising approach to cancer therapy. Front Pharmacol. 2024;15:1491802.","journal-title":"Front Pharmacol"},{"key":"2414_CR430","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106739","volume":"191","author":"C Xu","year":"2023","unstructured":"Xu C, Jiang Z-B, Shao L, Zhao Z-M, Fan X-X, Sui X, Yu L-L, Wang X-R, Zhang R-N, Wang W-J. \u03b2-Elemene enhances erlotinib sensitivity through induction of ferroptosis by upregulating lncRNA H19 in EGFR-mutant non-small cell lung cancer. Pharmacol Res. 2023;191: 106739.","journal-title":"Pharmacol Res"},{"key":"2414_CR431","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101246","author":"J Xu","year":"2025","unstructured":"Xu J, Wang B, Liu Q, Guo S, Chen C, Wu J, Zhao X, Li M, Ma Z, Zhou S, Qian Y, Huang Y, Wang Z, Shu C, Xu Q, Ben J, Wang Q, Wang S. MVP-LCN2 axis triggers evasion of ferroptosis to drive hepatocarcinogenesis and sorafenib resistance. Drug Resist Updat. 2025;81:101246.","journal-title":"Drug Resist Updat"},{"key":"2414_CR432","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101032","author":"X Lin","year":"2024","unstructured":"Lin X, Zhang Q, Li Q, Deng J, Shen S, Tang M, Ye X, Ji C, Yang Y, Chen Y, Zeng L, Zhao J, Kouwenhoven MBN, Lucero-Prisno DE, Huang J, Li Y, Zhang B, Hu J. Upregulation of CoQ shifts ferroptosis dependence from GPX4 to FSP1 in acquired radioresistance. Drug Resist Updat. 2024;73:101032.","journal-title":"Drug Resist Updat"},{"key":"2414_CR433","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101058","author":"KKW To","year":"2024","unstructured":"To KKW, Huang Z, Zhang H, Ashby CR, Fu L. Utilizing non-coding RNA-mediated regulation of ATP binding cassette (ABC) transporters to overcome multidrug resistance to cancer chemotherapy. Drug Resist Updat. 2024;73:101058.","journal-title":"Drug Resist Updat"},{"key":"2414_CR434","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101084","author":"H Zhao","year":"2024","unstructured":"Zhao H, Ling Y, He J, Dong J, Mo Q, Wang Y, Zhang Y, Yu H, Tang C. Potential targets and therapeutics for cancer stem cell-based therapy against drug resistance in hepatocellular carcinoma. Drug Resist Updat. 2024;74:101084.","journal-title":"Drug Resist Updat"},{"key":"2414_CR435","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101241","author":"Z Xu","year":"2025","unstructured":"Xu Z, Zhu M, Geng L, Zhang J, Xia J, Wang Q, An H, Xia A, Yu Y, Liu S, Tong J, Zhu W-G, Jiang Y, Sun B. Targeting NAT10 attenuates homologous recombination via destabilizing DNA:RNA hybrids and overcomes PARP inhibitor resistance in cancers. Drug Resist Updat. 2025;81:101241.","journal-title":"Drug Resist Updat"},{"key":"2414_CR436","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101229","author":"J-R Wei","year":"2025","unstructured":"Wei J-R, Lu M-Y, Wei T-H, Fleishman JS, Yu H, Chen X-L, Kong X-T, Sun S-L, Li N-G, Yang Y, Ni H-W. Overcoming cancer therapy resistance: from drug innovation to therapeutics. Drug Resist Updat. 2025;81:101229.","journal-title":"Drug Resist Updat"},{"key":"2414_CR437","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101214","author":"J Sun","year":"2025","unstructured":"Sun J, Zhao W, Zhang L, Wu S, Xue S, Cao H, Xu B, Li X, Hu N, Jiang T, Xu Y, Wang Z, Zhang C, Ren J. Centromere protein U mediates the ubiquitination and degradation of RPS3 to facilitate temozolomide resistance in glioblastoma. Drug Resist Updat. 2025;80:101214.","journal-title":"Drug Resist Updat"},{"key":"2414_CR438","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101148","author":"J Li","year":"2025","unstructured":"Li J, Chen Z-S, Pan Y, Zeng L. The important role of lactylation in regulating DNA damage repair and tumor chemotherapy resistance. Drug Resist Updat. 2025;78:101148.","journal-title":"Drug Resist Updat"},{"key":"2414_CR439","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101248","author":"Y Sun","year":"2025","unstructured":"Sun Y, Wang H, Cui Z, Yu T, Song Y, Gao H, Tang R, Wang X, Li B, Li W, Wang Z. Lactylation in cancer progression and drug resistance. Drug Resist Updat. 2025;81:101248.","journal-title":"Drug Resist Updat"},{"key":"2414_CR440","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/s41581-022-00631-7","volume":"19","author":"C Tang","year":"2023","unstructured":"Tang C, Livingston MJ, Safirstein R, Dong Z. Cisplatin nephrotoxicity: new insights and therapeutic implications. Nat Rev Nephrol. 2023;19:53\u201372.","journal-title":"Nat Rev Nephrol"},{"key":"2414_CR441","doi-asserted-by":"crossref","unstructured":"J. Li, L. Zeng, Z. Wang, H. Chen, S. Fang, J. Wang, C.Y. Cai, E. Xing, X. Liao, Z.W. Li, C.R. Ashby, Z.S. Chen, H. Chao, Y. Pan, Cycloruthenated Self\u2010Assembly with Metabolic Inhibition to Efficiently Overcome Multidrug Resistance in Cancers, Advanced Materials. 2021;34:e2100245.","DOI":"10.1002\/adma.202100245"},{"key":"2414_CR442","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01565-0","volume":"9","author":"X Zhao","year":"2023","unstructured":"Zhao X, Tian Z, Sun M, Dong D. Nrf2: a dark horse in doxorubicin-induced cardiotoxicity. Cell Death Discov. 2023;9: 261.","journal-title":"Cell Death Discov"},{"key":"2414_CR443","doi-asserted-by":"crossref","unstructured":"Xiong Y. The emerging role of PANoptosis in cancer treatment. Biomed Pharmacother. 2023;168:115696.","DOI":"10.1016\/j.biopha.2023.115696"},{"key":"2414_CR444","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175588","volume":"944","author":"A Sarkar","year":"2023","unstructured":"Sarkar A, Paul A, Banerjee T, Maji A, Saha S, Bishayee A, Maity TK. Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer. Eur J Pharmacol. 2023;944: 175588.","journal-title":"Eur J Pharmacol"},{"key":"2414_CR445","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101154","author":"Z Liu","year":"2024","unstructured":"Liu Z, Liu C, Fan C, Li R, Zhang S, Liu J, Li B, Zhang S, Guo L, Wang X, Qi Z, Shen Y. E3 ubiquitin ligase DTX2 fosters ferroptosis resistance via suppressing NCOA4-mediated ferritinophagy in non-small cell lung cancer. Drug Resist Updat. 2024;77:101154.","journal-title":"Drug Resist Updat"},{"key":"2414_CR446","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101224","author":"Z Zhang","year":"2025","unstructured":"Zhang Z, Zhou Q, Li Z, Huang F, Mo K, Shen C, Niu X, Hou B, Zhang C, Huang S. DTX2 attenuates lenvatinib-induced ferroptosis by suppressing docosahexaenoic acid biosynthesis through HSD17B4-dependent peroxisomal \u03b2-oxidation in hepatocellular carcinoma. Drug Resist Updat. 2025;81:101224.","journal-title":"Drug Resist Updat"},{"key":"2414_CR447","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1007\/s10549-024-07387-7","volume":"207","author":"K Mokhtarpour","year":"2024","unstructured":"Mokhtarpour K, Razi S, Rezaei N. Ferroptosis as a promising targeted therapy for triple negative breast cancer. Breast Cancer Res Treat. 2024;207:497\u2013513.","journal-title":"Breast Cancer Res Treat"},{"key":"2414_CR448","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2022.100916","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wu X, Ren Z, Li Y, Zou W, Chen J, Wang H. Overcoming cancer chemotherapy resistance by the induction of ferroptosis. Drug Resist Updat. 2023;66:100916.","journal-title":"Drug Resist Updat"},{"key":"2414_CR449","doi-asserted-by":"crossref","unstructured":"Z. Tang, H. Dong, T. Li, N. Wang, X. Wei, H. Wu, Y. Liu, W. Wang, Z. Guo, X. Xiao, X. Li. The Synergistic Reducing Drug Resistance Effect of Cisplatin and Ursolic Acid on Osteosarcoma through a Multistep Mechanism Involving Ferritinophagy. Oxidative Medicine and Cellular Longevity. 2021;2021:5192271.","DOI":"10.1155\/2021\/5192271"},{"key":"2414_CR450","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1156062","author":"H Shi","year":"2023","unstructured":"Shi H, Xiong L, Yan G, Du S, Liu J, Shi Y. Susceptibility of cervical cancer to dihydroartemisinin-induced ferritinophagy-dependent ferroptosis. Front Mol Biosci. 2023;10:1156062.","journal-title":"Front Mol Biosci"},{"key":"2414_CR451","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217396","author":"J Li","year":"2025","unstructured":"Li J, Zhong G, Hu F, Zhang Y, Ren X, Wang Z, Ma S, Zhu Q, Li J, Zeng S, Zhang Y, Wang T, Lin Q, Dong X, Zhai B. ASPH dysregulates cell death and induces chemoresistance in hepatocellular carcinoma. Cancer Lett. 2025;611:217396.","journal-title":"Cancer Lett"},{"key":"2414_CR452","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1038\/s41573-024-00979-4","volume":"23","author":"C Glorieux","year":"2024","unstructured":"Glorieux C, Liu S, Trachootham D, Huang P. Targeting ROS in cancer: rationale and strategies. Nat Rev Drug Discov. 