{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:08:23Z","timestamp":1792757303949,"version":"4.5.0"},"reference-count":171,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"vor","delay-in-days":29,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573543"],"award-info":[{"award-number":["82573543"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Original Exploration Project of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine","award":["JYYC012"],"award-info":[{"award-number":["JYYC012"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Cancer"],"DOI":"10.1186\/s12943-026-02585-x","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T06:24:17Z","timestamp":1770013457000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single-cell omics in tumor lymph node metastasis: mechanisms and therapeutic implications"],"prefix":"10.1186","volume":"25","author":[{"given":"Xuanhao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonglong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liren","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luoman","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"issue":"3","key":"2585_CR1","first-page":"229","volume":"74","author":"F Bray","year":"2024","unstructured":"Bray F, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2024;74(3):229\u201363.","journal-title":"CA Cancer J Clin"},{"key":"2585_CR2","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.oraloncology.2019.02.001","volume":"90","author":"DK Zanoni","year":"2019","unstructured":"Zanoni DK, et al. Survival outcomes after treatment of cancer of the oral cavity (1985\u20132015). Oral Oncol. 2019;90:115\u201321.","journal-title":"Oral Oncol"},{"issue":"3","key":"2585_CR3","first-page":"203","volume":"4","author":"H Zeng","year":"2024","unstructured":"Zeng H, et al. Cancer survival statistics in China 2019\u20132021: a multicenter, population-based study. J Natl Cancer Cent. 2024;4(3):203\u201313.","journal-title":"J Natl Cancer Cent"},{"issue":"1","key":"2585_CR4","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1097\/JS9.0000000000001953","volume":"111","author":"YF Yu","year":"2025","unstructured":"Yu YF, et al. Frequency of lymph node metastases at different neck levels in patients with oral squamous cell carcinoma: a systematic review and meta-analysis. Int J Surg. 2025;111(1):1285\u2013300.","journal-title":"Int J Surg"},{"key":"2585_CR5","doi-asserted-by":"publisher","first-page":"216740","DOI":"10.1016\/j.canlet.2024.216740","volume":"588","author":"ZY Xu","year":"2024","unstructured":"Xu ZY, et al. Seizing the fate of lymph nodes in immunotherapy: to preserve or not? Cancer Lett. 2024;588:216740.","journal-title":"Cancer Lett"},{"key":"2585_CR6","doi-asserted-by":"publisher","first-page":"104536","DOI":"10.1016\/j.critrevonc.2024.104536","volume":"204","author":"ZZ Li","year":"2024","unstructured":"Li ZZ, et al. Lymph node metastasis in cancer: clearing the clouds to see the dawn. Crit Rev Oncol Hematol. 2024;204:104536.","journal-title":"Crit Rev Oncol Hematol"},{"issue":"17","key":"2585_CR7","doi-asserted-by":"publisher","first-page":"e2417312","DOI":"10.1002\/advs.202417312","volume":"12","author":"X Meng","year":"2025","unstructured":"Meng X, et al. Plac1(+) tumor Cell-Treg interplay supports tumorigenesis and progression of head and neck cancer. Adv Sci (Weinh). 2025;12(17):e2417312.","journal-title":"Adv Sci (Weinh)"},{"issue":"15","key":"2585_CR8","doi-asserted-by":"publisher","first-page":"2468","DOI":"10.1158\/0008-5472.CAN-23-1344","volume":"84","author":"X Meng","year":"2024","unstructured":"Meng X, et al. Single-Cell analyses reveal the metabolic heterogeneity and plasticity of the tumor microenvironment during head and neck squamous cell carcinoma progression. Cancer Res. 2024;84(15):2468\u201383.","journal-title":"Cancer Res"},{"issue":"1","key":"2585_CR9","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.tig.2023.10.003","volume":"40","author":"MI Conte","year":"2024","unstructured":"Conte MI, Fuentes-Trillo A, Dominguez C, Conde. Opportunities and tradeoffs in single-cell transcriptomic technologies. Trends Genet. 2024;40(1):83\u201393.","journal-title":"Trends Genet"},{"issue":"1","key":"2585_CR10","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1038\/s41467-024-46912-6","volume":"15","author":"ZL Liu","year":"2024","unstructured":"Liu ZL, et al. Single cell Deciphering of progression trajectories of the tumor ecosystem in head and neck cancer. Nat Commun. 2024;15(1):2595.","journal-title":"Nat Commun"},{"issue":"1","key":"2585_CR11","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/s41698-025-00886-w","volume":"9","author":"XH Liu","year":"2025","unstructured":"Liu XH, et al. Multi-omics in immunotherapy research for HNSCC: present situation and future perspectives. NPJ Precis Oncol. 2025;9(1):93.","journal-title":"NPJ Precis Oncol"},{"issue":"4","key":"2585_CR12","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1177\/00220345241282256","volume":"104","author":"XH Liu","year":"2025","unstructured":"Liu XH, et al. Trends in research of odontogenic keratocyst and ameloblastoma. J Dent Res. 2025;104(4):347\u201368.","journal-title":"J Dent Res"},{"issue":"1","key":"2585_CR13","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1038\/s41467-023-35995-2","volume":"14","author":"M Lin","year":"2023","unstructured":"Lin M, et al. Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance. Nat Commun. 2023;14(1):610.","journal-title":"Nat Commun"},{"issue":"1","key":"2585_CR14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41392-024-01960-8","volume":"9","author":"J Cai","year":"2024","unstructured":"Cai J, et al. Single-cell exome sequencing reveals polyclonal seeding and TRPS1 mutations in colon cancer metastasis. Signal Transduct Target Ther. 2024;9(1):247.","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"2585_CR15","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1093\/hmg\/ddab042","volume":"30","author":"K Xu","year":"2021","unstructured":"Xu K, et al. Integrative analyses of scRNA-seq and scATAC-seq reveal CXCL14 as a key regulator of lymph node metastasis in breast cancer. Hum Mol Genet. 2021;30(5):370\u201380.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2585_CR16","doi-asserted-by":"publisher","first-page":"8170","DOI":"10.1038\/s41467-023-43991-9","volume":"14","author":"Q Zhu","year":"2023","unstructured":"Zhu Q, et al. Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines. Nat Commun. 2023;14(1):8170.","journal-title":"Nat Commun"},{"issue":"4","key":"2585_CR17","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.ccell.2024.02.002","volume":"42","author":"H Zheng","year":"2024","unstructured":"Zheng H, et al. PDGFRalpha(+)ITGA11(+) fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay. Cancer Cell. 2024;42(4):682\u2013e70012.","journal-title":"Cancer Cell"},{"issue":"10","key":"2585_CR18","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.medj.2023.07.010","volume":"4","author":"Z Zhang","year":"2023","unstructured":"Zhang Z, et al. Single-cell mapping reveals several immune subsets associated with liver metastasis of pancreatic ductal adenocarcinoma. Med. 2023;4(10):728\u2013e7437.","journal-title":"Med"},{"issue":"3","key":"2585_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.immuni.2024.02.007","volume":"57","author":"A Franken","year":"2024","unstructured":"Franken A, et al. CD4(+) T cell activation distinguishes response to anti-PD-L1\u2009+\u2009anti-CTLA4 therapy from anti-PD-L1 monotherapy. Immunity. 