{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:34:56Z","timestamp":1793871296248,"version":"4.6.1"},"reference-count":315,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82472700"],"award-info":[{"award-number":["82472700"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"DOI":"10.1186\/s12943-025-02523-3","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T15:22:46Z","timestamp":1765898566000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Amino acids metabolism: a potential target for cancer treatment"],"prefix":"10.1186","volume":"24","author":[{"given":"Shiqi","family":"Ren","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kefei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"2523_CR1","doi-asserted-by":"publisher","first-page":"113923","DOI":"10.1016\/j.biopha.2022.113923","volume":"156","author":"D Wang","year":"2022","unstructured":"Wang D, Wan X. Progress in research on the role of amino acid metabolic reprogramming in tumour therapy: A review. Biomed Pharmacother. 2022;156:113923.","journal-title":"Biomed Pharmacother"},{"key":"2523_CR2","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646\u201374.","journal-title":"Cell"},{"key":"2523_CR3","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1126\/science.123.3191.309","volume":"123","author":"O Warburg","year":"1956","unstructured":"Warburg O. On the origin of cancer cells. Science. 1956;123:309\u201314.","journal-title":"Science"},{"key":"2523_CR4","doi-asserted-by":"publisher","first-page":"5068","DOI":"10.1016\/j.cell.2023.09.011","volume":"186","author":"D Mossmann","year":"2023","unstructured":"Mossmann D, M\u00fcller C, Park S, Ryback B, Colombi M, Ritter N, Wei\u00dfenberger D, Dazert E, Coto-Llerena M, Nuciforo S, et al. Arginine reprograms metabolism in liver cancer via RBM39. Cell. 2023;186:5068\u2013e50835023.","journal-title":"Cell"},{"key":"2523_CR5","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1186\/s13046-023-02845-4","volume":"42","author":"Y Zheng","year":"2023","unstructured":"Zheng Y, Yao Y, Ge T, Ge S, Jia R, Song X, Zhuang A. Amino acid metabolism reprogramming: shedding new light on T cell anti-tumor immunity. J Exp Clin Cancer Res. 2023;42:291.","journal-title":"J Exp Clin Cancer Res"},{"key":"2523_CR6","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1053\/j.gastro.2022.11.014","volume":"164","author":"S Solanki","year":"2023","unstructured":"Solanki S, Sanchez K, Ponnusamy V, Kota V, Bell HN, Cho CS, Kowalsky AH, Green M, Lee JH, Shah YM. Dysregulated amino acid sensing drives colorectal cancer growth and metabolic reprogramming leading to chemoresistance. Gastroenterology. 2023;164:376\u2013e391313.","journal-title":"Gastroenterology"},{"key":"2523_CR7","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12964-022-00909-0","volume":"20","author":"G Ma","year":"2022","unstructured":"Ma G, Zhang Z, Li P, Zhang Z, Zeng M, Liang Z, Li D, Wang L, Chen Y, Liang Y, Niu H. Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment. Cell Commun Signal. 2022;20:114.","journal-title":"Cell Commun Signal"},{"key":"2523_CR8","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41586-020-2124-0","volume":"579","author":"N Kanarek","year":"2020","unstructured":"Kanarek N, Petrova B, Sabatini DM. Dietary modifications for enhanced cancer therapy. Nature. 2020;579:507\u201317.","journal-title":"Nature"},{"key":"2523_CR9","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s41419-022-05015-0","volume":"13","author":"DJ Cai","year":"2022","unstructured":"Cai DJ, Zhang ZY, Bu Y, Li L, Deng YZ, Sun LQ, Hu CP, Li M. Asparagine synthetase regulates lung-cancer metastasis by stabilizing the \u03b2-catenin complex and modulating mitochondrial response. Cell Death Dis. 2022;13:566.","journal-title":"Cell Death Dis"},{"key":"2523_CR10","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.tibs.2010.05.003","volume":"35","author":"DR Wise","year":"2010","unstructured":"Wise DR, Thompson CB. Glutamine addiction: a new therapeutic target in cancer. Trends Biochem Sci. 2010;35:427\u201333.","journal-title":"Trends Biochem Sci"},{"key":"2523_CR11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s12276-020-0375-3","volume":"52","author":"EL Lieu","year":"2020","unstructured":"Lieu EL, Nguyen T, Rhyne S, Kim J. Amino acids in cancer. Exp Mol Med. 2020;52:15\u201330.","journal-title":"Exp Mol Med"},{"key":"2523_CR12","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1016\/j.cmet.2024.10.001","volume":"36","author":"Y Liao","year":"2024","unstructured":"Liao Y, Chen Q, Liu L, Huang H, Sun J, Bai X, Jin C, Li H, Sun F, Xiao X, et al. Amino acid is a major carbon source for hepatic lipogenesis. Cell Metab. 2024;36:2437\u2013e24482438.","journal-title":"Cell Metab"},{"key":"2523_CR13","doi-asserted-by":"crossref","unstructured":"Ryan DG, Yang M, Prag HA, Blanco GR, Nikitopoulou E, Segarra-Mondejar M, Powell CA, Young T, Burger N, Miljkovic JL et al. Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism. Elife. 2021;10:e72593.","DOI":"10.7554\/eLife.72593"},{"key":"2523_CR14","doi-asserted-by":"publisher","first-page":"3678","DOI":"10.1172\/JCI69600","volume":"123","author":"CT Hensley","year":"2013","unstructured":"Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest. 2013;123:3678\u201384.","journal-title":"J Clin Invest"},{"key":"2523_CR15","doi-asserted-by":"publisher","first-page":"7379","DOI":"10.18632\/oncotarget.3132","volume":"6","author":"B Ratnikov","year":"2015","unstructured":"Ratnikov B, Aza-Blanc P, Ronai ZA, Smith JW, Osterman AL, Scott DA. Glutamate and asparagine cataplerosis underlie glutamine addiction in melanoma. Oncotarget. 2015;6:7379\u201389.","journal-title":"Oncotarget"},{"key":"2523_CR16","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.15252\/embj.201796436","volume":"36","author":"B Kim","year":"2017","unstructured":"Kim B, Li J, Jang C, Arany Z. Glutamine fuels proliferation but not migration of endothelial cells. Embo J. 2017;36:2321\u201333.","journal-title":"Embo J"},{"key":"2523_CR17","doi-asserted-by":"publisher","first-page":"3652","DOI":"10.1172\/JCI67228","volume":"123","author":"M Yang","year":"2013","unstructured":"Yang M, Soga T, Pollard PJ. Oncometabolites: linking altered metabolism with cancer. J Clin Invest. 2013;123:3652\u20138.","journal-title":"J Clin Invest"},{"key":"2523_CR18","doi-asserted-by":"publisher","first-page":"102037","DOI":"10.1016\/j.molmet.2024.102037","volume":"90","author":"DN Legge","year":"2024","unstructured":"Legge DN, Collard TJ, Stanko E, Hoskin AJ, Holt AK, Bull CJ, Kollareddy M, Bellamy J, Groves S, Ma EH, et al. Identifying targetable metabolic dependencies across colorectal cancer progression. Mol Metab. 2024;90:102037.","journal-title":"Mol Metab"},{"key":"2523_CR19","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1158\/1535-7163.MCT-13-0870","volume":"13","author":"MI Gross","year":"2014","unstructured":"Gross MI, Demo SD, Dennison JB, Chen L, Chernov-Rogan T, Goyal B, Janes JR, Laidig GJ, Lewis ER, Li J, et al. Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer. Mol Cancer Ther. 2014;13:890\u2013901.","journal-title":"Mol Cancer Ther"},{"key":"2523_CR20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1186\/s12964-024-01540-x","volume":"22","author":"Q Yuan","year":"2024","unstructured":"Yuan Q, Yin L, He J, Zeng Q, Liang Y, Shen Y, Zu X. Metabolism of asparagine in the physiological state and cancer. Cell Commun Signal. 2024;22:163.","journal-title":"Cell Commun Signal"},{"key":"2523_CR21","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","volume":"56","author":"C Yang","year":"2014","unstructured":"Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso MA, Lumata L, Mitsche M, et al. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol Cell. 2014;56:414\u201324.","journal-title":"Mol Cell"},{"key":"2523_CR22","doi-asserted-by":"publisher","first-page":"3354","DOI":"10.1038\/s41467-019-11331-5","volume":"10","author":"M Zampieri","year":"2019","unstructured":"Zampieri M, H\u00f6rl M, Hotz F, M\u00fcller NF, Sauer U. Regulatory mechanisms underlying coordination of amino acid and glucose catabolism in Escherichia coli. Nat Commun. 2019;10:3354.","journal-title":"Nat Commun"},{"key":"2523_CR23","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/s41586-025-09205-6","volume":"644","author":"O Lemke","year":"2025","unstructured":"Lemke O, Heineike BM, Viknander S, Cohen N, Li F, Steenwyk JL, Spranger L, Agostini F, Lee CT, Aulakh SK, et al. The role of metabolism in shaping enzyme structures over 400 million years. Nature. 2025;644:280\u20139.","journal-title":"Nature"},{"key":"2523_CR24","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tibs.2014.02.004","volume":"39","author":"I Amelio","year":"2014","unstructured":"Amelio I, Cutruzzol\u00e1 F, Antonov A, Agostini M, Melino G. Serine and Glycine metabolism in cancer. Trends Biochem Sci. 2014;39:191\u20138.","journal-title":"Trends Biochem Sci"},{"key":"2523_CR25","doi-asserted-by":"publisher","first-page":"11004","DOI":"10.18632\/oncotarget.2668","volume":"5","author":"A Antonov","year":"2014","unstructured":"Antonov A, Agostini M, Morello M, Minieri M, Melino G, Amelio I. Bioinformatics analysis of the Serine and Glycine pathway in cancer cells. Oncotarget. 2014;5:11004\u201313.","journal-title":"Oncotarget"},{"key":"2523_CR26","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","volume":"23","author":"NN Pavlova","year":"2016","unstructured":"Pavlova NN, Thompson CB. The emerging hallmarks of cancer metabolism. Cell Metab. 2016;23:27\u201347.","journal-title":"Cell Metab"},{"key":"2523_CR27","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1038\/nature10350","volume":"476","author":"R Possemato","year":"2011","unstructured":"Possemato R, Marks KM, Shaul YD, Pacold ME, Kim D, Birsoy K, Sethumadhavan S, Woo HK, Jang HG, Jha AK, et al. Functional genomics reveal that the Serine synthesis pathway is essential in breast cancer. Nature. 2011;476:346\u201350.","journal-title":"Nature"},{"key":"2523_CR28","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1038\/s41416-022-01965-6","volume":"127","author":"M Falcone","year":"2022","unstructured":"Falcone M, Uribe AH, Papalazarou V, Newman AC, Athineos D, Stevenson K, Sauv\u00e9 CG, Gao Y, Kim JK, Del Latto M, et al. Sensitisation of cancer cells to radiotherapy by Serine and Glycine starvation. Br J Cancer. 2022;127:1773\u201386.","journal-title":"Br J Cancer"},{"key":"2523_CR29","doi-asserted-by":"publisher","first-page":"6904","DOI":"10.1073\/pnas.1204176109","volume":"109","author":"J Ye","year":"2012","unstructured":"Ye J, Mancuso A, Tong X, Ward PS, Fan J, Rabinowitz JD, Thompson CB. Pyruvate kinase M2 promotes de Novo Serine synthesis to sustain mTORC1 activity and cell proliferation. Proc Natl Acad Sci U S A. 2012;109:6904\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2523_CR30","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1038\/nature11743","volume":"493","author":"OD Maddocks","year":"2013","unstructured":"Maddocks OD, Berkers CR, Mason SM, Zheng L, Blyth K, Gottlieb E, Vousden KH. Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells. Nature. 2013;493:542\u20136.","journal-title":"Nature"},{"key":"2523_CR31","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/s41392-020-00326-0","volume":"5","author":"HQ Ju","year":"2020","unstructured":"Ju HQ, Lin JF, Tian T, Xie D, Xu RH. NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications. Signal Transduct Target Ther. 2020;5:231.","journal-title":"Signal Transduct Target Ther"},{"key":"2523_CR32","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41580-024-00730-2","volume":"25","author":"H Sies","year":"2024","unstructured":"Sies H, Mailloux RJ, Jakob U. Fundamentals of redox regulation in biology. Nat Rev Mol Cell Biol. 2024;25:701\u201319.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2523_CR33","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.copbio.2021.03.001","volume":"68","author":"G Asantewaa","year":"2021","unstructured":"Asantewaa G, Harris IS. Glutathione and its precursors in cancer. Curr Opin Biotechnol. 2021;68:292\u20139.","journal-title":"Curr Opin Biotechnol"},{"key":"2523_CR34","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1016\/j.cmet.2016.04.016","volume":"23","author":"GS Ducker","year":"2016","unstructured":"Ducker GS, Chen L, Morscher RJ, Ghergurovich JM, Esposito M, Teng X, Kang Y, Rabinowitz JD. Reversal of cytosolic One-Carbon flux compensates for loss of the mitochondrial folate pathway. Cell Metab. 2016;23:1140\u201353.","journal-title":"Cell Metab"},{"key":"2523_CR35","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature13236","volume":"510","author":"J Fan","year":"2014","unstructured":"Fan J, Ye J, Kamphorst JJ, Shlomi T, Thompson CB, Rabinowitz JD. Quantitative flux analysis reveals folate-dependent NADPH production. Nature. 2014;510:298\u2013302.","journal-title":"Nature"},{"key":"2523_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s42255-020-00329-9","volume":"3","author":"SL Geeraerts","year":"2021","unstructured":"Geeraerts SL, Heylen E, De Keersmaecker K, Kampen KR. The Ins and outs of Serine and Glycine metabolism in cancer. Nat Metab. 2021;3:131\u201341.","journal-title":"Nat Metab"},{"key":"2523_CR37","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nrc.2016.114","volume":"16","author":"BJ Altman","year":"2016","unstructured":"Altman BJ, Stine ZE, Dang CV. From Krebs to clinic: glutamine metabolism to cancer therapy. Nat Rev Cancer. 2016;16:749.","journal-title":"Nat Rev Cancer"},{"key":"2523_CR38","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1038\/s41416-020-01156-1","volume":"124","author":"VDB Bonif\u00e1cio","year":"2021","unstructured":"Bonif\u00e1cio VDB, Pereira SA, Serpa J, Vicente JB. Cysteine metabolic circuitries: druggable targets in cancer. Br J Cancer. 2021;124:862\u201379.","journal-title":"Br J Cancer"},{"key":"2523_CR39","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1158\/1541-7786.MCR-20-0086","volume":"19","author":"TM Thomas","year":"2021","unstructured":"Thomas TM, Miyaguchi K, Edwards LA, Wang H, Wollebo H, Aiguo L, Murali R, Wang Y, Braas D, Michael JS, et al. Elevated asparagine biosynthesis drives brain tumor stem cell metabolic plasticity and resistance to oxidative stress. Mol Cancer Res. 2021;19:1375\u201388.","journal-title":"Mol Cancer Res"},{"key":"2523_CR40","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1158\/0008-5472.CAN-22-2370","volume":"83","author":"Y Li","year":"2023","unstructured":"Li Y, Chen H, Xie X, Yang B, Wang X, Zhang J, Qiao T, Guan J, Qiu Y, Huang YX, et al. PINK1-Mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce Drug-Tolerant persister cancer cells. Cancer Res. 2023;83:398\u2013413.","journal-title":"Cancer Res"},{"key":"2523_CR41","doi-asserted-by":"publisher","first-page":"103335","DOI":"10.1016\/j.redox.2024.103335","volume":"76","author":"W Li","year":"2024","unstructured":"Li W, Zeng Q, Wang B, Lv C, He H, Yang X, Cheng B, Tao X. Oxidative stress promotes oral carcinogenesis via Thbs1-mediated M1-like tumor-associated macrophages polarization. Redox Biol. 2024;76:103335.","journal-title":"Redox Biol"},{"key":"2523_CR42","doi-asserted-by":"publisher","first-page":"e70005","DOI":"10.1002\/mog2.70005","volume":"3","author":"M Du","year":"2024","unstructured":"Du M, Zhang J, Wicha MS, Luo M. Redox regulation of cancer stem cells: biology and therapeutic implications. MedComm\u2013Oncology. 