2024;23:583\u2013606.","journal-title":"Nat Rev Drug Discov"},{"key":"2414_CR453","doi-asserted-by":"crossref","unstructured":"Jin X, Jin W, Tong L, Lin N, Zhang L, Zhao J.\u00a0Therapeutic strategies of targeting non-apoptotic regulated cell death (RCD) with small-molecule compounds in cancer. Acta Pharmaceutica Sinica B. 2024;14:2815\u201353.","DOI":"10.1016\/j.apsb.2024.04.020"},{"key":"2414_CR454","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1021\/acschembio.9b00939","volume":"15","author":"LF Ye","year":"2020","unstructured":"Ye LF, Chaudhary KR, Zandkarimi F, Harken AD, Kinslow CJ, Upadhyayula PS, Dovas A, Higgins DM, Tan H, Zhang Y. Radiation-induced lipid peroxidation triggers ferroptosis and synergizes with ferroptosis inducers. ACS Chem Biol. 2020;15:469\u201384.","journal-title":"ACS Chem Biol"},{"key":"2414_CR455","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104496","author":"X Liu","year":"2023","unstructured":"Liu X, Peng S, Tang G, Xu G, Xie Y, Shen D, Zhu M, Huang Y, Wang X, Yu H. Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells. EBioMedicine. 2023;90:104496.","journal-title":"EBioMedicine"},{"key":"2414_CR456","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2025.101240","author":"H Lin","year":"2025","unstructured":"Lin H, Zhu S, Chen Y, Lu J, Xie C, Liao C, Huang X, Li G, Wu Y, Li Z, Hu J, Lin X, Tian Y, Li Q, Wang Z, Chen S. Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer. Drug Resist Updat. 2025;81:101240.","journal-title":"Drug Resist Updat"},{"key":"2414_CR457","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.trecan.2021.01.013","volume":"7","author":"TA Mishchenko","year":"2021","unstructured":"Mishchenko TA, Balalaeva IV, Vedunova MV, Krysko DV. Ferroptosis and photodynamic therapy synergism: enhancing anticancer treatment. Trends in cancer. 2021;7:484\u20137.","journal-title":"Trends in cancer"},{"key":"2414_CR458","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1111\/jog.14779","volume":"47","author":"Q Cheng","year":"2021","unstructured":"Cheng Q, Bao L, Li M, Chang K, Yi X. Erastin synergizes with cisplatin via ferroptosis to inhibit ovarian cancer growth in vitro and in vivo. J Obstet Gynaecol Res. 2021;47:2481\u201391.","journal-title":"J Obstet Gynaecol Res"},{"key":"2414_CR459","doi-asserted-by":"publisher","first-page":"1904197","DOI":"10.1002\/adma.201904197","volume":"31","author":"C Liang","year":"2019","unstructured":"Liang C, Zhang X, Yang M, Dong X. Recent progress in ferroptosis inducers for cancer therapy. Adv Mater. 2019;31:1904197.","journal-title":"Adv Mater"},{"key":"2414_CR460","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212761","volume":"136","author":"Z Li","year":"2022","unstructured":"Li Z, Bu J, Zhu X, Zhou H, Ren K, Chu PK, Li L, Hu X, Ding X. Anti-tumor immunity and ferroptosis of hepatocellular carcinoma are enhanced by combined therapy of sorafenib and delivering modified GO-based PD-L1 siRNAs. Biomaterials Advances. 2022;136: 212761.","journal-title":"Biomaterials Advances"},{"key":"2414_CR461","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2024.101126","author":"Y Zou","year":"2024","unstructured":"Zou Y, Yang A, Chen B, Deng X, Xie J, Dai D, Zhang J, Tang H, Wu T, Zhou Z, Xie X, Wang J. CrVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer. Drug Resist Updat. 2024;77:101126.","journal-title":"Drug Resist Updat"},{"key":"2414_CR462","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-52312-7","volume":"15","author":"J Jiang","year":"2024","unstructured":"Jiang J, Yang L, Xie Q, Liu X, Jiang J, Zhang J, Zhang S, Zheng H, Li W, Cai X. Synthetic vectors for activating the driving axis of ferroptosis. Nat Commun. 2024;15: 7923.","journal-title":"Nat Commun"},{"key":"2414_CR463","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100068","author":"LA Jadhav","year":"2025","unstructured":"Jadhav LA, Mandlik SK. Nanocarriers in skin cancer treatment: emerging drug delivery approaches and innovations. Nano TransMed. 2025;4:100068.","journal-title":"Nano TransMed"},{"key":"2414_CR464","doi-asserted-by":"crossref","unstructured":"Elemike EE, Onunkwo IC, Ughumiakpor O, Alawuru F, Mukoro A, Ishom P, Obarakpor F, Hossain I, Aziza AE. Bio-nanomaterials: promising anticancer properties and treatment strategies. Nano TransMed. 2025;4:100076.","DOI":"10.1016\/j.ntm.2025.100076"},{"key":"2414_CR465","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01865-0","volume":"22","author":"M Chehelgerdi","year":"2023","unstructured":"Chehelgerdi M, Chehelgerdi M, Allela OQB, Pecho RDC, Jayasankar N, Rao DP, Thamaraikani T, Vasanthan M, Viktor P, Lakshmaiya N. Progressing nanotechnology to improve targeted cancer treatment: overcoming hurdles in its clinical implementation. Mol Cancer. 2023;22: 169.","journal-title":"Mol Cancer"},{"key":"2414_CR466","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217392","author":"A Carlos","year":"2025","unstructured":"Carlos A, Mendes M, Cruz MT, Pais A, Vitorino C. Ferroptosis driven by nanoparticles for tackling glioblastoma. Cancer Lett. 2025;611:217392.","journal-title":"Cancer Lett"},{"key":"2414_CR467","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02939-3","volume":"11","author":"C Gai","year":"2020","unstructured":"Gai C, Liu C, Wu X, Yu M, Zheng J, Zhang W, Lv S, Li W. MT1DP loaded by folate-modified liposomes sensitizes erastin-induced ferroptosis via regulating miR-365a-3p\/NRF2 axis in non-small cell lung cancer cells. Cell Death Dis. 2020;11: 751.","journal-title":"Cell Death Dis"},{"key":"2414_CR468","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1021\/acsnano.1c08585","volume":"16","author":"Y Xu","year":"2022","unstructured":"Xu Y, Guo Y, Zhang C, Zhan M, Jia L, Song S, Jiang C, Shen M, Shi X. Fibronectin-coated metal\u2013phenolic networks for cooperative tumor chemo-\/chemodynamic\/immune therapy via enhanced ferroptosis-mediated immunogenic cell death. ACS Nano. 2022;16:984\u201396.","journal-title":"ACS Nano"},{"key":"2414_CR469","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41578-020-00269-6","volume":"6","author":"MT Manzari","year":"2021","unstructured":"Manzari MT, Shamay Y, Kiguchi H, Rosen N, Scaltriti M, Heller DA. Targeted drug delivery strategies for precision medicines. Nat Rev Mater. 2021;6:351\u201370.","journal-title":"Nat Rev Mater"},{"key":"2414_CR470","doi-asserted-by":"publisher","DOI":"10.1088\/1748-605X\/ad9aef","volume":"20","author":"Y-H Yan","year":"2024","unstructured":"Yan Y-H, Kong L, Lu Y-B, Li S-Y, Yan A-W, Song Y-W, Huang Z-H, Zhu H-N. Inhibition of hepatocellular carcinoma progression by methotrexate-modified pH-sensitive sorafenib and schisandrin B micelles. Biomed Mater. 2024;20: 015022.","journal-title":"Biomed Mater"},{"key":"2414_CR471","doi-asserted-by":"publisher","first-page":"7671","DOI":"10.1039\/D2TB01350A","volume":"10","author":"C Li","year":"2022","unstructured":"Li C, Wu X, Zheng C, Xu S, Liu Y, Qin J, Fan X, Ye Y, Fei W. Nanotechnology-integrated ferroptosis inducers: a sharp sword against tumor drug resistance. J Mater Chem B. 2022;10:7671\u201393.","journal-title":"J Mater Chem B"},{"key":"2414_CR472","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100484","volume":"17","author":"J Chen","year":"2022","unstructured":"Chen J, Wang Y, Han L, Wang R, Gong C, Yang G, Li Z, Gao S, Yuan Y. A ferroptosis-inducing biomimetic nanocomposite for the treatment of drug-resistant prostate cancer. Mater Today Bio. 2022;17: 100484.","journal-title":"Mater Today Bio"},{"key":"2414_CR473","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.2174\/1389200221666210101115148","volume":"22","author":"S Saad","year":"2021","unstructured":"Saad S, Beg S, Jain GK, Ahmad FJ. Nanostructured therapeutic systems of PUFAs for the treatment of glioblastoma multiforme. Curr Drug Metab. 