{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:38:38Z","timestamp":1790253518073,"version":"4.1.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12944-017-0510-x","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T14:59:57Z","timestamp":1497279597000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress"],"prefix":"10.1186","volume":"16","author":[{"given":"Daniel","family":"Medina-Luna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica Guadalupe","family":"Santamar\u00eda-Olmedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yessica","family":"Zamudio-Cuevas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Mart\u00ednez-Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Fern\u00e1ndez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela Ang\u00e9lica","family":"Mart\u00ednez-Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Clavijo-Cornejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Hern\u00e1ndez-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anell","family":"Olivos-Meza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Enrique","family":"Gomez-Quiroz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Concepci\u00f3n","family":"Guti\u00e9rrez-Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Pineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony M.","family":"Reginato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2575-2589","authenticated-orcid":false,"given":"Alberto","family":"L\u00f3pez-Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"510_CR1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1478-7547-6-21","volume":"6","author":"I Contreras-Hernandez","year":"2008","unstructured":"Contreras-Hernandez I, Mould-Quevedo JF, Torres-Gonzalez R, Goycochea-Robles MV, Pacheco-Dominguez RL, Sanchez-Garcia S. Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inhibitors. Cost Eff Resour Alloc. 2008;6:21.","journal-title":"Cost Eff Resour Alloc"},{"issue":"933","key":"510_CR2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1136\/pmj.79.933.377","volume":"79","author":"I Haq","year":"2003","unstructured":"Haq I, Murphy E, Dacre J. Osteoarthritis. Postgrad Med J. 2003;79(933):377\u201383.","journal-title":"Postgrad Med J"},{"issue":"9","key":"510_CR3","first-page":"646","volume":"81","author":"AD Woolf","year":"2003","unstructured":"Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003;81(9):646\u201356.","journal-title":"Bull World Health Organ"},{"key":"510_CR4","doi-asserted-by":"crossref","first-page":"203901","DOI":"10.1155\/2011\/203901","volume":"2011","author":"J Conde","year":"2011","unstructured":"Conde J, Scotece M, Gomez R, Lopez V, Gomez-Reino JJ, Gualillo O. Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease. Arthritis. 2011;2011:203901.","journal-title":"Arthritis"},{"issue":"1","key":"510_CR5","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1002\/art.1780400120","volume":"40","author":"E Josefsson","year":"1997","unstructured":"Josefsson E, Tarkowski A. Suppression of type II collagen-induced arthritis by the endogenous estrogen metabolite 2-methoxyestradiol. Arthritis Rheum. 1997;40(1):154\u201363.","journal-title":"Arthritis Rheum"},{"key":"510_CR6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/1471-2474-9-132","volume":"9","author":"M Grotle","year":"2008","unstructured":"Grotle M, Hagen KB, Natvig B, Dahl FA, Kvien TK. Obesity and osteoarthritis in knee, hip and\/or hand: an epidemiological study in the general population with 10 years follow-up. BMC Musculoskelet Disord. 2008;9:132.","journal-title":"BMC Musculoskelet Disord"},{"issue":"2","key":"510_CR7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/imj.12763","volume":"46","author":"G Jones","year":"2016","unstructured":"Jones G. What's new in osteoarthritis pathogenesis? Intern Med J. 2016;46(2):229\u201336.","journal-title":"Intern Med J"},{"issue":"2","key":"510_CR8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00001648-199903000-00013","volume":"10","author":"SA Oliveria","year":"1999","unstructured":"Oliveria SA, Felson DT, Cirillo PA, Reed JI, Walker AMM. Body weight, body mass index, and incident symptomatic osteoarthritis of the hand, hip, and knee. Epidemiology. 1999;10(2):161\u20136.","journal-title":"Epidemiology"},{"issue":"2","key":"510_CR9","first-page":"331","volume":"20","author":"DJ Hart","year":"1993","unstructured":"Hart DJ, Spector TD. The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford study. J Rheumatol. 