2024;3:e70005.","journal-title":"MedComm\u2013Oncology"},{"key":"2523_CR43","doi-asserted-by":"publisher","first-page":"e70007","DOI":"10.1002\/mog2.70007","volume":"3","author":"P Jin","year":"2024","unstructured":"Jin P, Feng XD, Huang CS, Li J, Wang H, Wang XM, Li L, Ma LQ. Oxidative stress and cellular senescence: roles in tumor progression and therapeutic opportunities. MedComm\u2013Oncology. 2024;3:e70007.","journal-title":"MedComm\u2013Oncology"},{"key":"2523_CR44","doi-asserted-by":"publisher","first-page":"e269","DOI":"10.1038\/emm.2016.119","volume":"48","author":"J Kim","year":"2016","unstructured":"Kim J, Kim J, Bae JS. ROS homeostasis and metabolism: a critical liaison for cancer therapy. Exp Mol Med. 2016;48:e269.","journal-title":"Exp Mol Med"},{"key":"2523_CR45","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1016\/j.molmed.2017.03.004","volume":"23","author":"IIC Chio","year":"2017","unstructured":"Chio IIC, Tuveson DA. ROS in cancer: the burning question. Trends Mol Med. 2017;23:411\u201329.","journal-title":"Trends Mol Med"},{"key":"2523_CR46","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","volume":"38","author":"JD Hayes","year":"2020","unstructured":"Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative stress in cancer. Cancer Cell. 2020;38:167\u201397.","journal-title":"Cancer Cell"},{"key":"2523_CR47","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1038\/s41589-022-01085-5","volume":"18","author":"Q Zhu","year":"2022","unstructured":"Zhu Q, Zhou H, Wu L, Lai Z, Geng D, Yang W, Zhang J, Fan Z, Qin W, Wang Y, et al. O-GlcNAcylation promotes pancreatic tumor growth by regulating malate dehydrogenase 1. Nat Chem Biol. 2022;18:1087\u201395.","journal-title":"Nat Chem Biol"},{"key":"2523_CR48","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/nature12040","volume":"496","author":"J Son","year":"2013","unstructured":"Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, et al. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013;496:101\u20135.","journal-title":"Nature"},{"key":"2523_CR49","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1152\/physrev.00003.2023","volume":"104","author":"Z Yao","year":"2024","unstructured":"Yao Z, Fan Y, Lin L, Kellems RE, Xia Y. Tissue transglutaminase: a multifunctional and multisite regulator in health and disease. Physiol Rev. 2024;104:281\u2013325.","journal-title":"Physiol Rev"},{"key":"2523_CR50","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.advnut.2023.05.007","volume":"14","author":"W Shunxi","year":"2023","unstructured":"Shunxi W, Xiaoxue Y, Guanbin S, Li Y, Junyu J, Wanqian L. Serine metabolic reprogramming in tumorigenesis, tumor Immunity, and clinical treatment. Adv Nutr. 2023;14:1050\u201366.","journal-title":"Adv Nutr"},{"key":"2523_CR51","doi-asserted-by":"publisher","first-page":"6458","DOI":"10.1158\/0008-5472.CAN-16-1730","volume":"76","author":"D Samanta","year":"2016","unstructured":"Samanta D, Semenza GL. Serine synthesis helps hypoxic cancer stem cells regulate redox. Cancer Res. 2016;76:6458\u201362.","journal-title":"Cancer Res"},{"key":"2523_CR52","doi-asserted-by":"crossref","unstructured":"Zhou X, He L, Wu C, Zhang Y, Wu X, Yin Y. Serine alleviates oxidative stress via supporting glutathione synthesis and methionine cycle in mice. Mol Nutr Food Res. 2017;61(11):10.","DOI":"10.1002\/mnfr.201700262"},{"key":"2523_CR53","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1158\/0008-5472.CAN-21-4328","volume":"82","author":"D Samanta","year":"2022","unstructured":"Samanta D, Park Y, Andrabi SA, Shelton LM, Gilkes DM, Semenza GL. Correction: PHGDH expression is required for mitochondrial redox Homeostasis, breast cancer stem cell Maintenance, and lung metastasis. Cancer Res. 2022;82:1153.","journal-title":"Cancer Res"},{"key":"2523_CR54","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1038\/s41416-020-0794-x","volume":"122","author":"AL Engel","year":"2020","unstructured":"Engel AL, Lorenz NI, Klann K, M\u00fcnch C, Depner C, Steinbach JP, Ronellenfitsch MW, Luger AL. Serine-dependent redox homeostasis regulates glioblastoma cell survival. Br J Cancer. 2020;122:1391\u20138.","journal-title":"Br J Cancer"},{"key":"2523_CR55","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.2174\/0929867329666220817141227","volume":"30","author":"Y Fan","year":"2023","unstructured":"Fan Y, Tan X, Zhao H, Tu X, Liu X, Wang Y. Cysteine metabolism in tumor redox homeostasis. Curr Med Chem. 2023;30:1813\u201323.","journal-title":"Curr Med Chem"},{"key":"2523_CR56","doi-asserted-by":"publisher","first-page":"7101","DOI":"10.1523\/JNEUROSCI.5258-04.2005","volume":"25","author":"WJ Chung","year":"2005","unstructured":"Chung WJ, Lyons SA, Nelson GM, Hamza H, Gladson CL, Gillespie GY, Sontheimer H. Inhibition of cystine uptake disrupts the growth of primary brain tumors. J Neurosci. 2005;25:7101\u201310.","journal-title":"J Neurosci"},{"key":"2523_CR57","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40880-017-0219-2","volume":"36","author":"YJ Li","year":"2017","unstructured":"Li YJ, Lei YH, Yao N, Wang CR, Hu N, Ye WC, Zhang DM, Chen ZS. Autophagy and multidrug resistance in cancer. Chin J Cancer. 2017;36:52.","journal-title":"Chin J Cancer"},{"key":"2523_CR58","doi-asserted-by":"publisher","first-page":"6416","DOI":"10.1038\/sj.onc.1209888","volume":"25","author":"Y Mamane","year":"2006","unstructured":"Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N. mTOR, translation initiation and cancer. Oncogene. 2006;25:6416\u201322.","journal-title":"Oncogene"},{"key":"2523_CR59","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.molcel.2008.03.003","volume":"30","author":"DM Gwinn","year":"2008","unstructured":"Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell. 2008;30:214\u201326.","journal-title":"Mol Cell"},{"key":"2523_CR60","doi-asserted-by":"publisher","first-page":"ra27","DOI":"10.1126\/scisignal.aaa0899","volume":"8","author":"J Wengrod","year":"2015","unstructured":"Wengrod J, Wang D, Weiss S, Zhong H, Osman I, Gardner LB. Phosphorylation of eIF2\u03b1 triggered by mTORC1 Inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma. Sci Signal. 2015;8:ra27.","journal-title":"Sci Signal"},{"key":"2523_CR61","doi-asserted-by":"publisher","first-page":"15065","DOI":"10.1038\/cddiscovery.2015.65","volume":"2","author":"XJ Xia","year":"2016","unstructured":"Xia XJ, Gao YY, Zhang J, Wang L, Zhao S, Che YY, Ao CJ, Yang HJ, Wang JQ, Lei LC. Autophagy mediated by arginine depletion activation of the nutrient sensor GCN2 contributes to interferon-\u03b3-induced malignant transformation of primary bovine mammary epithelial cells. Cell Death Discov. 2016;2:15065.","journal-title":"Cell Death Discov"},{"key":"2523_CR62","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11010-020-03685-y","volume":"466","author":"TYL Huynh","year":"2020","unstructured":"Huynh TYL, Zareba I, Baszanowska W, Lewoniewska S, Palka J. Understanding the role of key amino acids in regulation of proline dehydrogenase\/proline oxidase (prodh\/pox)-dependent apoptosis\/autophagy as an approach to targeted cancer therapy. Mol Cell Biochem. 2020;466:35\u201344.","journal-title":"Mol Cell Biochem"},{"key":"2523_CR63","doi-asserted-by":"publisher","first-page":"8048","DOI":"10.1038\/ncomms9048","volume":"6","author":"PM Wong","year":"2015","unstructured":"Wong PM, Feng Y, Wang J, Shi R, Jiang X. Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A. Nat Commun. 2015;6:8048.","journal-title":"Nat Commun"},{"key":"2523_CR64","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.molcel.2018.09.017","volume":"72","author":"W Wan","year":"2018","unstructured":"Wan W, You Z, Zhou L, Xu Y, Peng C, Zhou T, Yi C, Shi Y, Liu W. mTORC1-Regulated and HUWE1-Mediated WIPI2 degradation controls autophagy flux. Mol Cell. 2018;72:303\u2013e315306.","journal-title":"Mol Cell"},{"key":"2523_CR65","doi-asserted-by":"publisher","first-page":"405","DOI":"10.2174\/156652410791316995","volume":"10","author":"N Savaraj","year":"2010","unstructured":"Savaraj N, You M, Wu C, Wangpaichitr M, Kuo MT, Feun LG. Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma. Curr Mol Med. 2010;10:405\u201312.","journal-title":"Curr Mol Med"},{"key":"2523_CR66","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.cell.2018.03.001","volume":"173","author":"A Longchamp","year":"2018","unstructured":"Longchamp A, Mirabella T, Arduini A, MacArthur MR, Das A, Trevi\u00f1o-Villarreal JH, Hine C, Ben-Sahra I, Knudsen NH, Brace LE, et al. Amino acid restriction triggers angiogenesis via GCN2\/ATF4 regulation of VEGF and H(2)S production. Cell. 2018;173:117\u2013e129114.","journal-title":"Cell"},{"key":"2523_CR67","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.cell.2008.11.044","volume":"136","author":"P Nicklin","year":"2009","unstructured":"Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell. 2009;136:521\u201334.","journal-title":"Cell"},{"key":"2523_CR68","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/ncb2550","volume":"14","author":"M Sandri","year":"2012","unstructured":"Sandri M. FOXOphagy path to inducing stress resistance and cell survival. Nat Cell Biol. 2012;14:786\u20138.","journal-title":"Nat Cell Biol"},{"key":"2523_CR69","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/ncb2536","volume":"14","author":"KE van der Vos","year":"2012","unstructured":"van der Vos KE, Eliasson P, Proikas-Cezanne T, Vervoort SJ, van Boxtel R, Putker M, van Zutphen IJ, Mauthe M, Zellmer S, Pals C, et al. Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol. 2012;14:829\u201337.","journal-title":"Nat Cell Biol"},{"key":"2523_CR70","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1083\/jcb.201403009","volume":"206","author":"R Chen","year":"2014","unstructured":"Chen R, Zou Y, Mao D, Sun D, Gao G, Shi J, Liu X, Zhu C, Yang M, Ye W, et al. The general amino acid control pathway regulates mTOR and autophagy during serum\/glutamine starvation. J Cell Biol. 2014;206:173\u201382.","journal-title":"J Cell Biol"},{"key":"2523_CR71","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1038\/nrendo.2014.35","volume":"10","author":"KH Kim","year":"2014","unstructured":"Kim KH, Lee MS. Autophagy\u2013a key player in cellular and body metabolism. Nat Rev Endocrinol. 2014;10:322\u201337.","journal-title":"Nat Rev Endocrinol"},{"key":"2523_CR72","doi-asserted-by":"crossref","unstructured":"Saladini S, Aventaggiato M, Barreca F, Morgante E, Sansone L, Russo MA, Tafani M. Metformin impairs glutamine metabolism and autophagy in tumour cells. Cells. 2019;8(1):49.","DOI":"10.3390\/cells8010049"},{"key":"2523_CR73","doi-asserted-by":"publisher","first-page":"213","DOI":"10.4161\/auto.8.2.18563","volume":"8","author":"X Yan","year":"2012","unstructured":"Yan X, Sun Q, Ji J, Zhu Y, Liu Z, Zhong Q. Reconstitution of leucine-mediated autophagy via the mTORC1-Barkor pathway in vitro. Autophagy. 2012;8:213\u201321.","journal-title":"Autophagy"},{"key":"2523_CR74","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00726-015-2149-0","volume":"48","author":"SI Yokota","year":"2016","unstructured":"Yokota SI, Ando M, Aoyama S, Nakamura K, Shibata S. Leucine restores murine hepatic triglyceride accumulation induced by a low-protein diet by suppressing autophagy and excessive Endoplasmic reticulum stress. Amino Acids. 2016;48:1013\u201321.","journal-title":"Amino Acids"},{"key":"2523_CR75","doi-asserted-by":"publisher","first-page":"3148","DOI":"10.1038\/s41467-020-16886-2","volume":"11","author":"SM Son","year":"2020","unstructured":"Son SM, Park SJ, Stamatakou E, Vicinanza M, Menzies FM, Rubinsztein DC. Leucine regulates autophagy via acetylation of the mTORC1 component raptor. Nat Commun. 2020;11:3148.","journal-title":"Nat Commun"},{"key":"2523_CR76","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1080\/15384101.2020.1814044","volume":"19","author":"L Xin","year":"2020","unstructured":"Xin L, Li SH, Liu C, Zeng F, Cao JQ, Zhou LQ, Zhou Q, Yuan YW. Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37. Cell Cycle. 2020;19:2644\u201352.","journal-title":"Cell Cycle"},{"key":"2523_CR77","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1016\/j.ijbiomac.2018.09.051","volume":"122","author":"L Xin","year":"2019","unstructured":"Xin L, Zhou LQ, Liu L, Yuan YW, Zhang HT, Zeng F. METase promotes cell autophagy via promoting SNHG5 and suppressing miR-20a in gastric cancer. Int J Biol Macromol. 2019;122:1046\u201352.","journal-title":"Int J Biol Macromol"},{"key":"2523_CR78","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1080\/15548627.2015.1053680","volume":"11","author":"VH Villar","year":"2015","unstructured":"Villar VH, Merhi F, Djavaheri-Mergny M, Dur\u00e1n RV. Glutaminolysis and autophagy in cancer. Autophagy. 2015;11:1198\u2013208.","journal-title":"Autophagy"},{"key":"2523_CR79","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1016\/j.cmet.2019.03.003","volume":"29","author":"V Lahiri","year":"2019","unstructured":"Lahiri V, Hawkins WD, Klionsky DJ. Watch what you (Self-) eat: autophagic mechanisms that modulate metabolism. Cell Metab. 2019;29:803\u201326.","journal-title":"Cell Metab"},{"key":"2523_CR80","doi-asserted-by":"publisher","first-page":"115881","DOI":"10.1016\/j.bone.2021.115881","volume":"146","author":"A Suzuki","year":"2021","unstructured":"Suzuki A, Iwata J. Amino acid metabolism and autophagy in skeletal development and homeostasis. Bone. 2021;146:115881.","journal-title":"Bone"},{"key":"2523_CR81","doi-asserted-by":"publisher","first-page":"31582","DOI":"10.1074\/jbc.M506736200","volume":"280","author":"J Onodera","year":"2005","unstructured":"Onodera J, Ohsumi Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem. 2005;280:31582\u20136.","journal-title":"J Biol Chem"},{"key":"2523_CR82","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/s41467-020-20253-6","volume":"12","author":"K Liu","year":"2021","unstructured":"Liu K, Sutter BM, Tu BP. Autophagy sustains glutamate and aspartate synthesis in Saccharomyces cerevisiae during nitrogen starvation. Nat Commun. 2021;12:57.","journal-title":"Nat Commun"},{"key":"2523_CR83","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.4161\/auto.21228","volume":"8","author":"TC Lin","year":"2012","unstructured":"Lin TC, Chen YR, Kensicki E, Li AY, Kong M, Li Y, Mohney RP, Shen HM, Stiles B, Mizushima N, et al. Autophagy: resetting glutamine-dependent metabolism and oxygen consumption. Autophagy. 