2021;22:1087\u2013102.","journal-title":"Curr Drug Metab"},{"key":"2414_CR474","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aax1346","volume":"6","author":"C-C Xue","year":"2020","unstructured":"Xue C-C, Li M-H, Zhao Y, Zhou J, Hu Y, Cai K-Y, Zhao Y, Yu S-H, Luo Z. Tumor microenvironment-activatable Fe-doxorubicin preloaded amorphous CaCO3 nanoformulation triggers ferroptosis in target tumor cells. Sci Adv. 2020;6: eaax1346.","journal-title":"Sci Adv"},{"key":"2414_CR475","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2023.101018","volume":"72","author":"W Yumin","year":"2024","unstructured":"Yumin W, Yongming C, Junjing Z, Yihui Y, Joshua SF, Yan W, Jinhua W, Jichao C, Yuanfang L, Hongquan W. Cuproptosis: A novel therapeutic target for overcoming cancer drug resistance. Drug Resist Updates. 2024;72: 101018.","journal-title":"Drug Resist Updates"},{"key":"2414_CR476","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/s41392-022-01229-y","volume":"7","author":"L Chen","year":"2022","unstructured":"Chen L, Min J, Wang F. Copper homeostasis and cuproptosis in health and disease. Signal Transduct Target Ther. 2022;7:378.","journal-title":"Signal Transduct Target Ther"},{"key":"2414_CR477","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.canlet.2011.06.032","volume":"312","author":"H Jiang","year":"2011","unstructured":"Jiang H, Taggart JE, Zhang X, Benbrook DM, Lind SE, Ding WQ. Nitroxoline (8-hydroxy-5-nitroquinoline) is more a potent anti-cancer agent than clioquinol (5-chloro-7-iodo-8-quinoline). Cancer Lett. 2011;312:11\u20137.","journal-title":"Cancer Lett"},{"key":"2414_CR478","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.841814","volume":"9","author":"V Oliveri","year":"2022","unstructured":"Oliveri V. Selective targeting of cancer cells by copper ionophores: an overview. Front Mol Biosci. 2022;9: 841814.","journal-title":"Front Mol Biosci"},{"key":"2414_CR479","doi-asserted-by":"crossref","unstructured":"Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B. Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance. Cancer Cell. 2025;43:1076\u201392.e1075.","DOI":"10.1016\/j.ccell.2025.03.031"},{"key":"2414_CR480","doi-asserted-by":"crossref","unstructured":"Liao Q, Deng J, Tong J, Gan Y, Hong W, Dong H, Cao M, Xiong C, Chen Y, Xie B, Yang F-Y, Alifu A, Zhou G-B, Huang S, Xiong J, Hao Q, Zhou X. p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis. Mol Cell. 2025;85:132\u201349.e7.","DOI":"10.1016\/j.molcel.2024.11.013"},{"key":"2414_CR481","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2022.111865","volume":"233","author":"Y Li","year":"2022","unstructured":"Li Y, Fang M, Xu Z, Li X. Tetrathiomolybdate as an old drug in a new use: as a chemotherapeutic sensitizer for non-small cell lung cancer. J Inorg Biochem. 2022;233: 111865.","journal-title":"J Inorg Biochem"},{"key":"2414_CR482","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1517\/13543780902845622","volume":"18","author":"G Khan","year":"2009","unstructured":"Khan G, Merajver S. Copper chelation in cancer therapy using tetrathiomolybdate: an evolving paradigm. Expert Opin Investig Drugs. 2009;18:541\u20138.","journal-title":"Expert Opin Investig Drugs"},{"key":"2414_CR483","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1158\/1078-0432.CCR-16-1326","volume":"23","author":"N Chan","year":"2017","unstructured":"Chan N, Willis A, Kornhauser N, Ward MM, Lee SB, Nackos E, Seo BR, Chuang E, Cigler T, Moore A. Influencing the tumor microenvironment: a phase II study of copper depletion using tetrathiomolybdate in patients with breast cancer at high risk for recurrence and in preclinical models of lung metastases. Clin Cancer Res. 2017;23:666\u201376.","journal-title":"Clin Cancer Res"},{"key":"2414_CR484","doi-asserted-by":"crossref","unstructured":"Nan L, Yuan W, Guodong C, Yonghui H. Multitargeting strategy using tetrathiomolybdate and lenvatinib: maximizing antiangiogenesis activity in a preclinical liver cancer model. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents). 2023;23:786\u201393","DOI":"10.2174\/1871520622666220907115027"},{"key":"2414_CR485","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/j.freeradbiomed.2007.07.003","volume":"43","author":"G Anshul","year":"2007","unstructured":"Anshul G, Russell JM. Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells. Free Radic Biol Med. 2007;43:1271\u20138.","journal-title":"Free Radic Biol Med"},{"key":"2414_CR486","doi-asserted-by":"publisher","DOI":"10.1002\/btm2.10477","volume":"8","author":"HB Ji","year":"2023","unstructured":"Ji HB, Kim CR, Min CH, Han JH, Kim S-N, Lee C, Choy YB. Fe-containing metal\u2013organic framework with D-penicillamine for cancer-specific hydrogen peroxide generation and enhanced chemodynamic therapy. Bioeng Transl Med. 2023;8: e10477.","journal-title":"Bioeng Transl Med"},{"key":"2414_CR487","doi-asserted-by":"publisher","first-page":"115730","DOI":"10.1016\/j.biopha.2023.115730","volume":"168","author":"Z Xiaodan","year":"2023","unstructured":"Xiaodan Z, Tao T, Yishu Q, Xiaojun G, Xiao Z, Xiaorong Z. Copper-mediated novel cell death pathway in tumor cells and implications for innovative cancer therapies. Biomed Pharmacother. 2023;168:115730.","journal-title":"Biomed Pharmacother"},{"key":"2414_CR488","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2023.216157","volume":"561","author":"W Xidi","year":"2023","unstructured":"Xidi W, Miao Z, Yu L, Zizhen S. Cope with copper: from copper linked mechanisms to copper-based clinical cancer therapies. Cancer Lett. 2023;561: 216157.","journal-title":"Cancer Lett"},{"key":"2414_CR489","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3390\/cancers16030647","volume":"16","author":"C Springer","year":"2024","unstructured":"Springer C, Humayun D, Skouta R. Cuproptosis: Unraveling the Mechanisms of Copper-Induced Cell Death and Its Implication in Cancer Therapy. Cancers. 2024;16:647.","journal-title":"Cancers"},{"key":"2414_CR490","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121335","volume":"281","author":"Y Lu","year":"2022","unstructured":"Lu Y, Pan Q, Gao W, Pu Y, Luo K, He B, Gu Z. Leveraging disulfiram to treat cancer: mechanisms of action, delivery strategies, and treatment regimens. Biomaterials. 2022;281: 121335.","journal-title":"Biomaterials"},{"key":"2414_CR491","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09574-5","volume":"22","author":"H-Z Cao","year":"2022","unstructured":"Cao H-Z, Yang W-T, Zheng P-S. Cytotoxic effect of disulfiram\/copper on human cervical cancer cell lines and LGR5-positive cancer stem-like cells. BMC Cancer. 2022;22: 521.","journal-title":"BMC Cancer"},{"key":"2414_CR492","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.redox.2014.11.002","volume":"4","author":"K Salem","year":"2015","unstructured":"Salem K, McCormick ML, Wendlandt E, Zhan F, Goel A. Copper\u2013zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma. Redox Biol. 2015;4:23\u201333.","journal-title":"Redox Biol"},{"key":"2414_CR493","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1080\/10428194.2024.2422843","volume":"66","author":"C Arkan","year":"2024","unstructured":"Arkan C, Akcora-Yildiz D. FDA-approved disulfiram induces ferroptosis via alteration of redox balance and lipid peroxidation and overcomes carfilzomib resistance in multiple myeloma. Leuk Lymphoma. 2024;66:250\u201361.","journal-title":"Leuk Lymphoma"},{"key":"2414_CR494","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-022-02485-0","author":"P Zheng","year":"2022","unstructured":"Zheng P, Zhou C, Lu L, Liu B, Ding Y. Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy. J Exp Clin Cancer Res. 2022;41:271.","journal-title":"J Exp Clin Cancer Res"},{"key":"2414_CR495","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12061645","author":"BS Harrington","year":"2020","unstructured":"Harrington BS, Ozaki MK, Caminear MW, Hernandez LF, Jordan E, Kalinowski NJ, Goldlust IS, Guha R, Ferrer M, Thomas C, Shetty J, Tran B, Wong N, House CD, Annunziata CM. Drugs targeting tumor-initiating cells prolong survival in a post-surgery, post-chemotherapy ovarian cancer relapse model. Cancers (Basel). 2020;12:1645.","journal-title":"Cancers (Basel)"},{"key":"2414_CR496","first-page":"1692","volume":"14","author":"R Olar","year":"2022","unstructured":"Olar R, Maxim C, Badea M, Bacalum M, Raileanu M, Avram S, Koro\u0161in N\u010c, Burlanescu T, Rostas AM. Antiproliferative copper (II) complexes bearing mixed chelating ligands: structural characterization. ROS scavenging, in silico studies, and anti-melanoma activity, Pharmaceutics. 