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AIP was calculated using the following equation: AIP\u2009=\u2009Log (triglyceride [mg\/dL] \/ high-density lipoprotein cholesterol [mg\/dL]). AAV patients were divided into two groups according to the AIP cut-off of 0.11. The event of stroke, transient ischemic attack, and cerebral hemorrhage was recorded as CVA, and CAD events consisted of either myocardial infarction and angina pectoris. CVA- and CAD- free survival rate between those with AIP\u2009\u2265\u20090.11 and\u2009&lt;\u20090.11 were compared by the Kaplan-Meier analysis, and Cox hazard analysis was conducted to identify predictors of CVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age of AAV patients were 59.0\u2009years, and 54 (32.3%) patients were male. One-hundred and fifteen (68.9%) patients had AIP\u2009&lt;\u20090.11 and 52 (31.1%) had AIP\u2009\u2265\u20090.11. The mean Birmingham vasculitis activity score in AAV patients with AIP\u2009&lt;\u20090.11 was lower than that seen in patients with AIP\u2009\u2265\u20090.11 (12.0 vs. 14.0,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.041). AAV patients had a significantly higher AIP compared to controls (mean\u2009\u2212\u20090.01 vs. -0.10,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). During follow-up, the occurrence of CVA and CAD was observed in 16 (9.6%) and 14 (8.4%) patients, respectively. In Kaplan-Meier analysis, AAV patients with AIP\u2009\u2265\u20090.11 had significantly lower CVA-free survival rates than in those with AIP\u2009&lt;\u20090.11 (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.027), whereas there was no difference in CAD according to AIP (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.390). Multivariable Cox analysis indicated that AIP\u2009\u2265\u20090.11 at diagnosis was the sole predictor of CVA (Hazard ratio 3.392, 95% confidence interval 1.076, 10.696,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>AIP is significantly higher in AAV patients than in healthy controls, and AIP\u2009\u2265\u20090.11 at diagnosis is a significant predictor of CVA during follow-up. Stringent surveillance should be provided in AAV patients with AIP\u2009\u2265\u20090.11 regarding the occurrence of CVA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>Retrospectively registered (4\u20132017-0673).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12944-020-01360-1","type":"journal-article","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T13:03:12Z","timestamp":1597410192000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Atherogenic index of plasma predicts cerebrovascular accident occurrence in antineutrophil cytoplasmic antibody-associated vasculitis"],"prefix":"10.1186","volume":"19","author":[{"given":"Sung Soo","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy Eunju","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Yoon","family":"Pyo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason Jungsik","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Beom","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8038-3341","authenticated-orcid":false,"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,14]]},"reference":[{"issue":"1","key":"1360_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","volume":"65","author":"JC Jennette","year":"2013","unstructured":"Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised international Chapel Hill consensus conference nomenclature of vasculitides. 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The need for patients\u2019 written informed consent was waived, as this was a retrospective study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"184"}}