2024;57(3):541\u2013e5587.","journal-title":"Immunity"},{"issue":"1","key":"2585_CR20","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1038\/s41467-023-38009-3","volume":"14","author":"W Zhang","year":"2023","unstructured":"Zhang W, et al. Single-cell metabolic fingerprints discover a cluster of Circulating tumor cells with distinct metastatic potential. Nat Commun. 2023;14(1):2485.","journal-title":"Nat Commun"},{"issue":"1","key":"2585_CR21","doi-asserted-by":"publisher","first-page":"e70172","DOI":"10.1002\/ctm2.70172","volume":"15","author":"G Xiao","year":"2025","unstructured":"Xiao G, et al. Single-cell RNA-sequencing and Spatial transcriptomic analysis reveal a distinct population of APOE(-) cells yielding pathological lymph node metastasis in papillary thyroid cancer. Clin Transl Med. 2025;15(1):e70172.","journal-title":"Clin Transl Med"},{"key":"2585_CR22","doi-asserted-by":"crossref","unstructured":"Kahn BM et al. Intrinsic properties of the lymph node render it immunologically susceptible to metastasis. Cancer Discov. 2025.","DOI":"10.1158\/2159-8290.c.8016673"},{"key":"2585_CR23","doi-asserted-by":"crossref","unstructured":"Shao DD et al. Advances in single-cell DNA sequencing enable insights into human somatic mosaicism. Nat Rev Genet. 2025.","DOI":"10.1038\/s41576-025-00832-3"},{"issue":"1","key":"2585_CR24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/s41576-022-00509-1","volume":"24","author":"S Preissl","year":"2023","unstructured":"Preissl S, Gaulton KJ, Ren B. Characterizing cis-regulatory elements using single-cell epigenomics. Nat Rev Genet. 2023;24(1):21\u201343.","journal-title":"Nat Rev Genet"},{"key":"2585_CR25","doi-asserted-by":"publisher","first-page":"111814","DOI":"10.1016\/j.cellsig.2025.111814","volume":"132","author":"XH Liu","year":"2025","unstructured":"Liu XH, et al. NR2F2 and its contribution to lymph node metastasis in oral squamous cell carcinoma. Cell Signal. 2025;132:111814.","journal-title":"Cell Signal"},{"key":"2585_CR26","doi-asserted-by":"publisher","first-page":"1541582","DOI":"10.3389\/fcell.2025.1541582","volume":"13","author":"XH Liu","year":"2025","unstructured":"Liu XH, et al. Metal-dependent cell death resistance contribute to lymph node metastasis of oral squamous cell carcinoma. Front Cell Dev Biol. 2025;13:1541582.","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"2585_CR27","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/s41592-024-02243-4","volume":"21","author":"SE Irac","year":"2024","unstructured":"Irac SE, et al. Single-cell immune repertoire analysis. Nat Methods. 2024;21(5):777\u201392.","journal-title":"Nat Methods"},{"issue":"3","key":"2585_CR28","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41592-023-01791-5","volume":"20","author":"HM Bennett","year":"2023","unstructured":"Bennett HM, et al. Single-cell proteomics enabled by next-generation sequencing or mass spectrometry. Nat Methods. 2023;20(3):363\u201374.","journal-title":"Nat Methods"},{"issue":"10","key":"2585_CR29","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.jpha.2023.08.014","volume":"13","author":"Y Hou","year":"2023","unstructured":"Hou Y, Yao H, Lin JM. Recent advancements in single-cell metabolic analysis for Pharmacological research. J Pharm Anal. 2023;13(10):1102\u201316.","journal-title":"J Pharm Anal"},{"issue":"5","key":"2585_CR30","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s41587-021-01139-4","volume":"40","author":"V Kleshchevnikov","year":"2022","unstructured":"Kleshchevnikov V, et al. Cell2location maps fine-grained cell types in Spatial transcriptomics. Nat Biotechnol. 2022;40(5):661\u201371.","journal-title":"Nat Biotechnol"},{"issue":"1","key":"2585_CR31","doi-asserted-by":"publisher","first-page":"6533","DOI":"10.1038\/s41467-025-61667-4","volume":"16","author":"J Ke","year":"2025","unstructured":"Ke J, et al. High-resolution mapping of single cells in Spatial context. Nat Commun. 2025;16(1):6533.","journal-title":"Nat Commun"},{"issue":"9","key":"2585_CR32","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1038\/s41587-022-01273-7","volume":"40","author":"Y Ma","year":"2022","unstructured":"Ma Y, Zhou X. Spatially informed cell-type Deconvolution for Spatial transcriptomics. Nat Biotechnol. 2022;40(9):1349\u201359.","journal-title":"Nat Biotechnol"},{"issue":"12","key":"2585_CR33","doi-asserted-by":"publisher","first-page":"1794","DOI":"10.1038\/s41587-022-01483-z","volume":"40","author":"S He","year":"2022","unstructured":"He S, et al. High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by Spatial molecular imaging. Nat Biotechnol. 2022;40(12):1794\u2013806.","journal-title":"Nat Biotechnol"},{"issue":"10","key":"2585_CR34","doi-asserted-by":"publisher","first-page":"1830","DOI":"10.1038\/s41592-024-02408-1","volume":"21","author":"J Zhu","year":"2024","unstructured":"Zhu J, et al. Mapping cellular interactions from spatially resolved transcriptomics data. Nat Methods. 2024;21(10):1830\u201342.","journal-title":"Nat Methods"},{"issue":"3","key":"2585_CR35","doi-asserted-by":"publisher","first-page":"101275","DOI":"10.1016\/j.jhepr.2024.101275","volume":"7","author":"Z Li","year":"2025","unstructured":"Li Z, et al. Single-cell analyses reveal metastasis mechanism and microenvironment remodeling of lymph node in intrahepatic cholangiocarcinoma. JHEP Rep. 2025;7(3):101275.","journal-title":"JHEP Rep"},{"issue":"1","key":"2585_CR36","doi-asserted-by":"publisher","first-page":"8119","DOI":"10.1038\/s41467-023-43980-y","volume":"14","author":"C Wei","year":"2023","unstructured":"Wei C, et al. Delineating the early dissemination mechanisms of acral melanoma by integrating single-cell and Spatial transcriptomic analyses. Nat Commun. 2023;14(1):8119.","journal-title":"Nat Commun"},{"key":"2585_CR37","doi-asserted-by":"crossref","unstructured":"Chen C et al. B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity. Cancer Cell. 2026.","DOI":"10.1016\/j.ccell.2025.12.011"},{"issue":"1","key":"2585_CR38","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.immuni.2025.11.020","volume":"59","author":"B Zitti","year":"2026","unstructured":"Zitti B, et al. Positioning and reversible suppression of CCR7(+) dendritic cells in perivascular tumor niches shape cancer immunity. Immunity. 2026;59(1):161\u2013e17612.","journal-title":"Immunity"},{"issue":"8","key":"2585_CR39","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/j.ccell.2024.06.014","volume":"42","author":"S You","year":"2024","unstructured":"You S, et al. Lymphatic-localized Treg-mregDC crosstalk limits antigen trafficking and restrains anti-tumor immunity. Cancer Cell. 2024;42(8):1415\u2013e143312.","journal-title":"Cancer Cell"},{"issue":"11","key":"2585_CR40","doi-asserted-by":"publisher","first-page":"2830","DOI":"10.1016\/j.immuni.2025.08.015","volume":"58","author":"G Mattavelli","year":"2025","unstructured":"Mattavelli G, et al. A TLR4-dependent fibroblast-monocyte axis in tumor-draining lymph nodes contributes to metastasis in triple-negative breast cancer. Immunity. 2025;58(11):2830\u2013e284615.","journal-title":"Immunity"},{"issue":"43","key":"2585_CR41","doi-asserted-by":"publisher","first-page":"e2402242","DOI":"10.1002\/advs.202402242","volume":"11","author":"Y Yin","year":"2024","unstructured":"Yin Y, et al. Spatial isoforms reveal the mechanisms of metastasis. Adv Sci (Weinh). 