{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:28:22Z","timestamp":1791613702410,"version":"4.3.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T00:00:00Z","timestamp":1570752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CORPG3C0171~3C0172, CZRPG3C0053, CORPG3G0021, CORPG3G0022"],"award-info":[{"award-number":["CORPG3C0171~3C0172, CZRPG3C0053, CORPG3G0021, CORPG3G0022"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Lipids Health Dis"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n              <jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Previous studies have reported that the triglyceride to high-density lipoprotein cholesterol (TG\/HDL-C) ratio could be a simple clinical indicator of insulin resistance (IR), but the results indicated that there were heterogeneities between different ethnicities. We aimed to investigate the association between TG\/HDL-C and IR (as measured by homeostasis model assessment of IR [HOMA-IR]), and establish a clinical prediction rule for IR in middle-aged and elderly Taiwanese.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>A total of 398 subjects were recruited, and each subject completed a questionnaire that included personal and medical history data, and underwent anthropometric measurement and blood sampling. IR was defined as HOMA-IR index value \u22652.0. Chi-squared test, independent two-sample t-test, Pearson\u2019s correlation coefficient, and multiple logistic regression were used to evaluate the association between IR and TG\/HDL-C ratio. A receiver operating characteristic (ROC) analysis was conducted to evaluate the ability of the developed clinical prediction rule to correctly discriminate between subjects of IR positive and IR negative groups.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A significant association between IR and TG\/HDL-C ratio was identified with a Pearson\u2019s correlation coefficient of 0.35 (<jats:italic>p<\/jats:italic>-value&lt;\u20090.001). In multiple logistic regression, high BMI (OR\u2009=\u20091.23; 95% C.I. = 1.13\u20131.33), hypertension (OR\u2009=\u20091.90; 95% C.I. = 1.12\u20133.21), diabetes mellitus (OR\u2009=\u20095.44; 95% C.I. = 2.93\u201310.08) and high TG\/HDL ratio (OR\u2009=\u20091.45; 95% C.I. = 1.23\u20131.72) were significantly associated with the risk of elevated HOMA-IR.<\/jats:p>\n                <jats:p>The area under ROC curves for TG\/HDL-C ratio was 0.729 and the optimal threshold value was 2.197 where the corresponding of sensitivity and specificity were 72.4 and 65.1%.<\/jats:p>\n              <\/jats:sec>\n              <jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our findings showed that the elevated TG\/HDL-C ratio was significantly associated with IR and could be used as an indicator of IR among the middle-aged and elderly population in Taiwan. It is clinically available, thus eliminating any additional costs. Future research is warranted to investigate the use of TG\/HDL-C ratio combined with other risk factors for predicting IR under diverse ethnic backgrounds.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12944-019-1123-3","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T14:04:49Z","timestamp":1570802689000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Elevated triglyceride-to-HDL cholesterol ratio is an indicator for insulin resistance in middle-aged and elderly Taiwanese population: a cross-sectional study"],"prefix":"10.1186","volume":"18","author":[{"given":"Wei-Chung","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Chung","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Shiang","family":"Tzeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Sien","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9195-7833","authenticated-orcid":false,"given":"Jau-Yuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"key":"1123_CR1","doi-asserted-by":"publisher","first-page":"R1","DOI":"10.1530\/ERC-12-0324","volume":"20","author":"S Djiogue","year":"2013","unstructured":"Djiogue S, Kamdje AHN, Vecchio L, Kipanyula MJ, Farahna M, Aldebasi Y, Etet PFS. 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