{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:24:05Z","timestamp":1761744245109},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12944-015-0175-2","type":"journal-article","created":{"date-parts":[[2016,1,12]],"date-time":"2016-01-12T00:43:29Z","timestamp":1452559409000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Why high cholesterol levels help hematological malignancies: role of nuclear lipid microdomains"],"prefix":"10.1186","volume":"15","author":[{"given":"Michela","family":"Codini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuela","family":"Cataldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Lazzarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Tasegian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rachele","family":"Ceccarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Floridi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remo","family":"Lazzarini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco Saverio","family":"Ambesi-Impiombato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Curcio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Beccari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Albi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,1,12]]},"reference":[{"key":"175_CR1","doi-asserted-by":"crossref","first-page":"7438","DOI":"10.18632\/oncotarget.3476","volume":"6","author":"H Moon","year":"2015","unstructured":"Moon H, Ruelcke JE, Choi E, Sharpe LJ, Nassar ZD, Bielefeldt-Ohmann H, et al. Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1. Oncotarget. 2015;6:7438\u201353.","journal-title":"Oncotarget"},{"key":"175_CR2","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s10552-015-0557-9","volume":"26","author":"J Hu","year":"2015","unstructured":"Hu J, La Vecchia C, Negri E, de Groh M, Morrison H, Mery L. Macronutrient intake and stomach cancer. Cancer Causes Control. 2015;26:839\u201347.","journal-title":"Cancer Causes Control"},{"key":"175_CR3","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1016\/j.ajpath.2014.03.006","volume":"184","author":"K Pelton","year":"2014","unstructured":"Pelton K, Coticchia CM, Curatolo AS, Schaffner CP, Zurakowski D, Solomon KR, et al. Hypercholesterolemia induces angiogenesis and accelerates growth of breast tumors in vivo. Am J Pathol. 2014;184:2099\u2013110.","journal-title":"Am J Pathol"},{"key":"175_CR4","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ajpath.2010.11.005","volume":"178","author":"G Llaverias","year":"2011","unstructured":"Llaverias G, Danilo C, Mercier I, Daumer K, Capozza F, Williams TM, et al. Role of Cholesterol in the Development and Progression of Breast Cancer. Am J Pathol. 2011;178:402\u201313.","journal-title":"Am J Pathol"},{"key":"175_CR5","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1002\/ijc.24668","volume":"125","author":"H Iso","year":"2009","unstructured":"Iso H, Ikeda A, Inoue M, Sato S, Tsugane S. Serum cholesterol levels in relation to the incidence of cancer: the JPHC study cohorts. Int J Cancer. 2009;125:2679\u201386.","journal-title":"Int J Cancer"},{"key":"175_CR6","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1016\/j.ejca.2010.03.041","volume":"46","author":"L Pugliese","year":"2010","unstructured":"Pugliese L, Bernardini I, Pacifico N, Peverini M, Damaskopoulou E, Cataldi S, et al. Severe hypocholesterolaemia is often neglected in haematological malignancies. Eur J Cancer. 2010;46:1735\u201343.","journal-title":"Eur J Cancer"},{"key":"175_CR7","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1042\/bse0570189","volume":"57","author":"J Shankar","year":"2015","unstructured":"Shankar J, Boscher C, Nabi IR. Caveolin-1, galectin-3 and lipid raft domains in cancer cell signalling. Essays Biochem. 