2024;11(43):e2402242.","journal-title":"Adv Sci (Weinh)"},{"issue":"6","key":"2585_CR42","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.cell.2023.02.021","volume":"186","author":"MK Rahim","year":"2023","unstructured":"Rahim MK, et al. Dynamic CD8(+) T cell responses to cancer immunotherapy in human regional lymph nodes are disrupted in metastatic lymph nodes. Cell. 2023;186(6):1127\u2013e114318.","journal-title":"Cell"},{"issue":"10","key":"2585_CR43","doi-asserted-by":"publisher","first-page":"1894","DOI":"10.1158\/1078-0432.CCR-24-3135","volume":"31","author":"W Zhang","year":"2025","unstructured":"Zhang W, et al. PERK\u2009+\u2009Macrophages drive immunotherapy resistance in lymph node metastases of oral squamous cell carcinoma. Clin Cancer Res. 2025;31(10):1894\u2013911.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"2585_CR44","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/s41588-020-0633-2","volume":"52","author":"JG Reiter","year":"2020","unstructured":"Reiter JG, et al. Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases. Nat Genet. 2020;52(7):692\u2013700.","journal-title":"Nat Genet"},{"issue":"7","key":"2585_CR45","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/s41588-020-0628-z","volume":"52","author":"Z Hu","year":"2020","unstructured":"Hu Z, et al. Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases. Nat Genet. 2020;52(7):701\u20138.","journal-title":"Nat Genet"},{"key":"2585_CR46","doi-asserted-by":"publisher","first-page":"102793","DOI":"10.1016\/j.ebiom.2020.102793","volume":"56","author":"D Venet","year":"2020","unstructured":"Venet D, et al. Phylogenetic reconstruction of breast cancer reveals two routes of metastatic dissemination associated with distinct clinical outcome. EBioMedicine. 2020;56:102793.","journal-title":"EBioMedicine"},{"issue":"2","key":"2585_CR47","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1136\/gutjnl-2020-323703","volume":"71","author":"HN Chen","year":"2022","unstructured":"Chen HN, et al. Genomic evolution and diverse models of systemic metastases in colorectal cancer. Gut. 2022;71(2):322\u201332.","journal-title":"Gut"},{"issue":"1","key":"2585_CR48","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/s41392-024-01937-7","volume":"9","author":"Y Wang","year":"2024","unstructured":"Wang Y, et al. Pre-metastatic niche: formation, characteristics and therapeutic implication. Signal Transduct Target Ther. 2024;9(1):236.","journal-title":"Signal Transduct Target Ther"},{"issue":"11","key":"2585_CR49","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.1016\/j.cell.2022.04.019","volume":"185","author":"NE Reticker-Flynn","year":"2022","unstructured":"Reticker-Flynn NE, et al. Lymph node colonization induces tumor-immune tolerance to promote distant metastasis. Cell. 2022;185(11):1924\u201342. e23.","journal-title":"Cell"},{"issue":"9","key":"2585_CR50","doi-asserted-by":"publisher","first-page":"1949","DOI":"10.1158\/2159-8290.CD-24-1847","volume":"15","author":"BM Kahn","year":"2025","unstructured":"Kahn BM, et al. Intrinsic properties of the lymph node render it immunologically susceptible to metastasis. Cancer Discov. 2025;15(9):1949\u201368.","journal-title":"Cancer Discov"},{"issue":"3","key":"2585_CR51","doi-asserted-by":"publisher","first-page":"101323","DOI":"10.1016\/j.gendis.2024.101323","volume":"12","author":"Y Wang","year":"2025","unstructured":"Wang Y, et al. The scRNA-sequencing landscape of pancreatic ductal adenocarcinoma revealed distinct cell populations associated with tumor initiation and progression. Genes Dis. 2025;12(3):101323.","journal-title":"Genes Dis"},{"key":"2585_CR52","doi-asserted-by":"crossref","unstructured":"Li F et al. Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: A study based on single-cell and Spatial transcriptomic sequencing. Hepatology. 2025.","DOI":"10.1097\/HEP.0000000000001423"},{"issue":"1","key":"2585_CR53","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.1038\/s41467-020-16164-1","volume":"11","author":"N Kim","year":"2020","unstructured":"Kim N, et al. Single-cell RNA sequencing demonstrates the molecular and cellular reprogramming of metastatic lung adenocarcinoma. Nat Commun. 2020;11(1):2285.","journal-title":"Nat Commun"},{"issue":"1","key":"2585_CR54","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1038\/s41467-023-37379-y","volume":"14","author":"HS Quah","year":"2023","unstructured":"Quah HS, et al. Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis. Nat Commun. 2023;14(1):1680.","journal-title":"Nat Commun"},{"issue":"1","key":"2585_CR55","doi-asserted-by":"publisher","first-page":"10983","DOI":"10.1038\/s41467-025-66800-x","volume":"16","author":"L Meder","year":"2025","unstructured":"Meder L, et al. ERBB2 signaling drives immune cell evasion and resistance against immunotherapy in small cell lung cancer. Nat Commun. 2025;16(1):10983.","journal-title":"Nat Commun"},{"key":"2585_CR56","doi-asserted-by":"crossref","unstructured":"Xu N et al. LncRNA-CTD suppresses metastasis and immune evasion by modulating snail1 and MHC-I expression in colorectal cancer. J Immunother Cancer. 2025;13(9).","DOI":"10.1136\/jitc-2025-011766"},{"issue":"4","key":"2585_CR57","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s10456-025-10005-9","volume":"28","author":"MW Oo","year":"2025","unstructured":"Oo MW, et al. Cancer-associated fibroblast-derived SOD3 enhances lymphangiogenesis to drive metastasis in lung adenocarcinoma. Angiogenesis. 2025;28(4):51.","journal-title":"Angiogenesis"},{"issue":"24","key":"2585_CR58","doi-asserted-by":"publisher","first-page":"6754","DOI":"10.1016\/j.cell.2025.09.029","volume":"188","author":"Y Zhang","year":"2025","unstructured":"Zhang Y, et al. Cancer cells co-opt an inter-organ neuroimmune circuit to escape immune surveillance. Cell. 2025;188(24):6754\u2013e677329.","journal-title":"Cell"},{"issue":"1","key":"2585_CR59","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1186\/s12967-023-04102-w","volume":"21","author":"K Horny","year":"2023","unstructured":"Horny K, et al. Mesenchymal-epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression. J Transl Med. 2023;21(1):267.","journal-title":"J Transl Med"},{"issue":"2","key":"2585_CR60","doi-asserted-by":"publisher","first-page":"e730","DOI":"10.1002\/ctm2.730","volume":"12","author":"H Jiang","year":"2022","unstructured":"Jiang H, et al. Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA sequencing. Clin Transl Med. 2022;12(2):e730.","journal-title":"Clin Transl Med"},{"issue":"8096","key":"2585_CR61","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1038\/s41586-025-09709-1","volume":"649","author":"M Palma","year":"2026","unstructured":"Palma M, et al. Lymph node environment drives FSP1 targetability in metastasizing melanoma. Nature. 2026;649(8096):477\u201386.","journal-title":"Nature"},{"issue":"11","key":"2585_CR62","doi-asserted-by":"publisher","first-page":"e107333","DOI":"10.15252\/embj.2020107333","volume":"40","author":"B Pal","year":"2021","unstructured":"Pal B, et al. A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic States in the human breast. EMBO J. 2021;40(11):e107333.","journal-title":"EMBO J"},{"issue":"1","key":"2585_CR63","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1186\/s13073-022-01093-z","volume":"14","author":"R Wang","year":"2022","unstructured":"Wang R, et al. Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors. Genome Med. 2022;14(1):93.","journal-title":"Genome Med"},{"issue":"6","key":"2585_CR64","doi-asserted-by":"publisher","first-page":"e2205395","DOI":"10.1002\/advs.202205395","volume":"10","author":"YM Liu","year":"2023","unstructured":"Liu YM, et al. Combined Single-Cell and Spatial transcriptomics reveal the metabolic evolvement of breast cancer during early dissemination. Adv Sci (Weinh). 