2012;8:1477\u201393.","journal-title":"Autophagy"},{"key":"2523_CR84","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41467-017-00369-y","volume":"8","author":"HWS Tan","year":"2017","unstructured":"Tan HWS, Sim AYL, Long YC. Glutamine metabolism regulates autophagy-dependent mTORC1 reactivation during amino acid starvation. Nat Commun. 2017;8:338.","journal-title":"Nat Commun"},{"key":"2523_CR85","doi-asserted-by":"publisher","first-page":"5052","DOI":"10.1038\/s41467-020-18805-x","volume":"11","author":"AI May","year":"2020","unstructured":"May AI, Prescott M, Ohsumi Y. Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling Serine for one-carbon metabolism. Nat Commun. 2020;11:5052.","journal-title":"Nat Commun"},{"key":"2523_CR86","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1126\/science.1193497","volume":"330","author":"JD Rabinowitz","year":"2010","unstructured":"Rabinowitz JD, White E. Autophagy and metabolism. Science. 2010;330:1344\u20138.","journal-title":"Science"},{"key":"2523_CR87","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.semcancer.2013.06.007","volume":"23","author":"S Lorin","year":"2013","unstructured":"Lorin S, Hama\u00ef A, Mehrpour M, Codogno P. Autophagy regulation and its role in cancer. Semin Cancer Biol. 2013;23:361\u201379.","journal-title":"Semin Cancer Biol"},{"key":"2523_CR88","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nrc3262","volume":"12","author":"E White","year":"2012","unstructured":"White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer. 2012;12:401\u201310.","journal-title":"Nat Rev Cancer"},{"key":"2523_CR89","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.molmed.2013.04.005","volume":"19","author":"H Maes","year":"2013","unstructured":"Maes H, Rubio N, Garg AD, Agostinis P. Autophagy: shaping the tumor microenvironment and therapeutic response. Trends Mol Med. 2013;19:428\u201346.","journal-title":"Trends Mol Med"},{"key":"2523_CR90","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1101\/gad.283416.116","volume":"30","author":"JY Guo","year":"2016","unstructured":"Guo JY, Teng X, Laddha SV, Ma S, Van Nostrand SC, Yang Y, Khor S, Chan CS, Rabinowitz JD, White E. Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells. Genes Dev. 2016;30:1704\u201317.","journal-title":"Genes Dev"},{"key":"2523_CR91","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s12943-020-1138-4","volume":"19","author":"X Li","year":"2020","unstructured":"Li X, He S, Ma B. Autophagy and autophagy-related proteins in cancer. Mol Cancer. 2020;19:12.","journal-title":"Mol Cancer"},{"key":"2523_CR92","doi-asserted-by":"publisher","first-page":"109210","DOI":"10.1016\/j.biopha.2019.109210","volume":"118","author":"S Zou","year":"2019","unstructured":"Zou S, Wang X, Liu P, Ke C, Xu S. Arginine metabolism and deprivation in cancer therapy. Biomed Pharmacother. 2019;118:109210.","journal-title":"Biomed Pharmacother"},{"key":"2523_CR93","doi-asserted-by":"publisher","first-page":"174723","DOI":"10.1016\/j.ejphar.2021.174723","volume":"916","author":"HM Fares","year":"2022","unstructured":"Fares HM, Lyu X, Xu X, Dong R, Ding M, Mi S, Wang Y, Li X, Yuan S, Sun L. Autophagy in cancer: the cornerstone during glutamine deprivation. Eur J Pharmacol. 2022;916:174723.","journal-title":"Eur J Pharmacol"},{"key":"2523_CR94","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.4161\/auto.26123","volume":"9","author":"JY Guo","year":"2013","unstructured":"Guo JY, White E. Autophagy is required for mitochondrial function, lipid metabolism, growth, and fate of KRAS(G12D)-driven lung tumors. Autophagy. 2013;9:1636\u20138.","journal-title":"Autophagy"},{"key":"2523_CR95","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1158\/2159-8290.CD-13-0397","volume":"3","author":"AM Strohecker","year":"2013","unstructured":"Strohecker AM, Guo JY, Karsli-Uzunbas G, Price SM, Chen GJ, Mathew R, McMahon M, White E. Autophagy sustains mitochondrial glutamine metabolism and growth of BrafV600E-driven lung tumors. Cancer Discov. 2013;3:1272\u201385.","journal-title":"Cancer Discov"},{"key":"2523_CR96","doi-asserted-by":"publisher","first-page":"2749","DOI":"10.1080\/15548627.2022.2062875","volume":"18","author":"C Bodineau","year":"2022","unstructured":"Bodineau C, Tom\u00e9 M, Murdoch PDS, Dur\u00e1n RV. Glutamine, MTOR and autophagy: a multiconnection relationship. Autophagy. 2022;18:2749\u201350.","journal-title":"Autophagy"},{"key":"2523_CR97","doi-asserted-by":"publisher","first-page":"ra31","DOI":"10.1126\/scisignal.2000911","volume":"3","author":"CH Eng","year":"2010","unstructured":"Eng CH, Yu K, Lucas J, White E, Abraham RT. Ammonia derived from Glutaminolysis is a diffusible regulator of autophagy. Sci Signal. 2010;3:ra31.","journal-title":"Sci Signal"},{"key":"2523_CR98","doi-asserted-by":"publisher","first-page":"7844","DOI":"10.7150\/thno.58655","volume":"11","author":"A Mukha","year":"2021","unstructured":"Mukha A, Kahya U, Linge A, Chen O, L\u00f6ck S, Lukiyanchuk V, Richter S, Alves TC, Peitzsch M, Telychko V, et al. GLS-driven glutamine catabolism contributes to prostate cancer radiosensitivity by regulating the redox state, stemness and ATG5-mediated autophagy. Theranostics. 2021;11:7844\u201368.","journal-title":"Theranostics"},{"key":"2523_CR99","doi-asserted-by":"publisher","first-page":"3879","DOI":"10.1080\/15548627.2021.1962682","volume":"17","author":"A Mukha","year":"2021","unstructured":"Mukha A, Kahya U, Dubrovska A. Targeting glutamine metabolism and autophagy: the combination for prostate cancer radiosensitization. Autophagy. 2021;17:3879\u201381.","journal-title":"Autophagy"},{"key":"2523_CR100","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1158\/1541-7786.MCR-22-0843","volume":"21","author":"S Sannino","year":"2023","unstructured":"Sannino S, Manuel AM, Shang C, Wendell SG, Wipf P, Brodsky JL. Non-Essential amino acid availability influences proteostasis and breast cancer cell survival during proteotoxic stress. Mol Cancer Res. 2023;21:675\u201390.","journal-title":"Mol Cancer Res"},{"key":"2523_CR101","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12964-019-0412-9","volume":"17","author":"WJ Zhou","year":"2019","unstructured":"Zhou WJ, Zhang J, Yang HL, Wu K, Xie F, Wu JN, Wang Y, Yao L, Zhuang Y, Xiang JD, et al. Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism. Cell Commun Signal. 2019;17:99.","journal-title":"Cell Commun Signal"},{"key":"2523_CR102","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1016\/j.oraloncology.2012.06.004","volume":"48","author":"CC Huang","year":"2012","unstructured":"Huang CC, Tsai ST, Kuo CC, Chang JS, Jin YT, Chang JY, Hsiao JR. Arginine deprivation as a new treatment strategy for head and neck cancer. Oral Oncol. 2012;48:1227\u201335.","journal-title":"Oral Oncol"},{"key":"2523_CR103","doi-asserted-by":"publisher","first-page":"ra31","DOI":"10.1126\/scisignal.2004761","volume":"7","author":"F Qiu","year":"2014","unstructured":"Qiu F, Chen YR, Liu X, Chu CY, Shen LJ, Xu J, Gaur S, Forman HJ, Zhang H, Zheng S, et al. Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells. Sci Signal. 2014;7:ra31.","journal-title":"Sci Signal"},{"key":"2523_CR104","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1158\/0008-5472.CAN-08-3157","volume":"69","author":"RH Kim","year":"2009","unstructured":"Kim RH, Coates JM, Bowles TL, McNerney GP, Sutcliffe J, Jung JU, Gandour-Edwards R, Chuang FY, Bold RJ, Kung HJ. Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res. 2009;69:700\u20138.","journal-title":"Cancer Res"},{"key":"2523_CR105","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.toxlet.2014.11.011","volume":"232","author":"H Liu","year":"2015","unstructured":"Liu H, Zhang W, Wang K, Wang X, Yin F, Li C, Wang C, Zhao B, Zhong C, Zhang J, et al. Methionine and cystine double deprivation stress suppresses glioma proliferation via inducing ROS\/autophagy. Toxicol Lett. 2015;232:349\u201355.","journal-title":"Toxicol Lett"},{"key":"2523_CR106","doi-asserted-by":"crossref","unstructured":"Vernizzi L, Paiardi C, Licata G, Vitali T, Santarelli S, Raneli M, Manelli V, Rizzetto M, Gioria M, Pasini ME et al. Glutamine Synthetase 1 Increases Autophagy Lysosomal Degradation of Mutant Huntingtin Aggregates in Neurons, Ameliorating Motility in a Drosophila Model for Huntington\u2019s Disease. Cells. 2020;9(1):196.","DOI":"10.3390\/cells9010196"},{"key":"2523_CR107","doi-asserted-by":"crossref","unstructured":"Liu C, Ji L, Hu J, Zhao Y, Johnston LJ, Zhang X, Ma X. Functional amino acids and autophagy: diverse signal transduction and application. Int J Mol Sci. 2021;22(21):11427.","DOI":"10.3390\/ijms222111427"},{"key":"2523_CR108","doi-asserted-by":"publisher","first-page":"e840","DOI":"10.1038\/cddis.2013.359","volume":"4","author":"X Zeng","year":"2013","unstructured":"Zeng X, Li Y, Fan J, Zhao H, Xian Z, Sun Y, Wang Z, Wang S, Zhang G, Ju D. Recombinant human arginase induced caspase-dependent apoptosis and autophagy in non-Hodgkin\u2019s lymphoma cells. Cell Death Dis. 2013;4:e840.","journal-title":"Cell Death Dis"},{"key":"2523_CR109","doi-asserted-by":"publisher","first-page":"2377404","DOI":"10.1080\/23723556.2024.2377404","volume":"11","author":"T Fukui","year":"2024","unstructured":"Fukui T, Yabumoto M, Nishida M, Hirokawa S, Sato R, Kurisu T, Nakai M, Hassan MA, Kishimoto K. Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors. Mol Cell Oncol. 2024;11:2377404.","journal-title":"Mol Cell Oncol"},{"key":"2523_CR110","doi-asserted-by":"publisher","first-page":"26941","DOI":"10.1016\/S0021-9258(19)74201-X","volume":"268","author":"A D\u2019Aniello","year":"1993","unstructured":"D\u2019Aniello A, D\u2019Onofrio G, Pischetola M, D\u2019Aniello G, Vetere A, Petrucelli L, Fisher GH. Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids. J Biol Chem. 1993;268:26941\u20139.","journal-title":"J Biol Chem"},{"key":"2523_CR111","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1038\/nature25465","volume":"554","author":"SRV Knott","year":"2018","unstructured":"Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, Turgeon MO, Fish L, Erard N, Gable AL, et al. Asparagine bioavailability governs metastasis in a model of breast cancer. Nature. 2018;554:378\u201381.","journal-title":"Nature"},{"key":"2523_CR112","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.1038\/s41467-020-15573-6","volume":"11","author":"L Deng","year":"2020","unstructured":"Deng L, Yao P, Li L, Ji F, Zhao S, Xu C, Lan X, Jiang P. p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival. Nat Commun. 2020;11:1755.","journal-title":"Nat Commun"},{"key":"2523_CR113","doi-asserted-by":"publisher","first-page":"4855","DOI":"10.1038\/s41388-022-02474-9","volume":"41","author":"S Srivastava","year":"2022","unstructured":"Srivastava S, Jiang J, Misra J, Seim G, Staschke KA, Zhong M, Zhou L, Liu Y, Chen C, Dav\u00e9 U, et al. Asparagine bioavailability regulates the translation of MYC oncogene. Oncogene. 2022;41:4855\u201365.","journal-title":"Oncogene"},{"key":"2523_CR114","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s41556-020-00615-4","volume":"23","author":"J Wu","year":"2021","unstructured":"Wu J, Li G, Li L, Li D, Dong Z, Jiang P. Asparagine enhances LCK signalling to potentiate CD8(+) T-cell activation and anti-tumour responses. Nat Cell Biol. 2021;23:75\u201386.","journal-title":"Nat Cell Biol"},{"key":"2523_CR115","doi-asserted-by":"crossref","unstructured":"Wei W, Li H, Tian S, Zhang C, Liu J, Tao W, Cai T, Dong Y, Wang C, Lu D et al. Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling. J Clin Invest. 2025;135(8):e186648.","DOI":"10.1172\/JCI186648"},{"key":"2523_CR116","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1038\/s42255-023-00856-1","volume":"5","author":"JNR Gnanaprakasam","year":"2023","unstructured":"Gnanaprakasam JNR, Kushwaha B, Liu L, Chen X, Kang S, Wang T, Cassel TA, Adams CM, Higashi RM, Scott DA, et al. Asparagine restriction enhances CD8(+) T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response. Nat Metab. 2023;5:1423\u201339.","journal-title":"Nat Metab"},{"key":"2523_CR117","doi-asserted-by":"publisher","first-page":"11457","DOI":"10.1038\/ncomms11457","volume":"7","author":"AS Krall","year":"2016","unstructured":"Krall AS, Xu S, Graeber TG, Braas D, Christofk HR. Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nat Commun. 2016;7:11457.","journal-title":"Nat Commun"},{"key":"2523_CR118","doi-asserted-by":"publisher","first-page":"e31738","DOI":"10.1002\/pbc.31738","volume":"72","author":"J Catanzaro","year":"2025","unstructured":"Catanzaro J, van Doorninck J, Castells M. Hypersensitivity to Recombinant erwinia asparaginase (JZP458) in acute lymphoblastic leukemia and management with desensitization. Pediatr Blood Cancer. 2025;72:e31738.","journal-title":"Pediatr Blood Cancer"},{"key":"2523_CR119","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1097\/HEP.0000000000000237","volume":"79","author":"AD Ladd","year":"2024","unstructured":"Ladd AD, Duarte S, Sahin I, Zarrinpar A. Mechanisms of drug resistance in HCC. Hepatology. 2024;79:926\u201340.","journal-title":"Hepatology"},{"key":"2523_CR120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/s41408-022-00654-0","volume":"12","author":"KR Juluri","year":"2022","unstructured":"Juluri KR, Siu C, Cassaday RD. Asparaginase in the treatment of acute lymphoblastic leukemia in adults: current evidence and place in therapy. Blood Lymphat Cancer. 2022;12:55\u201379.","journal-title":"Blood Lymphat Cancer"},{"key":"2523_CR121","doi-asserted-by":"publisher","first-page":"1690","DOI":"10.1158\/2159-8290.CD-19-1472","volume":"10","author":"L Hinze","year":"2020","unstructured":"Hinze L, Labrosse R, Degar J, Han T, Schatoff EM, Schreek S, Karim S, McGuckin C, Sacher JR, Wagner F, et al. Exploiting the therapeutic interaction of WNT pathway activation and asparaginase for colorectal cancer therapy. Cancer Discov. 2020;10:1690\u2013705.","journal-title":"Cancer Discov"},{"key":"2523_CR122","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.ijbiomac.2020.12.141","volume":"170","author":"S Mazloum-Ravasan","year":"2021","unstructured":"Mazloum-Ravasan S, Madadi E, Mohammadi A, Mansoori B, Amini M, Mokhtarzadeh A, Baradaran B, Darvishi F. Yarrowia lipolytica L-asparaginase inhibits the growth and migration of lung (A549) and breast (MCF7) cancer cells. Int J Biol Macromol. 2021;170:406\u201314.","journal-title":"Int J Biol Macromol"},{"key":"2523_CR123","doi-asserted-by":"publisher","first-page":"5675","DOI":"10.1038\/s41467-025-60798-y","volume":"16","author":"Y Shen","year":"2025","unstructured":"Shen Y, Wang H, Guo D, Liu J, Sun J, Chen N, Song H, Ji X. Dual asparagine-depriving nanoparticles against solid tumors. Nat Commun. 2025;16:5675.","journal-title":"Nat Commun"},{"key":"2523_CR124","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1081-1206(10)60078-6","volume":"102","author":"C Lee","year":"2009","unstructured":"Lee C, Gianos M, Klaustermeyer WB. Diagnosis and management of hypersensitivity reactions related to common cancer chemotherapy agents. Ann Allergy Asthma Immunol. 