2015;57:189\u2013201.","journal-title":"Essays Biochem"},{"key":"175_CR8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jbior.2014.10.003","volume":"57","author":"F Mollinedo","year":"2015","unstructured":"Mollinedo F, Gajate C. Lipid rafts as major platforms for signaling regulation in cancer. Adv Biol Regul. 2015;57:130\u201346.","journal-title":"Adv Biol Regul"},{"key":"175_CR9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1177\/030089160809400501","volume":"94","author":"D Vizio Di","year":"2008","unstructured":"Di Vizio D, Solomon KR, Freeman MR. Cholesterol and cholesterol-rich membranes in prostate cancer: an update. Tumori. 2008;94:633\u20139.","journal-title":"Tumori"},{"key":"175_CR10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1172\/JCI200519935","volume":"115","author":"L Zhuang","year":"2005","unstructured":"Zhuang L, Kim J, Adam RM, Solomon KR, Freeman MR. Cholesterol targeting alters lipid raft composition and cell survival in prostate. cancer cells and xenografts. J Clin Invest. 2005;115:959\u201368.","journal-title":"J Clin Invest"},{"key":"175_CR11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.7603\/s40681-015-0007-8","volume":"5","author":"CJ Lin","year":"2015","unstructured":"Lin CJ, Lai CK, Kao MC, Wu LT, Lo UG, Lin LC, et al. Impact of cholesterol on disease progression. Biomedicine. 2015;5:7.","journal-title":"Biomedicine"},{"key":"175_CR12","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1091\/mbc.E08-05-0517","volume":"19","author":"G Cascianelli","year":"2008","unstructured":"Cascianelli G, Villani M, Tosti M, Marini F, Bartoccini E, Magni MV, et al. Lipid microdomains in cell nucleus. Mol Biol Cell. 2008;19:5289\u201395.","journal-title":"Mol Biol Cell"},{"key":"175_CR13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4161\/cib.2.1.7376","volume":"2","author":"E Albi","year":"2009","unstructured":"Albi E, Villani M. Nuclear lipid microdomains regulate cell function. Commun Integr Biol. 2009;2:23\u20134.","journal-title":"Commun Integr Biol"},{"issue":"13","key":"175_CR14","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1091\/mbc.E15-04-0229","volume":"26","author":"A Lazzarini","year":"2015","unstructured":"Lazzarini A, Macchiarulo A, Floridi A, Coletti A, Cataldi S, Codini M, et al. Very long chain fatty acid sphingomyelin in nuclear lipid microdomains of hepatocytes and hepatoma cells: can the exchange from c24:0 to c16:0 affect signal proteins and vitamin d receptor? Mol Biol Cell. 2015;26(13):2418\u201325. doi: 10.1091\/mbc.E15-02-0071 .","journal-title":"Mol Biol Cell"},{"key":"175_CR15","doi-asserted-by":"crossref","first-page":"19832","DOI":"10.3390\/ijms151119832","volume":"15","author":"S Cataldi","year":"2014","unstructured":"Cataldi S, Codini M, Cascianelli G, Tringali S, Tringali AR, Lazzarini A, et al. Nuclear lipid microdomain as resting place of dexamethasone to impair cell proliferation. Int J Mol Sci. 2014;15:19832\u201346.","journal-title":"Int J Mol Sci"},{"key":"175_CR16","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","volume":"326","author":"D Thomas","year":"2009","unstructured":"Thomas D, Pollard TD, Cooper JA. Actin, a Central Player in Cell Shape and Movement. Science. 2009;326:1208\u201312.","journal-title":"Science"},{"key":"175_CR17","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/j.biocel.2004.01.024","volume":"36","author":"A Lambrechts","year":"2004","unstructured":"Lambrechts A, Van Troys M, Ampe C. The actin cytoskeleton in normal and pathological cell motility. Int J Biochem Cell Biol. 2004;36:1890\u2013909.","journal-title":"Int J Biochem Cell Biol"},{"key":"175_CR18","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1073\/pnas.1121343109","volume":"109","author":"JG Lohr","year":"2012","unstructured":"Lohr JG, Stojanov P, Lawrence MS, Auclair D, Chapuy B, Sougnez C, et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci. 2012;109:3879\u201384.","journal-title":"Proc Natl Acad Sci"},{"key":"175_CR19","first-page":"167","volume":"65","author":"RJ Bu\u0142dak","year":"2014","unstructured":"Bu\u0142dak RJ, Bu\u0142dak \u0141, Kukla M, Gabriel A, Zwirska-Korczala K. Pol: Significance of selected antioxidant enzymes in cancer cell progression. J Pathol. 