2023;10(6):e2205395.","journal-title":"Adv Sci (Weinh)"},{"issue":"1","key":"2585_CR65","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1097\/HEP.0000000000000784","volume":"80","author":"H Zhang","year":"2024","unstructured":"Zhang H, et al. Oleic acid-PPARgamma-FABP4 loop fuels cholangiocarcinoma colonization in lymph node metastases microenvironment. Hepatology. 2024;80(1):69\u201386.","journal-title":"Hepatology"},{"issue":"1","key":"2585_CR66","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","volume":"19","author":"R Dhanasekaran","year":"2022","unstructured":"Dhanasekaran R, et al. The MYC oncogene - the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol. 2022;19(1):23\u201336.","journal-title":"Nat Rev Clin Oncol"},{"issue":"4","key":"2585_CR67","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cmet.2017.09.009","volume":"26","author":"KM Lee","year":"2017","unstructured":"Lee KM, et al. MYC and MCL1 cooperatively promote Chemotherapy-Resistant breast cancer stem cells via regulation of mitochondrial oxidative phosphorylation. Cell Metab. 2017;26(4):633\u2013e6477.","journal-title":"Cell Metab"},{"issue":"10","key":"2585_CR68","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1038\/s41375-025-02712-5","volume":"39","author":"Y Wang","year":"2025","unstructured":"Wang Y, et al. The bone marrow immune ecosystem shapes daratumumab acquired resistance in plasma cell myeloma. Leukemia. 2025;39(10):2504\u201315.","journal-title":"Leukemia"},{"issue":"1","key":"2585_CR69","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41698-024-00509-w","volume":"8","author":"Q Huang","year":"2024","unstructured":"Huang Q, et al. Multi-omics analysis reveals NNMT as a master metabolic regulator of metastasis in esophageal squamous cell carcinoma. NPJ Precis Oncol. 2024;8(1):24.","journal-title":"NPJ Precis Oncol"},{"issue":"1","key":"2585_CR70","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s13578-024-01201-z","volume":"14","author":"L Cao","year":"2024","unstructured":"Cao L, et al. Macrophage heterogeneity and its interactions with stromal cells in tumour microenvironment. Cell Biosci. 2024;14(1):16.","journal-title":"Cell Biosci"},{"issue":"6","key":"2585_CR71","doi-asserted-by":"publisher","first-page":"e462","DOI":"10.1002\/ctm2.462","volume":"11","author":"P Chen","year":"2021","unstructured":"Chen P, et al. Diversity and intratumoral heterogeneity in human gallbladder cancer progression revealed by single-cell RNA sequencing. Clin Transl Med. 2021;11(6):e462.","journal-title":"Clin Transl Med"},{"key":"2585_CR72","doi-asserted-by":"crossref","unstructured":"He M et al. Intratumoral tertiary lymphoid structure (TLS) maturation is influenced by draining lymph nodes of lung cancer. J Immunother Cancer. 2023;11(4).","DOI":"10.1136\/jitc-2022-005539"},{"issue":"6","key":"2585_CR73","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1002\/cac2.12545","volume":"44","author":"XY Zhang","year":"2024","unstructured":"Zhang XY, et al. Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine\/Siglec-15 axis in immune escape. Cancer Commun (Lond). 2024;44(6):670\u201394.","journal-title":"Cancer Commun (Lond)"},{"key":"2585_CR74","doi-asserted-by":"crossref","unstructured":"Jiao S et al. Intratumor expanded T cell clones can be non-sentinel lymph node derived in breast cancer revealed by single-cell immune profiling. J Immunother Cancer. 2022;10(1).","DOI":"10.1136\/jitc-2021-003325"},{"issue":"2","key":"2585_CR75","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.trecan.2024.11.005","volume":"11","author":"PSW Cheng","year":"2025","unstructured":"Cheng PSW, Zaccaria M, Biffi G. Functional heterogeneity of fibroblasts in primary tumors and metastases. Trends Cancer. 2025;11(2):135\u201353.","journal-title":"Trends Cancer"},{"issue":"63","key":"2585_CR76","doi-asserted-by":"publisher","first-page":"eabg3551","DOI":"10.1126\/sciimmunol.abg3551","volume":"6","author":"H du Bois","year":"2021","unstructured":"du Bois H, Heim TA, Lund AW. Tumor-draining lymph nodes: at the crossroads of metastasis and immunity. Sci Immunol. 2021;6(63):eabg3551.","journal-title":"Sci Immunol"},{"issue":"1","key":"2585_CR77","doi-asserted-by":"publisher","first-page":"1830513","DOI":"10.1080\/2162402X.2020.1830513","volume":"9","author":"YL Li","year":"2020","unstructured":"Li YL, et al. Single-cell analysis reveals immune modulation and metabolic switch in tumor-draining lymph nodes. Oncoimmunology. 2020;9(1):1830513.","journal-title":"Oncoimmunology"},{"issue":"7","key":"2585_CR78","doi-asserted-by":"publisher","first-page":"e2204565","DOI":"10.1002\/advs.202204565","volume":"10","author":"Y Jia","year":"2023","unstructured":"Jia Y, et al. Single-Cell transcriptomic analysis of primary and metastatic tumor ecosystems in esophageal squamous cell carcinoma. Adv Sci (Weinh). 2023;10(7):e2204565.","journal-title":"Adv Sci (Weinh)"},{"issue":"6","key":"2585_CR79","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1177\/00220345241307894","volume":"104","author":"C Cao","year":"2025","unstructured":"Cao C, et al. Deciphering the premetastatic lymphatic niche of oral squamous cell carcinoma. J Dent Res. 2025;104(6):679\u201389.","journal-title":"J Dent Res"},{"issue":"7969","key":"2585_CR80","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1038\/s41586-023-06231-0","volume":"619","author":"L Bod","year":"2023","unstructured":"Bod L, et al. B-cell-specific checkpoint molecules that regulate anti-tumour immunity. Nature. 2023;619(7969):348\u201356.","journal-title":"Nature"},{"issue":"44","key":"2585_CR81","doi-asserted-by":"publisher","first-page":"e2400524","DOI":"10.1002\/advs.202400524","volume":"11","author":"L Dong","year":"2024","unstructured":"Dong L, et al. SPP1(+) TAM regulates the metastatic colonization of CXCR4(+) Metastasis-Associated tumor cells by remodeling the lymph node microenvironment. Adv Sci (Weinh). 2024;11(44):e2400524.","journal-title":"Adv Sci (Weinh)"},{"issue":"5","key":"2585_CR82","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.ccell.2025.02.017","volume":"43","author":"S Lamorte","year":"2025","unstructured":"Lamorte S, et al. Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33. Cancer Cell. 2025;43(5):955\u2013e96910.","journal-title":"Cancer Cell"},{"issue":"15","key":"2585_CR83","doi-asserted-by":"publisher","first-page":"e2411241122","DOI":"10.1073\/pnas.2411241122","volume":"122","author":"SS Li","year":"2025","unstructured":"Li SS, et al. FAO-fueled OXPHOS and NRF2-mediated stress resilience in mics drive lymph node metastasis. Proc Natl Acad Sci U S A. 2025;122(15):e2411241122.