2022;14:1692.","journal-title":"ROS scavenging, in silico studies, and anti-melanoma activity, Pharmaceutics"},{"key":"2414_CR497","doi-asserted-by":"publisher","first-page":"2705332","DOI":"10.1155\/2022\/2705332","volume":"2022","author":"V Graur","year":"2022","unstructured":"Graur V, Chumakov Y, Garbuz O, Hureau C, Tsapkov V, Gulea A. Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2-Formylpyridine N4-Allylthiosemicarbazone. Bioinorg Chem Appl. 2022;2022:2705332.","journal-title":"Bioinorg Chem Appl"},{"key":"2414_CR498","doi-asserted-by":"crossref","unstructured":"Xiaoyan Z, Hussein H, Nor Zakiah Nor H, Juzheng Z, Xianli M, Lilan W, Xiaoqun Z. Synthesis and anti-cancer investigations of copper(II) complexes based on adenine. J Mol Struct. 2024;1315:138836.","DOI":"10.1016\/j.molstruc.2024.138836"},{"key":"2414_CR499","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2025.100075","author":"K Elumalai","year":"2025","unstructured":"Elumalai K, Srinivasan S. Harnessing nanoparticle technology for precision medicine in head and neck cancer: targeted delivery, immunomodulation, and clinical translation. Nano TransMed. 2025;4:100075.","journal-title":"Nano TransMed"},{"key":"2414_CR500","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100036","author":"P Ma","year":"2024","unstructured":"Ma P, Wang G, Men K, Li C, Gao N, Li L. Advances in clinical application of nanoparticle-based therapy for cancer treatment: a systematic review. Nano TransMed. 2024;3:100036.","journal-title":"Nano TransMed"},{"key":"2414_CR501","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1080\/10717544.2022.2039804","volume":"29","author":"J-J Xu","year":"2022","unstructured":"Xu J-J, Zhang W-C, Guo Y-W, Chen X-Y, Zhang Y-N. Metal nanoparticles as a promising technology in targeted cancer treatment. Drug Deliv. 2022;29:664\u201378.","journal-title":"Drug Deliv"},{"key":"2414_CR502","doi-asserted-by":"crossref","unstructured":"Roshani M, Rezaian-Isfahni A, Lotfalizadeh MH, Khassafi N, Abadi MHJN, Nejati M. Metal nanoparticles as a potential technique for the diagnosis and treatment of gastrointestinal cancer: a comprehensive review. Cancer Cell Int. 2023;23:280.","DOI":"10.1186\/s12935-023-03115-1"},{"key":"2414_CR503","doi-asserted-by":"publisher","first-page":"10461","DOI":"10.1039\/D0TB02138E","volume":"8","author":"W Fei","year":"2020","unstructured":"Fei W, Zhang Y, Ye Y, Li C, Yao Y, Zhang M, Li F, Zheng C. Bioactive metal-containing nanomaterials for ferroptotic cancer therapy. J Mater Chem B. 2020;8:10461\u201373.","journal-title":"J Mater Chem B"},{"key":"2414_CR504","doi-asserted-by":"publisher","first-page":"52374","DOI":"10.1021\/acsami.1c14944","volume":"13","author":"A Qi","year":"2021","unstructured":"Qi A, Wang C, Ni S, Meng Y, Wang T, Yue Z, Yang K, Li Y, Cheng Z, Guo P. Intravesical mucoadhesive hydrogel induces chemoresistant bladder cancer ferroptosis through delivering iron oxide nanoparticles in a three-tier strategy. ACS Appl Mater Interfaces. 2021;13:52374\u201384.","journal-title":"ACS Appl Mater Interfaces"},{"key":"2414_CR505","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/s41420-023-01490-2","volume":"9","author":"Y Chen","year":"2023","unstructured":"Chen Y, Hou S. Recent progress in the effect of magnetic iron oxide nanoparticles on cells and extracellular vesicles. Cell Death Discov. 2023;9:195.","journal-title":"Cell Death Discov"},{"key":"2414_CR506","doi-asserted-by":"crossref","unstructured":"Yang Y, Liu Y, Song L, Cui X, Zhou J, Jin G, Boccaccini AR, Virtanen S. Iron oxide nanoparticle-based nanocomposites in biomedical application. Trends Biotechnol. 2023;41:1471\u20131487.","DOI":"10.1016\/j.tibtech.2023.06.001"},{"key":"2414_CR507","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1186\/s12951-022-01595-3","volume":"20","author":"S Dash","year":"2022","unstructured":"Dash S, Das T, Patel P, Panda PK, Suar M, Verma SK. Emerging trends in the nanomedicine applications of functionalized magnetic nanoparticles as novel therapies for acute and chronic diseases. J Nanobiotechnology. 2022;20:393.","journal-title":"J Nanobiotechnology"},{"key":"2414_CR508","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.mattod.2023.04.008","volume":"66","author":"FZ Simnani","year":"2023","unstructured":"Simnani FZ, Singh D, Patel P, Choudhury A, Sinha A, Nandi A, Samal SK, Verma SK, Panda PK. Nanocarrier vaccine therapeutics for global infectious and chronic diseases. Mater Today. 2023;66:371\u2013408.","journal-title":"Mater Today"},{"key":"2414_CR509","doi-asserted-by":"publisher","first-page":"32","DOI":"10.3390\/nano11010032","volume":"11","author":"S Al-Musawi","year":"2020","unstructured":"Al-Musawi S, Albukhaty S, Al-Karagoly H, Almalki F. Design and synthesis of multi-functional superparamagnetic core-gold shell nanoparticles coated with chitosan and folate for targeted antitumor therapy. Nanomaterials. 2020;11:32.","journal-title":"Nanomaterials"},{"key":"2414_CR510","doi-asserted-by":"publisher","first-page":"4721","DOI":"10.3390\/molecules25204721","volume":"25","author":"S Albukhaty","year":"2020","unstructured":"Albukhaty S, Al-Musawi S, Abdul Mahdi S, Sulaiman GM, Alwahibi MS, Dewir YH, Soliman DA, Rizwana H. Investigation of dextran-coated superparamagnetic nanoparticles for targeted vinblastine controlled release, delivery, apoptosis induction, and gene expression in pancreatic cancer cells. Molecules. 2020;25:4721.","journal-title":"Molecules"},{"key":"2414_CR511","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.124517","volume":"241","author":"M Shirazi","year":"2023","unstructured":"Shirazi M, Allafchian A, Salamati H. Design and fabrication of magnetic Fe3O4-QSM nanoparticles loaded with ciprofloxacin as a potential antibacterial agent. Int J Biol Macromol. 2023;241: 124517.","journal-title":"Int J Biol Macromol"},{"key":"2414_CR512","doi-asserted-by":"publisher","first-page":"2302856","DOI":"10.1002\/smll.202302856","volume":"19","author":"J Yang","year":"2023","unstructured":"Yang J, Feng J, Yang S, Xu Y, Shen Z. Exceedingly Small Magnetic Iron Oxide Nanoparticles for T1-Weighted Magnetic Resonance Imaging and Imaging-Guided Therapy of Tumors. Small. 2023;19:2302856.","journal-title":"Small"},{"key":"2414_CR513","first-page":"315","volume":"31","author":"H Zhou","year":"2020","unstructured":"Zhou H, Ge J, Miao Q, Zhu R, Wen L, Zeng J. Biodegradable Inorganic Nanoparticles for Cancer Theranostics: Insights into the Degradation Behavior. 2020;31:315\u201331.","journal-title":"Biodegradable Inorganic Nanoparticles for Cancer Theranostics: Insights into the Degradation Behavior"},{"key":"2414_CR514","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201903512","volume":"7","author":"C Xie","year":"2020","unstructured":"Xie C, Cen D, Ren Z, Wang Y, Wu Y, Li X, Han G, Cai X. FeS@ BSA nanoclusters to enable H2S-amplified ROS-based therapy with MRI guidance. Adv Sci. 2020;7: 1903512.","journal-title":"Adv Sci"},{"key":"2414_CR515","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12951-021-01023-y","volume":"19","author":"S Ning","year":"2021","unstructured":"Ning S, Zheng Y, Qiao K, Li G, Bai Q, Xu S. Laser-triggered combination therapy by iron sulfide-doxorubicin@ functionalized nanozymes for breast cancer therapy. J Nanobiotechnology. 2021;19:1\u201314.","journal-title":"J Nanobiotechnology"},{"key":"2414_CR516","doi-asserted-by":"publisher","first-page":"8231","DOI":"10.1002\/adfm.201603776","volume":"26","author":"Z Meng","year":"2016","unstructured":"Meng Z, Wei F, Ma W, Yu N, Wei P, Wang Z, Tang Y, Chen Z, Wang H, Zhu M. Design and synthesis of \u201call-in-one\u201d multifunctional FeS2 nanoparticles for magnetic resonance and near-infrared imaging guided photothermal therapy of tumors. Adv Funct Mater. 2016;26:8231\u201342.","journal-title":"Adv Funct Mater"},{"key":"2414_CR517","doi-asserted-by":"publisher","DOI":"10.3390\/nano14221854","volume":"14","author":"F Eker","year":"2024","unstructured":"Eker F, Akda\u015f\u00e7i E, Duman H, Bechelany M, Karav S. Gold nanoparticles in nanomedicine: unique properties and therapeutic potential. Nanomaterials. 