2014;65:167\u201375.","journal-title":"J Pathol"},{"key":"175_CR20","first-page":"25","volume":"17","author":"C Diehl","year":"2009","unstructured":"Diehl C, Lipozenci\u0107 J, Ledi\u0107-Drvar D. The basis of topical superoxide dismutase antipruritic activity. Acta Dermatovenerol Croat. 2009;17:25\u201339.","journal-title":"Acta Dermatovenerol Croat"},{"issue":"24","key":"175_CR21","doi-asserted-by":"crossref","first-page":"20578","DOI":"10.18632\/oncotarget.3987","volume":"6","author":"C Lin","year":"2015","unstructured":"Lin C, Zeng H, Lu J, Xie Z, Sun W, Luo C, et al. Acetylation at lysine 71 inactivates superoxide dismutase 1 and sensitizes cancer cells to genotoxic agents. Oncotarget. 2015;6(24):20578\u201391.","journal-title":"Oncotarget"},{"key":"175_CR22","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.freeradbiomed.2005.02.026","volume":"38","author":"SG Rhee","year":"2005","unstructured":"Rhee SG, Chae HZ, Kim K. Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signaling. Free Radic Biol Med. 2005;38:1543\u201352.","journal-title":"Free Radic Biol Med"},{"key":"175_CR23","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3109\/14756366.2011.649267","volume":"28","author":"SS Sadhu","year":"2013","unstructured":"Sadhu SS, Callegari E, Zhao Y, Guan X, Seefeldt T. Evaluation of a dithiocarbamate derivative as an inhibitor of human glutaredoxin-1. J Enzyme Inhib Med Chem. 2013;28:456\u201362.","journal-title":"J Enzyme Inhib Med Chem"},{"key":"175_CR24","doi-asserted-by":"crossref","first-page":"24176","DOI":"10.1074\/jbc.274.34.24176","volume":"274","author":"A Jilani","year":"1999","unstructured":"Jilani A, Ramotar D, Slack C, Ong C, Yang XM, Scherer SW, et al. Molecular cloning of the human gene, PNKP, encoding a polynucleotide kinase 3\u2032-phosphatase and evidence for its role in repair of DNA strand breaks caused by oxidative damage. J Biol Chem. 1999;274:24176\u201386.","journal-title":"J Biol Chem"},{"key":"175_CR25","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.3390\/ijms16022307","volume":"16","author":"M Codini","year":"2015","unstructured":"Codini M, Cataldi S, Ambesi-Impiombato FS, Lazzarini A, Floridi A, Lazzarini R, et al. Gentamicin arrests cancer cell growth: the intriguing involvement of nuclear sphingomyelin metabolism. Int J Mol Sci. 2015;16:2307\u2013019.","journal-title":"Int J Mol Sci"},{"key":"175_CR26","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1091\/mbc.E11-03-0196","volume":"22","author":"E Bartoccini","year":"2011","unstructured":"Bartoccini E, Marini F, Damaskopoulou E, Lazzarini R, Cataldi S, Cascianelli G, et al. Nuclear lipid microdomains regulate nuclear vitamin D3 uptake and influence embryonic hippocampal cell differentiation. Mol Biol Cell. 2011;22:3022\u201331.","journal-title":"Mol Biol Cell"},{"key":"175_CR27","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s13277-014-2766-3","volume":"36","author":"J Chai","year":"2015","unstructured":"Chai J, Wang S, Han D, Dong W, Xie C, Guo H. MicroRNA-455 inhibits proliferation and invasion of colorectal cancer by targeting RAF proto-oncogene serine\/threonine-protein kinase. Tumour Biol. 2015;36:1313\u201313121.","journal-title":"Tumour Biol"},{"key":"175_CR28","first-page":"5579","volume":"9","author":"L Zhang","year":"2015","unstructured":"Zhang L, Kim S, Ding W, Tong Y, Zhang X, Pan M, et al. Arsenic sulfide inhibits cell migration and invasion of gastric cancer in vitro and in vivo. Drug Des Devel Ther. 2015;9:5579\u201390.","journal-title":"Drug Des Devel Ther"},{"key":"175_CR29","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1158\/1055-9965.EPI-07-0160","volume":"16","author":"D Kang","year":"2007","unstructured":"Kang D, Lee KM, Park SK, Berndt SI, Peters U, Reding D, et al. Functional variant of manganese superoxide dismutase (SOD2 V16A) polymorphism is associated with prostate cancer risk in the prostate, lung, colorectal, and ovarian cancer study. Cancer Epidemiol Biomarkers Prev. 2007;16:1581\u20136.