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The present study aimed to assess the possible associations between the lipid profile and atherogenic indexes and the severity of HS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This case-control study enrolled 78 HS patients and 62 healthy controls. Classic lipid profile and lipoprotein ratios, including the atherogenic index of plasma (AIP), were evaluated. The severity of HS was measured by the HS Physician Global Assessment (PGA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      HS-patients had lower serum total cholesterol and HDL-C levels and higher AIP than the control group. AIP was positively correlated to BMI, waist circumference, systolic and diastolic blood pressure, LDL-C, triglycerides, non-HDL-C, ApoB, HOMA, and hs-CRP and negatively to HDL-C and ApoA1. For the overall lipid profile, only AIP was related to a more severe HS (PGA\u2009\u2265\u20093) after controlling for age, sex, BMI, insulin resistance (IR), active smoking, and statin use (\n                      <jats:italic>r\u2009=<\/jats:italic>\n                      \u00a00.268;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.023). Multiple logistic regression adjusted for age, sex, BMI, IR, smoking status and statin use, showed that AIP\u2009\u2265\u20090.11 was significantly associated with the severity of HS (OR, 4.38; CI 95%, 1.09\u201317.50;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, these results showed that AIP is significantly and independently associated with HS severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12944-020-01377-6","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T12:05:05Z","timestamp":1598702705000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Atherogenic index of plasma is associated with the severity of Hidradenitis Suppurativa: a case-control study"],"prefix":"10.1186","volume":"19","author":[{"given":"Jos\u00e9 L.","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Balde\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana E.","family":"L\u00f3pez-Sundh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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Written informed consent was obtained from each patient included in the study.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"Dr. Hernandez reports research grants from Amgen, and fees for participation in company-sponsored speaker\u2019s bureau from Amgen, MSD, and Bayer. Dr. R. Blanco received grants\/research supports from Abbvie, MSD, and Roche, and had consultation fees\/participation in company-sponsored speaker\u2019s bureau from Abbvie, Pfizer, Roche, Bristol Myers, Janssen, and MSD. Dr. Gonz\u00e1lez-L\u00f3pez had consultation fees\/participation in company-sponsored speaker\u2019s bureau from Abbvie. The rest of the authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"200"}}