2024;14: 1854.","journal-title":"Nanomaterials"},{"key":"2414_CR518","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100045","author":"G Xu","year":"2024","unstructured":"Xu G, Li J, Zhang S, Cai J, Deng X, Wang Y, Pei P. Two-dimensional nano-biomaterials in regulating the tumor microenvironment for immunotherapy. Nano TransMed. 2024;3:100045.","journal-title":"Nano TransMed"},{"key":"2414_CR519","doi-asserted-by":"publisher","first-page":"13195","DOI":"10.1021\/acsnano.3c00048","volume":"17","author":"L Zeng","year":"2023","unstructured":"Zeng L, Ding S, Cao Y, Li C, Zhao B, Ma Z, Zhou J, Hu Y, Zhang X, Yang Y. A MOF-based potent ferroptosis inducer for enhanced radiotherapy of triple negative breast cancer. ACS Nano. 2023;17:13195\u2013210.","journal-title":"ACS Nano"},{"key":"2414_CR520","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32474-y","volume":"13","author":"K Xiao","year":"2022","unstructured":"Xiao K, Zhang N, Li F, Hou D, Zhai X, Xu W, Wang G, Wang H, Zhao L. Pro-oxidant response and accelerated ferroptosis caused by synergetic Au (I) release in hypercarbon-centered gold (I) cluster prodrugs. Nat Commun. 2022;13: 4669.","journal-title":"Nat Commun"},{"key":"2414_CR521","doi-asserted-by":"crossref","unstructured":"Rojas-Cessa MA. Recent plant-synthesized gold nanoparticle advancements for gastric cancer therapy. Nano TransMed. 2024;3:100050.","DOI":"10.1016\/j.ntm.2024.100050"},{"key":"2414_CR522","doi-asserted-by":"publisher","first-page":"5809","DOI":"10.7150\/ijbs.77734","volume":"18","author":"X-j Mi","year":"2022","unstructured":"Mi X-j, Park H-R, Dhandapani S, Lee S, Kim Y-J. Biologically synthesis of gold nanoparticles using Cirsium japonicum var. maackii extract and the study of anti-cancer properties on AGS gastric cancer cells. Int J Biol Sci. 2022;18:5809\u201326.","journal-title":"Int J Biol Sci"},{"key":"2414_CR523","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202400652","volume":"13","author":"J Lu","year":"2024","unstructured":"Lu J, Miao Y, Li Y. Cuproptosis: Advances in Stimulus-Responsive Nanomaterials for Cancer Therapy. Adv Healthc Mater. 2024;13: e2400652.","journal-title":"Adv Healthc Mater"},{"key":"2414_CR524","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122805","volume":"313","author":"SR Li","year":"2025","unstructured":"Li SR, Tao SY, Li Q, Hu CY, Sun ZJ. Harnessing nanomaterials for copper-induced cell death. Biomaterials. 2025;313: 122805.","journal-title":"Biomaterials"},{"key":"2414_CR525","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100996","volume":"25","author":"L Ye","year":"2024","unstructured":"Ye L, Yu C, Xia J, Ni K, Zhang Y, Ying X, Xie D, Jin Y, Sun R, Tang R, Fan S, Yao S. Multifunctional nanomaterials via cell cuproptosis and oxidative stress for treating osteosarcoma and OS-induced bone destruction. Mater Today Bio. 2024;25: 100996.","journal-title":"Mater Today Bio"},{"key":"2414_CR526","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202314568","author":"YB Song","year":"2024","unstructured":"Song YB, Zhan GW, Zhou SF. Design of near infrared light-powered copper phyllosilicate nanomotors for Cuproptosis-based synergistic cancer therapy. Adv Funct Mater. 2024;34:2314568.","journal-title":"Adv Funct Mater"},{"key":"2414_CR527","doi-asserted-by":"publisher","first-page":"10206","DOI":"10.1021\/acsnano.3c00326","volume":"17","author":"S Ning","year":"2023","unstructured":"Ning S, Lyu M, Zhu D, Lam JWY, Huang Q, Zhang T, Tang BZ. Type-I AIE photosensitizer loaded biomimetic system boosting cuproptosis to inhibit breast cancer metastasis and rechallenge. ACS Nano. 2023;17:10206\u201317.","journal-title":"ACS Nano"},{"key":"2414_CR528","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202303694","volume":"10","author":"W Chen","year":"2023","unstructured":"Chen W, Xie W, Gao Z, Lin C, Tan M, Zhang Y, Hou Z. Mild-Photothermal Effect Induced High Efficiency Ferroptosis-Boosted-Cuproptosis Based on Cu(2) O@Mn(3) Cu(3) O(8) Nanozyme. Adv Sci (Weinh). 2023;10: e2303694.","journal-title":"Adv Sci (Weinh)"},{"key":"2414_CR529","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202204733","volume":"34","author":"Y Xu","year":"2022","unstructured":"Xu Y, Liu SY, Zeng L, Ma H, Zhang Y, Yang H, Liu Y, Fang S, Zhao J, Xu Y, Ashby CR Jr, He Y, Dai Z, Pan Y. An Enzyme-Engineered Nonporous Copper(I) Coordination Polymer Nanoplatform for Cuproptosis-Based Synergistic Cancer Therapy. Adv Mater. 2022;34: e2204733.","journal-title":"Adv Mater"},{"key":"2414_CR530","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2023.145795","author":"J Zhong","year":"2023","unstructured":"Zhong J, Zheng X, Wen Y, Wang SB, Zhan GW, Chen AZ. In situ sacrificial growth of metastable copper-enriched nanomedicine for cuproptosis-based synergistic cancer therapy. Chem Eng J. 2023;474:145795.","journal-title":"Chem Eng J"},{"key":"2414_CR531","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202302537","volume":"13","author":"Y Ruan","year":"2024","unstructured":"Ruan Y, Zhuang H, Zeng X, Lin L, Wang X, Xue P, Xu S, Chen Q, Yan S, Huang W. Engineered Microbial Nanohybrids for Tumor-Mediated NIR II Photothermal Enhanced Ferroptosis\/Cuproptosis and Immunotherapy. Adv Healthc Mater. 2024;13: e2302537.","journal-title":"Adv Healthc Mater"},{"key":"2414_CR532","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2024.148522","author":"XL He","year":"2024","unstructured":"He XL, Li MJ, Fan SJ, Li YY, Fang L, Xiang GY, Yang T. Copper peroxide and cisplatin co-loaded silica nanoparticles-based trinity strategy for cooperative cuproptosis\/chemo\/chemodynamic cancer therapy. Chem Eng J. 2024;473:145173.","journal-title":"Chem Eng J"},{"key":"2414_CR533","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301429","volume":"12","author":"Q Yu","year":"2023","unstructured":"Yu Q, Zhou J, Liu Y, Li XQ, Li S, Zhou H, Kang B, Chen HY, Xu JJ. DNAzyme-Mediated Cascade Nanoreactor for Cuproptosis-Promoted Pancreatic Cancer Synergistic Therapy. Adv Healthc Mater. 2023;12: e2301429.","journal-title":"Adv Healthc Mater"},{"key":"2414_CR534","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202306263","volume":"20","author":"R Li","year":"2024","unstructured":"Li R, Zhao W, Han Z, Feng N, Wu T, Xiong H, Jiang W. Self-Cascade Nanozyme Reactor as a Cuproptosis Inducer Synergistic Inhibition of Cellular Respiration Boosting Radioimmunotherapy. Small. 2024;20: e2306263.","journal-title":"Small"},{"key":"2414_CR535","doi-asserted-by":"publisher","DOI":"10.1002\/smsc.202300164","author":"W Xiao","year":"2024","unstructured":"Xiao W, Qu K, Zhang W, Lai L, He L, Cheng F, Wang L. High immunogenic cuproptosis evoked by in\u2009situ sulfidation\u2010activated pyroptosis for tumor\u2010targeted immunotherapy of colorectal cancer. Small Sci. 2024;4:2300164.","journal-title":"Small Sci"},{"key":"2414_CR536","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202306584","author":"HL Tian","year":"2023","unstructured":"Tian HL, Duan JF, Li BW, Qin SY, Nice EC, Zhang W, Lang TY, Zhang HY, Huang CH. Clinical chemotherapeutic agent coordinated copper-based nanoadjuvants for efficiently sensitizing cancer chemo-immunotherapy by cuproptosis-mediated mitochondrial metabolic reprogramming. Adv Funct Mater. 2023;33:2306584.","journal-title":"Adv Funct Mater"},{"key":"2414_CR537","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1021\/acs.nanolett.3c00434","volume":"23","author":"K Chen","year":"2023","unstructured":"Chen K, Zhou A, Zhou X, Liu Y, Xu Y, Ning X. An intelligent cell-derived nanorobot bridges synergistic crosstalk between sonodynamic therapy and cuproptosis to promote cancer treatment. Nano Lett. 2023;23:3038\u201347.","journal-title":"Nano Lett"},{"key":"2414_CR538","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2023.101911","author":"QX Huang","year":"2023","unstructured":"Huang QX, Liang JL, Chen QW, Jin XK, Niu MT, Dong CY, Zhang XZ. Metal-organic framework nanoagent induces cuproptosis for effective immunotherapy of malignant glioblastoma. Nano Today. 2023;51:101911.","journal-title":"Nano Today"},{"key":"2414_CR539","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123025","volume":"640","author":"J Zhang","year":"2023","unstructured":"Zhang J, Han M, Zhang J, Abdalla M, Sun P, Yang Z, Zhang C, Liu Y, Chen C, Jiang X. Syphilis mimetic nanoparticles for cuproptosis-based synergistic cancer therapy via reprogramming copper metabolism. Int J Pharm. 