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"175_CR30","first-page":"361","volume":"9","author":"AI Fiaschi","year":"2005","unstructured":"Fiaschi AI, Cozzolino A, Ruggiero G, Giorgi G. Glutathione, ascorbic acid and antioxidant enzymes in the tumor tissue and blood of patients with oral squamous cell carcinoma. Eur Rev Med Pharmacol Sci. 2005;9:361\u20137.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"175_CR31","author":"AD Kim","year":"2015","unstructured":"Kim AD, Zhang R, Han X, Kang KA, Piao MJ, Maeng YH, et al. Involvement of glutathione and glutathione metabolizing enzymes in human colorectal cancer cell lines and tissues. Mol Med Rep. 2015. doi: 10.3892\/mmr.2015.3902 .","journal-title":"Mol Med Rep"},{"key":"175_CR32","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.3892\/or.2013.2714","volume":"30","author":"P Ren","year":"2013","unstructured":"Ren P, Ye H, Dai L, Liu M, Liu X, Chai Y, et al. Peroxiredoxin 1 is a tumor-associated antigen in esophageal squamous cell carcinoma. Oncol Rep. 2013;30:2297\u2013303.","journal-title":"Oncol Rep"},{"key":"175_CR33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12032-014-0455-0","volume":"32","author":"F Gong","year":"2015","unstructured":"Gong F, Hou G, Liu H, Zhang M. Peroxiredoxin 1 promotes tumorigenesis through regulating the activity of mTOR\/p70S6K pathway in esophageal squamous cell carcinoma. Med Oncol. 2015;32:455.","journal-title":"Med Oncol"},{"key":"175_CR34","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00428-013-1433-1","volume":"463","author":"AP Demasi","year":"2013","unstructured":"Demasi AP, Martinez EF, Napimoga MH, Freitas LL, Vassallo J, Duarte AS, et al. Expression of peroxiredoxins I and IV in multiple myeloma: association with immunoglobulin accumulation. Virchows Arch. 2013;463:47\u201355.","journal-title":"Virchows Arch"},{"key":"175_CR35","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1007\/s12032-013-0786-2","volume":"31","author":"QK Sun","year":"2014","unstructured":"Sun QK, Zhu JY, Wang W, Lv Y, Zhou HC, Yu JH, et al. Diagnostic and prognostic significance of peroxiredoxin 1 expression in human hepatocellular carcinoma. Med Oncol. 2014;31:786.","journal-title":"Med Oncol"},{"key":"175_CR36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4046\/trd.2013.75.2.59","volume":"75","author":"KE Hwang","year":"2013","unstructured":"Hwang KE, Park C, Seol CH, Hwang YR, Hwang JS, Jung JW, et al. Elevated prx1 provides resistance to docetaxel, but is not associated with predictive significance in lung cancer. Tuberc Respir Dis. 2013;75:59\u201366.","journal-title":"Tuberc Respir Dis"},{"key":"175_CR37","first-page":"624","volume":"2015","author":"G Poschmann","year":"1854","unstructured":"Poschmann G, Grzendowski M, Stefanski A, Bruns E, Meyer HE, St\u00fchler K. Redox proteomics reveal stress responsive proteins linking peroxiredoxin-1 status in glioma to chemosensitivity and oxidative stress. Biochim Biophys Acta. 1854;2015:624\u201331.","journal-title":"Biochim Biophys Acta"},{"key":"175_CR38","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/01635580701365043","volume":"59","author":"SM Tsao","year":"2007","unstructured":"Tsao SM, Yin MC, Liu WH. Oxidant stress and B vitamins status in patients with non-small cell lung cancer. Nutr Cancer. 