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QT2025191, Approval No.: ZJPPHEC 20250 (194), Date: September 1, 2025). Written informed consent was obtained from all participants in the 30-patient cohort contributed by our center prior to their inclusion in the study. The mouse animal studies were approved by the Ethics Committee of the Zhejiang Provincial People's Hospital (Acceptance no. QT2025190, Approval No.: ZJPPHEC 20250 (193), Date: August 26, 2025). All animal experiments were conducted in accordance with protocols approved by the Institutional Animal Care and Use Committee (IACUC).Copies of the aforementioned ethical approval documents are available upon request to the co-corresponding author, Xinye Hu.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors approved the final version of the manuscript for publication.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"200"}}