2009;102:179\u201387. quiz 187\u2009\u2013\u2009179, 222.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2523_CR125","doi-asserted-by":"publisher","first-page":"409","DOI":"10.3324\/haematol.2022.281390","volume":"108","author":"M Van Trimpont","year":"2023","unstructured":"Van Trimpont M, Schalk AM, De Visser Y, Nguyen HA, Reunes L, Vandemeulebroecke K, Peeters E, Su Y, Lee H, Lorenzi PL, et al. In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia. Haematologica. 2023;108:409\u201319.","journal-title":"Haematologica"},{"key":"2523_CR126","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41419-019-1481-9","volume":"10","author":"F Du","year":"2019","unstructured":"Du F, Chen J, Liu H, Cai Y, Cao T, Han W, Yi X, Qian M, Tian D, Nie Y, et al. SOX12 promotes colorectal cancer cell proliferation and metastasis by regulating asparagine synthesis. Cell Death Dis. 2019;10:239.","journal-title":"Cell Death Dis"},{"key":"2523_CR127","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1158\/0008-5472.CAN-22-3561","volume":"83","author":"Q Zhou","year":"2023","unstructured":"Zhou Q, Li L, Sha F, Lei Y, Tian X, Chen L, Chen Y, Liu H, Guo Y. PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression. Cancer Res. 2023;83:2372\u201386.","journal-title":"Cancer Res"},{"key":"2523_CR128","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.1158\/0008-5472.CAN-06-2519","volume":"67","author":"H Cui","year":"2007","unstructured":"Cui H, Darmanin S, Natsuisaka M, Kondo T, Asaka M, Shindoh M, Higashino F, Hamuro J, Okada F, Kobayashi M, et al. Enhanced expression of asparagine synthetase under glucose-deprived conditions protects pancreatic cancer cells from apoptosis induced by glucose deprivation and cisplatin. Cancer Res. 2007;67:3345\u201355.","journal-title":"Cancer Res"},{"key":"2523_CR129","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.58.3.10","volume":"58","author":"TC Chou","year":"2006","unstructured":"Chou TC. Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev. 2006;58:621\u201381.","journal-title":"Pharmacol Rev"},{"key":"2523_CR130","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.canlet.2020.01.035","volume":"475","author":"R Xiao","year":"2020","unstructured":"Xiao R, Ding C, Zhu H, Liu X, Gao J, Liu Q, Lu D, Zhang N, Zhang A, Zhou H. Suppression of asparagine synthetase enhances the antitumor potency of ART and Artemalogue SOMCL-14-221 in non-small cell lung cancer. Cancer Lett. 2020;475:22\u201333.","journal-title":"Cancer Lett"},{"key":"2523_CR131","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/s12276-023-00971-9","volume":"55","author":"J Jin","year":"2023","unstructured":"Jin J, Byun JK, Choi YK, Park KG. Targeting glutamine metabolism as a therapeutic strategy for cancer. Exp Mol Med. 2023;55:706\u201315.","journal-title":"Exp Mol Med"},{"key":"2523_CR132","doi-asserted-by":"crossref","unstructured":"Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S et al. Selective glutamine metabolism Inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021;131(4):e140100.","DOI":"10.1172\/JCI140100"},{"key":"2523_CR133","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s43018-023-00649-1","volume":"5","author":"MV Recouvreux","year":"2024","unstructured":"Recouvreux MV, Grenier SF, Zhang Y, Esparza E, Lambies G, Galapate CM, Maganti S, Duong-Polk K, Bhullar D, Naeem R, et al. Glutamine mimicry suppresses tumor progression through asparagine metabolism in pancreatic ductal adenocarcinoma. Nat Cancer. 2024;5:100\u201313.","journal-title":"Nat Cancer"},{"key":"2523_CR134","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13046-024-02994-0","volume":"43","author":"B Wang","year":"2024","unstructured":"Wang B, Pei J, Xu S, Liu J, Yu J. A glutamine tug-of-war between cancer and immune cells: recent advances in unraveling the ongoing battle. J Exp Clin Cancer Res. 2024;43:74.","journal-title":"J Exp Clin Cancer Res"},{"key":"2523_CR135","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/nm.4464","volume":"24","author":"ML Schulte","year":"2018","unstructured":"Schulte ML, Fu A, Zhao P, Li J, Geng L, Smith ST, Kondo J, Coffey RJ, Johnson MO, Rathmell JC, et al. Pharmacological Blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models. Nat Med. 2018;24:194\u2013202.","journal-title":"Nat Med"},{"key":"2523_CR136","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1126\/science.aav2588","volume":"366","author":"RD Leone","year":"2019","unstructured":"Leone RD, Zhao L, Englert JM, Sun IM, Oh MH, Sun IH, Arwood ML, Bettencourt IA, Patel CH, Wen J, et al. Glutamine Blockade induces divergent metabolic programs to overcome tumor immune evasion. Science. 2019;366:1013\u201321.","journal-title":"Science"},{"key":"2523_CR137","doi-asserted-by":"publisher","first-page":"216727","DOI":"10.1016\/j.canlet.2024.216727","volume":"588","author":"A Song","year":"2024","unstructured":"Song A, Wu L, Zhang BX, Yang QC, Liu YT, Li H, Mao L, Xiong D, Yu HJ, Sun ZJ. Glutamine Inhibition combined with CD47 Blockade enhances radiotherapy-induced ferroptosis in head and neck squamous cell carcinoma. Cancer Lett. 2024;588:216727.","journal-title":"Cancer Lett"},{"key":"2523_CR138","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41586-023-06299-8","volume":"620","author":"C Guo","year":"2023","unstructured":"Guo C, You Z, Shi H, Sun Y, Du X, Palacios G, Guy C, Yuan S, Chapman NM, Lim SA, et al. SLC38A2 and glutamine signalling in cDC1s dictate anti-tumour immunity. Nature. 2023;620:200\u20138.","journal-title":"Nature"},{"key":"2523_CR139","doi-asserted-by":"publisher","first-page":"6038","DOI":"10.7150\/thno.73896","volume":"12","author":"S Cao","year":"2022","unstructured":"Cao S, Hung YW, Wang YC, Chung Y, Qi Y, Ouyang C, Zhong X, Hu W, Coblentz A, Maghami E, et al. Glutamine is essential for overcoming the immunosuppressive microenvironment in malignant salivary gland tumors. Theranostics. 2022;12:6038\u201356.","journal-title":"Theranostics"},{"key":"2523_CR140","doi-asserted-by":"publisher","first-page":"8981","DOI":"10.1158\/0008-5472.CAN-10-1666","volume":"70","author":"MJ Seltzer","year":"2010","unstructured":"Seltzer MJ, Bennett BD, Joshi AD, Gao P, Thomas AG, Ferraris DV, Tsukamoto T, Rojas CJ, Slusher BS, Rabinowitz JD, et al. Inhibition of glutaminase preferentially slows growth of glioma cells with mutant IDH1. Cancer Res. 2010;70:8981\u20137.","journal-title":"Cancer Res"},{"key":"2523_CR141","first-page":"1093","volume":"7","author":"F Huang","year":"2014","unstructured":"Huang F, Zhang Q, Ma H, Lv Q, Zhang T. Expression of glutaminase is upregulated in colorectal cancer and of clinical significance. Int J Clin Exp Pathol. 2014;7:1093\u2013100.","journal-title":"Int J Clin Exp Pathol"},{"key":"2523_CR142","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00428-021-03210-6","volume":"480","author":"M Zhou","year":"2022","unstructured":"Zhou M, Chen QX, Yang YZ, Liang ZZ, Li YL, Huang ZY, Weng ZJ, Zhang XF, Guan JX, Tang LY, Ren ZF. Prognostic value of glutaminase 1 in breast cancer depends on H3K27me3 expression and menopausal status. Virchows Arch. 2022;480:259\u201367.","journal-title":"Virchows Arch"},{"key":"2523_CR143","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1038\/s41419-018-1291-5","volume":"10","author":"L Xiang","year":"2019","unstructured":"Xiang L, Mou J, Shao B, Wei Y, Liang H, Takano N, Semenza GL, Xie G. Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization. Cell Death Dis. 2019;10:40.","journal-title":"Cell Death Dis"},{"key":"2523_CR144","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1016\/j.trecan.2021.04.003","volume":"7","author":"WH Yang","year":"2021","unstructured":"Yang WH, Qiu Y, Stamatatos O, Janowitz T, Lukey MJ. Enhancing the efficacy of glutamine metabolism inhibitors in cancer therapy. Trends Cancer. 2021;7:790\u2013804.","journal-title":"Trends Cancer"},{"key":"2523_CR145","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s43018-020-00160-x","volume":"2","author":"S Wu","year":"2021","unstructured":"Wu S, Fukumoto T, Lin J, Nacarelli T, Wang Y, Ong D, Liu H, Fatkhutdinov N, Zundell JA, Karakashev S, et al. Targeting glutamine dependence through GLS1 Inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma. Nat Cancer. 2021;2:189\u2013200.","journal-title":"Nat Cancer"},{"key":"2523_CR146","first-page":"4265","volume":"8","author":"L Yuan","year":"2016","unstructured":"Yuan L, Sheng X, Clark LH, Zhang L, Guo H, Jones HM, Willson AK, Gehrig PA, Zhou C, Bae-Jump VL. Glutaminase inhibitor compound 968 inhibits cell proliferation and sensitizes Paclitaxel in ovarian cancer. Am J Transl Res. 2016;8:4265\u201377.","journal-title":"Am J Transl Res"},{"key":"2523_CR147","doi-asserted-by":"publisher","first-page":"3209","DOI":"10.1158\/0008-5472.CAN-21-3914","volume":"82","author":"S Suzuki","year":"2022","unstructured":"Suzuki S, Venkatesh D, Kanda H, Nakayama A, Hosokawa H, Lee E, Miki T, Stockwell BR, Yokote K, Tanaka T, Prives C. GLS2 is a tumor suppressor and a regulator of ferroptosis in hepatocellular carcinoma. Cancer Res. 2022;82:3209\u201322.","journal-title":"Cancer Res"},{"key":"2523_CR148","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s00109-013-1105-2","volume":"92","author":"M Mart\u00edn-Rufi\u00e1n","year":"2014","unstructured":"Mart\u00edn-Rufi\u00e1n M, Nascimento-Gomes R, Higuero A, Crisma AR, Campos-Sandoval JA, G\u00f3mez-Garc\u00eda MC, Cardona C, Cheng T, Lobo C, Segura JA, et al. Both GLS Silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells. J Mol Med (Berl). 2014;92:277\u201390.","journal-title":"J Mol Med (Berl)"},{"key":"2523_CR149","doi-asserted-by":"crossref","unstructured":"Ramirez-Pe\u00f1a E, Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, den Hollander P, Bhangre N, Allegakoen P, Prasad R, Conley Z et al. The epithelial to mesenchymal transition promotes glutamine independence by suppressing GLS2 expression. Cancers (Basel). 2019;11(10):1610.","DOI":"10.3390\/cancers11101610"},{"key":"2523_CR150","doi-asserted-by":"publisher","first-page":"7455","DOI":"10.1073\/pnas.1001006107","volume":"107","author":"W Hu","year":"2010","unstructured":"Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A. 2010;107:7455\u201360.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2523_CR151","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.canlet.2019.09.011","volume":"467","author":"JM Mat\u00e9s","year":"2019","unstructured":"Mat\u00e9s JM, Campos-Sandoval JA, Santos-Jim\u00e9nez JL, M\u00e1rquez J. Dysregulation of glutaminase and glutamine synthetase in cancer. Cancer Lett. 2019;467:29\u201339.","journal-title":"Cancer Lett"},{"key":"2523_CR152","doi-asserted-by":"crossref","unstructured":"Kim GW, Lee DH, Jeon YH, Yoo J, Kim SY, Lee SW, Cho HY, Kwon SH. Glutamine synthetase as a therapeutic target for cancer treatment. Int J Mol Sci. 2021;22(4):1701.","DOI":"10.3390\/ijms22041701"},{"key":"2523_CR153","doi-asserted-by":"publisher","first-page":"102248","DOI":"10.1016\/j.clinre.2023.102248","volume":"47","author":"J Jiang","year":"2023","unstructured":"Jiang J, Hu Y, Fang D, Luo J. Glutamine synthetase and hepatocellular carcinoma. Clin Res Hepatol Gastroenterol. 2023;47:102248.","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"2523_CR154","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s42255-021-00524-2","volume":"4","author":"JS Zhao","year":"2022","unstructured":"Zhao JS, Shi S, Qu HY, Keckesova Z, Cao ZJ, Yang LX, Yu X, Feng L, Shi Z, Krakowiak J, et al. Glutamine synthetase licenses APC\/C-mediated mitotic progression to drive cell growth. Nat Metab. 2022;4:239\u201353.","journal-title":"Nat Metab"},{"key":"2523_CR155","doi-asserted-by":"crossref","unstructured":"Tsai PY, Lee MS, Jadhav U, Naqvi I, Madha S, Adler A, Mistry M, Naumenko S, Lewis CA, Hitchcock DS et al. Adaptation of pancreatic cancer cells to nutrient deprivation is reversible and requires glutamine synthetase stabilization by mTORC1. Proc Natl Acad Sci U S A. 2021;118(10):e2003014118.","DOI":"10.1073\/pnas.2003014118"},{"key":"2523_CR156","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.1016\/j.celrep.2017.07.054","volume":"20","author":"EM Palmieri","year":"2017","unstructured":"Palmieri EM, Menga A, Mart\u00edn-P\u00e9rez R, Quinto A, Riera-Domingo C, De Tullio G, Hooper DC, Lamers WH, Ghesqui\u00e8re B, McVicar DW, et al. Pharmacologic or genetic targeting of glutamine synthetase skews macrophages toward an M1-like phenotype and inhibits tumor metastasis. Cell Rep. 2017;20:1654\u201366.","journal-title":"Cell Rep"},{"key":"2523_CR157","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.cmet.2016.10.011","volume":"24","author":"L Yang","year":"2016","unstructured":"Yang L, Achreja A, Yeung TL, Mangala LS, Jiang D, Han C, Baddour J, Marini JC, Ni J, Nakahara R, et al. Targeting stromal glutamine synthetase in tumors disrupts tumor Microenvironment-Regulated cancer cell growth. Cell Metab. 2016;24:685\u2013700.","journal-title":"Cell Metab"},{"key":"2523_CR158","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.cytogfr.2020.07.011","volume":"55","author":"VK Xie","year":"2020","unstructured":"Xie VK, He J, Xie K. Protein arginine methylation promotes therapeutic resistance in human pancreatic cancer. Cytokine Growth Factor Rev. 2020;55:58\u201369.","journal-title":"Cytokine Growth Factor Rev"},{"key":"2523_CR159","doi-asserted-by":"publisher","first-page":"3548","DOI":"10.1038\/s41388-021-01785-7","volume":"40","author":"L Liu","year":"2021","unstructured":"Liu L, Zhang X, Ding H, Liu X, Cao D, Liu Y, Liu J, Lin C, Zhang N, Wang G, et al. Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS. Oncogene. 2021;40:3548\u201363.","journal-title":"Oncogene"},{"key":"2523_CR160","doi-asserted-by":"crossref","unstructured":"Chen CL, Hsu SC, Ann DK, Yen Y, Kung HJ. Arginine signaling and cancer metabolism. Cancers (Basel). 2021;13(14):3541.","DOI":"10.3390\/cancers13143541"},{"key":"2523_CR161","doi-asserted-by":"publisher","first-page":"113661","DOI":"10.1016\/j.celrep.2023.113661","volume":"43","author":"K Zhang","year":"2024","unstructured":"Zhang K, Zakeri A, Alban T, Dong J, Ta HM, Zalavadia AH, Branicky A, Zhao H, Juric I, Husich H, et al. VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms. Cell Rep. 2024;43:113661.","journal-title":"Cell Rep"},{"key":"2523_CR162","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.cell.2016.09.031","volume":"167","author":"R Geiger","year":"2016","unstructured":"Geiger R, Rieckmann JC, Wolf T, Basso C, Feng Y, Fuhrer T, Kogadeeva M, Picotti P, Meissner F, Mann M, et al. L-Arginine modulates T cell metabolism and enhances survival and Anti-tumor activity. Cell. 2016;167:829\u2013e842813.","journal-title":"Cell"},{"key":"2523_CR163","doi-asserted-by":"publisher","first-page":"113995","DOI":"10.1016\/j.celrep.2024.113995","volume":"43","author":"Z Zou","year":"2024","unstructured":"Zou Z, Cheng Q, Zhou J, Guo C, Hadjinicolaou AV, Salio M, Liang X, Yang C, Du Y, Yao W, et al. ATF4-SLC7A11-GSH axis mediates the acquisition of immunosuppressive properties by activated CD4(+) T cells in low arginine condition. Cell Rep. 2024;43:113995.","journal-title":"Cell Rep"},{"key":"2523_CR164","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1002\/jso.24490","volume":"115","author":"VL Albaugh","year":"2017","unstructured":"Albaugh VL, Pinzon-Guzman C, Barbul A. Arginine-Dual roles as an onconutrient and immunonutrient. J Surg Oncol. 