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Inclusion criteria included \u22651 serum TG value during the overlapping study period of the EMR and claims databases, \u22651 claim in the 12-month baseline period, and\u2009\u2265\u20091 claim in the 12\u2009months post index. All TG measurements were assigned to the highest category reached: &lt;\u20092.26, \u22652.26 to \u22645.65, &gt;\u20095.65 to \u22649.94, &gt;\u20099.94, and\u2009&gt;\u200911.29\u2009mmol\/L (&lt;\u2009200, \u2265200 to \u2264500, &gt;\u2009500 to \u2264880, &gt;\u2009880, and\u2009&gt;\u20091000\u2009mg\/dL, respectively). The outcome of interest was AP, defined as a hospitalization event with AP as the principal diagnosis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 7,119,195 patients met the inclusion\/exclusion criteria, of whom 4158 (0.058%) had \u22651 AP events in the prior 12\u2009months. Most patients (83%) had TGs &lt;\u20092.26\u2009mmol\/L (&lt;\u2009200\u2009mg\/dL), while &lt;\u20091% had TGs &gt;\u20099.94\u2009mmol\/L (&gt;\u2009880\u2009mg\/dL). Overall, the IR of AP was low (0.08%; 95% confidence internal [CI], 0.08\u20130.08%), but increased with increasing TGs (0.08% in TGs &lt;\u20092.26\u2009mmol\/L [&lt;\u2009200\u2009mg\/dL] to 1.21% in TGs &gt;\u200911.29\u2009mmol\/L [&gt;\u20091000\u2009mg\/dL]). In patients with a prior history of AP, the IR of AP increased dramatically; patients with \u22652 AP events at baseline had an IR of 29.98% (95% CI, 25.1\u201334.9%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The risk of AP increases with increasing TG strata; however, the risk increases dramatically among patients with a recent history of AP.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12944-021-01488-8","type":"journal-article","created":{"date-parts":[[2021,7,18]],"date-time":"2021-07-18T06:02:51Z","timestamp":1626588171000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["The association of triglyceride levels with the incidence of initial and recurrent acute pancreatitis"],"prefix":"10.1186","volume":"20","author":[{"given":"Robert J.","family":"Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhen","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish P.","family":"Ponda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Rosenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,18]]},"reference":[{"issue":"4","key":"1488_CR1","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1001\/jama.2020.20317","volume":"325","author":"MA Mederos","year":"2021","unstructured":"Mederos MA, Reber HA, Girgis MD. 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J. Sanchez, W. Ge, W. Wei, and M. Ponda are employees of and stockholders in Regeneron Pharmaceuticals, Inc. R. S. Rosenson has received research grants through his institution from Amgen, Novartis, and Regeneron Pharmaceuticals, Inc.; serves on advisory boards for Amgen, Amyrt, C5, CVS Caremark, Novartis, and 89 Bio; is a speaker (non-promotional) for Amgen, Kowa, and Regeneron; receives royalties from Wolters Kluwer (UpToDate); and has stock ownership in MediMergent, LLC.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"72"}}