2023;640: 123025.","journal-title":"Int J Pharm"},{"key":"2414_CR540","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202205013","author":"WJ Xu","year":"2022","unstructured":"Xu WJ, Qian JM, Hou GH, Wang TB, Wang JL, Wang YP, Yang LJ, Cui XK, Suo AL. A hollow amorphous bimetal organic framework for synergistic cuproptosis\/ferroptosis\/apoptosis anticancer therapy via disrupting intracellular redox homeostasis and copper\/iron metabolisms. Adv Funct Mater. 2022;32:2205013.","journal-title":"Adv Funct Mater"},{"key":"2414_CR541","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202312795","author":"C Hao","year":"2023","unstructured":"Hao C, Huang L, Zhang H, Xu L, Sun M, Kuang H, Wang Q, Xu C. Chiral CuxOS@Fe\u2010MOFs for enhanced cancer therapy. Adv Funct Mater. 2023;34:2312795.","journal-title":"Adv Funct Mater"},{"key":"2414_CR542","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.actbio.2023.04.003","volume":"164","author":"C Ni","year":"2023","unstructured":"Ni C, Ouyang Z, Li G, Liu J, Cao X, Zheng L, Shi X, Guo R. A tumor microenvironment-responsive core-shell tecto dendrimer nanoplatform for magnetic resonance imaging-guided and cuproptosis-promoted chemo-chemodynamic therapy. Acta Biomater. 2023;164:474\u201386.","journal-title":"Acta Biomater"},{"key":"2414_CR543","doi-asserted-by":"publisher","first-page":"21134","DOI":"10.1021\/acsnano.3c04903","volume":"17","author":"J Xia","year":"2023","unstructured":"Xia J, Hu C, Ji Y, Wang M, Jin Y, Ye L, Xie D, Jiang S, Li R, Hu Z, Dai J. Copper-loaded nanoheterojunction enables superb orthotopic osteosarcoma therapy via oxidative stress and cell cuproptosis. ACS Nano. 2023;17:21134\u201352.","journal-title":"ACS Nano"},{"key":"2414_CR544","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304407","author":"J Zheng","year":"2023","unstructured":"Zheng J, Ge H, Guo M, Zhang T, Hu Q, Yao Q, Long S, Sun W, Fan J, Du J, Peng X. Photoinduced cuproptosis with tumor\u2010specific for metastasis\u2010inhibited cancer therapy. Small. 2023;20:2304407.","journal-title":"Small"},{"key":"2414_CR545","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202309388","author":"F Hu","year":"2024","unstructured":"Hu F, Huang J, Bing T, Mou W, Li D, Zhang H, Chen Y, Jin Q, Yu Y, Yang Z. Stimulus\u2010responsive copper complex nanoparticles induce cuproptosis for augmented cancer immunotherapy. Adv Sci. 2024;11:2309388.","journal-title":"Adv Sci"},{"key":"2414_CR546","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2023.112568","author":"P Hu","year":"2024","unstructured":"Hu P, Li Y, Zhang L, Lan X, Ren X, Liang W, Wang S, Wang Y, Zhao Y, Zhang Y, Liu C, Liu C. Defect-engineered photothermal nanozyme with NIR-II absorption induces cuproptosis-apoptosis for synergized cancer immunotherapy and fast wound healing. Mater Des. 2024;237:112568.","journal-title":"Mater Des"},{"key":"2414_CR547","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202300167","author":"J Zhang","year":"2023","unstructured":"Zhang J, Peng L, Hao Y, Yang H, Zhao W, Mao C. Biodegradable CuMoO4 nanodots with multienzyme activities for multimodal treatment of tumor. Adv Healthc Mater. 2023;12:2300167.","journal-title":"Adv Healthc Mater"},{"key":"2414_CR548","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202311549","volume":"62","author":"H Ding","year":"2023","unstructured":"Ding H, Ren F, Liu P, Feng Y, Ma X, Shen Z, Shi Q, Xu M, Li W, Chen H. Cu(2+) -Anchored Carbon Nano-Photocatalysts for Visible Water Splitting to Boost Hydrogen Cuproptosis. Angew Chem Int Ed Engl. 2023;62: e202311549.","journal-title":"Angew Chem Int Ed Engl"},{"key":"2414_CR549","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301346","author":"F Zhao","year":"2023","unstructured":"Zhao F, Yu H, Liang L, Wang C, Shi D, Zhang X, Ying Y, Cai W, Li W, Li J, Zheng J, Qiao L, Che S, Yu J. Redox homeostasis disruptors based on metal\u2010phenolic network nanoparticles for chemo\/chemodynamic synergistic tumor therapy through activating apoptosis and cuproptosis. Adv Healthc Mater. 2023;12:2301346.","journal-title":"Adv Healthc Mater"},{"key":"2414_CR550","doi-asserted-by":"publisher","first-page":"14025","DOI":"10.1021\/acs.analchem.3c02661","volume":"95","author":"Y-Y Wang","year":"2023","unstructured":"Wang Y-Y, Zhang X-Y, Li S-L, Jiang F-L, Jiang P, Liu Y. AuPt-loaded Cu-doped polydopamine nanocomposites with multienzyme-mimic activities for dual-modal imaging-guided and cuproptosis-enhanced photothermal\/nanocatalytic therapy. Anal Chem. 2023;95:14025\u201335.","journal-title":"Anal Chem"},{"key":"2414_CR551","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1021\/acs.chemmater.3c02323","volume":"36","author":"X Tian","year":"2024","unstructured":"Tian X, Xu H, Zhou F, Gong X, Tan S, He Y. An intelligent cupreous nanoplatform with self-supplied H2O2 and Cu2+\/Cu+ conversion to boost cuproptosis and chemodynamic combined therapy. Chem Mater. 2024;36:815\u201328.","journal-title":"Chem Mater"},{"key":"2414_CR552","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100034","author":"J Lv","year":"2024","unstructured":"Lv J, Qiu Y, Pan L, Zhang X, Li M, Yin X. Photothermal\/photodynamic antibacterial hydrogel embedded with copper carbon dots and Au nanoparticles. Nano TransMed. 2024;3:100034.","journal-title":"Nano TransMed"},{"key":"2414_CR553","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s40824-023-00461-z","volume":"27","author":"R Wang","year":"2023","unstructured":"Wang R, Huang Z, Xiao Y, Huang T, Ming J. Photothermal therapy of copper incorporated nanomaterials for biomedicine. Biomater Res. 2023;27:121.","journal-title":"Biomater Res"},{"key":"2414_CR554","doi-asserted-by":"publisher","first-page":"4171","DOI":"10.1039\/D2QI00951J","volume":"9","author":"J Shen","year":"2022","unstructured":"Shen J, Liao X, Wu W, Feng T, Karges J, Lin M, Luo H, Chen Y, Chao H. A pH-responsive iridium(iii) two-photon photosensitizer loaded CaCO3 nanoplatform for combined Ca2+ overload and photodynamic therapy. Inorg Chem Front. 2022;9:4171\u201383.","journal-title":"Inorg Chem Front"},{"key":"2414_CR555","doi-asserted-by":"publisher","first-page":"27597","DOI":"10.1021\/acsnano.4c08690","volume":"18","author":"L Zheng","year":"2024","unstructured":"Zheng L, Ding Y, Fang S, Yang W, Chen J, Ma J, Wang M, Wang J, Zhang F, Guo X, Zhang K, Shu G-F, Weng Q, Wu F, Zhao Z, Chen M, Jiansong J. Potentiated calcium carbonate with enhanced calcium overload induction and acid neutralization capabilities to boost chemoimmunotherapy against liver cancer. ACS Nano. 2024;18:27597\u2013616.","journal-title":"ACS Nano"},{"key":"2414_CR556","doi-asserted-by":"publisher","first-page":"24953","DOI":"10.1021\/acsnano.4c05771","volume":"18","author":"J He","year":"2024","unstructured":"He J, Wang Y, Ren Y, Yuan Q, Zhang Z, Li L, Bao B, Jia W, Zhang X, Li M, Tang Y. Calcium-mediated cell adhesion enhancement-based antimetastasis and synergistic antitumor therapy by conjugated polymer-calcium composite nanoparticles. ACS Nano. 2024;18:24953\u201367.","journal-title":"ACS Nano"},{"key":"2414_CR557","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202403245","author":"J Yan","year":"2024","unstructured":"Yan J, Chen H, Guimar\u00e3es CF, Reis RL, Zhu Z, Wang T, Zhang F, Lv Y, Zhou Q, Kong X, Shi J. Cu+\/Ca2+ dual\u2010overload strategy assisted by metabolic\u2010symbiotic\u2010destruction for tumor apoptosis and tumor immune activation. Adv Funct Mater. 2024;34:2403245.","journal-title":"Adv Funct Mater"},{"key":"2414_CR558","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202309891","author":"L Liu","year":"2024","unstructured":"Liu L, Chen Y, Ye L, Yu L, Kang Y, Mou X, Cai Y. NIR\u2010II absorbed dithienopyrrole\u2010benzobisthiadiazole based nanosystems for autophagy inhibition and calcium overload enhanced photothermal therapy. Small. 2024;20:2309891.","journal-title":"Small"},{"key":"2414_CR559","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202317578","author":"JJ Hu","year":"2024","unstructured":"Hu JJ, Yuan L, Zhang Y, Kuang J, Song W, Lou X, Xia F, Yoon J. Photo\u2010controlled calcium overload from endogenous sources for tumor therapy. Angew Chem Int Ed Engl. 2024;63:e202317578.","journal-title":"Angew Chem Int Ed Engl"},{"key":"2414_CR560","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122332","author":"J Wu","year":"2023","unstructured":"Wu J, Yi S, Cao Y, Zu M, Li B, Yang W, Shahbazi M-A, Wan Y, Reis RL, Kundu SC, Shi X, Xiao B. Dual-driven nanomotors enable tumor penetration and hypoxia alleviation for calcium overload-photo-immunotherapy against colorectal cancer. Biomaterials. 