2007;59:8\u201313.","journal-title":"Nutr Cancer"},{"key":"175_CR39","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1440-1843.2007.01212.x","volume":"13","author":"H Esme","year":"2008","unstructured":"Esme H, Cemek M, Sezer M, Saglam H, Demir A, Melek H, et al. High levels of oxidative stress in patients with advanced lung cancer. Respirology. 2008;13:112\u20136.","journal-title":"Respirology"},{"key":"175_CR40","doi-asserted-by":"crossref","first-page":"7739","DOI":"10.1158\/0008-5472.CAN-09-1805","volume":"69","author":"GK Freschauf","year":"2009","unstructured":"Freschauf GK, Karimi-Busheri F, Ulaczyk-Lesanko A, Mereniuk TR, Ahrens A, Koshy JM, et al. Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase\/phosphatase. Cancer Res. 2009;69:7739\u201346.","journal-title":"Cancer Res"},{"key":"175_CR41","doi-asserted-by":"crossref","first-page":"273103","DOI":"10.1088\/0953-8984\/27\/27\/273103","volume":"27","author":"P Sens","year":"2015","unstructured":"Sens P, Plastino J. Membrane tension and cytoskeleton organization in cell motility. J Phys Condens Matter. 2015;27:273103.","journal-title":"J Phys Condens Matter"},{"key":"175_CR42","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1038\/ncomms8465","volume":"6","author":"FK Huang","year":"2015","unstructured":"Huang FK, Han S, Xing B, Huang J, Liu B, Bordeleau F, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. Nat Commun. 2015;6:7465.","journal-title":"Nat Commun"},{"key":"175_CR43","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.abb.2005.04.004","volume":"438","author":"E Albi","year":"2005","unstructured":"Albi E, La Porta CA, Cataldi S, Magni MV. Nuclear sphingomyelin-synthase and protein kinase C delta in melanoma cells. Arch Biochem Biophys. 2005;438:156\u201361.","journal-title":"Arch Biochem Biophys"},{"key":"175_CR44","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.3390\/ijms14046529","volume":"14","author":"E Albi","year":"2013","unstructured":"Albi E, Lazzarini A, Lazzarini R, Floridi A, Damaskopoulou E, Curcio F, et al. Nuclear lipid microdomain as place of interaction between sphingomyelin and DNA during liver regeneration. Int J Mol Sci. 2013;14:6529\u201341.","journal-title":"Int J Mol Sci"},{"key":"175_CR45","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/187231312130720002","volume":"7","author":"E Damaskopoulou","year":"2013","unstructured":"Damaskopoulou E, Keri G, Jacob V, Lazzarini R, Cataldi S, Orfi L, et al. Protein kinase C\u03b6 drives Sphingomyelin Metabolism in the Nucleus during Cell Proliferation. Curr Chem Biol. 2013;7:131\u20138.","journal-title":"Curr Chem Biol"},{"key":"175_CR46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.abb.2006.11.020","volume":"459","author":"G Rossi","year":"2007","unstructured":"Rossi G, Magni MV, Albi E. Sphingomyelin-cholesterol and double stranded RNA relationship in the intranuclear complex. Arch Biochem Biophys. 2007;459:27\u201332.","journal-title":"Arch Biochem Biophys"},{"key":"175_CR47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/jcp.20448","volume":"206","author":"E Albi","year":"2006","unstructured":"Albi E, Cataldi S, Bartoccini E, Magni MV, Marini F, Mazzoni F, et al. Nuclear sphingomyelin pathway in serum deprivation-induced apoptosis of embryonic hippocampal cells. J Cell Physiol. 2006;206:189\u201395.","journal-title":"J Cell Physiol"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-015-0175-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T12:34:07Z","timestamp":1567514047000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.lipidworld.com\/content\/15\/1\/4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,12]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["175"],"URL":"https:\/\/doi.org\/10.1186\/s12944-015-0175-2","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,12]]},"article-number":"4"}}