2017;115:273\u201380.","journal-title":"J Surg Oncol"},{"key":"2523_CR165","doi-asserted-by":"publisher","first-page":"e2303812","DOI":"10.1002\/advs.202303812","volume":"10","author":"Y Wang","year":"2023","unstructured":"Wang Y, Wang C, Guan X, Ma Y, Zhang S, Li F, Yin Y, Sun Z, Chen X, Yin H. PRMT3-Mediated arginine methylation of METTL14 promotes malignant progression and treatment resistance in endometrial carcinoma. Adv Sci (Weinh). 2023;10:e2303812.","journal-title":"Adv Sci (Weinh)"},{"key":"2523_CR166","doi-asserted-by":"publisher","first-page":"2898","DOI":"10.1038\/s41375-019-0489-6","volume":"33","author":"F Zhu","year":"2019","unstructured":"Zhu F, Guo H, Bates PD, Zhang S, Zhang H, Nomie KJ, Li Y, Lu L, Seibold KR, Wang F, et al. PRMT5 is upregulated by B-cell receptor signaling and forms a positive-feedback loop with PI3K\/AKT in lymphoma cells. Leukemia. 2019;33:2898\u2013911.","journal-title":"Leukemia"},{"key":"2523_CR167","doi-asserted-by":"publisher","first-page":"e686","DOI":"10.1002\/ctm2.686","volume":"12","author":"Y Lei","year":"2022","unstructured":"Lei Y, Han P, Chen Y, Wang H, Wang S, Wang M, Liu J, Yan W, Tian D, Liu M. Protein arginine methyltransferase 3 promotes Glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A. Clin Transl Med. 2022;12:e686.","journal-title":"Clin Transl Med"},{"key":"2523_CR168","doi-asserted-by":"publisher","first-page":"3444","DOI":"10.1038\/s41467-021-23833-2","volume":"12","author":"S Yin","year":"2021","unstructured":"Yin S, Liu L, Brobbey C, Palanisamy V, Ball LE, Olsen SK, Ostrowski MC, Gan W. PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis. Nat Commun. 2021;12:3444.","journal-title":"Nat Commun"},{"key":"2523_CR169","doi-asserted-by":"publisher","first-page":"173697","DOI":"10.1016\/j.ejphar.2020.173697","volume":"891","author":"P Singh","year":"2021","unstructured":"Singh P, Charles S, Madhavan T, Munusamy-Ramanujam G, Saraswathi NT, Arasu MV, Al-Dhabi NA, Arshad A, Arockiaraj J, Mala K. Pharmacologic downregulation of protein arginine methyltransferase1 expression by adenosine dialdehyde increases cell senescence in breast cancer. Eur J Pharmacol. 2021;891:173697.","journal-title":"Eur J Pharmacol"},{"key":"2523_CR170","doi-asserted-by":"publisher","first-page":"e23537","DOI":"10.1002\/jbt.23537","volume":"38","author":"Z Li","year":"2024","unstructured":"Li Z, Meng D, Liu Y, Bi F, Tian K, Xu J, Sun J, Gu C, Li Y. Knockdown of PRMT1 suppresses the malignant biological behavior of osteosarcoma cells and increases cisplatin sensitivity via c-Myc-mediated BCAT1 downregulation. J Biochem Mol Toxicol. 2024;38:e23537.","journal-title":"J Biochem Mol Toxicol"},{"key":"2523_CR171","doi-asserted-by":"publisher","first-page":"101016","DOI":"10.1016\/j.drup.2023.101016","volume":"72","author":"Y Zhu","year":"2024","unstructured":"Zhu Y, Xia T, Chen DQ, Xiong X, Shi L, Zuo Y, Xiao H, Liu L. Promising role of protein arginine methyltransferases in overcoming anti-cancer drug resistance. Drug Resist Updat. 2024;72:101016.","journal-title":"Drug Resist Updat"},{"key":"2523_CR172","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1158\/2326-6066.CIR-21-0614","volume":"10","author":"A Fedoriw","year":"2022","unstructured":"Fedoriw A, Shi L, O\u2019Brien S, Smitheman KN, Wang Y, Hou J, Sherk C, Rajapurkar S, Laraio J, Williams LJ, et al. Inhibiting type I arginine methyltransferase activity promotes T Cell-Mediated antitumor immune responses. Cancer Immunol Res. 2022;10:420\u201336.","journal-title":"Cancer Immunol Res"},{"key":"2523_CR173","doi-asserted-by":"publisher","first-page":"e2720","DOI":"10.1038\/cddis.2017.137","volume":"8","author":"W Shen","year":"2017","unstructured":"Shen W, Zhang X, Fu X, Fan J, Luan J, Cao Z, Yang P, Xu Z, Ju D. A novel and promising therapeutic approach for NSCLC: Recombinant human arginase alone or combined with autophagy inhibitor. Cell Death Dis. 2017;8:e2720.","journal-title":"Cell Death Dis"},{"key":"2523_CR174","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1158\/1535-7163.MCT-22-0721","volume":"22","author":"B Borek","year":"2023","unstructured":"Borek B, Nowicka J, Gzik A, Dziegielewski M, Jedrzejczak K, Brzezinska J, Grzybowski M, Stanczak P, Pomper P, Zagozdzon A, et al. Arginase 1\/2 inhibitor OATD-02: from discovery to First-in-man setup in cancer immunotherapy. Mol Cancer Ther. 2023;22:807\u201317.","journal-title":"Mol Cancer Ther"},{"key":"2523_CR175","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1038\/s41388-023-02884-3","volume":"43","author":"FA Akinjiyan","year":"2024","unstructured":"Akinjiyan FA, Ibitoye Z, Zhao P, Shriver LP, Patti GJ, Longmore GD, Fuh KC. DDR2-regulated arginase activity in ovarian cancer-associated fibroblasts promotes collagen production and tumor progression. Oncogene. 2024;43:189\u2013201.","journal-title":"Oncogene"},{"key":"2523_CR176","doi-asserted-by":"crossref","unstructured":"Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F et al. Arginase 1 is a key driver of immune suppression in pancreatic cancer. Elife. 2023;12:e80721.","DOI":"10.7554\/eLife.80721"},{"key":"2523_CR177","doi-asserted-by":"publisher","first-page":"3043","DOI":"10.1158\/0008-5472.CAN-14-3443","volume":"75","author":"F Mussai","year":"2015","unstructured":"Mussai F, Egan S, Hunter S, Webber H, Fisher J, Wheat R, McConville C, Sbirkov Y, Wheeler K, Bendle G, et al. Neuroblastoma arginase activity creates an immunosuppressive microenvironment that impairs autologous and engineered immunity. Cancer Res. 2015;75:3043\u201353.","journal-title":"Cancer Res"},{"key":"2523_CR178","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1016\/j.jtho.2022.06.011","volume":"17","author":"JV Park","year":"2022","unstructured":"Park JV, Chandra R, Cai L, Ganguly D, Li H, Toombs JE, Girard L, Brekken RA, Minna JD. Tumor cells modulate macrophage phenotype in a novel in vitro Co-Culture model of the NSCLC tumor microenvironment. J Thorac Oncol. 2022;17:1178\u201391.","journal-title":"J Thorac Oncol"},{"key":"2523_CR179","doi-asserted-by":"publisher","first-page":"3000","DOI":"10.1038\/s41467-019-10979-3","volume":"10","author":"M Czystowska-Kuzmicz","year":"2019","unstructured":"Czystowska-Kuzmicz M, Sosnowska A, Nowis D, Ramji K, Szajnik M, Chlebowska-Tuz J, Wolinska E, Gaj P, Grazul M, Pilch Z, et al. Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma. Nat Commun. 2019;10:3000.","journal-title":"Nat Commun"},{"key":"2523_CR180","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1186\/s13046-023-02888-7","volume":"42","author":"Y Lv","year":"2023","unstructured":"Lv Y, Li M, Weng L, Huang H, Mao Y, Yang DA, Wei Q, Zhao M, Wei Q, Rui K, et al. Ginseng-derived nanoparticles reprogram macrophages to regulate arginase-1 release for ameliorating T cell exhaustion in tumor microenvironment. J Exp Clin Cancer Res. 2023;42:322.","journal-title":"J Exp Clin Cancer Res"},{"key":"2523_CR181","doi-asserted-by":"publisher","first-page":"eabq6221","DOI":"10.1126\/scitranslmed.abq6221","volume":"15","author":"S Can\u00e8","year":"2023","unstructured":"Can\u00e8 S, Barouni RM, Fabbi M, Cuozzo J, Fracasso G, Adamo A, Ugel S, Trovato R, De Sanctis F, Giacca M, et al. Neutralization of NET-associated human ARG1 enhances cancer immunotherapy. Sci Transl Med. 2023;15:eabq6221.","journal-title":"Sci Transl Med"},{"key":"2523_CR182","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1007\/s10637-021-01178-3","volume":"40","author":"T Yau","year":"2022","unstructured":"Yau T, Cheng PNM, Chiu J, Kwok GGW, Leung R, Liu AM, Cheung TT, Ng CT. A phase 1 study of pegylated Recombinant arginase (PEG-BCT-100) in combination with systemic chemotherapy (capecitabine and oxaliplatin)[PACOX] in advanced hepatocellular carcinoma patients. Invest New Drugs. 2022;40:314\u201321.","journal-title":"Invest New Drugs"},{"key":"2523_CR183","doi-asserted-by":"publisher","first-page":"5839","DOI":"10.1158\/0008-5472.CAN-04-0465","volume":"64","author":"PC Rodriguez","year":"2004","unstructured":"Rodriguez PC, Quiceno DG, Zabaleta J, Ortiz B, Zea AH, Piazuelo MB, Delgado A, Correa P, Brayer J, Sotomayor EM, et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res. 2004;64:5839\u201349.","journal-title":"Cancer Res"},{"key":"2523_CR184","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1021\/acsmedchemlett.9b00508","volume":"11","author":"R Blaszczyk","year":"2020","unstructured":"Blaszczyk R, Brzezinska J, Dymek B, Stanczak PS, Mazurkiewicz M, Olczak J, Nowicka J, Dzwonek K, Zagozdzon A, Golab J, Golebiowski A. Discovery and pharmacokinetics of sulfamides and guanidines as potent human arginase 1 inhibitors. ACS Med Chem Lett. 2020;11:433\u20138.","journal-title":"ACS Med Chem Lett"},{"key":"2523_CR185","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/j.cmet.2019.01.014","volume":"29","author":"AE Rodriguez","year":"2019","unstructured":"Rodriguez AE, Ducker GS, Billingham LK, Martinez CA, Mainolfi N, Suri V, Friedman A, Manfredi MG, Weinberg SE, Rabinowitz JD, Chandel NS. Serine metabolism supports macrophage IL-1\u03b2 production. Cell Metab. 2019;29:1003\u2013e10111004.","journal-title":"Cell Metab"},{"key":"2523_CR186","doi-asserted-by":"publisher","first-page":"4030","DOI":"10.1158\/0008-5472.CAN-23-1065","volume":"83","author":"Y Ouyang","year":"2023","unstructured":"Ouyang Y, Ou Z, Zhong W, Yang J, Fu S, Ouyang N, Chen J, Xu L, Wu D, Qian J, et al. FGFR3 alterations in bladder cancer stimulate Serine synthesis to induce Immune-Inert macrophages that suppress T-cell recruitment and activation. Cancer Res. 2023;83:4030\u201346.","journal-title":"Cancer Res"},{"key":"2523_CR187","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1038\/ng.3421","volume":"47","author":"GM DeNicola","year":"2015","unstructured":"DeNicola GM, Chen PH, Mullarky E, Sudderth JA, Hu Z, Wu D, Tang H, Xie Y, Asara JM, Huffman KE, et al. NRF2 regulates Serine biosynthesis in non-small cell lung cancer. Nat Genet. 2015;47:1475\u201381.","journal-title":"Nat Genet"},{"key":"2523_CR188","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1038\/s41416-023-02216-y","volume":"128","author":"E Heylen","year":"2023","unstructured":"Heylen E, Verstraete P, Van Aerschot L, Geeraerts SL, Venken T, Timcheva K, Nittner D, Verbeeck J, Royaert J, Gijbels M, et al. Transcription factor NKX2-1 drives Serine and Glycine synthesis addiction in cancer. Br J Cancer. 2023;128:1862\u201378.","journal-title":"Br J Cancer"},{"key":"2523_CR189","doi-asserted-by":"publisher","first-page":"109706","DOI":"10.1016\/j.celrep.2021.109706","volume":"36","author":"X Li","year":"2021","unstructured":"Li X, Gracilla D, Cai L, Zhang M, Yu X, Chen X, Zhang J, Long X, Ding HF, Yan C. ATF3 promotes the Serine synthesis pathway and tumor growth under dietary Serine restriction. Cell Rep. 2021;36:109706.","journal-title":"Cell Rep"},{"key":"2523_CR190","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41586-020-2609-x","volume":"586","author":"T Muthusamy","year":"2020","unstructured":"Muthusamy T, Cordes T, Handzlik MK, You L, Lim EW, Gengatharan J, Pinto AFM, Badur MG, Kolar MJ, Wallace M, et al. Serine restriction alters sphingolipid diversity to constrain tumour growth. Nature. 2020;586:790\u20135.","journal-title":"Nature"},{"key":"2523_CR191","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.cmet.2016.12.011","volume":"25","author":"EH Ma","year":"2017","unstructured":"Ma EH, Bantug G, Griss T, Condotta S, Johnson RM, Samborska B, Mainolfi N, Suri V, Guak H, Balmer ML, et al. Serine is an essential metabolite for effector T cell expansion. Cell Metab. 2017;25:345\u201357.","journal-title":"Cell Metab"},{"key":"2523_CR192","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1016\/j.cmet.2024.10.019","volume":"36","author":"H Tong","year":"2024","unstructured":"Tong H, Jiang Z, Song L, Tan K, Yin X, He C, Huang J, Li X, Jing X, Yun H, et al. Dual impacts of serine\/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation. Cell Metab. 2024;36:2493\u2013e25102499.","journal-title":"Cell Metab"},{"key":"2523_CR193","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cmet.2023.01.010","volume":"35","author":"D Zhang","year":"2023","unstructured":"Zhang D, Li AM, Hu G, Huang M, Yang F, Zhang L, Wellen KE, Xu X, Conn CS, Zou W, et al. PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy. Cell Metab. 2023;35:517\u2013e534518.","journal-title":"Cell Metab"},{"key":"2523_CR194","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1016\/j.cmet.2020.03.004","volume":"31","author":"H Kurniawan","year":"2020","unstructured":"Kurniawan H, Franchina DG, Guerra L, Bonetti L, Baguet LS, Grusdat M, Schlicker L, Hunewald O, Dostert C, Merz MP, et al. Glutathione restricts Serine metabolism to preserve regulatory T cell function. Cell Metab. 2020;31:920\u2013e936927.","journal-title":"Cell Metab"},{"key":"2523_CR195","doi-asserted-by":"publisher","first-page":"2966","DOI":"10.7150\/thno.48699","volume":"11","author":"C Liu","year":"2021","unstructured":"Liu C, Wang L, Liu X, Tan Y, Tao L, Xiao Y, Deng P, Wang H, Deng Q, Lin Y, et al. Cytoplasmic SHMT2 drives the progression and metastasis of colorectal cancer by inhibiting \u03b2-catenin degradation. Theranostics. 2021;11:2966\u201386.","journal-title":"Theranostics"},{"key":"2523_CR196","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13046-019-1053-y","volume":"38","author":"X Ma","year":"2019","unstructured":"Ma X, Li B, Liu J, Fu Y, Luo Y. Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E. J Exp Clin Cancer Res. 2019;38:66.","journal-title":"J Exp Clin Cancer Res"},{"key":"2523_CR197","first-page":"2917","volume":"30","author":"JL Davis","year":"1970","unstructured":"Davis JL, Fallon HJ, Morris HP. Two enzymes of Serine metabolism in rat liver and hepatomas. Cancer Res. 1970;30:2917\u201320.","journal-title":"Cancer Res"},{"key":"2523_CR198","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1038\/nrd.2018.169","volume":"17","author":"L Cassetta","year":"2018","unstructured":"Cassetta L, Pollard JW. Targeting macrophages: therapeutic approaches in cancer. Nat Rev Drug Discov. 2018;17:887\u2013904.","journal-title":"Nat Rev Drug Discov"},{"key":"2523_CR199","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1038\/s41423-024-01134-0","volume":"21","author":"Z Cai","year":"2024","unstructured":"Cai Z, Li W, Hager S, Wilson JL, Afjehi-Sadat L, Heiss EH, Weichhart T, Heffeter P, Weckwerth W. Targeting PHGDH reverses the immunosuppressive phenotype of tumor-associated macrophages through \u03b1-ketoglutarate and mTORC1 signaling. Cell Mol Immunol. 