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This multi-center study was approved by the Institutional Review Board of the Second Affiliated Hospital, Zhejiang University School of Medicine (Approval No. 2023\u2009\u2212\u20091048) as the coordinating center, as well as by the Institutional Review Boards of all participating institutions.Written informed consent was obtained from all participants prior to enrollment in the study. All participants provided voluntary consent for participation and for the use of their clinical data and biological samples for research purposes.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All authors contributed to the writing of the manuscript. All authors approved the final version of the manuscript.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"We gratefully acknowledge Cosmos Wisdom for providing sequencing services and technical support.","order":4,"name":"Ethics","label":"Acknowledgements","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"203"}}