1993;20(2):331\u20135.","journal-title":"J Rheumatol"},{"issue":"11","key":"510_CR10","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1136\/ard.2006.061994","volume":"65","author":"P Pottie","year":"2006","unstructured":"Pottie P, Presle N, Terlain B, Netter P, Mainard D, Berenbaum F. Obesity and osteoarthritis: more complex than predicted! Ann Rheum Dis. 2006;65(11):1403\u20135.","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"510_CR11","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/ard.2010.132399","volume":"70","author":"J Conde","year":"2011","unstructured":"Conde J, Gomez R, Bianco G, Scotece M, Lear P, Dieguez C. Expanding the adipokine network in cartilage: identification and regulation of novel factors in human and murine chondrocytes. Ann Rheum Dis. 2011;70(3):551\u20139.","journal-title":"Ann Rheum Dis"},{"issue":"5091","key":"510_CR12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1126\/science.7678183","volume":"259","author":"GS Hotamisligil","year":"1993","unstructured":"Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science. 1993;259(5091):87\u201391.","journal-title":"Science"},{"key":"510_CR13","doi-asserted-by":"crossref","first-page":"345838","DOI":"10.1155\/2009\/345838","volume":"2009","author":"K Vuolteenaho","year":"2009","unstructured":"Vuolteenaho K, Koskinen A, Kukkonen M, Nieminen R, Paivarinta U, Moilanen T. Leptin enhances synthesis of proinflammatory mediators in human osteoarthritic cartilage--mediator role of NO in leptin-induced PGE2, IL-6, and IL-8 production. Mediat Inflamm. 2009;2009:345838.","journal-title":"Mediat Inflamm"},{"key":"510_CR14","first-page":"1","volume":"27","author":"BR Beecher","year":"2007","unstructured":"Beecher BR, Martin JA, Pedersen DR, Heiner AD, Buckwalter JA. Antioxidants block cyclic loading induced chondrocyte death. Iowa Orthop J. 2007;27:1\u20138.","journal-title":"Iowa Orthop J"},{"issue":"10","key":"510_CR15","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1063-4584(03)00150-X","volume":"11","author":"YE Henrotin","year":"2003","unstructured":"Henrotin YE, Bruckner P, Pujol JP. The role of reactive oxygen species in homeostasis and degradation of cartilage. Osteoarthr Cartil. 2003;11(10):747\u201355.","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"510_CR16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/ard.50.4.219","volume":"50","author":"N Hutadilok","year":"1991","unstructured":"Hutadilok N, Smith MM, Ghosh P. Effects of hydrogen peroxide on the metabolism of human rheumatoid and osteoarthritic synovial fibroblasts in vitro. Ann Rheum Dis. 1991;50(4):219\u201326.","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"510_CR17","doi-asserted-by":"crossref","first-page":"20793","DOI":"10.3390\/ijms141020793","volume":"14","author":"A Villalvilla","year":"2013","unstructured":"Villalvilla A, Gomez R, Largo R, Herrero-Beaumont G. Lipid transport and metabolism in healthy and osteoarthritic cartilage. Int J Mol Sci. 2013;14(10):20793\u2013808.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"510_CR18","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.1021\/pr200331k","volume":"10","author":"V Calamia","year":"2011","unstructured":"Calamia V, Rocha B, Mateos J, Fernandez-Puente P, Ruiz-Romero C, Blanco FJ. Metabolic labeling of chondrocytes for the quantitative analysis of the interleukin-1-beta-mediated modulation of their intracellular and extracellular proteomes. J Proteome Res. 2011;10(8):3701\u201311.","journal-title":"J Proteome Res"},{"issue":"1","key":"510_CR19","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s004180100297","volume":"116","author":"R Koopman","year":"2001","unstructured":"Koopman R, Schaart G, Hesselink MK. Optimisation of oil red O staining permits combination with immunofluorescence and automated quantification of lipids. Histochem Cell Biol. 2001;116(1):63\u20138.","journal-title":"Histochem Cell Biol"},{"issue":"1","key":"510_CR20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11926-007-0016-z","volume":"9","author":"JU Scher","year":"2007","unstructured":"Scher JU, Pillinger MH, Abramson SB. Nitric oxide synthases and osteoarthritis. Curr Rheumatol Rep. 2007;9(1):9\u201315.","journal-title":"Curr Rheumatol Rep"},{"issue":"3","key":"510_CR21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1053\/joca.2001.0497","volume":"10","author":"J Greisberg","year":"2002","unstructured":"Greisberg J, Bliss M, Terek R. The prevalence of nitric oxide in apoptotic chondrocytes of osteoarthritis. Osteoarthr Cartil. 