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The current study purposed to investigate how the\n                      <jats:italic>APOE<\/jats:italic>\n                      gene SNPs (rs429358 and rs7412) and lipid profile are associated with the risk for AF among the Hakka population in southern China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Finally, 1367 patients were enrolled in this study, including 706 participants with AF (41\u2009~\u200998 years old, 58.64\u2009% male) and 661 non-AF subjects (28\u2009~\u200995 years old, 59.46\u2009% male). The collected data included baseline characteristics, medical history, laboratory tests and echocardiography parameters. A general linear model (two-way analysis of variance (ANOVA)) and Tukey post-hoc tests were applied to identify an\n                      <jats:italic>APOE<\/jats:italic>\n                      allele, AF group, and interaction effect on lipid profiles. Logistic regression analysis was performed to identify risk factors for AF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      For AF group, the most common genotype was E3\/E3 (53.82\u2009%), followed by E3\/E4 (28.19\u2009%), E2\/E3 (13.60\u2009%), E4\/E4 (1.98\u2009%), E2\/E4 (1.84\u2009%) and E2\/E2 (0.57\u2009%). The two-way ANOVA followed by the Tukey procedure showed the following: the lipid levels depended significantly on AF and\n                      <jats:italic>APOE<\/jats:italic>\n                      allele groups for TG, TC, LDL-C and Apo-B (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), and statistically significant interactions between AF and\n                      <jats:italic>APOE<\/jats:italic>\n                      allele were observed in the above 4 variables (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.05). Multivariate regression analysis indicated that age\u2009\u2265\u200965years (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001), high diastolic blood pressure (DBP\u2009\u2265\u200990mm Hg,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.018), a high levels of total cholesterol (TC\u2009\u2265\u20095.2mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001) and triglyceride (TG\u2009\u2265\u20091.7mmol\/L,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.028), but not the two SNPs of the\n                      <jats:italic>APOE<\/jats:italic>\n                      gene (rs7412 and rs429358) (OR 1.079,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.683), were significant independent risk factors for AF in the study population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The principal findings of this study showed that individuals at high risk for AF were those over 65 years of age, higher DBP as well as high levels of TC and TG among the southern China Hakka population. The levels of TG, TC, LDL-C and Apo-B depended significantly on AF and\n                      <jats:italic>APOE<\/jats:italic>\n                      allele groups, and statistically significant interactions between AF and\n                      <jats:italic>APOE<\/jats:italic>\n                      allele were observed in the above 4 variables, although the\n                      <jats:italic>APOE<\/jats:italic>\n                      gene SNPs (rs429358 and rs7412) were no significant risk for AF incidence. Further investigation is needed to elucidate whether other SNPs of the\n                      <jats:italic>APOE<\/jats:italic>\n                      gene have a bearing on AF incidents.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12944-021-01551-4","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T12:03:23Z","timestamp":1632917003000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association between the APOE gene polymorphism and lipid profile and the risk of atrial fibrillation"],"prefix":"10.1186","volume":"20","author":[{"given":"Xunwei","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoting","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3200-3105","authenticated-orcid":false,"given":"Zhixiong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,9,29]]},"reference":[{"issue":"3","key":"1551_CR1","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.chest.2018.09.011","volume":"155","author":"YG Li","year":"2019","unstructured":"Li YG, Pastori D, Farcomeni A, Yang PS, Jang E, Joung B, et al. 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