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2585_CR84","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1158\/2326-6066.CIR-22-0225","volume":"10","author":"T Virgilio","year":"2022","unstructured":"Virgilio T, et al. Subcapsular sinus macrophages promote melanoma metastasis to the Sentinel lymph nodes via an IL1alpha-STAT3 axis. Cancer Immunol Res. 2022;10(12):1525\u201341.","journal-title":"Cancer Immunol Res"},{"key":"2585_CR85","doi-asserted-by":"publisher","first-page":"217180","DOI":"10.1016\/j.canlet.2024.217180","volume":"600","author":"Q Zhang","year":"2024","unstructured":"Zhang Q, et al. Single-cell RNA sequencing of OSCC primary tumors and lymph nodes reveals distinct origin and phenotype of fibroblasts. Cancer Lett. 2024;600:217180.","journal-title":"Cancer Lett"},{"issue":"15","key":"2585_CR86","doi-asserted-by":"publisher","first-page":"3953","DOI":"10.1016\/j.cell.2024.05.055","volume":"187","author":"M Schott","year":"2024","unstructured":"Schott M, et al. Open-ST: High-resolution Spatial transcriptomics in 3D. Cell. 2024;187(15):3953\u2013e397226.","journal-title":"Cell"},{"issue":"10","key":"2585_CR87","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1158\/0008-5472.CAN-24-2580","volume":"85","author":"T Zhang","year":"2025","unstructured":"Zhang T, et al. Intratumoral Fusobacterium nucleatum recruits Tumor-Associated neutrophils to promote gastric cancer progression and immune evasion. Cancer Res. 2025;85(10):1819\u201341.","journal-title":"Cancer Res"},{"key":"2585_CR88","doi-asserted-by":"crossref","unstructured":"Xie J et al. Paracrine orchestration of tumor microenvironment remodeling induced by GLO1 potentiates lymph node metastasis in breast cancer. Adv Sci (Weinh), 2025: p. e00722.","DOI":"10.1002\/advs.202500722"},{"issue":"1","key":"2585_CR89","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1186\/s12916-024-03319-w","volume":"22","author":"Y Liu","year":"2024","unstructured":"Liu Y, et al. Single-cell and Spatial transcriptomics reveal metastasis mechanism and microenvironment remodeling of lymph node in osteosarcoma. BMC Med. 2024;22(1):200.","journal-title":"BMC Med"},{"key":"2585_CR90","doi-asserted-by":"publisher","first-page":"217874","DOI":"10.1016\/j.canlet.2025.217874","volume":"628","author":"W Dai","year":"2025","unstructured":"Dai W, et al. Characterizing chromosome instability reveals its association with lipid-associated macrophages and clonal evolution of lymph node metastasis in esophageal squamous cell carcinoma. Cancer Lett. 2025;628:217874.","journal-title":"Cancer Lett"},{"issue":"1","key":"2585_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.immuni.2013.07.012","volume":"39","author":"DS Chen","year":"2013","unstructured":"Chen DS, Mellman I. Oncology Meets immunology: the cancer-immunity cycle. Immunity. 2013;39(1):1\u201310.","journal-title":"Immunity"},{"issue":"10","key":"2585_CR92","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1016\/j.immuni.2023.09.011","volume":"56","author":"I Mellman","year":"2023","unstructured":"Mellman I, et al. The cancer-immunity cycle: Indication, genotype, and immunotype. Immunity. 2023;56(10):2188\u2013205.","journal-title":"Immunity"},{"issue":"10","key":"2585_CR93","doi-asserted-by":"publisher","first-page":"2231","DOI":"10.1016\/j.immuni.2023.09.005","volume":"56","author":"JR Giles","year":"2023","unstructured":"Giles JR, et al. CD8(+) T cells in the cancer-immunity cycle. Immunity. 2023;56(10):2231\u201353.","journal-title":"Immunity"},{"issue":"10","key":"2585_CR94","doi-asserted-by":"publisher","first-page":"2254","DOI":"10.1016\/j.immuni.2023.08.009","volume":"56","author":"WH Fridman","year":"2023","unstructured":"Fridman WH, et al. Tertiary lymphoid structures and B cells: an intratumoral immunity cycle. Immunity. 2023;56(10):2254\u201369.","journal-title":"Immunity"},{"issue":"10","key":"2585_CR95","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41389-021-00355-6","volume":"10","author":"K Xu","year":"2021","unstructured":"Xu K, et al. Single-cell RNA sequencing reveals cell heterogeneity and transcriptome profile of breast cancer lymph node metastasis. Oncogenesis. 2021;10(10):66.","journal-title":"Oncogenesis"},{"issue":"7802","key":"2585_CR96","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41586-020-2134-y","volume":"580","author":"B Maier","year":"2020","unstructured":"Maier B, et al. A conserved dendritic-cell regulatory program limits antitumour immunity. Nature. 2020;580(7802):257\u201362.","journal-title":"Nature"},{"issue":"19","key":"2585_CR97","doi-asserted-by":"publisher","first-page":"3596","DOI":"10.1158\/0008-5472.CAN-24-3595","volume":"85","author":"T Ma","year":"2025","unstructured":"Ma T, et al. Pan-Cancer analyses refine the Single-Cell portrait of Tumor-Infiltrating dendritic cells. Cancer Res. 2025;85(19):3596\u2013613.","journal-title":"Cancer Res"},{"issue":"1","key":"2585_CR98","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/s41467-024-44787-1","volume":"15","author":"CYC Lee","year":"2024","unstructured":"Lee CYC, et al. Tumour-retained activated CCR7(+) dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity. Nat Commun. 2024;15(1):682.","journal-title":"Nat Commun"},{"issue":"8079","key":"2585_CR99","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1038\/s41586-025-09202-9","volume":"645","author":"H Tang","year":"2025","unstructured":"Tang H, et al. Rescuing dendritic cell interstitial motility sustains antitumour immunity. Nature. 2025;645(8079):244\u201353.","journal-title":"Nature"},{"issue":"1","key":"2585_CR100","doi-asserted-by":"publisher","first-page":"7834","DOI":"10.1038\/s41467-025-63200-z","volume":"16","author":"X Guan","year":"2025","unstructured":"Guan X, et al. Lymph nodes molecular subtypes unravel lymph nodes heterogeneity and clinical implications in colorectal cancer. Nat Commun. 2025;16(1):7834.","journal-title":"Nat Commun"},{"issue":"8095","key":"2585_CR101","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1038\/s41586-025-09440-x","volume":"649","author":"JL Hor","year":"2026","unstructured":"Hor JL, et al. Inhibitory PD-1 axis maintains high-avidity stem-like CD8(+) T cells. Nature. 2026;649(8095):194\u2013204.","journal-title":"Nature"},{"issue":"1","key":"2585_CR102","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41416-025-03241-9","volume":"134","author":"Y Zhou","year":"2026","unstructured":"Zhou Y, et al. Galectin-9-driven immunosuppressive macrophage population shapes the lymph node metastatic microenvironment. Br J Cancer. 2026;134(1):45\u201359.","journal-title":"Br J Cancer"},{"key":"2585_CR103","doi-asserted-by":"crossref","unstructured":"Engelbrecht E et al. Single-cell transcriptomics of melanoma Sentinel lymph nodes identifies immune cell signatures associated with metastasis. JCI Insight. 2025;10(7).","DOI":"10.1172\/jci.insight.183080"},{"issue":"1","key":"2585_CR104","doi-asserted-by":"publisher","first-page":"10056","DOI":"10.1038\/s41467-025-64981-z","volume":"16","author":"D Eichin","year":"2025","unstructured":"Eichin D, et al. Breast cancer remodels lymphatics in Sentinel lymph nodes. Nat Commun. 2025;16(1):10056.","journal-title":"Nat Commun"},{"issue":"1","key":"2585_CR105","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/s41568-025-00883-y","volume":"26","author":"TG Kang","year":"2026","unstructured":"Kang TG, et al. Epigenetic regulation of T cell exhaustion in cancer. Nat Rev Cancer. 2026;26(1):46\u201361.","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"2585_CR106","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/s41590-021-00940-2","volume":"22","author":"Y Guo","year":"2021","unstructured":"Guo Y, et al. Metabolic reprogramming of terminally exhausted CD8(+) T cells by IL-10 enhances anti-tumor immunity. Nat Immunol. 2021;22(6):746\u201356.","journal-title":"Nat Immunol"},{"issue":"11","key":"2585_CR107","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1158\/2159-8290.CD-21-1714","volume":"12","author":"JA Grout","year":"2022","unstructured":"Grout JA, et al. Spatial positioning and matrix programs of Cancer-Associated fibroblasts promote T-cell exclusion in human lung tumors. Cancer Discov. 2022;12(11):2606\u201325.","journal-title":"Cancer Discov"},{"issue":"1","key":"2585_CR108","doi-asserted-by":"publisher","first-page":"5110","DOI":"10.1038\/s41467-023-40850-5","volume":"14","author":"Z Xiao","year":"2023","unstructured":"Xiao Z, et al. Desmoplastic stroma restricts T cell extravasation and mediates immune exclusion and immunosuppression in solid tumors. Nat Commun. 