2023;302:122332.","journal-title":"Biomaterials"},{"key":"2414_CR561","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202304212","author":"Y Lu","year":"2024","unstructured":"Lu Y, Liu S, Liang J, Wang Z, Hou Y. Self\u2010propelled nanomotor for cancer precision combination therapy. Adv Healthc Mater. 2024;13:2304212.","journal-title":"Adv Healthc Mater"},{"key":"2414_CR562","doi-asserted-by":"publisher","first-page":"6560","DOI":"10.7150\/thno.99931","volume":"14","author":"B Xie","year":"2024","unstructured":"Xie B, Dong L, Wang L, Wang R, Li C. Supramolecularly engineered bacteria mediated calcium overload and immunotherapy of tumors. Theranostics. 2024;14:6560\u201370.","journal-title":"Theranostics"},{"key":"2414_CR563","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202202424","author":"D Guo","year":"2023","unstructured":"Guo D, Dai X, Liu K, Liu Y, Wu J, Wang K, Jiang S, Sun F, Wang L, Guo B, Yang D, Huang L. A self\u2010reinforcing nanoplatform for highly effective synergistic targeted combinatary calcium\u2010overload and photodynamic therapy of cancer. Adv Healthc Mater. 2023;12:2202424.","journal-title":"Adv Healthc Mater"},{"key":"2414_CR564","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-021-01069-y","author":"X Pan","year":"2021","unstructured":"Pan X, Qi Y, Du Z, He J, Yao S, Lu W, Ding K, Zhou M. Zinc oxide nanosphere for hydrogen sulfide scavenging and ferroptosis of colorectal cancer. J Nanobiotechnology. 2021;19:392.","journal-title":"J Nanobiotechnology"},{"key":"2414_CR565","doi-asserted-by":"publisher","first-page":"2414","DOI":"10.1073\/pnas.96.5.2414","volume":"96","author":"SL Sensi","year":"1999","unstructured":"Sensi SL, Yin HZ, Carriedo SG, Rao SS, Weiss JH. Preferential Zn 2+ influx through Ca 2+ -permeable AMPA\/kainate channels triggers prolonged mitochondrial superoxide production. Proc Natl Acad Sci. 1999;96:2414\u20139.","journal-title":"Proc Natl Acad Sci"},{"key":"2414_CR566","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1097\/00001756-199906030-00018","volume":"10","author":"SL Sensi","year":"1999","unstructured":"Sensi SL, Yin HZ, Weiss JH. Glutamate triggers preferential Zn2+ flux through Ca2+ permeable AMPA channels and consequent ROS production. Neuroreport. 1999;10:1723\u20137.","journal-title":"Neuroreport"},{"key":"2414_CR567","doi-asserted-by":"publisher","first-page":"2402","DOI":"10.1039\/D3RA07441B","volume":"14","author":"M Khan","year":"2024","unstructured":"Khan M, Ahmad B, Hayat K, Ullah F, Sfina N, Elhadi M, Khan AA, Husain M, Rahman N. Synthesis of ZnO and PEG-ZnO nanoparticles (NPs) with controlled size for biological evaluation. RSC Adv. 2024;14:2402\u20139.","journal-title":"RSC Adv"},{"key":"2414_CR568","first-page":"1","volume":"2015","author":"C Wang","year":"2015","unstructured":"Wang C, Hu X, Gao Y, Ji Y. ZnO nanoparticles treatment induces apoptosis by increasing intracellular ROS levels in LTEP-a-2 cells. Biomed Res Int. 2015;2015:1\u20139.","journal-title":"Biomed Res Int"},{"key":"2414_CR569","doi-asserted-by":"crossref","unstructured":"Fan P, Yang C, Wang L, Wang Q, Zhang Y, Zhou J, Weng J, Feng B. Weng, B. Feng. ZnO nanoparticles stimulate oxidative stress to induce apoptosis of B16F10 melanoma cells: In vitro and in vivo studies.\u00a0Biomed Phys Eng Express. 2021;7:065014.","DOI":"10.1088\/2057-1976\/ac251f"},{"key":"2414_CR570","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.jphotobiol.2016.03.002","volume":"158","author":"M Pandurangan","year":"2016","unstructured":"Pandurangan M, Enkhtaivan G, Kim DH. Anticancer studies of synthesized ZnO nanoparticles against human cervical carcinoma cells. J Photochem Photobiol B. 2016;158:206\u201311.","journal-title":"J Photochem Photobiol B"},{"key":"2414_CR571","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21051612","author":"S-W Wang","year":"2020","unstructured":"Wang S-W, Lee C-H, Lin M-S, Chi C-W, Chen Y-J, Wang G-S, Liao K-W, Chiu L-P, Wu S-H, Huang D-M, Chen L, Shen Y-S. ZnO nanoparticles induced caspase-dependent apoptosis in gingival squamous cell carcinoma through mitochondrial dysfunction and p70S6K signaling pathway. Int J Mol Sci. 2020;21(5):1612.","journal-title":"Int J Mol Sci"},{"key":"2414_CR572","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02530-4","author":"S Dong","year":"2024","unstructured":"Dong S, Huang Y, Yan H, Tan H, Fan L, Chao M, Ren Y, Guan M, Zhang J, Liu Z, Gao F. Ternary heterostructure-driven photoinduced electron-hole separation enhanced oxidative stress for triple-negative breast cancer therapy. J Nanobiotechnology. 2024;22:240.","journal-title":"J Nanobiotechnology"},{"key":"2414_CR573","doi-asserted-by":"publisher","first-page":"10350","DOI":"10.1021\/acs.nanolett.3c02941","volume":"23","author":"M Zhou","year":"2023","unstructured":"Zhou M, Liang S, Liu D, Ma K, Yun K, Yao J, Peng Y, Hai L, Zhang Q, Wang Z. Manganese-enriched zinc peroxide functional nanoparticles for potentiating cancer immunotherapy. Nano Lett. 2023;23:10350\u20139.","journal-title":"Nano Lett"},{"key":"2414_CR574","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202402320","author":"Y Sun","year":"2024","unstructured":"Sun Y, Qin L, Yang Y, Gao J, Zhang Y, Wang H, Wu Q, Xu B, Liu H. Zinc\u2010based ROS amplifiers trigger cancer chemodynamic\/ion interference therapy through self\u2010cascade catalysis. Small. 2024;20(42):e2402320.","journal-title":"Small"},{"key":"2414_CR575","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230061","author":"J Yang","year":"2023","unstructured":"Yang J, He Y, Zhang M, Liang C, Li T, Ji T, Zu M, Ma X, Zhang Z, Liang C, Zhang Q, Chen Y, Hou L. Programmed initiation and enhancement of cGAS\/STING pathway for tumour immunotherapy via tailor\u2010designed ZnFe2O4\u2010based nanosystem. Exploration. 2023;3(6):20230061.","journal-title":"Exploration"},{"key":"2414_CR576","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2021.102399","author":"H Deng","year":"2021","unstructured":"Deng H, Yang Y, Zuo T, Fang T, Xu Y, Yang J, Zhang J, Shen Q. Multifunctional ZnO@CuS nanoparticles cluster synergize chemotherapy and photothermal therapy for tumor metastasis. Nanomedicine Nanotechnol Biol Med. 2021;34:102399.","journal-title":"Nanomedicine Nanotechnol Biol Med"},{"issue":"12","key":"2414_CR577","doi-asserted-by":"publisher","first-page":"12380","DOI":"10.1021\/acsnano.8b06399","volume":"12","author":"S Wang","year":"2018","unstructured":"Wang S, Li F, Qiao R, Hu X, Liao H, Chen L, Wu J, Wu H, Zhao M, Liu J, Chen R, Ma X, Kim D, Sun J, Davis TP, Chen C, Tian J, Hyeon T, Ling D. Arginine-rich manganese silicate nanobubbles as a ferroptosis-inducing agent for tumor-targeted theranostics. ACS Nano. 2018;12:12380\u201392.","journal-title":"ACS Nano"},{"key":"2414_CR578","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmt.2021.101027","author":"X Liu","year":"2021","unstructured":"Liu X, Sui B, Camargo PHC, Wang J, Sun J. Tuning band gap of MnO2 nanoflowers by alkali metal doping for enhanced ferroptosis\/phototherapy synergism in cancer. Appl Mater Today. 2021;23:101027.","journal-title":"Appl Mater Today"},{"key":"2414_CR579","doi-asserted-by":"publisher","first-page":"6404","DOI":"10.1021\/acsami.1c22861","volume":"14","author":"W Tao","year":"2022","unstructured":"Tao W, Wang N, Ruan J, Cheng X, Fan L, Zhang P, Lu C, Hu Y, Che C, Sun D, Duan J, Zhao M. Enhanced ROS-boosted phototherapy against pancreatic cancer via Nrf2-mediated stress-defense pathway suppression and ferroptosis induction. ACS Appl Mater Interfaces. 2022;14:6404\u201316.","journal-title":"ACS Appl Mater Interfaces"},{"key":"2414_CR580","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122745","author":"H Chen","year":"2025","unstructured":"Chen H, Qu H, Pan Y, Cheng W, Xue X. Manganese-coordinated nanoparticle with high drug-loading capacity and synergistic photo-\/immuno-therapy for cancer treatments. Biomaterials. 