2002;10(3):207\u201311.","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"510_CR22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/cs1010593","volume":"101","author":"I Mazzetti","year":"2001","unstructured":"Mazzetti I, Grigolo B, Pulsatelli L, Dolzani P, Silvestri T, Roseti L. Differential roles of nitric oxide and oxygen radicals in chondrocytes affected by osteoarthritis and rheumatoid arthritis. Clin Sci (Lond). 2001;101(6):593\u20139.","journal-title":"Clin Sci (Lond)"},{"issue":"26","key":"510_CR23","doi-asserted-by":"crossref","first-page":"20069","DOI":"10.1074\/jbc.M907604199","volume":"275","author":"ML Tiku","year":"2000","unstructured":"Tiku ML, Shah R, Allison GT. Evidence linking chondrocyte lipid peroxidation to cartilage matrix protein degradation. Possible role in cartilage aging and the pathogenesis of osteoarthritis. J Biol Chem. 2000;275(26):20069\u201376.","journal-title":"J Biol Chem"},{"issue":"3","key":"510_CR24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/oxfordjournals.jbchem.a021955","volume":"123","author":"K Sasaki","year":"1998","unstructured":"Sasaki K, Hattori T, Fujisawa T, Takahashi K, Inoue H, Takigawa M. Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes. J Biochem. 1998;123(3):431\u20139.","journal-title":"J Biochem"},{"issue":"2","key":"510_CR25","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/art.10056","volume":"46","author":"M Carlo Del","year":"2002","unstructured":"Del Carlo M, Loeser RF. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum. 2002;46(2):394\u2013403.","journal-title":"Arthritis Rheum"},{"key":"510_CR26","doi-asserted-by":"crossref","first-page":"561459","DOI":"10.1155\/2014\/561459","volume":"2014","author":"P Wojdasiewicz","year":"2014","unstructured":"Wojdasiewicz P, Poniatowski LA, Szukiewicz D. The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis. Mediat Inflamm. 2014;2014:561459.","journal-title":"Mediat Inflamm"},{"issue":"11","key":"510_CR27","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","volume":"18","author":"O Stannus","year":"2010","unstructured":"Stannus O, Jones G, Cicuttini F, Parameswaran V, Quinn S, Burgess J. Circulating levels of IL-6 and TNF-alpha are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults. Osteoarthr Cartil. 2010;18(11):1441\u20137.","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"510_CR28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4161\/adna.21061","volume":"3","author":"A Finotti","year":"2012","unstructured":"Finotti A, Borgatti M, Bezzerri V, Nicolis E, Lampronti I, Dechecchi M. Effects of decoy molecules targeting NF-kappaB transcription factors in cystic fibrosis IB3-1 cells: recruitment of NF-kappaB to the IL-8 gene promoter and transcription of the IL-8 gene. Artif DNA PNA XNA. 2012;3(2):97\u2013296.","journal-title":"Artif DNA PNA XNA"},{"issue":"16","key":"510_CR29","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1001\/jama.288.16.2008","volume":"288","author":"G Davi","year":"2002","unstructured":"Davi G, Guagnano MT, Ciabattoni G, Basili S, Falco A, Marinopiccoli M. Platelet activation in obese women: role of inflammation and oxidant stress. JAMA. 2002;288(16):2008\u201314.","journal-title":"JAMA"},{"issue":"6","key":"510_CR30","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.jbspin.2011.12.013","volume":"79","author":"K Chauffier","year":"2012","unstructured":"Chauffier K, Laiguillon MC, Bougault C, Gosset M, Priam S, Salvat C. Induction of the chemokine IL-8\/Kc by the articular cartilage: possible influence on osteoarthritis. Joint Bone Spine. 2012;79(6):604\u20139.","journal-title":"Joint Bone Spine"},{"issue":"7","key":"510_CR31","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/art.38399","volume":"66","author":"O \u00c1lvarez-Garc\u00eda","year":"2014","unstructured":"\u00c1lvarez-Garc\u00eda O, Rogers NH, Smith RG, Lotz MK. Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1. Arthritis Rheumatol. 2014;66(7):1779\u201388.","journal-title":"Arthritis Rheumatol"}],"container-title":["Lipids in Health and Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12944-017-0510-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,10]],"date-time":"2020-10-10T02:05:53Z","timestamp":1602295553000},"score":1,"resource":{"primary":{"URL":"http:\/\/lipidworld.biomedcentral.com\/articles\/10.1186\/s12944-017-0510-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,12]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["510"],"URL":"https:\/\/doi.org\/10.1186\/s12944-017-0510-x","relation":{},"ISSN":["1476-511X"],"issn-type":[{"value":"1476-511X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,12]]},"article-number":"114"}}