2023;14(1):5110.","journal-title":"Nat Commun"},{"issue":"7","key":"2585_CR109","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/s43018-024-00775-4","volume":"5","author":"KM Tharp","year":"2024","unstructured":"Tharp KM, et al. Tumor-associated macrophages restrict CD8(+) T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment. Nat Cancer. 2024;5(7):1045\u201362.","journal-title":"Nat Cancer"},{"key":"2585_CR110","doi-asserted-by":"publisher","first-page":"897366","DOI":"10.3389\/fimmu.2022.897366","volume":"13","author":"C Li","year":"2022","unstructured":"Li C, Hua K. Dissecting the Single-Cell transcriptome network of immune environment underlying cervical premalignant Lesion, cervical cancer and metastatic lymph nodes. Front Immunol. 2022;13:897366.","journal-title":"Front Immunol"},{"key":"2585_CR111","doi-asserted-by":"publisher","first-page":"966291","DOI":"10.3389\/fimmu.2022.966291","volume":"13","author":"C Li","year":"2022","unstructured":"Li C, et al. Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis. Front Immunol. 2022;13:966291.","journal-title":"Front Immunol"},{"issue":"1","key":"2585_CR112","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1038\/s41588-024-01998-y","volume":"57","author":"Y Yan","year":"2025","unstructured":"Yan Y, et al. Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer. Nat Genet. 2025;57(1):126\u201339.","journal-title":"Nat Genet"},{"issue":"9","key":"2585_CR113","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1038\/s41568-024-00728-0","volume":"24","author":"JL Teillaud","year":"2024","unstructured":"Teillaud JL, et al. Tertiary lymphoid structures in anticancer immunity. Nat Rev Cancer. 2024;24(9):629\u201346.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"2585_CR114","doi-asserted-by":"publisher","first-page":"4228","DOI":"10.1038\/s41467-025-59341-w","volume":"16","author":"H Li","year":"2025","unstructured":"Li H, et al. Mature tertiary lymphoid structures evoke intra-tumoral T and B cell responses via progenitor exhausted CD4(+) T cells in head and neck cancer. Nat Commun. 2025;16(1):4228.","journal-title":"Nat Commun"},{"issue":"11","key":"2585_CR115","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1016\/j.immuni.2025.09.018","volume":"58","author":"P Cakmak","year":"2025","unstructured":"Cakmak P, et al. Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures. Immunity. 2025;58(11):2847\u2013e28638.","journal-title":"Immunity"},{"issue":"1","key":"2585_CR116","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1186\/s12885-025-14913-3","volume":"25","author":"J Wen","year":"2025","unstructured":"Wen J, et al. Effect of tumor draining lymph nodes in the formation and maturation of tertiary lymphoid structure in patients with lung adenocarcinoma. BMC Cancer. 2025;25(1):1507.","journal-title":"BMC Cancer"},{"issue":"6","key":"2585_CR117","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1007\/s00262-022-03353-8","volume":"72","author":"S Wakasu","year":"2023","unstructured":"Wakasu S, et al. Preventive effect of tertiary lymphoid structures on lymph node metastasis of lung adenocarcinoma. Cancer Immunol Immunother. 2023;72(6):1823\u201334.","journal-title":"Cancer Immunol Immunother"},{"key":"2585_CR118","doi-asserted-by":"crossref","unstructured":"Badillo-Godinez O et al. Brain tumors induce immunoregulatory dendritic cells in draining lymph nodes that can be targeted by OX40 agonist treatment. J Immunother Cancer. 2025;13(5).","DOI":"10.1136\/jitc-2025-011548"},{"issue":"1","key":"2585_CR119","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1038\/s41467-024-45358-0","volume":"15","author":"KF Bol","year":"2024","unstructured":"Bol KF, et al. Adjuvant dendritic cell therapy in stage IIIB\/C melanoma: the MIND-DC randomized phase III trial. Nat Commun. 2024;15(1):1632.","journal-title":"Nat Commun"},{"issue":"25","key":"2585_CR120","doi-asserted-by":"publisher","first-page":"e2417593","DOI":"10.1002\/advs.202417593","volume":"12","author":"D Zeng","year":"2025","unstructured":"Zeng D, et al. Immunotyping the tumor microenvironment reveals molecular heterogeneity for personalized immunotherapy in cancer. Adv Sci (Weinh). 2025;12(25):e2417593.","journal-title":"Adv Sci (Weinh)"},{"issue":"10","key":"2585_CR121","doi-asserted-by":"publisher","first-page":"102416","DOI":"10.1016\/j.xcrm.2025.102416","volume":"6","author":"F Lodi","year":"2025","unstructured":"Lodi F, et al. Decoding tumor heterogeneity: A spatially informed pan-cancer analysis of the tumor microenvironment. Cell Rep Med. 2025;6(10):102416.","journal-title":"Cell Rep Med"},{"issue":"1","key":"2585_CR122","doi-asserted-by":"publisher","first-page":"6142","DOI":"10.1038\/s41467-024-50478-8","volume":"15","author":"W Li","year":"2024","unstructured":"Li W, et al. A single-cell pan-cancer analysis to show the variability of tumor-infiltrating myeloid cells in immune checkpoint Blockade. Nat Commun. 2024;15(1):6142.","journal-title":"Nat Commun"},{"issue":"5","key":"2585_CR123","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/j.cell.2024.01.027","volume":"187","author":"F Petralia","year":"2024","unstructured":"Petralia F, et al. Pan-cancer proteogenomics characterization of tumor immunity. Cell. 2024;187(5):1255\u2013e127727.","journal-title":"Cell"},{"issue":"7","key":"2585_CR124","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1038\/s41568-024-00705-7","volume":"24","author":"AM Holder","year":"2024","unstructured":"Holder AM, et al. Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours. Nat Rev Cancer. 2024;24(7):498\u2013512.","journal-title":"Nat Rev Cancer"},{"key":"2585_CR125","doi-asserted-by":"publisher","first-page":"102257","DOI":"10.1016\/j.ctrv.2021.102257","volume":"99","author":"C Boman","year":"2021","unstructured":"Boman C, et al. Discordance of PD-L1 status between primary and metastatic breast cancer: A systematic review and meta-analysis. Cancer Treat Rev. 2021;99:102257.","journal-title":"Cancer Treat Rev"},{"issue":"1","key":"2585_CR126","doi-asserted-by":"publisher","first-page":"2453825","DOI":"10.1080\/07853890.2025.2453825","volume":"57","author":"Y Xu","year":"2025","unstructured":"Xu Y, et al. Prognostic significance of pathological response and lymph node status in neoadjuvant immunotherapy for potentially resectable non-small cell lung cancer. Ann Med. 2025;57(1):2453825.","journal-title":"Ann Med"},{"key":"2585_CR127","doi-asserted-by":"crossref","unstructured":"Leidner R et al. Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma. J Immunother Cancer. 2021;9(5).","DOI":"10.1136\/jitc-2021-002485"},{"key":"2585_CR128","doi-asserted-by":"crossref","unstructured":"Zhai WY et al. Response of primary tumor and lymph node in non-small cell lung cancer after neoadjuvant immunotherapy: a pooled analysis. J Immunother Cancer. 2022;10(9).","DOI":"10.1136\/jitc-2022-005160"},{"key":"2585_CR129","doi-asserted-by":"crossref","unstructured":"Fransen MF et al. Tumor-draining lymph nodes are pivotal in PD-1\/PD-L1 checkpoint therapy. JCI Insight. 2018;3(23).","DOI":"10.1172\/jci.insight.124507"},{"issue":"1","key":"2585_CR130","doi-asserted-by":"publisher","first-page":"4298","DOI":"10.1038\/s41467-022-31941-w","volume":"13","author":"R Saddawi-Konefka","year":"2022","unstructured":"Saddawi-Konefka R, et al. Lymphatic-preserving treatment sequencing with immune checkpoint Inhibition unleashes cDC1-dependent antitumor immunity in HNSCC. Nat Commun. 