2025;312:122745.","journal-title":"Biomaterials"},{"key":"2414_CR581","doi-asserted-by":"publisher","first-page":"11862","DOI":"10.1021\/acsnano.2c00969","volume":"16","author":"Z Sun","year":"2022","unstructured":"Sun Z, Wang Z, Wang T, Wang J, Zhang H, Li Z, Wang S, Sheng F, Yu J, Hou Y. Biodegradable Mno-based nanoparticles with engineering surface for tumor therapy: simultaneous Fenton-like ion delivery and immune activation. ACS Nano. 2022;16:11862\u201375.","journal-title":"ACS Nano"},{"key":"2414_CR582","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2024.122472","author":"B Wang","year":"2024","unstructured":"Wang B, Wang T, Jiang T, Li S, Zhang L, Zhao X, Yang X, Wang X. Circulating immunotherapy strategy based on pyroptosis and STING pathway: Mn-loaded paclitaxel prodrug nanoplatform against tumor progression and metastasis. Biomaterials. 2024;306:122472.","journal-title":"Biomaterials"},{"key":"2414_CR583","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202205409","author":"K Zhang","year":"2023","unstructured":"Zhang K, Qi C, Cai K. Manganese\u2010Based tumor immunotherapy. Adv Mater. 2023;35:e2205409.","journal-title":"Adv Mater"},{"key":"2414_CR584","doi-asserted-by":"crossref","unstructured":"Nejati M, Rostami M, Mirzaei H, Rahimi-Nasrabadi M, Vosoughifar M, Nasab AS, Ganjali MR. Green methods for the preparation of MgO nanomaterials and their drug delivery, anti-cancer and anti-bacterial potentials: a review. Inorg Chem Commun. 2022;136:109107.","DOI":"10.1016\/j.inoche.2021.109107"},{"key":"2414_CR585","doi-asserted-by":"crossref","unstructured":"Rostami M, Sharafi P, Mozaffari S, Adib K, Sobhani-Nasab A, Rahimi-Nasrabadi M, Fasihi-Ramandi M, Ganjali MR, Badiei A. A facile preparation of ZnFe2O4\u2013CuO-N\/B\/RGO and ZnFe2O4\u2013CuO\u2013C3N4 ternary heterojunction nanophotocatalyst: characterization, biocompatibility, photo-Fenton-like degradation of MO and magnetic properties. J Mater Sci Mater Electron. 2021;32:5457\u201372.","DOI":"10.1007\/s10854-021-05268-z"},{"key":"2414_CR586","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2019.101069","author":"D MubarakAli","year":"2019","unstructured":"MubarakAli D, Manzoor MAP, Sabarinathan A, Devi C. Anchana, Rekha PD, Thajuddin N, Lee S-Y. An investigation of antibiofilm and cytotoxic property of MgO nanoparticles. Biocatal Agric Biotechnol. 2019;18:101069.","journal-title":"Biocatal Agric Biotechnol"},{"key":"2414_CR587","doi-asserted-by":"publisher","DOI":"10.3390\/nano10010066","author":"TTV Phan","year":"2019","unstructured":"Phan TTV, Huynh T-C, Manivasagan P, Mondal S, Oh J. An up-to-date review on biomedical applications of Palladium nanoparticles. Nanomaterials. 2019;10:66.","journal-title":"Nanomaterials"},{"key":"2414_CR588","doi-asserted-by":"crossref","unstructured":"Choudhary S, Kumawat G, Kher K, Baroliya PK, Gupta AK, Tripathy MK. Green synthesis of palladium nanoparticles using Asterarcys sp. and their applications. Nano TransMed.2024;3:100046.","DOI":"10.1016\/j.ntm.2024.100046"},{"key":"2414_CR589","doi-asserted-by":"crossref","unstructured":"Islam MA, Jacob MV, Antunes E. A critical review on silver nanoparticles: from synthesis and applications to its mitigation through low-cost adsorption by biochar. J Environ Manage. 2021;281:111918.","DOI":"10.1016\/j.jenvman.2020.111918"},{"key":"2414_CR590","doi-asserted-by":"publisher","first-page":"8996","DOI":"10.7150\/thno.45413","volume":"10","author":"L Xu","year":"2020","unstructured":"Xu L, Wang Y-Y, Huang J, Chen C-Y, Wang Z-X, Xie H. Silver nanoparticles: Synthesis, medical applications and biosafety. Theranostics. 2020;10:8996\u20139031.","journal-title":"Theranostics"},{"key":"2414_CR591","doi-asserted-by":"publisher","DOI":"10.1002\/asia.202400162","author":"NX Thai","year":"2024","unstructured":"Thai NX, Chinh NT, Linh BT, Thuy TT, Hoang T. Optimizing green synthesis of hydrotalcite \u2013 silver nanoparticles using Syzygium nervosum based reducing agent. Chem Asian J. 2024;19:e202400162.","journal-title":"Chem Asian J"},{"key":"2414_CR592","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100052","author":"SM Bhavi","year":"2024","unstructured":"Bhavi SM, Padti AC, Thokchom B, Singh SR, Bhat SS, Bajire SK, Shastry RP, Srinath BS, Gummani SS, Harini BP, Yarajarla RB. Biogenic silver nanoparticles from Simarouba glauca DC leaf extract: Synthesis, characterization, and anticancer efficacy in lung cancer cells with protective effects in Caenorhabditis elegans. Nano TransMed. 2024;3:100052.","journal-title":"Nano TransMed"},{"key":"2414_CR593","doi-asserted-by":"crossref","unstructured":"Shaaban MT, Mohamed BS, Zayed M, El-Sabbagh SM. Antibacterial. antibiofilm, and anticancer activity of silver-nanoparticles synthesized from the cell-filtrate of Streptomyces enissocaesilis. BMC Biotechnol. 2024;24(1):8.","DOI":"10.1186\/s12896-024-00833-w"},{"key":"2414_CR594","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112254","author":"RR Miranda","year":"2022","unstructured":"Miranda RR, Sampaio I, Zucolotto V. Exploring silver nanoparticles for cancer therapy and diagnosis. Colloids Surf B Biointerfaces. 2022;210:112254.","journal-title":"Colloids Surf B Biointerfaces"},{"key":"2414_CR595","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.2174\/1871520619666190710121727","volume":"20","author":"TQ Huy","year":"2020","unstructured":"Huy TQ, Huyen PTM, Le A-T, Tonezzer M. Recent advances of silver nanoparticles in cancer diagnosis and treatment. Anticancer Agents Med Chem. 2020;20:1276\u201387.","journal-title":"Anticancer Agents Med Chem"},{"key":"2414_CR596","doi-asserted-by":"crossref","unstructured":"Abbigeri MB, Thokchom B, Singh SR, Bhavi SM, Harini BP, Yarajarla RB. Antioxidant and anti-diabetic potential of the green synthesized silver nanoparticles using Martynia annua L. root extract. Nano TransMed. 2025;4:100070.","DOI":"10.1016\/j.ntm.2025.100070"},{"key":"2414_CR597","doi-asserted-by":"crossref","unstructured":"Ravishankar TN, Ananda A, Shilpa BM, Adarsh JR. Eco-friendly synthesis of NiO and Ag\/NiO nanoparticles: applications in photocatalytic and antibacterial activities.\u00a0Royal Soc Open Sci. 2025;12:241733.","DOI":"10.1098\/rsos.241733"},{"key":"2414_CR598","doi-asserted-by":"crossref","unstructured":"AlSalhi MS, Aziz MH, Atif M, Fatima M, Shaheen F, Devanesan S, Farooq W. Aslam. Synthesis of NiO nanoparticles and their evaluation for photodynamic therapy against HeLa cancer cells. Journal of King Saud University - Science. 2020;32:1395\u2013402.","DOI":"10.1016\/j.jksus.2019.11.033"},{"key":"2414_CR599","doi-asserted-by":"publisher","DOI":"10.1016\/j.rechem.2023.101120","author":"J Deng","year":"2023","unstructured":"Deng J, Li D, Chen R, Zeng X, Liu Y. Fabrication of Marsdenia tenacissima with decorated nickel oxide nanoparticles: investigation of anticancer activity in lung cancer cells and its apoptosis. Results Chem. 2023;6:101120","journal-title":"Results Chem"},{"key":"2414_CR600","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntm.2024.100049","author":"V Mani","year":"2024","unstructured":"Mani V, Gopinath KS, Varadharaju N, Wankhar D, Annavi A. Abutilon indicum-mediated green synthesis of NiO and ZnO nanoparticles: Spectral profiling and anticancer potential against human cervical cancer for public health progression. Nano TransMed. 2024;3:100049.","journal-title":"Nano TransMed"},{"key":"2414_CR601","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031685","author":"D Mundekkad","year":"2022","unstructured":"Mundekkad D, Cho WC. Nanoparticles in clinical translation for cancer therapy. Int J Mol Sci. 2022; 23:1685.","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-025-02414-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-025-02414-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-025-02414-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T02:04:16Z","timestamp":1760580256000},"score":1,"resource":{"primary":{"URL":"https:\/\/molecular-cancer.biomedcentral.com\/articles\/10.1186\/s12943-025-02414-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,16]]},"references-count":601,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2414"],"URL":"https:\/\/doi.org\/10.1186\/s12943-025-02414-7","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,16]]},"assertion":[{"value":"31 March 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All of the authors are aware of and agree with the content of the paper and are listed as coauthors of the paper.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"260"}}