2024;21:448\u201365.","journal-title":"Cell Mol Immunol"},{"key":"2523_CR200","doi-asserted-by":"publisher","first-page":"5459","DOI":"10.7150\/ijbs.74546","volume":"18","author":"L Shen","year":"2022","unstructured":"Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, et al. PHGDH inhibits ferroptosis and promotes malignant progression by upregulating SLC7A11 in bladder cancer. Int J Biol Sci. 2022;18:5459\u201374.","journal-title":"Int J Biol Sci"},{"key":"2523_CR201","doi-asserted-by":"publisher","first-page":"9029544","DOI":"10.1155\/2022\/9029544","volume":"2022","author":"X Zhang","year":"2022","unstructured":"Zhang X, Sun M, Jiao Y, Lin B, Yang Q. PHGDH inhibitor CBR-5884 inhibits epithelial ovarian cancer progression via ROS\/Wnt\/\u03b2-Catenin pathway and plays a synergistic role with PARP inhibitor Olaparib. Oxid Med Cell Longev. 2022;2022:9029544.","journal-title":"Oxid Med Cell Longev"},{"key":"2523_CR202","doi-asserted-by":"publisher","first-page":"1200538","DOI":"10.3389\/fphar.2023.1200538","volume":"14","author":"K Wang","year":"2023","unstructured":"Wang K, Lu H, Wang X, Liu Q, Hu J, Liu Y, Jin M, Kong D. Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC. Front Pharmacol. 2023;14:1200538.","journal-title":"Front Pharmacol"},{"key":"2523_CR203","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1038\/s41419-020-03215-0","volume":"11","author":"A Bouzidi","year":"2020","unstructured":"Bouzidi A, Magnifico MC, Paiardini A, Macone A, Boumis G, Giardina G, Rinaldo S, Liberati FR, Lauro C, Limatola C, et al. Cytosolic Serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity. Cell Death Dis. 2020;11:1012.","journal-title":"Cell Death Dis"},{"key":"2523_CR204","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/ijc.21332","volume":"118","author":"M Lomnytska","year":"2006","unstructured":"Lomnytska M, Dubrovska A, Hellman U, Volodko N, Souchelnytskyi S. Increased expression of cSHMT, Tbx3 and utrophin in plasma of ovarian and breast cancer patients. Int J Cancer. 2006;118:412\u201321.","journal-title":"Int J Cancer"},{"key":"2523_CR205","doi-asserted-by":"publisher","first-page":"32","DOI":"10.18632\/oncotarget.28168","volume":"13","author":"RA Clark","year":"2022","unstructured":"Clark RA, Qiao J, Jacobson JC, Chung DH. Induction of Serine hydroxymethyltransferase 2 promotes tumorigenesis and metastasis in neuroblastoma. Oncotarget. 2022;13:32\u201345.","journal-title":"Oncotarget"},{"key":"2523_CR206","doi-asserted-by":"crossref","unstructured":"Wang W, Wang M, Du T, Hou Z, You S, Zhang S, Ji M, Xue N, Chen X. SHMT2 promotes gastric cancer development through regulation of HIF1\u03b1\/VEGF\/STAT3 signaling. Int J Mol Sci. 2023;24(8):7150.","DOI":"10.3390\/ijms24087150"},{"key":"2523_CR207","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1182\/blood.2021012081","volume":"139","author":"AC Wilke","year":"2022","unstructured":"Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, et al. SHMT2 Inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma. Blood. 2022;139:538\u201353.","journal-title":"Blood"},{"key":"2523_CR208","doi-asserted-by":"publisher","first-page":"4014","DOI":"10.1038\/onc.2017.37","volume":"36","author":"R Gupta","year":"2017","unstructured":"Gupta R, Yang Q, Dogra SK, Wajapeyee N. Serine hydroxymethyl transferase 1 stimulates pro-oncogenic cytokine expression through Sialic acid to promote ovarian cancer tumor growth and progression. Oncogene. 2017;36:4014\u201324.","journal-title":"Oncogene"},{"key":"2523_CR209","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41375-021-01361-8","volume":"36","author":"Y Pikman","year":"2022","unstructured":"Pikman Y, Ocasio-Martinez N, Alexe G, Dimitrov B, Kitara S, Diehl FF, Robichaud AL, Conway AS, Ross L, Su A, et al. Targeting Serine hydroxymethyltransferases 1 and 2 for T-cell acute lymphoblastic leukemia therapy. Leukemia. 2022;36:348\u201360.","journal-title":"Leukemia"},{"key":"2523_CR210","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1038\/s42255-024-01066-z","volume":"6","author":"HM Lee","year":"2024","unstructured":"Lee HM, Muhammad N, Lieu EL, Cai F, Mu J, Ha YS, Cao G, Suchors C, Joves K, Chronis C, et al. Concurrent loss of LKB1 and KEAP1 enhances SHMT-mediated antioxidant defence in KRAS-mutant lung cancer. Nat Metab. 2024;6:1310\u201328.","journal-title":"Nat Metab"},{"key":"2523_CR211","doi-asserted-by":"publisher","first-page":"11404","DOI":"10.1073\/pnas.1706617114","volume":"114","author":"GS Ducker","year":"2017","unstructured":"Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Human SHMT inhibitors reveal defective Glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2017;114:11404\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2523_CR212","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/s41375-020-0845-6","volume":"35","author":"JC Garc\u00eda-Ca\u00f1averas","year":"2021","unstructured":"Garc\u00eda-Ca\u00f1averas JC, Lancho O, Ducker GS, Ghergurovich JM, Xu X, da Silva-Diz V, Minuzzo S, Indraccolo S, Kim H, Herranz D, Rabinowitz JD. SHMT Inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. Leukemia. 2021;35:377\u201388.","journal-title":"Leukemia"},{"key":"2523_CR213","doi-asserted-by":"publisher","first-page":"4726","DOI":"10.7150\/ijbs.85893","volume":"19","author":"MK Chen","year":"2023","unstructured":"Chen MK, Xiao ZY, Huang ZP, Xue KY, Xia H, Zhou JW, Liao DY, Liang ZJ, Xie X, Wei QZ, et al. Glycine decarboxylase (GLDC) plays a crucial role in regulating energy Metabolism, Invasion, metastasis and immune escape for prostate cancer. Int J Biol Sci. 2023;19:4726\u201343.","journal-title":"Int J Biol Sci"},{"key":"2523_CR214","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","volume":"6","author":"Y He","year":"2021","unstructured":"He Y, Sun MM, Zhang GG, Yang J, Chen KS, Xu WW, Li B. Targeting PI3K\/Akt signal transduction for cancer therapy. Signal Transduct Target Ther. 2021;6:425.","journal-title":"Signal Transduct Target Ther"},{"key":"2523_CR215","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.cell.2011.11.050","volume":"148","author":"WC Zhang","year":"2012","unstructured":"Zhang WC, Shyh-Chang N, Yang H, Rai A, Umashankar S, Ma S, Soh BS, Sun LL, Tai BC, Nga ME, et al. Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell. 2012;148:259\u201372.","journal-title":"Cell"},{"key":"2523_CR216","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.cmet.2022.04.006","volume":"34","author":"D Mukha","year":"2022","unstructured":"Mukha D, Fokra M, Feldman A, Sarvin B, Sarvin N, Nevo-Dinur K, Besser E, Hallo E, Aizenshtein E, Schug ZT, Shlomi T. Glycine decarboxylase maintains mitochondrial protein lipoylation to support tumor growth. Cell Metab. 2022;34:775\u2013e782779.","journal-title":"Cell Metab"},{"key":"2523_CR217","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1159\/000441595","volume":"38","author":"X Li","year":"2015","unstructured":"Li X, Cui C, Guo Y, Yang G. Glycine decarboxylase expression increased in p53-Mutated B cell lymphoma mice. Oncol Res Treat. 2015;38:586\u20139.","journal-title":"Oncol Res Treat"},{"key":"2523_CR218","doi-asserted-by":"publisher","first-page":"7504","DOI":"10.1038\/s41388-019-0967-3","volume":"38","author":"A Alptekin","year":"2019","unstructured":"Alptekin A, Ye B, Yu Y, Poole CJ, van Riggelen J, Zha Y, Ding HF. Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity. Oncogene. 2019;38:7504\u201320.","journal-title":"Oncogene"},{"key":"2523_CR219","doi-asserted-by":"publisher","first-page":"4227","DOI":"10.1038\/s41467-021-24321-3","volume":"12","author":"R Liu","year":"2021","unstructured":"Liu R, Zeng LW, Gong R, Yuan F, Shu HB, Li S. mTORC1 activity regulates post-translational modifications of Glycine decarboxylase to modulate Glycine metabolism and tumorigenesis. Nat Commun. 2021;12:4227.","journal-title":"Nat Commun"},{"key":"2523_CR220","doi-asserted-by":"publisher","first-page":"387","DOI":"10.14740\/wjon1539","volume":"13","author":"YD Chen","year":"2022","unstructured":"Chen YD, Gao KX, Wang Z, Deng Q, Chen YT, Liang H. Glycine decarboxylase suppresses the renal cell carcinoma growth and regulates its gene expressions and functions. World J Oncol. 2022;13:387\u2013402.","journal-title":"World J Oncol"},{"key":"2523_CR221","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1038\/s41419-019-1446-z","volume":"10","author":"H Zhuang","year":"2019","unstructured":"Zhuang H, Wu F, Wei W, Dang Y, Yang B, Ma X, Han F, Li Y. Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma. Cell Death Dis. 2019;10:192.","journal-title":"Cell Death Dis"},{"key":"2523_CR222","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.03.003","volume":"120","author":"H Zhuang","year":"2018","unstructured":"Zhuang H, Li Q, Zhang X, Ma X, Wang Z, Liu Y, Yi X, Chen R, Han F, Zhang N, Li Y. Downregulation of Glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells. Free Radic Biol Med. 2018;120:1\u201312.","journal-title":"Free Radic Biol Med"},{"key":"2523_CR223","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1038\/s41467-020-20223-y","volume":"12","author":"M Tajan","year":"2021","unstructured":"Tajan M, Hennequart M, Cheung EC, Zani F, Hock AK, Legrave N, Maddocks ODK, Ridgway RA, Athineos D, Su\u00e1rez-Bonnet A, et al. Serine synthesis pathway Inhibition cooperates with dietary Serine and Glycine limitation for cancer therapy. Nat Commun. 2021;12:366.","journal-title":"Nat Commun"},{"key":"2523_CR224","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/s41568-019-0187-8","volume":"19","author":"SM Sanderson","year":"2019","unstructured":"Sanderson SM, Gao X, Dai Z, Locasale JW. Methionine metabolism in health and cancer: a nexus of diet and precision medicine. Nat Rev Cancer. 2019;19:625\u201337.","journal-title":"Nat Rev Cancer"},{"key":"2523_CR225","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1038\/s41467-023-36630-w","volume":"14","author":"PS Upadhyayula","year":"2023","unstructured":"Upadhyayula PS, Higgins DM, Mela A, Banu M, Dovas A, Zandkarimi F, Patel P, Mahajan A, Humala N, Nguyen TTT, et al. Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism. Nat Commun. 2023;14:1187.","journal-title":"Nat Commun"},{"key":"2523_CR226","doi-asserted-by":"publisher","first-page":"504","DOI":"10.1038\/nrclinonc.2016.24","volume":"13","author":"ST Mayne","year":"2016","unstructured":"Mayne ST, Playdon MC, Rock CL. Diet, nutrition, and cancer: past, present and future. Nat Rev Clin Oncol. 2016;13:504\u201315.","journal-title":"Nat Rev Clin Oncol"},{"key":"2523_CR227","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s43018-023-00671-3","volume":"5","author":"F Li","year":"2024","unstructured":"Li F, Liu P, Mi W, Li L, Anderson NM, Lesner NP, Burrows M, Plesset J, Majer A, Wang G, et al. Blocking methionine catabolism induces senescence and confers vulnerability to GSK3 Inhibition in liver cancer. Nat Cancer. 2024;5:131\u201346.","journal-title":"Nat Cancer"},{"key":"2523_CR228","doi-asserted-by":"crossref","unstructured":"Saini N, Naaz A, Metur SP, Gahlot P, Walvekar A, Dutta A, Davathamizhan U, Sarin A, Laxman S. Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survival. Life Sci Alliance. 2022;5(12):e202201663.","DOI":"10.26508\/lsa.202201663"},{"key":"2523_CR229","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/s41586-020-2682-1","volume":"585","author":"Y Bian","year":"2020","unstructured":"Bian Y, Li W, Kremer DM, Sajjakulnukit P, Li S, Crespo J, Nwosu ZC, Zhang L, Czerwonka A, Paw\u0142owska A, et al. Cancer SLC43A2 alters T cell methionine metabolism and histone methylation. Nature. 2020;585:277\u201382.","journal-title":"Nature"},{"key":"2523_CR230","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1136\/gutjnl-2022-326928","volume":"72","author":"T Li","year":"2023","unstructured":"Li T, Tan YT, Chen YX, Zheng XJ, Wang W, Liao K, Mo HY, Lin J, Yang W, Piao HL, et al. Methionine deficiency facilitates antitumour immunity by altering m(6)A methylation of immune checkpoint transcripts. Gut. 2023;72:501\u201311.","journal-title":"Gut"},{"key":"2523_CR231","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1038\/s41467-023-38316-9","volume":"14","author":"M Pandit","year":"2023","unstructured":"Pandit M, Kil YS, Ahn JH, Pokhrel RH, Gu Y, Mishra S, Han Y, Ouh YT, Kang B, Jeong MS, et al. Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells. Nat Commun. 2023;14:2593.","journal-title":"Nat Commun"},{"key":"2523_CR232","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1038\/s42255-023-00854-3","volume":"5","author":"M Ji","year":"2023","unstructured":"Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, et al. Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota. Nat Metab. 2023;5:1526\u201343.","journal-title":"Nat Metab"},{"key":"2523_CR233","doi-asserted-by":"publisher","first-page":"67223","DOI":"10.18632\/oncotarget.11615","volume":"7","author":"H Jeon","year":"2016","unstructured":"Jeon H, Kim JH, Lee E, Jang YJ, Son JE, Kwon JY, Lim TG, Kim S, Park JH, Kim JE, Lee KW. Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo. Oncotarget. 2016;7:67223\u201334.","journal-title":"Oncotarget"},{"key":"2523_CR234","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.tem.2024.01.009","volume":"35","author":"M Ji","year":"2024","unstructured":"Ji M, Xu Q, Li X. Dietary methionine restriction in cancer development and antitumor immunity. Trends Endocrinol Metab. 2024;35:400\u201312.","journal-title":"Trends Endocrinol Metab"},{"key":"2523_CR235","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1182\/blood.2022017575","volume":"140","author":"A Cunningham","year":"2022","unstructured":"Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel FAJ, Wierenga ATJ, Ten Berge H, Dennebos R, et al. Dietary methionine starvation impairs acute myeloid leukemia progression. Blood. 2022;140:2037\u201352.","journal-title":"Blood"},{"key":"2523_CR236","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41419-023-05860-7","volume":"14","author":"H Peng","year":"2023","unstructured":"Peng H, Yan Y, He M, Li J, Wang L, Jia W, Yang L, Jiang J, Chen Y, Li F, et al. SLC43A2 and NF\u03baB signaling pathway regulate methionine\/cystine restriction-induced ferroptosis in esophageal squamous cell carcinoma via a feedback loop. Cell Death Dis. 2023;14:347.","journal-title":"Cell Death Dis"},{"key":"2523_CR237","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41586-019-1437-3","volume":"572","author":"X Gao","year":"2019","unstructured":"Gao X, Sanderson SM, Dai Z, Reid MA, Cooper DE, Lu M, Richie JP Jr., Ciccarella A, Calcagnotto A, Mikhael PG, et al. Dietary methionine influences therapy in mouse cancer models and alters human metabolism. Nature. 