2022;13(1):4298.","journal-title":"Nat Commun"},{"issue":"5","key":"2585_CR131","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/j.ccell.2020.09.001","volume":"38","author":"F Dammeijer","year":"2020","unstructured":"Dammeijer F, et al. The PD-1\/PD-L1-Checkpoint restrains T cell immunity in Tumor-Draining lymph nodes. Cancer Cell. 2020;38(5):685\u2013e7008.","journal-title":"Cancer Cell"},{"issue":"1","key":"2585_CR132","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1097\/JS9.0000000000000774","volume":"110","author":"H Deng","year":"2024","unstructured":"Deng H, et al. Impact of lymphadenectomy extent on immunotherapy efficacy in postresectional recurred non-small cell lung cancer: a multi-institutional retrospective cohort study. Int J Surg. 2024;110(1):238\u201352.","journal-title":"Int J Surg"},{"issue":"7","key":"2585_CR133","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1016\/j.trecan.2025.04.008","volume":"11","author":"J von Renesse","year":"2025","unstructured":"von Renesse J, Lin MC, Ho PC. Tumor-draining lymph nodes - friend or foe during immune checkpoint therapy? Trends Cancer. 2025;11(7):676\u201390.","journal-title":"Trends Cancer"},{"issue":"1","key":"2585_CR134","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.trecan.2023.09.006","volume":"10","author":"I Delclaux","year":"2024","unstructured":"Delclaux I, et al. The tumor-draining lymph node as a reservoir for systemic immune surveillance. Trends Cancer. 2024;10(1):28\u201337.","journal-title":"Trends Cancer"},{"issue":"23","key":"2585_CR135","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1056\/NEJMoa1613210","volume":"376","author":"MB Faries","year":"2017","unstructured":"Faries MB, et al. Completion dissection or observation for Sentinel-Node metastasis in melanoma. N Engl J Med. 2017;376(23):2211\u201322.","journal-title":"N Engl J Med"},{"issue":"4","key":"2585_CR136","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1470-2045(13)70035-4","volume":"14","author":"V Galimberti","year":"2013","unstructured":"Galimberti V, et al. Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23\u2009\u2013\u200901): a phase 3 randomised controlled trial. Lancet Oncol. 2013;14(4):297\u2013305.","journal-title":"Lancet Oncol"},{"issue":"18","key":"2585_CR137","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.1200\/JCO.20.03637","volume":"39","author":"Y Hasegawa","year":"2021","unstructured":"Hasegawa Y, et al. Neck dissections based on Sentinel lymph node navigation versus elective neck dissections in early oral cancers: A Randomized, Multicenter, and noninferiority trial. J Clin Oncol. 2021;39(18):2025\u201336.","journal-title":"J Clin Oncol"},{"issue":"1","key":"2585_CR138","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12943-024-02182-w","volume":"24","author":"R Lusby","year":"2025","unstructured":"Lusby R, et al. Pan-cancer drivers of metastasis. Mol Cancer. 2025;24(1):2.","journal-title":"Mol Cancer"},{"issue":"5","key":"2585_CR139","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1007\/s11427-024-2770-x","volume":"68","author":"J Wang","year":"2025","unstructured":"Wang J, et al. Advances and applications in single-cell and Spatial genomics. Sci China Life Sci. 2025;68(5):1226\u201382.","journal-title":"Sci China Life Sci"},{"issue":"5","key":"2585_CR140","doi-asserted-by":"publisher","first-page":"110331","DOI":"10.1016\/j.celrep.2022.110331","volume":"38","author":"J Nagasaki","year":"2022","unstructured":"Nagasaki J, et al. PD-1 Blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes. Cell Rep. 2022;38(5):110331.","journal-title":"Cell Rep"},{"issue":"18","key":"2585_CR141","doi-asserted-by":"publisher","first-page":"e2501269122","DOI":"10.1073\/pnas.2501269122","volume":"122","author":"Y Che","year":"2025","unstructured":"Che Y, et al. Induced B cell receptor diversity predicts PD-1 Blockade immunotherapy response. Proc Natl Acad Sci U S A. 2025;122(18):e2501269122.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"657","key":"2585_CR142","doi-asserted-by":"publisher","first-page":"eabo7604","DOI":"10.1126\/scitranslmed.abo7604","volume":"14","author":"AM D\u2019Alise","year":"2022","unstructured":"D\u2019Alise AM, et al. Adenoviral-based vaccine promotes neoantigen-specific CD8(+) T cell stemness and tumor rejection. Sci Transl Med. 2022;14(657):eabo7604.","journal-title":"Sci Transl Med"},{"issue":"1","key":"2585_CR143","doi-asserted-by":"publisher","first-page":"6578","DOI":"10.1038\/s41467-025-61780-4","volume":"16","author":"R Saddawi-Konefka","year":"2025","unstructured":"Saddawi-Konefka R, et al. The tumor-sentinel lymph node immuno-migratome reveals CCR7(+) dendritic cells drive response to sequenced immunoradiotherapy. Nat Commun. 2025;16(1):6578.","journal-title":"Nat Commun"},{"key":"2585_CR144","doi-asserted-by":"crossref","unstructured":"Huang N, Wang Y, Wei W et al. A systematic review of neoadjuvant targeted therapy in locally advanced thyroid cancer. Holist Integ Oncol. 2022;1(16).","DOI":"10.1007\/s44178-022-00016-7"},{"issue":"6","key":"2585_CR145","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/s43018-025-00990-7","volume":"6","author":"G Awada","year":"2025","unstructured":"Awada G, et al. The rapidly evolving paradigm of neoadjuvant immunotherapy across cancer types. Nat Cancer. 2025;6(6):967\u201387.","journal-title":"Nat Cancer"},{"key":"2585_CR146","doi-asserted-by":"crossref","unstructured":"Han P, Liang F, Song P et al. Neoadjuvant programmed cell death 1 Blockade combined with chemotherapy for locally advanced head and neck squamous cell carcinoma. Holist Integ Oncol. 2024;3(31).","DOI":"10.1007\/s44178-024-00098-5"},{"issue":"2","key":"2585_CR147","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1097\/SLA.0000000000003123","volume":"272","author":"KC Honselmann","year":"2020","unstructured":"Honselmann KC, et al. Timing but not patterns of recurrence is different between Node-negative and Node-positive resected pancreatic cancer. Ann Surg. 2020;272(2):357\u201365.","journal-title":"Ann Surg"},{"issue":"1","key":"2585_CR148","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1186\/s12885-025-14237-2","volume":"25","author":"W Guo","year":"2025","unstructured":"Guo W, et al. Patients with macroscopic lymph node metastasis expect poor prognosis after neoadjuvant chemotherapy in advanced ovarian cancer: a retrospective cohort study based on a single gynecological team. BMC Cancer. 2025;25(1):832.","journal-title":"BMC Cancer"},{"key":"2585_CR149","doi-asserted-by":"publisher","first-page":"1562700","DOI":"10.3389\/fimmu.2025.1562700","volume":"16","author":"X Zhang","year":"2025","unstructured":"Zhang X, et al. BTG2-deficient mast cells remodel the tumor and tumor-draining lymph node microenvironment leading to chemotherapy resistance in breast cancer. Front Immunol. 2025;16:1562700.","journal-title":"Front Immunol"},{"issue":"4","key":"2585_CR150","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.annonc.2023.01.004","volume":"34","author":"JM Versluis","year":"2023","unstructured":"Versluis JM, et al. Survival update of neoadjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma in the opacin and opacin-neo trials. Ann Oncol. 