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All animal experiments were conducted under protocols (A30615, A50214, and A00005433-20-R23) approved by the Mayo Clinic Institutional Animal Care and Use Committee (IACUC) and were performed in accordance with relevant institutional and national guidelines and regulations.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"300"}}