2019;572:397\u2013401.","journal-title":"Nature"},{"key":"2523_CR238","doi-asserted-by":"publisher","first-page":"4758","DOI":"10.1038\/s41467-023-40518-0","volume":"14","author":"Y Xue","year":"2023","unstructured":"Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, et al. Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint Blockade. Nat Commun. 2023;14:4758.","journal-title":"Nat Commun"},{"key":"2523_CR239","first-page":"2932","volume":"51","author":"GG Gonzalez","year":"1991","unstructured":"Gonzalez GG, Byus CV. Effect of dietary arginine restriction upon ornithine and polyamine metabolism during two-stage epidermal carcinogenesis in the mouse. Cancer Res. 1991;51:2932\u20139.","journal-title":"Cancer Res"},{"key":"2523_CR240","first-page":"171","volume":"13","author":"MA Lea","year":"1993","unstructured":"Lea MA, Xiao Q, Klein KM, Grote-Holman E. Inhibitory effect of arginine restriction on hepatoma growth. Cancer Biochem Biophys. 1993;13:171\u20139.","journal-title":"Cancer Biochem Biophys"},{"key":"2523_CR241","doi-asserted-by":"publisher","first-page":"7527","DOI":"10.7150\/thno.54695","volume":"11","author":"SC Hsu","year":"2021","unstructured":"Hsu SC, Chen CL, Cheng ML, Chu CY, Changou CA, Yu YL, Yeh SD, Kuo TC, Kuo CC, Chuu CP, et al. Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic Silencing of metabolic and DNA-repair genes. Theranostics. 2021;11:7527\u201345.","journal-title":"Theranostics"},{"key":"2523_CR242","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1038\/s42003-018-0178-4","volume":"1","author":"CT Cheng","year":"2018","unstructured":"Cheng CT, Qi Y, Wang YC, Chi KK, Chung Y, Ouyang C, Chen YR, Oh ME, Sheng X, Tang Y, et al. Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Commun Biol. 2018;1:178.","journal-title":"Commun Biol"},{"key":"2523_CR243","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1158\/1535-7163.MCT-16-0807","volume":"17","author":"CN Hinrichs","year":"2018","unstructured":"Hinrichs CN, Ingargiola M, K\u00e4ubler T, L\u00f6ck S, Temme A, K\u00f6hn-Luque A, Deutsch A, Vovk O, Stasyk O, Kunz-Schughart LA. Arginine deprivation therapy: putative strategy to eradicate glioblastoma cells by radiosensitization. Mol Cancer Ther. 2018;17:393\u2013406.","journal-title":"Mol Cancer Ther"},{"key":"2523_CR244","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.cmet.2022.06.010","volume":"34","author":"R Missiaen","year":"2022","unstructured":"Missiaen R, Anderson NM, Kim LC, Nance B, Burrows M, Skuli N, Carens M, Riscal R, Steensels A, Li F, Simon MC. GCN2 Inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment. Cell Metab. 2022;34:1151\u2013e11671157.","journal-title":"Cell Metab"},{"key":"2523_CR245","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.advms.2018.08.018","volume":"64","author":"J Szefel","year":"2019","unstructured":"Szefel J, Danielak A, Kruszewski WJ. Metabolic pathways of L-arginine and therapeutic consequences in tumors. Adv Med Sci. 2019;64:104\u201310.","journal-title":"Adv Med Sci"},{"key":"2523_CR246","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1186\/s12885-016-2376-0","volume":"16","author":"Y Cao","year":"2016","unstructured":"Cao Y, Feng Y, Zhang Y, Zhu X, Jin F. L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo. BMC Cancer. 2016;16:343.","journal-title":"BMC Cancer"},{"key":"2523_CR247","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1038\/s41586-021-04003-2","volume":"598","author":"FP Canale","year":"2021","unstructured":"Canale FP, Basso C, Antonini G, Perotti M, Li N, Sokolovska A, Neumann J, James MJ, Geiger S, Jin W, et al. Metabolic modulation of tumours with engineered bacteria for immunotherapy. Nature. 2021;598:662\u20136.","journal-title":"Nature"},{"key":"2523_CR248","first-page":"238","volume":"84","author":"SD Heys","year":"1997","unstructured":"Heys SD, Segar A, Payne S, Bruce DM, Kernohan N, Eremin O. Dietary supplementation with L-arginine: modulation of tumour-infiltrating lymphocytes in patients with colorectal cancer. Br J Surg. 1997;84:238\u201341.","journal-title":"Br J Surg"},{"key":"2523_CR249","doi-asserted-by":"publisher","first-page":"s721","DOI":"10.1158\/1078-0432.CCR-06-2197","volume":"13","author":"AC Ochoa","year":"2007","unstructured":"Ochoa AC, Zea AH, Hernandez C, Rodriguez PC. Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. Clin Cancer Res. 2007;13:s721\u20136.","journal-title":"Clin Cancer Res"},{"key":"2523_CR250","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1158\/0008-5472.CAN-14-1491","volume":"75","author":"M Fletcher","year":"2015","unstructured":"Fletcher M, Ramirez ME, Sierra RA, Raber P, Thevenot P, Al-Khami AA, Sanchez-Pino D, Hernandez C, Wyczechowska DD, Ochoa AC. Rodriguez PC: l-Arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells. Cancer Res. 2015;75:275\u201383.","journal-title":"Cancer Res"},{"key":"2523_CR251","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/nri1668","volume":"5","author":"V Bronte","year":"2005","unstructured":"Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol. 2005;5:641\u201354.","journal-title":"Nat Rev Immunol"},{"key":"2523_CR252","first-page":"467","volume":"20","author":"J Brittenden","year":"1994","unstructured":"Brittenden J, Heys SD, Ross J, Park KG, Eremin O. Natural cytotoxicity in breast cancer patients receiving neoadjuvant chemotherapy: effects of L-arginine supplementation. Eur J Surg Oncol. 1994;20:467\u201372.","journal-title":"Eur J Surg Oncol"},{"key":"2523_CR253","doi-asserted-by":"publisher","first-page":"103286","DOI":"10.1016\/j.redox.2024.103286","volume":"75","author":"Z Lin","year":"2024","unstructured":"Lin Z, Yang S, Qiu Q, Cui G, Zhang Y, Yao M, Li X, Chen C, Gu J, Wang T, et al. Hypoxia-induced cysteine metabolism reprogramming is crucial for the tumorigenesis of colorectal cancer. Redox Biol. 2024;75:103286.","journal-title":"Redox Biol"},{"key":"2523_CR254","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1126\/science.aaw9872","volume":"368","author":"MA Badgley","year":"2020","unstructured":"Badgley MA, Kremer DM, Maurer HC, DelGiorno KE, Lee HJ, Purohit V, Sagalovskiy IR, Ma A, Kapilian J, Firl CEM, et al. Cysteine depletion induces pancreatic tumor ferroptosis in mice. Science. 2020;368:85\u20139.","journal-title":"Science"},{"key":"2523_CR255","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1038\/s41392-021-00581-9","volume":"6","author":"J Wu","year":"2021","unstructured":"Wu J, Yeung SJ, Liu S, Qdaisat A, Jiang D, Liu W, Cheng Z, Liu W, Wang H, Li L, et al. Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS. Signal Transduct Target Ther. 2021;6:188.","journal-title":"Signal Transduct Target Ther"},{"key":"2523_CR256","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.ccell.2020.04.005","volume":"37","author":"M Tajan","year":"2020","unstructured":"Tajan M, Vousden KH. Dietary approaches to cancer therapy. Cancer Cell. 2020;37:767\u201385.","journal-title":"Cancer Cell"},{"key":"2523_CR257","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.cmet.2019.09.009","volume":"30","author":"J Zhu","year":"2019","unstructured":"Zhu J, Berisa M, Schw\u00f6rer S, Qin W, Cross JR, Thompson CB. Transsulfuration activity can support cell growth upon extracellular cysteine limitation. Cell Metab. 2019;30:865\u2013e876865.","journal-title":"Cell Metab"},{"key":"2523_CR258","doi-asserted-by":"publisher","first-page":"3326","DOI":"10.1038\/s41467-020-17181-w","volume":"11","author":"MB Ishak Gabra","year":"2020","unstructured":"Ishak Gabra MB, Yang Y, Li H, Senapati P, Hanse EA, Lowman XH, Tran TQ, Zhang L, Doan LT, Xu X, et al. Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth. Nat Commun. 2020;11:3326.","journal-title":"Nat Commun"},{"key":"2523_CR259","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1093\/jn\/129.8.1524","volume":"129","author":"S Kew","year":"1999","unstructured":"Kew S, Wells SM, Yaqoob P, Wallace FA, Miles EA, Calder PC. Dietary glutamine enhances murine T-lymphocyte responsiveness. J Nutr. 1999;129:1524\u201331.","journal-title":"J Nutr"},{"key":"2523_CR260","doi-asserted-by":"crossref","unstructured":"Anderson PM, Lalla RV. Glutamine for amelioration of radiation and chemotherapy associated mucositis during cancer therapy. Nutrients. 2020;12(6):1675.","DOI":"10.3390\/nu12061675"},{"key":"2523_CR261","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/S0305-7372(03)00133-6","volume":"29","author":"DM Savarese","year":"2003","unstructured":"Savarese DM, Savy G, Vahdat L, Wischmeyer PE, Corey B. Prevention of chemotherapy and radiation toxicity with glutamine. Cancer Treat Rev. 2003;29:501\u201313.","journal-title":"Cancer Treat Rev"},{"key":"2523_CR262","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1186\/s13045-021-01096-0","volume":"14","author":"Z Cheng","year":"2021","unstructured":"Cheng Z, Li M, Dey R, Chen Y. Nanomaterials for cancer therapy: current progress and perspectives. J Hematol Oncol. 2021;14:85.","journal-title":"J Hematol Oncol"},{"key":"2523_CR263","doi-asserted-by":"publisher","first-page":"e67","DOI":"10.1002\/mog2.67","volume":"3","author":"X Huang","year":"2024","unstructured":"Huang X, He T, Liang X, Xiang Z, Liu C, Zhou S, Luo R, Bai L, Kou X, Li X, et al. Advances and applications of nanoparticles in cancer therapy. MedComm \u2013 Oncol. 2024;3:e67.","journal-title":"MedComm \u2013 Oncol"},{"key":"2523_CR264","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.actbio.2021.12.012","volume":"140","author":"K Wang","year":"2022","unstructured":"Wang K, Jiang L, Qiu L. Near infrared light triggered ternary synergistic cancer therapy via L-arginine-loaded nanovesicles with modification of pegylated indocyanine green. Acta Biomater. 2022;140:506\u201317.","journal-title":"Acta Biomater"},{"key":"2523_CR265","doi-asserted-by":"publisher","first-page":"e2303253","DOI":"10.1002\/smll.202303253","volume":"19","author":"H Du","year":"2023","unstructured":"Du H, Meng S, Geng M, Zhao P, Gong L, Zheng X, Li X, Yuan Z, Yang H, Zhao Y, Dai L. Detachable MOF-Based Core\/Shell nanoreactor for cancer Dual-Starvation therapy with reversing glucose and glutamine metabolisms. Small. 2023;19:e2303253.","journal-title":"Small"},{"key":"2523_CR266","doi-asserted-by":"publisher","first-page":"120642","DOI":"10.1016\/j.biomaterials.2020.120642","volume":"269","author":"C Du","year":"2021","unstructured":"Du C, Zhou M, Jia F, Ruan L, Lu H, Zhang J, Zhu B, Liu X, Chen J, Chai Z, Hu Y. D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy. Biomaterials. 2021;269:120642.","journal-title":"Biomaterials"},{"key":"2523_CR267","doi-asserted-by":"publisher","first-page":"4647","DOI":"10.1038\/s41467-023-40345-3","volume":"14","author":"Y Huang","year":"2023","unstructured":"Huang Y, Qin G, Cui T, Zhao C, Ren J, Qu X. A bimetallic nanoplatform for STING activation and CRISPR\/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses. Nat Commun. 2023;14:4647.","journal-title":"Nat Commun"},{"key":"2523_CR268","doi-asserted-by":"publisher","first-page":"e2202695","DOI":"10.1002\/adhm.202202695","volume":"12","author":"X Zheng","year":"2023","unstructured":"Zheng X, Liu Y, Zhang T, Zhao Y, Liu Y, Zang J, Chong G, Li Y, Yang Y, Yang Y, et al. Labeling assembly of hydrophilic methionine into nanoparticle for Mild-Heat mediated immunometabolic therapy. Adv Healthc Mater. 2023;12:e2202695.","journal-title":"Adv Healthc Mater"},{"key":"2523_CR269","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1039\/C7BM00699C","volume":"5","author":"Q He","year":"2017","unstructured":"He Q. Precision gas therapy using intelligent nanomedicine. Biomater Sci. 2017;5:2226\u201330.","journal-title":"Biomater Sci"},{"key":"2523_CR270","doi-asserted-by":"publisher","first-page":"10816","DOI":"10.1021\/acsnano.6b04921","volume":"10","author":"K Zhang","year":"2016","unstructured":"Zhang K, Xu H, Jia X, Chen Y, Ma M, Sun L, Chen H. Ultrasound-Triggered nitric oxide release platform based on energy transformation for targeted Inhibition of pancreatic tumor. ACS Nano. 2016;10:10816\u201328.","journal-title":"ACS Nano"},{"key":"2523_CR271","doi-asserted-by":"publisher","first-page":"2230","DOI":"10.1039\/D0BM01932A","volume":"9","author":"H Yang","year":"2021","unstructured":"Yang H, Jiang F, Zhang L, Wang L, Luo Y, Li N, Guo Y, Wang Q, Zou J. Multifunctional l-arginine-based magnetic nanoparticles for multiple-synergistic tumor therapy. Biomater Sci. 2021;9:2230\u201343.","journal-title":"Biomater Sci"},{"key":"2523_CR272","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1021\/acsnano.9b05976","volume":"14","author":"S Gao","year":"2020","unstructured":"Gao S, Zhang W, Wang R, Hopkins SP, Spagnoli JC, Racin M, Bai L, Li L, Jiang W, Yang X, et al. Nanoparticles encapsulating nitrosylated Maytansine to enhance radiation therapy. ACS Nano. 2020;14:1468\u201381.","journal-title":"ACS Nano"},{"key":"2523_CR273","doi-asserted-by":"publisher","first-page":"5670","DOI":"10.1021\/jacs.8b01072","volume":"140","author":"G Lan","year":"2018","unstructured":"Lan G, Ni K, Xu Z, Veroneau SS, Song Y, Lin W. Nanoscale Metal-Organic framework overcomes hypoxia for photodynamic therapy primed cancer immunotherapy. J Am Chem Soc. 2018;140:5670\u20133.","journal-title":"J Am Chem Soc"},{"key":"2523_CR274","doi-asserted-by":"publisher","first-page":"4703","DOI":"10.1021\/acsabm.9b00879","volume":"2","author":"L Ruan","year":"2019","unstructured":"Ruan L, Wang M, Zhou M, Lu H, Zhang J, Gao J, Chen J, Hu Y. Doxorubicin-Metal coordinated micellar nanoparticles for intracellular codelivery and Chemo\/Chemodynamic therapy in vitro. ACS Appl Bio Mater. 2019;2:4703\u20137.","journal-title":"ACS Appl Bio Mater"},{"key":"2523_CR275","doi-asserted-by":"publisher","first-page":"8383","DOI":"10.1002\/anie.201800594","volume":"57","author":"W Fan","year":"2018","unstructured":"Fan W, Yung BC, Chen X. Stimuli-Responsive NO release for On-Demand Gas-Sensitized synergistic cancer therapy. Angew Chem Int Ed Engl. 2018;57:8383\u201394.","journal-title":"Angew Chem Int Ed Engl"},{"key":"2523_CR276","doi-asserted-by":"publisher","first-page":"e2005728","DOI":"10.1002\/smll.202005728","volume":"17","author":"M Wang","year":"2021","unstructured":"Wang M, Hou Z, Liu S, Liang S, Ding B, Zhao Y, Chang M, Han G, Kheraif AAA, Lin J. A multifunctional nanovaccine based on L-Arginine-Loaded black mesoporous titania: Ultrasound-Triggered synergistic cancer sonodynamic Therapy\/Gas Therapy\/Immunotherapy with remarkably enhanced efficacy. Small. 2021;17:e2005728.","journal-title":"Small"},{"key":"2523_CR277","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","volume":"16","author":"X Sun","year":"2021","unstructured":"Sun X, Zhang Y, Li J, Park KS, Han K, Zhou X, Xu Y, Nam J, Xu J, Shi X, et al. Amplifying STING activation by Cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy. Nat Nanotechnol. 