2023;34(4):420\u201330.","journal-title":"Ann Oncol"},{"issue":"9","key":"2585_CR151","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1056\/NEJMoa2211437","volume":"388","author":"SP Patel","year":"2023","unstructured":"Patel SP, et al. Neoadjuvant-Adjuvant or Adjuvant-Only pembrolizumab in advanced melanoma. N Engl J Med. 2023;388(9):813\u201323.","journal-title":"N Engl J Med"},{"issue":"19","key":"2585_CR152","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1056\/NEJMoa2311926","volume":"390","author":"T Cascone","year":"2024","unstructured":"Cascone T, et al. Perioperative nivolumab in resectable lung cancer. N Engl J Med. 2024;390(19):1756\u201369.","journal-title":"N Engl J Med"},{"issue":"1","key":"2585_CR153","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1056\/NEJMoa2415434","volume":"393","author":"R Uppaluri","year":"2025","unstructured":"Uppaluri R, et al. Neoadjuvant and adjuvant pembrolizumab in locally advanced head and neck cancer. N Engl J Med. 2025;393(1):37\u201350.","journal-title":"N Engl J Med"},{"issue":"1","key":"2585_CR154","doi-asserted-by":"publisher","first-page":"9097","DOI":"10.1038\/s41467-024-52977-0","volume":"15","author":"Z Yang","year":"2024","unstructured":"Yang Z, et al. Single-cell sequencing reveals immune features of treatment response to neoadjuvant immunochemotherapy in esophageal squamous cell carcinoma. Nat Commun. 2024;15(1):9097.","journal-title":"Nat Commun"},{"issue":"1","key":"2585_CR155","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s13073-023-01164-9","volume":"15","author":"J Hu","year":"2023","unstructured":"Hu J, et al. Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing. Genome Med. 2023;15(1):14.","journal-title":"Genome Med"},{"issue":"10","key":"2585_CR156","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1002\/cac2.12480","volume":"43","author":"S Ren","year":"2023","unstructured":"Ren S, et al. Intratumoral CD103(+) CD8(+) T cells predict response to neoadjuvant chemoimmunotherapy in advanced head and neck squamous cell carcinoma. Cancer Commun (Lond). 2023;43(10):1143\u201363.","journal-title":"Cancer Commun (Lond)"},{"issue":"8","key":"2585_CR157","doi-asserted-by":"publisher","first-page":"2220","DOI":"10.1097\/JS9.0000000000000489","volume":"109","author":"Y Huang","year":"2023","unstructured":"Huang Y, et al. Neoadjuvant immunochemotherapy for locally advanced resectable oral squamous cell carcinoma: a prospective single-arm trial (Illuminate Trial). Int J Surg. 2023;109(8):2220\u20137.","journal-title":"Int J Surg"},{"issue":"1","key":"2585_CR158","doi-asserted-by":"publisher","first-page":"5378","DOI":"10.1038\/s41467-022-33080-8","volume":"13","author":"WT Ju","year":"2022","unstructured":"Ju WT, et al. A pilot study of neoadjuvant combination of anti-PD-1 camrelizumab and VEGFR2 inhibitor apatinib for locally advanced resectable oral squamous cell carcinoma. Nat Commun. 2022;13(1):5378.","journal-title":"Nat Commun"},{"issue":"5","key":"2585_CR159","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1038\/s41571-025-01003-3","volume":"22","author":"E Boxer","year":"2025","unstructured":"Boxer E, et al. Emerging clinical applications of single-cell RNA sequencing in oncology. Nat Rev Clin Oncol. 2025;22(5):315\u201326.","journal-title":"Nat Rev Clin Oncol"},{"issue":"8","key":"2585_CR160","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1038\/s41588-025-02285-0","volume":"57","author":"KA Klotzer","year":"2025","unstructured":"Klotzer KA, et al. Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas. Nat Genet. 2025;57(8):1922\u201334.","journal-title":"Nat Genet"},{"issue":"8","key":"2585_CR161","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1038\/s41588-025-02236-9","volume":"57","author":"T Zhou","year":"2025","unstructured":"Zhou T, et al. Multi-omic analysis of gallbladder cancer identifies distinct tumor microenvironments associated with disease progression. Nat Genet. 2025;57(8):1935\u201349.","journal-title":"Nat Genet"},{"issue":"7","key":"2585_CR162","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1016\/j.ccell.2025.03.025","volume":"43","author":"X Xing","year":"2025","unstructured":"Xing X, et al. Pan-cancer human brain metastases atlas at single-cell resolution. Cancer Cell. 2025;43(7):1242\u2013e12609.","journal-title":"Cancer Cell"},{"key":"2585_CR163","doi-asserted-by":"crossref","unstructured":"Pitino E et al. STAMP: Single-cell transcriptomics analysis and multimodal profiling through imaging. Cell. 2025.","DOI":"10.1101\/2024.10.03.616013"},{"issue":"6","key":"2585_CR164","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1038\/s41592-024-02586-y","volume":"22","author":"Y Li","year":"2025","unstructured":"Li Y, et al. UDA-seq: universal droplet microfluidics-based combinatorial indexing for massive-scale multimodal single-cell sequencing. Nat Methods. 2025;22(6):1199\u2013212.","journal-title":"Nat Methods"},{"issue":"7","key":"2585_CR165","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1038\/s41588-025-02247-6","volume":"57","author":"H Wu","year":"2025","unstructured":"Wu H, et al. Single-cell Micro-C profiles 3D genome structures at high resolution and characterizes multi-enhancer hubs. Nat Genet. 2025;57(7):1777\u201386.","journal-title":"Nat Genet"},{"issue":"7924","key":"2585_CR166","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/s41586-022-05046-9","volume":"608","author":"W Chen","year":"2022","unstructured":"Chen W, et al. Live-seq enables Temporal transcriptomic recording of single cells. Nature. 2022;608(7924):733\u201340.","journal-title":"Nature"},{"key":"2585_CR167","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.semcancer.2023.07.002","volume":"95","author":"NN Zhong","year":"2023","unstructured":"Zhong NN, et al. Enhancing head and neck tumor management with artificial intelligence: integration and perspectives. Semin Cancer Biol. 2023;95:52\u201374.","journal-title":"Semin Cancer Biol"},{"key":"2585_CR168","doi-asserted-by":"crossref","unstructured":"Fu S et al. Benchmarking single-cell multi-modal data integrations. Nat Methods. 2025.","DOI":"10.1101\/2025.04.01.646578"},{"issue":"31","key":"2585_CR169","doi-asserted-by":"publisher","first-page":"28021","DOI":"10.1021\/acsnano.5c00706","volume":"19","author":"HL Tran","year":"2025","unstructured":"Tran HL, et al. Extracellular vesicles for clinical diagnostics: from bulk measurements to Single-Vesicle analysis. ACS Nano. 2025;19(31):28021\u2013109.","journal-title":"ACS Nano"},{"key":"2585_CR170","doi-asserted-by":"crossref","unstructured":"Chia SB et al. Respiratory viral infections awaken metastatic breast cancer cells in lungs. Nature. 2025.","DOI":"10.1038\/s41586-025-09332-0"},{"issue":"5","key":"2585_CR171","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1038\/s41591-020-0844-1","volume":"26","author":"M Slyper","year":"2020","unstructured":"Slyper M, et al. A single-cell and single-nucleus RNA-Seq toolbox for fresh and frozen human tumors. Nat Med. 2020;26(5):792\u2013802.","journal-title":"Nat Med"}],"container-title":["Molecular Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12943-026-02585-x","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-026-02585-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12943-026-02585-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:06:38Z","timestamp":1772582798000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12943-026-02585-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,2]]},"references-count":171,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["2585"],"URL":"https:\/\/doi.org\/10.1186\/s12943-026-02585-x","relation":{},"ISSN":["1476-4598"],"issn-type":[{"value":"1476-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,2]]},"assertion":[{"value":"31 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"57"}}