2021;16:1260\u201370.","journal-title":"Nat Nanotechnol"},{"key":"2523_CR278","doi-asserted-by":"publisher","first-page":"e2211866","DOI":"10.1002\/adma.202211866","volume":"35","author":"W Wang","year":"2023","unstructured":"Wang W, Zhang L, Liu Z, Zhang Y, Zhu J, Liu M, Ren J, Qu X. Selective methionine pool exhaustion mediated by a sequential positioned MOF nanotransformer for intense cancer immunotherapy. Adv Mater. 2023;35:e2211866.","journal-title":"Adv Mater"},{"key":"2523_CR279","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.cmet.2019.11.020","volume":"31","author":"HC Yoo","year":"2020","unstructured":"Yoo HC, Park SJ, Nam M, Kang J, Kim K, Yeo JH, Kim JK, Heo Y, Lee HS, Lee MY, et al. A variant of SLC1A5 is a mitochondrial glutamine transporter for metabolic reprogramming in cancer cells. Cell Metab. 2020;31:267\u2013e283212.","journal-title":"Cell Metab"},{"key":"2523_CR280","first-page":"26","volume":"24","author":"L Zhou","year":"2023","unstructured":"Zhou L, Feng W, Mao Y, Chen Y, Zhang X. Nanoengineered sonosensitive platelets for synergistically augmented sonodynamic tumor therapy by glutamine deprivation and cascading thrombosis. Bioact Mater. 2023;24:26\u201336.","journal-title":"Bioact Mater"},{"key":"2523_CR281","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12951-022-01429-2","volume":"20","author":"Y Ding","year":"2022","unstructured":"Ding Y, Wang L, Li H, Miao F, Zhang Z, Hu C, Yu W, Tang Q, Shao G. Application of lipid nanovesicle drug delivery system in cancer immunotherapy. J Nanobiotechnol. 2022;20:214.","journal-title":"J Nanobiotechnol"},{"key":"2523_CR282","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1021\/acs.molpharmaceut.0c00937","volume":"18","author":"Z Sun","year":"2021","unstructured":"Sun Z, Wang X, Liu J, Wang Z, Wang W, Kong D, Leng X. ICG\/l-Arginine encapsulated PLGA Nanoparticle-Thermosensitive hydrogel hybrid delivery system for cascade cancer Photodynamic-NO therapy with promoted collagen depletion in tumor tissues. Mol Pharm. 2021;18:928\u201339.","journal-title":"Mol Pharm"},{"key":"2523_CR283","first-page":"924","volume":"17","author":"L Jiang","year":"2022","unstructured":"Jiang L, Wang K, Qiu L. Doxorubicin hydrochloride and L-arginine co-loaded nanovesicle for drug resistance reversal stimulated by near-infrared light. Asian J Pharm Sci. 2022;17:924\u201337.","journal-title":"Asian J Pharm Sci"},{"key":"2523_CR284","doi-asserted-by":"publisher","first-page":"12964","DOI":"10.1021\/acsnano.2c05408","volume":"16","author":"J Zhang","year":"2022","unstructured":"Zhang J, Wang S, Guo X, Lu Y, Liu X, Jiang M, Li X, Qin B, Luo Z, Liu H, et al. Arginine supplementation targeting tumor-Killing immune cells reconstructs the tumor microenvironment and enhances the antitumor immune response. ACS Nano. 2022;16:12964\u201378.","journal-title":"ACS Nano"},{"key":"2523_CR285","doi-asserted-by":"publisher","first-page":"3821","DOI":"10.1038\/s41467-022-31579-8","volume":"13","author":"B Wang","year":"2022","unstructured":"Wang B, Chen J, Caserto JS, Wang X, Ma M. An in situ hydrogel-mediated chemo-immunometabolic cancer therapy. Nat Commun. 2022;13:3821.","journal-title":"Nat Commun"},{"key":"2523_CR286","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.carbpol.2017.01.023","volume":"162","author":"T Zeng","year":"2017","unstructured":"Zeng T, Zhang Y, Yan Q, Huang Z, Zhang L, Yi X, Chen J, He G, Yin Y. Construction and in vitro evaluation of enzyme nanoreactors based on carboxymethyl Chitosan for arginine deprivation in cancer therapy. Carbohydr Polym. 2017;162:35\u201341.","journal-title":"Carbohydr Polym"},{"key":"2523_CR287","doi-asserted-by":"publisher","first-page":"102311","DOI":"10.1016\/j.nano.2020.102311","volume":"31","author":"X He","year":"2021","unstructured":"He X, Feng J, Yan S, Zhang Y, Zhong C, Liu Y, Shi D, Abagyan R, Xiang T, Zhang J. Biomimetic microbioreactor-supramolecular nanovesicles improve enzyme therapy of hepatic cancer. Nanomedicine. 2021;31:102311.","journal-title":"Nanomedicine"},{"key":"2523_CR288","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/s41586-021-03442-1","volume":"593","author":"BI Reinfeld","year":"2021","unstructured":"Reinfeld BI, Madden MZ, Wolf MM, Chytil A, Bader JE, Patterson AR, Sugiura A, Cohen AS, Ali A, Do BT, et al. Cell-programmed nutrient partitioning in the tumour microenvironment. Nature. 2021;593:282\u20138.","journal-title":"Nature"},{"key":"2523_CR289","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","volume":"162","author":"CH Chang","year":"2015","unstructured":"Chang CH, Qiu J, O\u2019Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell. 2015;162:1229\u201341.","journal-title":"Cell"},{"key":"2523_CR290","doi-asserted-by":"publisher","first-page":"15965","DOI":"10.1038\/ncomms15965","volume":"8","author":"DE Biancur","year":"2017","unstructured":"Biancur DE, Paulo JA, Ma\u0142achowska B, Del Quiles M, Sousa CM, Wang X, Sohn ASW, Chu GC, Gygi SP, Harper JW, et al. Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism. Nat Commun. 2017;8:15965.","journal-title":"Nat Commun"},{"key":"2523_CR291","doi-asserted-by":"publisher","first-page":"111691","DOI":"10.1016\/j.celrep.2022.111691","volume":"41","author":"D Yang","year":"2022","unstructured":"Yang D, Liu H, Cai Y, Lu K, Zhong X, Xing S, Song W, Zhang Y, Ye L, Zhu X, et al. Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression. Cell Rep. 2022;41:111691.","journal-title":"Cell Rep"},{"key":"2523_CR292","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/s42255-020-0195-8","volume":"2","author":"A M\u00e9ndez-Lucas","year":"2020","unstructured":"M\u00e9ndez-Lucas A, Lin W, Driscoll PC, Legrave N, Novellasdemunt L, Xie C, Charles M, Wilson Z, Jones NP, Rayport S, et al. Identifying strategies to target the metabolic flexibility of tumours. Nat Metab. 2020;2:335\u201350.","journal-title":"Nat Metab"},{"key":"2523_CR293","first-page":"516","volume":"2","author":"LC Rogers","year":"2019","unstructured":"Rogers LC, Van Tine BA. Innate and adaptive resistance mechanisms to arginine deprivation therapies in sarcoma and other cancers. Cancer Drug Resist. 2019;2:516\u201326.","journal-title":"Cancer Drug Resist"},{"key":"2523_CR294","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.omto.2021.01.001","volume":"20","author":"P Chen","year":"2021","unstructured":"Chen P, Liu XQ, Lin X, Gao LY, Zhang S, Huang X. Targeting YTHDF1 effectively re-sensitizes cisplatin-resistant colon cancer cells by modulating GLS-mediated glutamine metabolism. Mol Ther Oncolytics. 2021;20:228\u201339.","journal-title":"Mol Ther Oncolytics"},{"key":"2523_CR295","doi-asserted-by":"publisher","first-page":"41637","DOI":"10.18632\/oncotarget.9317","volume":"7","author":"CD Hudson","year":"2016","unstructured":"Hudson CD, Savadelis A, Nagaraj AB, Joseph P, Avril S, DiFeo A, Avril N. Altered glutamine metabolism in platinum resistant ovarian cancer. Oncotarget. 2016;7:41637\u201349.","journal-title":"Oncotarget"},{"key":"2523_CR296","doi-asserted-by":"crossref","unstructured":"Fallah Y, Brundage J, Allegakoen P, Shajahan-Haq AN. MYC-Driven pathways in breast cancer subtypes. Biomolecules. 2017;7(3):53.","DOI":"10.3390\/biom7030053"},{"key":"2523_CR297","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41419-024-06435-w","volume":"15","author":"J Chen","year":"2024","unstructured":"Chen J, Cui L, Lu S, Xu S. Amino acid metabolism in tumor biology and therapy. Cell Death Dis. 2024;15:42.","journal-title":"Cell Death Dis"},{"key":"2523_CR298","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1146\/annurev-nutr-121415-112634","volume":"36","author":"C Sapienza","year":"2016","unstructured":"Sapienza C, Issa JP. Diet, Nutrition, and cancer epigenetics. Annu Rev Nutr. 2016;36:665\u201381.","journal-title":"Annu Rev Nutr"},{"key":"2523_CR299","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/bs.ircmb.2022.02.004","volume":"373","author":"J Connolly-Schoonen","year":"2022","unstructured":"Connolly-Schoonen J, Biamonte SF, Danowski L, Montrose DC. Modifying dietary amino acids in cancer patients. Int Rev Cell Mol Biol. 2022;373:1\u201336.","journal-title":"Int Rev Cell Mol Biol"},{"key":"2523_CR300","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/S0002-9610(02)00823-1","volume":"183","author":"PE May","year":"2002","unstructured":"May PE, Barber A, D\u2019Olimpio JT, Hourihane A, Abumrad NN. Reversal of cancer-related wasting using oral supplementation with a combination of beta-hydroxy-beta-methylbutyrate, arginine, and glutamine. Am J Surg. 2002;183:471\u20139.","journal-title":"Am J Surg"},{"key":"2523_CR301","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.clnu.2011.05.008","volume":"30","author":"NE Deutz","year":"2011","unstructured":"Deutz NE, Safar A, Schutzler S, Memelink R, Ferrando A, Spencer H, van Helvoort A, Wolfe RR. Muscle protein synthesis in cancer patients can be stimulated with a specially formulated medical food. Clin Nutr. 2011;30:759\u201368.","journal-title":"Clin Nutr"},{"key":"2523_CR302","first-page":"1525","volume":"84","author":"Long-term oral","year":"1997","unstructured":"Long-term oral. Administration of branched chain amino acids after curative resection of hepatocellular carcinoma: a prospective randomized trial. The San-in group of liver surgery. Br J Surg. 1997;84:1525\u201331.","journal-title":"Br J Surg"},{"key":"2523_CR303","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1038\/s41568-022-00513-x","volume":"22","author":"MR Fernandes","year":"2022","unstructured":"Fernandes MR, Aggarwal P, Costa RGF, Cole AM, Trinchieri G. Targeting the gut microbiota for cancer therapy. Nat Rev Cancer. 2022;22:703\u201322.","journal-title":"Nat Rev Cancer"},{"key":"2523_CR304","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1126\/science.aar5986","volume":"360","author":"A Muir","year":"2018","unstructured":"Muir A, Vander Heiden MG. The nutrient environment affects therapy. Science. 2018;360:962\u20133.","journal-title":"Science"},{"key":"2523_CR305","doi-asserted-by":"publisher","first-page":"e2204932","DOI":"10.1002\/advs.202204932","volume":"10","author":"J Li","year":"2023","unstructured":"Li J, Lu W, Yang Y, Xiang R, Ling Y, Yu C, Zhou Y. Hybrid nanomaterials for cancer immunotherapy. Adv Sci (Weinh). 2023;10:e2204932.","journal-title":"Adv Sci (Weinh)"},{"key":"2523_CR306","doi-asserted-by":"publisher","first-page":"7025","DOI":"10.1039\/c0cc05271j","volume":"47","author":"Y Teow","year":"2011","unstructured":"Teow Y, Asharani PV, Hande MP, Valiyaveettil S. Health impact and safety of engineered nanomaterials. Chem Commun (Camb). 2011;47:7025\u201338.","journal-title":"Chem Commun (Camb)"},{"key":"2523_CR307","doi-asserted-by":"publisher","first-page":"4488","DOI":"10.1039\/D2CS00840H","volume":"52","author":"J Shin","year":"2023","unstructured":"Shin J, Kang N, Kim B, Hong H, Yu L, Kim J, Kang H, Kim JS. One-dimensional nanomaterials for cancer therapy and diagnosis. Chem Soc Rev. 2023;52:4488\u2013514.","journal-title":"Chem Soc Rev"},{"key":"2523_CR308","doi-asserted-by":"publisher","first-page":"12576","DOI":"10.1039\/D0CS01571G","volume":"50","author":"QW Chen","year":"2021","unstructured":"Chen QW, Qiao JY, Liu XH, Zhang C, Zhang XZ. Customized materials-assisted microorganisms in tumor therapeutics. Chem Soc Rev. 2021;50:12576\u2013615.","journal-title":"Chem Soc Rev"},{"key":"2523_CR309","doi-asserted-by":"publisher","first-page":"122846","DOI":"10.1016\/j.biomaterials.2024.122846","volume":"314","author":"L Hu","year":"2025","unstructured":"Hu L, Li T, Deng S, Gao H, Jiang Y, Chen Q, Chen H, Xiao Z, Shuai X, Su Z. Tertiary lymphoid structure formation induced by LIGHT-engineered and photosensitive nanoparticles-decorated bacteria enhances immune response against colorectal cancer. Biomaterials. 2025;314:122846.","journal-title":"Biomaterials"},{"key":"2523_CR310","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1038\/s41467-023-37225-1","volume":"14","author":"X Ma","year":"2023","unstructured":"Ma X, Liang X, Li Y, Feng Q, Cheng K, Ma N, Zhu F, Guo X, Yue Y, Liu G, et al. Modular-designed engineered bacteria for precision tumor immunotherapy via Spatiotemporal manipulation by magnetic field. Nat Commun. 2023;14:1606.","journal-title":"Nat Commun"},{"key":"2523_CR311","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.ccr.2010.08.009","volume":"18","author":"JB Wang","year":"2010","unstructured":"Wang JB, Erickson JW, Fuji R, Ramachandran S, Gao P, Dinavahi R, Wilson KF, Ambrosio AL, Dias SM, Dang CV, Cerione RA. Targeting mitochondrial glutaminase activity inhibits oncogenic transformation. Cancer Cell. 2010;18:207\u201319.","journal-title":"Cancer Cell"},{"key":"2523_CR312","doi-asserted-by":"publisher","first-page":"176156","DOI":"10.1016\/j.ejphar.2023.176156","volume":"960","author":"Y Pan","year":"2023","unstructured":"Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H. Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells. Eur J Pharmacol. 2023;960:176156.","journal-title":"Eur J Pharmacol"},{"key":"2523_CR313","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41467-022-35778-1","volume":"14","author":"ZA Hing","year":"2023","unstructured":"Hing ZA, Walker JS, Whipp EC, Brinton L, Cannon M, Zhang P, Sher S, Cempre CB, Brown F, Smith PL, et al. Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of richter\u2019s transformation. Nat Commun. 2023;14:97.","journal-title":"Nat Commun"},{"key":"2523_CR314","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.1158\/2159-8290.CD-23-0669","volume":"13","author":"LD Engstrom","year":"2023","unstructured":"Engstrom LD, Aranda R, Waters L, Moya K, Bowcut V, Vegar L, Trinh D, Hebbert A, Smith CR, Kulyk S, et al. MRTX1719 is an MTA-Cooperative PRMT5 inhibitor that exhibits synthetic lethality in preclinical models and patients with MTAP-Deleted cancer. Cancer Discov. 2023;13:2412\u201331.","journal-title":"Cancer Discov"},{"key":"2523_CR315","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1007\/s11010-022-04577-z","volume":"478","author":"R Yang","year":"2023","unstructured":"Yang R, Dong S, Zhang J, Zhu S, Miao G, Zhang B. Downregulation of PRMT5 by AMI-1 enhances therapeutic efficacy of compound Kushen injection in lung carcinoma in vitro and in vivo. Mol Cell Biochem. 2023;478:1031\u201344.","journal-title":"Mol Cell Biochem"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-025-02523-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-025-02523-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-025-02523-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T03:02:19Z","timestamp":1765940539000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12943-025-02523-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,16]]},"references-count":315,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2523"],"URL":"https:\/\/doi.org\/10.1186\/s12943-025-02523-3","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,16]]},"assertion":[{"value":"13 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"All subjects have written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"307"}}